Exam 1 - Phintern 2

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    A class of raw materials which are to be subjected to tests and assays by the QC department.

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About This Quiz

EXAM 1 - PHINTERN 2 focuses on evaluating knowledge in pharmaceutical tablet and capsule formulation. It assesses understanding of excipients, processing issues, and quality control tests, crucial for professionals in pharmaceutical technology.

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  • 2. 

    An ideal property of tablet formulations in which the material ready forms a stable, compact mass when pressure is applied

    • Compressibility

    • Flow rate

    • Fluidity

    Correct Answer
    A. Compressibility
    Explanation
    Compressibility refers to the ability of a material to be compressed and form a stable, compact mass when pressure is applied. In the context of tablet formulations, it is important for the material to have good compressibility as it ensures that the tablets maintain their shape and integrity during manufacturing processes such as compression. A material with high compressibility will result in tablets that are easy to handle, have uniform weight and thickness, and disintegrate properly when consumed. Therefore, compressibility is an ideal property for tablet formulations to ensure the production of high-quality tablets.

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  • 3. 

    Which of the following statements about liniments is false?

    • Oily liniments are preferred for massages.

    • Liniments were formerly called embrocations.

    • Alcohol-based liniments are milder than oily liniments.

    • Liniments should not be applied to broken skin.

    Correct Answer
    A. Alcohol-based liniments are milder than oily liniments.
    Explanation
    Oily liniments are milder than alcohol-based liniments.

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  • 4. 

    This method produces finely divided particles by spraying a mist of liquid through a heated chamber, drying immediately, and collecting the dried powders in a clean receptacle.

    • Micronization

    • Spray-drying

    • Freeze-drying

    • Homogenization

    Correct Answer
    A. Spray-drying
    Explanation
    Spray-drying is the correct answer because it involves the process of producing finely divided particles by spraying a mist of liquid through a heated chamber. The liquid quickly dries in the hot air, leaving behind dried powders that are collected in a clean receptacle. This method is commonly used in various industries to create powdered products such as food ingredients, pharmaceuticals, and chemicals.

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  • 5. 

    A parenteral route of administration in which an aqueous solution is preferred for optimum absorption. It produces instantaneous pharmacological effect, since it bypasses absorption.

    • Intraspinal

    • Intramuscular

    • Intravenous

    • Subcutaneous

    Correct Answer
    A. Intravenous
    Explanation
    Intravenous administration is the correct answer because it involves injecting a solution directly into the veins. This route allows for immediate absorption of the medication into the bloodstream, bypassing the need for absorption through the gastrointestinal tract or other tissues. Intravenous administration is preferred when an instantaneous pharmacological effect is desired, as it allows for rapid and efficient delivery of the medication to the target site.

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  • 6. 

    Which of the following tablet production problems describes a defect where color distribution is not uniform throughout the tablet?

    • Double impression

    • Mottling

    • Lamination

    • Cracking

    Correct Answer
    A. Mottling
    Explanation
    Mottling is a tablet production problem that refers to a defect where the color distribution is not uniform throughout the tablet. This means that there are variations in color intensity or patches of different colors on the surface of the tablet. This defect can occur due to issues with the mixing or distribution of the colorants during the tablet manufacturing process.

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  • 7. 

    Which of the following is the specific use of titanium dioxide in tablet coating?

    • Plasticizer

    • Glossant

    • Opaquant

    • Surfactant

    Correct Answer
    A. Opaquant
    Explanation
    Titanium dioxide is used as an opaquant in tablet coating. Opaquants are substances that provide opacity or whiteness to the coating, making it more visually appealing and masking the color of the tablet's core. Titanium dioxide is commonly used in pharmaceutical tablet coatings to achieve a solid, opaque, and uniform appearance. It helps to ensure that the tablet's color and any imperfections in the core are not visible, enhancing the overall aesthetic appeal of the tablet.

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  • 8. 

    Which of the following statements about labeling of medicinal preparations is false?

    • The area of the principal display panel shall be 40% the total surface of the container.

    • The brand name shall have the highest point size, written in the same font as the generic.

    • Rx symbol must be printed in contrasting color as the background.

    • Storage conditions shall appear outside the principal panel of the label.

    Correct Answer
    A. The brand name shall have the highest point size, written in the same font as the generic.
    Explanation
    Generic name should have the highest point size, written in the same font as the brand name.

