Regional Slam On Monthly Inputs-may'14

Explanation
In the study conducted by Sechter et al, the drug AMISULPHRIDE was compared with OLANZEPINE, RISPIRIDONE, HALOPERIDOL, and NOTA. The correct answer, RISPIRIDONE, suggests that the study specifically compared the effectiveness or other aspects of AMISULPHRIDE with RISPIRIDONE. The comparison may have been based on factors such as efficacy, side effects, or other relevant outcomes.

Explanation
Phenytoin is a medication that is known to cross the blood-brain barrier (BBB). The blood-brain barrier is a protective barrier in the brain that prevents certain substances from entering the brain tissue. However, some medications, like phenytoin, are able to cross this barrier and reach the brain. This is important for phenytoin because it is commonly used as an anticonvulsant medication to treat seizures, and it needs to reach the brain in order to be effective. Therefore, the statement that phenytoin crosses the BBB is true.

Explanation
AMISULPHRIDE cannot be given to children below 18 years of age.

Explanation
The correct answer is "wet granulation to direct compression." This means that the process in PACITANE has changed from using wet granulation to using direct compression. Wet granulation is a process where the active pharmaceutical ingredient and excipients are mixed with a liquid binder to form granules, which are then dried and compressed into tablets. Direct compression, on the other hand, involves directly compressing the blend of active ingredient and excipients into tablets without the need for wet granulation. This change in process may have been implemented to improve efficiency, reduce production time, or enhance the stability or bioavailability of the drug.

Explanation
The correct answer is 100mg/2ml. This means that each 2ml of DILANTIN injection contains 100mg of PHENYTOIN.

Explanation
The clinical trial conducted by Clayton et al. lasted for 12 weeks. This duration was likely chosen to allow for a sufficient amount of time to observe and evaluate the effects of the treatment or intervention being tested. A longer trial period can provide more accurate and reliable data regarding the safety and efficacy of the treatment, as it allows for a better understanding of any potential long-term effects or benefits. Additionally, a 12-week trial duration may also be necessary to assess any potential side effects or adverse reactions that may occur over an extended period of time.

Explanation
The response to DILANTIN injection will be noted within 20 minutes. This means that after administering the injection, the effects or changes resulting from the medication will start to become apparent within a relatively short period of time, specifically within 20 minutes.

Explanation
Vitamin B12 corrects the deficiencies caused due to METFORMIN. Metformin is a medication commonly used to treat type 2 diabetes, but it can lead to a deficiency in vitamin B12. Vitamin B12 is important for the proper functioning of the nervous system and the production of red blood cells. Therefore, taking vitamin B12 supplements can help correct the deficiencies caused by metformin and ensure that the body has enough of this essential vitamin.

Explanation
The statement is false because it states that the disintegration time has been increased from 10-15 min to 1 min in the case of NEW PACITANE. However, if the disintegration time has been increased, it would mean that it takes longer for the medication to disintegrate, not shorter. Therefore, the correct answer is false.

Explanation
The rapidly disintegrating PACITANE TABLETS have the advantage of allowing dissolution in the oral cavity without water. This means that patients can take the medication easily and conveniently, even without access to water. These tablets also have the advantage of smooth esophageal movement and less retention, which means that they are less likely to cause discomfort or get stuck in the esophagus. Additionally, these tablets are suitable for paranoid patients of Schizophrenia, indicating that they are specifically designed to meet the needs of this particular patient population.

Explanation
The statement "Patients with mood disorders are more responsive to pain" is false. Research has shown that individuals with mood disorders, such as depression or anxiety, may actually experience a decreased sensitivity to pain. This could be due to alterations in the brain's pain processing pathways or the presence of certain neurotransmitters that can dampen pain signals. Therefore, it is incorrect to say that patients with mood disorders are more responsive to pain.

Explanation
A film-coated tablet refers to a tablet that has a thin layer of a polymeric material applied to its surface. This coating helps to protect the tablet from moisture, light, and air, as well as to improve the tablet's appearance and make it easier to swallow. Therefore, LEVEFREE being a film-coated tablet means that it has a thin layer of a polymeric material applied to its surface.

Explanation
PACITANE is not recommended in patients with TD without concomitant Parkinson's disease.

Explanation
The maximum dose of AMISANT administered once daily at an oral dose is 300mg.

Explanation
The loading dose of DILANTIN injection in case of status epilepticus is 10-15mg/kg. This means that for every kilogram of the patient's body weight, a dose of 10-15mg of DILANTIN should be administered. This loading dose is necessary to quickly reach therapeutic levels of the medication in the bloodstream in order to control the seizures associated with status epilepticus.

Explanation
The initial dose of DAXID (sertraline) for depression and OCD is 50mg. This dose is commonly prescribed as it is effective for most patients and has a lower risk of side effects compared to higher doses. Starting with a lower dose allows for monitoring of the patient's response and adjustment of the dosage if necessary.

Explanation
Co-occurring diabetes and alcohol abuse can indeed complicate neuropathy. Diabetes can cause damage to the nerves, leading to neuropathy, and alcohol abuse can further worsen this condition. Alcohol can have toxic effects on the nerves and can also impair the body's ability to regulate blood sugar levels, which can further exacerbate neuropathy in individuals with diabetes. Therefore, it is true that the co-occurrence of diabetes and alcohol abuse can complicate neuropathy.

Explanation
The correct answer is 13% & 30%. This means that the new PACITANE has a 13% reduction in size and a 30% reduction in weight compared to its previous version.

Explanation
AMISANT cannot be administered to patients below 18 years of age.