Block 9 Path Cellular Injury

24 Questions | By Chachelly | Updated: Mar 20, 2022 | Attempts: 524

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1.

A pathologist notes the following findings after light microscopic examination of a section of liver from a chronic alcoholic. Which of the following is an example of a reversible injury?
- A.
  
  Pyknosis
- B.
  
  Cytoplasmic vacuoles
- C.
  
  Rupture of cell membrane
- D.
  
  Karyolysis
- E.
  
  Karyorrhexis
2.

You are asked to review an electron micrograph of a section of liver from a chronic alcoholic Which of the following is an example of an irreversible injury?
- A.
  
  Cellular edema
- B.
  
  Chromatin clumping
- C.
  
  Cytoplasmic inclusions
- D.
  
  Mitochondrial swelling
- E.
  
  Rupture of cell membrane
3.

A patient is admitted with severe substernal chest pain of 4 hours duration. Lab tests reveal increased level of the serum creatine kinase. This is most likely due to:
- A.
  
  Mitochondrial swelling
- B.
  
  Nuclear lysis
- C.
  
  Damage of plasma membranes
- D.
  
  Increased endoplasmic reticulum
- E.
  
  Increased golgi activity
4.

You are asked to review a liver biopsy from a patient with history of alcohol abuse. Which of the following pathologic changes will most likely lead to death of hepatocytes and liver cirrhosis?
- A.
  
  Fatty change in liver cells
- B.
  
  Hydropic change of hepatocytes
- C.
  
  Karyolysis in myocardial cells
- D.
  
  Glycogen deposition in hepatocyte nuclei
5.

A pathologist notes that a biopsy from the lung of living patients shows the morphologic changes indicative of irreversible injury and cell death. Which of the following is most likely responsible for cell death in a living body?
- A.
  
  Cytolysis
- B.
  
  Necrosis
- C.
  
  Putrefaction
- D.
  
  Autolysis
- E.
  
  Somatic death
6.

You are asked to participate in a research project on myocardial infarctions in a rat model. Which of the following occurs in ischemic cell injury?
- A.
  
  Efflux of K+ and Na+
- B.
  
  Influx of K+ and Ca++
- C.
  
  Influx of K+ and H2O
- D.
  
  Influx of Na+ and Ca++
- E.
  
  Influx of Na+ and K+
7.

Cell death causes by autolysis is produced by
- A.
  
  Antibodies
- B.
  
  Endogenous enzymes
- C.
  
  Phagocytic leukocytes
- D.
  
  Bacterial enzymes
- E.
  
  Anoxia
8.

A 10-year-old black man with a known history of sickle cell disease presents to the emergency department complaining of left upper quadrant pain suggestive of a splenic infarct. Microscopic examination of the spleen would most likely reveal
- A.
  
  Caseous necrosis
- B.
  
  Coagulative necrosis
- C.
  
  Fibrinoid necrosis
- D.
  
  Gangrenous necrosis
- E.
  
  Liquefactive necrosis
9.

A pathologist notes cloudy swelling, hydropic change and fatty change in the liver of a patient with a history of alcohol abuse. These morphological changes are all examples of
- A.
  
  Early neoplastic change
- B.
  
  Hyaline change
- C.
  
  Patterns of cell death
- D.
  
  Postmortem artefact
- E.
  
  Reversible cell injury
10.

•Which of the following is an example of an agent capable of producing a toxic metabolite and indirect chemical injury?
- A.
  
  Alcohol
- B.
  
  Aspirin
- C.
  
  Carbon monoxide
- D.
  
  Mercury poisoning
- E.
  
  Cyanide
11.

A circumscribed mass of light yellow crumbly to pasty material associated microscopically with a macrophage response is characteristic of
- A.
  
  Caseous necrosis
- B.
  
  Coagulative necrosis
- C.
  
  Fibrinoid necrosis
- D.
  
  Gangrenous necrosis
12.

A well-demarcated lesion with increased cytoplasmic eosinophilia, karyolysis, and intact tissue architecture is characteristic of
- A.
  
  Caseous necrosis
- B.
  