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  • 9. 

    Which of the following is not an ideal property for tablet fillers?

    • Hygroscopic

    • Relatively cheap

    • Inert

    • Compatible with the formulation

    Correct Answer
    A. Hygroscopic
    Explanation
    Hygroscopicity refers to the ability of a substance to absorb moisture from the surrounding environment. In the context of tablet fillers, a hygroscopic filler would absorb moisture from the formulation, leading to changes in the tablet's physical properties and potentially affecting its stability. Therefore, being hygroscopic is not an ideal property for tablet fillers as it can compromise the quality and performance of the tablets.

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  • 10. 

    Which of the following is an in-vitro method of pyrogen testing based on color development with lysate from amoebecytes of the horseshoe crab?

    • Qualitative fever response in rabbits

    • Qualitative fever response in mice

    • Limulus method

    • All of the above

    Correct Answer
    A. Limulus method
    Explanation
    The correct answer is the Limulus method. This method is an in-vitro method of pyrogen testing that uses lysate from amoebocytes of the horseshoe crab. The lysate reacts with pyrogens, causing a color development that can be measured. The other options, qualitative fever response in rabbits and qualitative fever response in mice, are not in-vitro methods and do not involve the use of horseshoe crab lysate.

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  • 11. 

    This parameter determines the homogeneity of distribution of active ingredients in a batch of finished tablets.

    • Content uniformity

    • Stability

    • Weight variation

    • Quantitative assay

    Correct Answer
    A. Content uniformity
    Explanation
    Content uniformity refers to the consistency of the distribution of active ingredients in a batch of finished tablets. It ensures that each tablet contains the same amount of active ingredient, allowing for consistent and accurate dosing. This parameter is important to ensure the effectiveness and safety of the medication, as variations in content can lead to inconsistent therapeutic effects or potential overdosing. Therefore, content uniformity is the correct answer for this question.

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  • 12. 

    Which of the following solid dosage forms does not need to conform to USP disintegration time?

    • Chewable tablets

    • Film-coated tablets

    • Enteric-coated tablets

    • Sugar-coated tablets

    Correct Answer
    A. Chewable tablets
    Explanation
    Chewable tablets do not need to conform to USP disintegration time because they are designed to be chewed and dissolved in the mouth before swallowing. The disintegration time is not relevant for these tablets as they are intended to be broken down and absorbed in the oral cavity rather than in the stomach or intestines like other solid dosage forms.

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  • 13. 

    Which of the following apparatus is used to check the tightness of cap closures?

    • Crimper

    • PH meter

    • Torque tester

    • Digital caliper

    Correct Answer
    A. Torque tester
    Explanation
    A torque tester is used to check the tightness of cap closures. It measures the amount of rotational force required to open or close a cap. By using a torque tester, manufacturers can ensure that caps are tightened to the correct level, preventing leaks or contamination. This is especially important in industries such as pharmaceuticals or food and beverage, where product integrity is crucial. The other apparatus listed (Crimper, pH meter, and Digital caliper) are not specifically designed for checking the tightness of cap closures.

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  • 14. 

    Regarding emulsions, which of the following statements is/are true?I. Emulsions are thermodynamically stable systems.II. Oil is the continuous phase in O/W emulsions.III. Emulsifying agents promote stability in emulsions.

    • I only

    • I and II

    • II and III

    • III only

    Correct Answer
    A. III only
    Explanation
    I. Emulsions are thermodynamically unstable systems, and oil is the dispersed phase in O/W emulsions.

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  • 15. 

    The following information must appear on the primary display panel of medicinal preparations, EXCEPT:

    • Pharmacologic category

    • Name of manufacturer

    • "For External Use Only"

    • Formulation

    Correct Answer
    A. Formulation
    Explanation
    The primary display panel of medicinal preparations should include important information such as the pharmacologic category, name of the manufacturer, and whether it is for external use only. However, the formulation of the preparation does not need to be mentioned on the primary display panel. The formulation refers to the specific ingredients and composition of the medication, which is typically provided in the package insert or on the product label itself, but not on the primary display panel.

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  • 16. 

    What tablet processing problem appears as the separation of the tablet into several distinct horizontal layers?

    • Lamination

    • Capping

    • Cracking

    • Chipping

    Correct Answer
    A. Lamination
    Explanation
    Lamination is the tablet processing problem that appears as the separation of the tablet into several distinct horizontal layers. This occurs when the tablet formulation does not bind properly, causing the layers to separate.

