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Pharmacokinetics Questions and Answers


  • What 4 processes of pharmacokinetics determines magnitude & duration of drug effects?
    What 4 processes of pharmacokinetics determines magnitude & duration of drug effects?
    Absorption, distribution, metabolism, elimination/excretion
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  • What type of drug will pass through stomach walls in the most effective way?  
    What type of drug will pass through stomach walls in the most effective way?  
    1. AcidicIn the acidic environment of the stomach, an acidic drug becomes uncharged and lipid-soluble, thereby able to cross the stomach walls whose cell membranes are phospholipid.
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  • What is cirrhosis of the liver?
    What is cirrhosis of the liver?
    A
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  • What does renal disease cause?
    What does renal disease cause?
    Decrease in clearance of drugs eliminated by the kidney
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  • Is the given definition of bioavailability true or false? Bioavailability is known as the extent to which a drug reaches the systemic circulation (% of drug administered that reaches the...
    Is the given definition of bioavailability true or false? Bioavailability is known as the extent to which a drug reaches the systemic circulation (% of drug administered that reaches the...
    1. TrueAUC = area under the curve... see pg 9 for graph
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  • Which of the following are true?
    Which of the following are true?
    1. Pharmacokinetics relates dosage regimen and plasma concentration.2. Pharmacodynamics relates plasma concentration and the effect.
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  • Which is true regarding drugs with a higher partition coefficient?
    Which is true regarding drugs with a higher partition coefficient?
    Are better orally absorbed May be less likely to partition out of the bilayer again Are retained in the body for longer Are often extensively metabolised
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  • Which does the term pharmacokinetics not include?
    Which does the term pharmacokinetics not include?
    Clinical response to a drug ie; toxicity & efficacy
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  • Which of the following are true regarding tylenol use in alcoholics?
    Which of the following are true regarding tylenol use in alcoholics?
    Alcoholics have overexpression of 2E1. In non-drinkers APAP is metabolized by Phase II. NAPQI is a very reactive intermediate that covalently binds to proteins in the liver.
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  • Which is true regarding the elderly?
    Which is true regarding the elderly?
    Absorption is generally delayed Gastric emptying rate decreases Intestinal blood flow AND intestinal surface area decreases Phase II conjugation stays the same, but Phase I decreases Total body water and muscle mass decrease, while fat increases
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  • Which of the following can be absorbed dermally?
    Which of the following can be absorbed dermally?
    Nicotine Testosterone Oestrogen Fentanyl (a strong opiate to control pain in the terminally ill) Nitroglycerine (releases NO to treat angina) Lidocaine (local anesthetic which blocks Na+ channels) Clonidine (high blood pressure treatment)
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  • Which of the following are parenteral methods of administration (the others being enteral)?
    Which of the following are parenteral methods of administration (the others being enteral)?
    Subcutaneous Intramuscular Intravenous IntrathecalEnteral- via the gastrointestinal tract Sublingual- under tongue Buccal- under cheek Rectal- where someone is vomiting, where a compound is volatile in the stomach (e.g. penicillin), less likely to be broken down, can be absorbed easily Parenteral- Administered in some way other than by the gastrointestinal tract Subcutaneous- Fatty layer under skin Intramuscular Intravenous Intrathecal- Though membranes in the spinal olumn
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