Block 9 Path Cellular Injury
- 1.A pathologist notes the following findings after light microscopic examination of a section of liver from a chronic alcoholic. Which of the following is an example of a reversible injury?
- A.
Pyknosis
- B.
Cytoplasmic vacuoles
- C.
Rupture of cell membrane
- D.
Karyolysis
- E.
Karyorrhexis
- 2.You are asked to review an electron micrograph of a section of liver from a chronic alcoholic Which of the following is an example of an irreversible injury?
- A.
Cellular edema
- B.
Chromatin clumping
- C.
Cytoplasmic inclusions
- D.
Mitochondrial swelling
- E.
Rupture of cell membrane
- 3.A patient is admitted with severe substernal chest pain of 4 hours duration. Lab tests reveal increased level of the serum creatine kinase. This is most likely due to:
- A.
Mitochondrial swelling
- B.
Nuclear lysis
- C.
Damage of plasma membranes
- D.
Increased endoplasmic reticulum
- E.
Increased golgi activity
- 4.You are asked to review a liver biopsy from a patient with history of alcohol abuse. Which of the following pathologic changes will most likely lead to death of hepatocytes and liver cirrhosis?
- A.
Fatty change in liver cells
- B.
Hydropic change of hepatocytes
- C.
Karyolysis in myocardial cells
- D.
Glycogen deposition in hepatocyte nuclei
- 5.A pathologist notes that a biopsy from the lung of living patients shows the morphologic changes indicative of irreversible injury and cell death. Which of the following is most likely responsible for cell death in a living body?
- A.
Cytolysis
- B.
Necrosis
- C.
Putrefaction
- D.
Autolysis
- E.
Somatic death
- 6.You are asked to participate in a research project on myocardial infarctions in a rat model. Which of the following occurs in ischemic cell injury?
- A.
Efflux of K+ and Na+
- B.
Influx of K+ and Ca++
- C.
Influx of K+ and H2O
- D.
Influx of Na+ and Ca++
- E.
Influx of Na+ and K+
- 7.Cell death causes by autolysis is produced by
- A.
Antibodies
- B.
Endogenous enzymes
- C.
Phagocytic leukocytes
- D.
Bacterial enzymes
- E.
Anoxia
- 8.A 10-year-old black man with a known history of sickle cell disease presents to the emergency department complaining of left upper quadrant pain suggestive of a splenic infarct. Microscopic examination of the spleen would most likely reveal
- A.
Caseous necrosis
- B.
Coagulative necrosis
- C.
Fibrinoid necrosis
- D.
Gangrenous necrosis
- E.
Liquefactive necrosis
- 9.A pathologist notes cloudy swelling, hydropic change and fatty change in the liver of a patient with a history of alcohol abuse. These morphological changes are all examples of
- A.
Early neoplastic change
- B.
Hyaline change
- C.
Patterns of cell death
- D.
Postmortem artefact
- E.
Reversible cell injury
- 10.•Which of the following is an example of an agent capable of producing a toxic metabolite and indirect chemical injury?
- A.
Alcohol
- B.
Aspirin
- C.
Carbon monoxide
- D.
Mercury poisoning
- E.
Cyanide
- 11.A circumscribed mass of light yellow crumbly to pasty material associated microscopically with a macrophage response is characteristic of
- A.
Caseous necrosis
- B.
Coagulative necrosis
- C.
Fibrinoid necrosis
- D.
Gangrenous necrosis
- 12.A well-demarcated lesion with increased cytoplasmic eosinophilia, karyolysis, and intact tissue architecture is characteristic of
- A.
Caseous necrosis
- B.
Enzymatic fat necrosis
- C.
Coagulative necrosis
- D.
Cloudy swelling
- E.
Liquefactive necrosis
- 13.The pattern of cell death that is characterized by conversion of a single cell to an acidophilic body, usually with loss of the nucleus but with preservation of its shape to permit recognition of cell boundaries is termed
- A.
