1.
A pathologist notes the following findings after
light microscopic examination of a section of liver
from a chronic alcoholic. Which of the following is
an example of a reversible injury?
A. 
B. 
C. 
D. 
E. 
2.
You are asked to review an electron micrograph
of a section of liver from a chronic alcoholic
Which of the following is an example of an
irreversible injury?
A. 
B. 
C. 
D. 
E. 
3.
A patient is admitted with severe substernal chest pain of 4 hours duration. Lab tests reveal increased level of the serum creatine kinase. This is most likely due to:
A. 
B. 
C. 
Damage of plasma membranes
D. 
Increased endoplasmic reticulum
E. 
4.
You are asked to review a liver biopsy from a patient with history of alcohol abuse. Which of the following pathologic changes will most likely lead to death of hepatocytes and liver cirrhosis?
A. 
Fatty change in liver cells
B. 
Hydropic change of hepatocytes
C. 
Karyolysis in myocardial cells
D. 
Glycogen deposition in hepatocyte nuclei
5.
A pathologist notes that a biopsy from the lung of living patients shows the morphologic changes indicative of irreversible injury and cell death. Which of the following is most likely responsible for cell death in a living body?
A. 
B. 
C. 
D. 
E. 
6.
You are asked to participate in a research project on myocardial infarctions in a rat model. Which of the following occurs in ischemic cell injury?
A. 
B. 
C. 
D. 
E. 
7.
Cell death causes by autolysis is produced by
A. 
B. 
C. 
D. 
E. 
8.
A 10-year-old black man with a known history of sickle cell disease presents to the emergency department complaining of left upper quadrant pain suggestive of a splenic infarct. Microscopic examination of the spleen would most likely reveal
A. 
B. 
C. 
D. 
E. 
9.
A pathologist notes cloudy swelling, hydropic change and fatty change in the liver of a patient with a history of alcohol abuse. These morphological changes are all examples of
A. 
B. 
C. 
D. 
E. 
10.
•Which of the following is an example of an agent capable of producing a toxic metabolite and indirect chemical injury?
A. 
B. 
C. 
D. 
E. 
11.
A circumscribed mass of light yellow crumbly to pasty material associated microscopically with a macrophage response is characteristic of
A. 
B. 
C. 
D. 
12.
A well-demarcated lesion with increased cytoplasmic eosinophilia, karyolysis, and intact tissue architecture is characteristic of
A. 
B. 
C. 
D. 
E. 
13.
The pattern of cell death that is characterized by conversion of a single cell to an acidophilic body, usually with loss of the nucleus but with preservation of its shape to permit recognition of cell boundaries is termed
A. 
B. 
C. 
D. 
14.
A 65 year old man presents with angina and dyspnea. He has a family history of hypercholesterolemia. Unfortunately despite thrombolytic therapy he dies. What would you expect to see on light microscopic examination of cardiac tissue?
A. 
B. 
C. 
D. 
15.
Laproscopic examination of the abdomen was performed on a 50 year old chronic alcoholic man. The surgeon noted digestion of tissue with soap formation and calcification. Which of the following is this most likely characteristic of?
A. 
B. 
C. 
D. 
16.
The action of putrefactive bacteria on necrotic tissue results in
A. 
B. 
C. 
D. 
E. 
17.
A well-demarcated area of myocardium appears paler than surrounding tissue and microscopically consists of eosinophilic muscle fibers with only a few karyorrhectic and pyknotic nuclei remaining. Many polys are seen, especially at the margin of this area. The age of the myocardial infarct is most likely
A. 
B. 
C. 
D. 
E. 
18.
You are asked to write a microscopic description of the coagulative necrosis that was noted in the heart of a patient who died of a heart attack because of cocaine abuse. Which of the following best described coagulative necrosis?
A. 
Eosinophilic cytoplasm with cell outlines preserved
B. 
Granular, friable mass of material devoid of cell outlines
C. 
Localized, solid, basophilic lesion with calcification
D. 
Necrosis in which tissue is converted into a fluid
19.
Caseous necrosis is characterized morphologically by
A. 
Preservation of tissue outlines
B. 
C. 
D. 
E. 
20.
Caseous necrosis is characterized morphologically by
A. 
Preservation of tissue outlines
B. 
C. 
D. 
E. 
21.
Which tissue is the most susceptible to liquefactive necrosis following ischemic injury?
A. 
B. 
C. 
D. 
E. 
22.
A patient suffers a stroke and has left sided weakness and paralysis in the upper extremity. The type of necrosis associated with a well-developed infarct of the brain is
A. 
B. 
C. 
D. 
23.
75-year-old woman has a complaint of shortness of breath and chest pain that radiates to the left shoulder. Serum levels of CK-MB (myocardial creatine kinase) and cardiac muscle troponin I (cTnI) are elevated. Which of the following types of myocardial cell death would best account for these findings?
A. 
B. 
C. 
D. 
E. 
24.
Coagulative necrosis usually results from
A. 
B. 
C. 
D. 
E.