  Enzymatic fat necrosis
- C.
  
  Coagulative necrosis
- D.
  
  Cloudy swelling
- E.
  
  Liquefactive necrosis
13.

The pattern of cell death that is characterized by conversion of a single cell to an acidophilic body, usually with loss of the nucleus but with preservation of its shape to permit recognition of cell boundaries is termed
- A.
  
  Apoptosis
- B.
  
  Caseous necrosis
- C.
  
  Fibrinoid necrosis
- D.
  
  Liquefactive necrosis
14.

A 65 year old man presents with angina and dyspnea. He has a family history of hypercholesterolemia. Unfortunately despite thrombolytic therapy he dies. What would you expect to see on light microscopic examination of cardiac tissue?
- A.
  
  Caseous necrosis
- B.
  
  Enzymatic fat necrosis
- C.
  
  Liquefactive necrosis
- D.
  
  Coagulative necrosis
15.

Laproscopic examination of the abdomen was performed on a 50 year old chronic alcoholic man. The surgeon noted digestion of tissue with soap formation and calcification. Which of the following is this most likely characteristic of?
- A.
  
  Coagulative necrosis
- B.
  
  Caseous necrosis
- C.
  
  Enzymatic fat necrosis
- D.
  
  Liquefactive necrosi
16.

The action of putrefactive bacteria on necrotic tissue results in
- A.
  
  Coagulation
- B.
  
  Infarction
- C.
  
  Gangrene
- D.
  
  Embolism
- E.
  
  Caseation
17.

A well-demarcated area of myocardium appears paler than surrounding tissue and microscopically consists of eosinophilic muscle fibers with only a few karyorrhectic and pyknotic nuclei remaining. Many polys are seen, especially at the margin of this area. The age of the myocardial infarct is most likely
- A.
  
  2 minutes
- B.
  
  2 hours
- C.
  
  2 days
- D.
  
  2 weeks
- E.
  
  2 months
18.

You are asked to write a microscopic description of the coagulative necrosis that was noted in the heart of a patient who died of a heart attack because of cocaine abuse. Which of the following best described coagulative necrosis?
- A.
  
  Eosinophilic cytoplasm with cell outlines preserved
- B.
  
  Granular, friable mass of material devoid of cell outlines
- C.
  
  Localized, solid, basophilic lesion with calcification
- D.
  
  Necrosis in which tissue is converted into a fluid
19.

Caseous necrosis is characterized morphologically by
- A.
  
  Preservation of tissue outlines
- B.
  
  Basophilia
- C.
  
  Semi-liquid consistency
- D.
  
  Wedge-shaped periphery
- E.
  
  Amorphous appearance
20.

Caseous necrosis is characterized morphologically by
- A.
  
  Preservation of tissue outlines
- B.
  
  Basophilia
- C.
  
  Semi-liquid consistency
- D.
  
  Wedge-shaped periphery
- E.
  
  Amorphous appearance
21.

Which tissue is the most susceptible to liquefactive necrosis following ischemic injury?
- A.
  
  Pancreas
- B.
  
  Liver
- C.
  
  Spleen
- D.
  
  Brain
- E.
  
  Intestine
22.

A patient suffers a stroke and has left sided weakness and paralysis in the upper extremity. The type of necrosis associated with a well-developed infarct of the brain is
- A.
  
  Coagulative
- B.
  
  Enzymatic fat
- C.
  
  Liquefactive
- D.
  
  Gangrenous
23.

75-year-old woman has a complaint of shortness of breath and chest pain that radiates to the left shoulder. Serum levels of CK-MB (myocardial creatine kinase) and cardiac muscle troponin I (cTnI) are elevated. Which of the following types of myocardial cell death would best account for these findings?
- A.
  
  Apoptosis
- B.
  
  Caseous necrosis
- C.
  
  Coagulative necrosis
- D.
  
  Fat necrosis
- E.
  
  Liquefactive necrosis
24.

Coagulative necrosis usually results from
- A.
  
  Abscess formation
- B.
  
  Ischemia
- C.
  
  Trauma
- D.
  
  Tuberculosis
- E.
  
  Syphilis