C-Reactive Protein

1. Synthesis of CRP by liver is influenced by a component/factor that released by macrophages.

True

False

The synthesis of CRP (C-reactive protein) by the liver is indeed influenced by a component or factor that is released by macrophages. Macrophages are immune cells that play a crucial role in the inflammatory response. When there is an infection or tissue damage, macrophages release certain signaling molecules, such as interleukin-6 (IL-6), which can stimulate the liver to produce CRP. CRP is an acute-phase protein that is produced in response to inflammation, and its levels can be used as a marker for various diseases and conditions. Therefore, the statement is true.

Explanation

The synthesis of CRP (C-reactive protein) by the liver is indeed influenced by a component or factor that is released by macrophages. Macrophages are immune cells that play a crucial role in the inflammatory response. When there is an infection or tissue damage, macrophages release certain signaling molecules, such as interleukin-6 (IL-6), which can stimulate the liver to produce CRP. CRP is an acute-phase protein that is produced in response to inflammation, and its levels can be used as a marker for various diseases and conditions. Therefore, the statement is true.

2. CRP is present in healthy human blood.

True

False

CRP (C-reactive protein) is indeed present in healthy human blood. It is an acute-phase protein that is produced by the liver in response to inflammation or infection. The levels of CRP in the blood can increase significantly during acute inflammatory conditions, making it a useful biomarker for diagnosing and monitoring various diseases. Therefore, the statement "CRP is present in healthy human blood" is correct.

Explanation

CRP (C-reactive protein) is indeed present in healthy human blood. It is an acute-phase protein that is produced by the liver in response to inflammation or infection. The levels of CRP in the blood can increase significantly during acute inflammatory conditions, making it a useful biomarker for diagnosing and monitoring various diseases. Therefore, the statement "CRP is present in healthy human blood" is correct.

3. CRP can be used for these purposes

Screening and monitoring for organic disease (ie. affecting physiology or bodily organ)

Assessment of the activity of inflammatory disease

Used post-operatively to detect wound infections

Management of neonatal septicemia and meningitis or effectiveness of the treatment

All the above

CRP, or C-reactive protein, can be used for screening and monitoring organic diseases that affect the physiology or bodily organs. It can also be used to assess the activity of inflammatory diseases. Additionally, CRP can be used post-operatively to detect wound infections. It is also helpful in the management of neonatal septicemia and meningitis, as well as determining the effectiveness of the treatment. Therefore, all of the above options are correct uses of CRP.

Explanation

CRP, or C-reactive protein, can be used for screening and monitoring organic diseases that affect the physiology or bodily organs. It can also be used to assess the activity of inflammatory diseases. Additionally, CRP can be used post-operatively to detect wound infections. It is also helpful in the management of neonatal septicemia and meningitis, as well as determining the effectiveness of the treatment. Therefore, all of the above options are correct uses of CRP.

4. The method used by Beckman Coulter LX 20 to measure CRP is

Particle-enchanced immunoturbidimetry (IT) or nephelometry (IN)

Immunofluorescence

Immunochemiluminescene

Radial immunodiffusion (RID)

The Beckman Coulter LX 20 uses particle-enhanced immunoturbidimetry (IT) or nephelometry (IN) to measure CRP. This method involves measuring the amount of light scattered by particles in a sample to determine the concentration of CRP. This technique is commonly used in clinical laboratories for its accuracy and reliability in quantifying CRP levels. Immunofluorescence, immunochemiluminescence, and radial immunodiffusion are other methods used in laboratory testing, but they are not the specific methods employed by the Beckman Coulter LX 20 for CRP measurement.

Explanation

The Beckman Coulter LX 20 uses particle-enhanced immunoturbidimetry (IT) or nephelometry (IN) to measure CRP. This method involves measuring the amount of light scattered by particles in a sample to determine the concentration of CRP. This technique is commonly used in clinical laboratories for its accuracy and reliability in quantifying CRP levels. Immunofluorescence, immunochemiluminescence, and radial immunodiffusion are other methods used in laboratory testing, but they are not the specific methods employed by the Beckman Coulter LX 20 for CRP measurement.

5. This sample condition will interfere with the CRP measurement by Beckman Coulter LX 20

Haemolysed

Lipaemic

Icteric

High packed cell volume

Lipaemia refers to the presence of excess lipids or fats in the blood, which can interfere with the measurement of certain substances, including CRP (C-reactive protein). Beckman Coulter LX 20 is a type of laboratory equipment used for measuring various parameters in blood samples. Lipaemic samples can cause inaccuracies in the measurement of CRP, potentially leading to false results. Therefore, the given answer suggests that lipaemia is the sample condition that will interfere with the CRP measurement by Beckman Coulter LX 20.

Explanation

Lipaemia refers to the presence of excess lipids or fats in the blood, which can interfere with the measurement of certain substances, including CRP (C-reactive protein). Beckman Coulter LX 20 is a type of laboratory equipment used for measuring various parameters in blood samples. Lipaemic samples can cause inaccuracies in the measurement of CRP, potentially leading to false results. Therefore, the given answer suggests that lipaemia is the sample condition that will interfere with the CRP measurement by Beckman Coulter LX 20.

C-reactive Protein