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  • 17. 

    Which of the following are false about Syrup USP?

    • It can be used as a vehicle or sweetening agent.

    • It requires the addition of a preservative.

    • It is an 85% sugar solution.

    • It is also known as Simple Syrup.

    Correct Answer
    A. It requires the addition of a preservative.
    Explanation
    Simple Syrup USP is fully self-preserving.

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  • 18. 

    Which of the following are potential sources of pyrogens in the manufacture of parenterals?I. Contaminated water and solutesII. Contaminated equipmentIII. Manufacturing methods

    • I and II

    • II and III

    • I and III

    • I, II, and III

    Correct Answer
    A. I, II, and III
    Explanation
    Pyrogens are substances that can cause fever when introduced into the body. In the manufacture of parenterals (products that are injected into the body), potential sources of pyrogens can include contaminated water and solutes, contaminated equipment, and even the manufacturing methods themselves. All three options (I, II, and III) are potential sources of pyrogens and can contribute to the presence of these fever-inducing substances in parenteral products.

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  • 19. 

    Which of the following statements are true?I. Gelatin is obtained by the partial hydrolysis of collagen obtained from the skin, white connective tissue and bones of animals.II. Although gelatin is insoluble in cold water, it does soften through the absorption of up to ten times the weight of the water.III. Gelatin is soluble in hot water and in warm gastric fluid; a gelatin capsule rapidly dissolves and exposes its contents.

    • I only

    • III only

    • I and II

    • II and III

    • I, II, and III

    Correct Answer
    A. I, II, and III
    Explanation
    The correct answer is I, II, and III.

    Gelatin is indeed obtained through the partial hydrolysis of collagen, which is derived from the skin, white connective tissue, and bones of animals. Gelatin is insoluble in cold water but can soften and absorb up to ten times its weight in water. It is also soluble in hot water and warm gastric fluid, which allows for rapid dissolution of gelatin capsules and exposure of their contents. Therefore, all three statements are true.

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  • 20. 

    Which of the following is the correct order of tablet sugarcoating?

    • Sealing, smoothing, subcoating, color coating, polishing

    • Subcoating, sealing, smoothing, color coating, polishing

    • Smoothing, sealing, subcoating, color coating, polishing

    • Sealing, subcoating, smoothing, color coating, polishing

    Correct Answer
    A. Sealing, subcoating, smoothing, color coating, polishing
    Explanation
    The correct order of tablet sugarcoating is sealing, subcoating, smoothing, color coating, and polishing. The process begins with sealing the tablet to prevent moisture and other substances from entering. Then, a subcoating is applied to create a smooth surface for the color coating. After that, the tablet is smoothed to remove any imperfections. Next, a color coating is added to give the tablet its desired appearance. Finally, the tablet is polished to enhance its shine and overall aesthetic appeal.

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  • 21. 

    A tablet formulation contains two (2) APIs which are chemically incompatible with one another. Which of the following is the best method to use for tablet formation?

    • Dry granulation

    • Wet granulation

    • Slugging

    • Multiple-layered compression

    Correct Answer
    A. Multiple-layered compression
    Explanation
    Multiple-layered compression is the best method to use for tablet formation when the tablet formulation contains two APIs that are chemically incompatible with each other. This method involves compressing multiple layers of different materials, allowing for the physical separation of the incompatible APIs. This prevents direct contact between the APIs, reducing the chances of chemical reactions or degradation. Dry granulation, wet granulation, and slugging methods may not provide the same level of physical separation and may lead to chemical interactions between the APIs.

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  • 22. 

    The most commonly used fixed oils in injections are the following, EXCEPT:

    • Cottonseed oil

    • Peanut oil

    • Coconut oil

    • Sesame oil

    Correct Answer
    A. Coconut oil
    Explanation
    Most commonly used fixed oils for injections: Mnemonic, CoCoPeSe

    1. Cottonseed oil
    2. Corn oil
    3. Peanut oil
    4. Sesame oil

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  • 23. 

    This is a non-thermal form of sterilization which reduces airborne microbes by the action of mercury vapor lamps.