Apoptosis
- B.
Caseous necrosis
- C.
Fibrinoid necrosis
- D.
Liquefactive necrosis
- 14.A 65 year old man presents with angina and dyspnea. He has a family history of hypercholesterolemia. Unfortunately despite thrombolytic therapy he dies. What would you expect to see on light microscopic examination of cardiac tissue?
- A.
Caseous necrosis
- B.
Enzymatic fat necrosis
- C.
Liquefactive necrosis
- D.
Coagulative necrosis
- 15.Laproscopic examination of the abdomen was performed on a 50 year old chronic alcoholic man. The surgeon noted digestion of tissue with soap formation and calcification. Which of the following is this most likely characteristic of?
- A.
Coagulative necrosis
- B.
Caseous necrosis
- C.
Enzymatic fat necrosis
- D.
Liquefactive necrosi
- 16.The action of putrefactive bacteria on necrotic tissue results in
- A.
Coagulation
- B.
Infarction
- C.
Gangrene
- D.
Embolism
- E.
Caseation
- 17.A well-demarcated area of myocardium appears paler than surrounding tissue and microscopically consists of eosinophilic muscle fibers with only a few karyorrhectic and pyknotic nuclei remaining. Many polys are seen, especially at the margin of this area. The age of the myocardial infarct is most likely
- A.
2 minutes
- B.
2 hours
- C.
2 days
- D.
2 weeks
- E.
2 months
- 18.You are asked to write a microscopic description of the coagulative necrosis that was noted in the heart of a patient who died of a heart attack because of cocaine abuse. Which of the following best described coagulative necrosis?
- A.
Eosinophilic cytoplasm with cell outlines preserved
- B.
Granular, friable mass of material devoid of cell outlines
- C.
Localized, solid, basophilic lesion with calcification
- D.
Necrosis in which tissue is converted into a fluid
- 19.Caseous necrosis is characterized morphologically by
- A.
Preservation of tissue outlines
- B.
Basophilia
- C.
Semi-liquid consistency
- D.
Wedge-shaped periphery
- E.
Amorphous appearance
- 20.Caseous necrosis is characterized morphologically by
- A.
Preservation of tissue outlines
- B.
Basophilia
- C.
Semi-liquid consistency
- D.
Wedge-shaped periphery
- E.
Amorphous appearance
- 21.Which tissue is the most susceptible to liquefactive necrosis following ischemic injury?
- A.
Pancreas
- B.
Liver
- C.
Spleen
- D.
Brain
- E.
Intestine
- 22.A patient suffers a stroke and has left sided weakness and paralysis in the upper extremity. The type of necrosis associated with a well-developed infarct of the brain is
- A.
Coagulative
- B.
Enzymatic fat
- C.
Liquefactive
- D.
Gangrenous
- 23.75-year-old woman has a complaint of shortness of breath and chest pain that radiates to the left shoulder. Serum levels of CK-MB (myocardial creatine kinase) and cardiac muscle troponin I (cTnI) are elevated. Which of the following types of myocardial cell death would best account for these findings?
- A.
Apoptosis
- B.
Caseous necrosis
- C.
Coagulative necrosis
- D.
Fat necrosis
- E.
Liquefactive necrosis
- 24.Coagulative necrosis usually results from
- A.
Abscess formation
- B.
Ischemia
- C.
Trauma
- D.
Tuberculosis
- E.
Syphilis
Questions: 15 | Attempts: 101945 | Last updated: May 3, 2021
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Sample QuestionWhat did you injure?
Questions: 24 | Attempts: 22146 | Last updated: May 10, 2021
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Sample QuestionA pathologist notes the following findings after light microscopic examination of a section of liver from a chronic alcoholic. Which of the following is an example of a reversible injury?
Questions: 13 | Attempts: 9653 | Last updated: Aug 18, 2020
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Sample QuestionWhich of the following is the most common cause of cell injury?
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