    • UV radiation method

    • Ionization method

    • Gas sterilization method

    • Tyndallization method

    Correct Answer
    A. UV radiation method
    Explanation
    UV radiation method is a non-thermal form of sterilization that uses mercury vapor lamps to reduce airborne microbes. UV radiation damages the DNA of microorganisms, preventing them from reproducing and causing infections. This method is commonly used in hospitals, laboratories, and other environments where a high level of cleanliness is required. It is effective against a wide range of pathogens and does not leave any residue or chemical by-products, making it a safe and environmentally friendly sterilization option.

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  • 24. 

    Which of the following QC tests for tablets may be used to assess the strength of a binder excipient in the formulation? I. Friability II. Hardness III. Drug content IV. Disintegration time

    • I and II

    • III and IV

    • I, II, and III

    • I, II, and IV

    Correct Answer
    A. I and II
    Explanation
    Friability testing assesses the ability of the tablet to withstand mechanical stress and abrasion, which indirectly evaluates the strength of the binder. Hardness testing directly measures the tablet's resistance to crushing or breaking, which is affected by the strength of the binder. Therefore, both friability and hardness tests are relevant for assessing the strength of a binder excipient in tablet formulation.

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  • 25. 

    Which of the following excipients are matched incorrectly with their specific use?

    • Avicel: Diluent

    • Binder: Acacia gum

    • Disintegrant: Magnesium stearate

    • Glidant: Talc

    Correct Answer
    A. Disintegrant: Magnesium stearate
    Explanation
    Magnesium stearate is an antiadherent / lubricant.

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  • 26. 

    Sweetening agent which is 200 times sweeter than sucrose, has no aftertaste, and provides approximately 4 kcal per 1 g.

    • Aspartame

    • Cyclamate

    • Saccharin

    • Sucralose

    Correct Answer
    A. Aspartame
    Explanation
    Aspartame is the correct answer because it is a sweetening agent that is 200 times sweeter than sucrose (table sugar), has no aftertaste, and provides approximately 4 kcal per 1 g. Saccharin and cyclamate are also artificial sweeteners, but they do not meet all the given criteria. Sucralose is another artificial sweetener, but it is not 200 times sweeter than sucrose. Therefore, aspartame is the best fit for the given description.

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  • 27. 

    Which manufacturing variables would be likely to affect the dissolution of a prednisone tablet in the body?I. the amount and type of binder addedII. the amount and type of disintegrant addedIII. the force of compression used during tableting

    • I only

    • III only

    • I and II

    • II and III

    • I, II, and III

    Correct Answer
    A. I, II, and III
    Explanation
    The dissolution of a prednisone tablet in the body can be affected by several manufacturing variables. The amount and type of binder added can influence the rate at which the tablet disintegrates and releases the drug. Similarly, the amount and type of disintegrant added can also affect the tablet's ability to break down. Additionally, the force of compression used during tableting can impact the tablet's overall structure and disintegration properties. Therefore, all three variables (I, II, and III) are likely to affect the dissolution of a prednisone tablet in the body.

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  • 28. 

    Which of the following preparations would likely have the shortest shelf life?

    • Aqueous solution, 2% drug

    • Tincture, 60% ethanol

    • Syrup, 85% sugar

    • Chlorpheniramine elixir, 15% ethanol

    Correct Answer
    A. Aqueous solution, 2% drug
    Explanation
    The ethanol content in tinctures & elixirs and the high concentration of sugar in syrup prevent microbial growth. Aqueous solutions are most susceptible to microbial growth, thus shortening shelf life.

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  • 29. 

    In which of the following non-Newtonian systems does viscosity increase with the application of shear stress?I. DilatantII. PseudoplasticIII. Shear-thinningIV. Shear-thickening

    • I and III

    • I and IV

    • II and III

    • II and IV

    Correct Answer
    A. I and IV
    Explanation
    A dilatant or shear-thickening substance is a Non-Newtonian fluid where the shear viscosity increases with applied shear stress.

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  • 30. 

    Which of the following choices increase the risk of contamination in the manufacturing process?I. Curved corners in production roomsII. Multi-directional movement of personnel between roomsIII. Proper sanitation, hygiene, and apparel of personnel

    • I and II

    • II and III

    • I only

    • II only

    Correct Answer
    A. II only
    Explanation
    Multi-directional movement between rooms increases the risk of cross-contamination and mix-ups.

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  • 31. 

    Which of the following tablet processing problems involves the adhesion of a tablet surface to the face of the punch?

    • Erosion

    • Capping

    • Sticking

    • Picking

    Correct Answer
    A. Picking
    Explanation
    Sticking - adhesion of tablet particles to the die wall
    Picking - adhesion of tablet particles to the punch

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  • 32. 

    What are intimate mixtures of dry, finely divided drugs and/or chemicals that may be intended for internal or external use?

    • Powders

    • Granules

    • Binders

    • A and B

    Correct Answer
    A. Powders
    Explanation
    Powders are intimate mixtures of dry, finely divided drugs and/or chemicals that may be intended for internal or external use. Powders are commonly used in pharmaceuticals, cosmetics, and other industries for their ease of administration and versatility. They can be dissolved in liquids, applied topically, or taken orally. Powders are preferred for their ability to be accurately measured and their rapid dissolution or dispersion in the body. They can be formulated to have specific properties such as controlled release or improved bioavailability. Overall, powders are a widely used form of medication or substance delivery.

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  • 33. 

    Which of the following adjuvants are the most important additions to parenterals packaged in multiple-dose containers?

    • Antioxidants

    • Antimicrobial agents

    • Tonicity contributors

    • Buffers

    Correct Answer
    A. Antimicrobial agents
    Explanation
    Multiple-dose parenterals have an increased risk for microbial contamination due to exposure of remaining product to the environment each time a dose is administered.

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  • 34. 

    At which temperature range are most biological products stored?

    • 2 - 8 °F

    • 2 - 8 °C

    • 8 - 15 °F

    • 8 - 15 °C

    Correct Answer
    A. 2 - 8 °C
    Explanation
    Most biological products are stored at temperatures between 2 - 8 °C. This temperature range is commonly used for storing vaccines, blood products, and other sensitive biological materials. It helps to maintain the stability and integrity of these products, preventing spoilage or degradation. The range of 2 - 8 °C is considered ideal for preserving the potency and efficacy of biological products, ensuring that they remain safe and effective for use.

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  • 35. 

    Picking is an indication of:

    • Excessive moisture in the granulation

    • Entrapment of air

    • Tablet friability

    • Degraded drug

    Correct Answer
    A. Excessive moisture in the granulation
    Explanation
    Picking refers to the phenomenon where the granules in a tablet formulation stick to the surface of the tablet press and are pulled away during ejection, resulting in a rough or pitted appearance on the tablet surface. This issue is often caused by excessive moisture in the granulation. When the granulation is too wet, it can lead to poor binding and cohesion of the particles, causing them to stick to the tablet press surfaces instead of forming a solid tablet. Therefore, excessive moisture in the granulation is a likely explanation for picking in tablet manufacturing.

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  • 36. 

    A surfactant with an HLB value of 7-11 is used primarily as a __________.

    • W/O emulsifier

    • O/W emulsifier

    • Detergent

    • Anti-foaming agent

    Correct Answer
    A. W/O emulsifier
  • 37. 

    Over the span of two months, a distributor delivers four consecutive shipments of substandard raw materials to your manufacturing plant. In order to uphold the quality of your products, you decide to apply a more rigorous inspection level for their materials. What inspection level do you assign them?

    • General Inspection Level I

    • General Inspection Level II

    • General Inspection Level III

    • Special Inspection Level S1

    Correct Answer
    A. General Inspection Level III
    Explanation
    General Inspection Level I - Less stringent inspection level for trusted companies which consistently deliver quality materials
    General Inspection Level II - Default inspection level
    General Inspection Level III - Rigorous inspection level for companies which have delivered substandard materials

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  • 38. 

    This phenomenon refers to the movement of components from the packaging and into its contents.

    • Sorption

    • Leaching

    • Adsorption

    • Absorption

    Correct Answer
    A. Leaching
    Explanation
    Leaching refers to the process of components moving from the packaging material into the contents it holds. This phenomenon can occur when there is a chemical interaction between the packaging material and the contents, causing the components to dissolve or be released into the product. Leaching can lead to contamination of the contents and potentially affect their quality or safety.

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  • 39. 

    This term refers to the incorporation of excess materials in a pharmaceutical preparation to compensate for expected loss during manufacture

    • Manufacturing overage

    • Manufacturing allowance

    • Chemical modification

    Correct Answer
    A. Manufacturing overage
    Explanation
    Manufacturing overage refers to the incorporation of excess materials in a pharmaceutical preparation to compensate for expected loss during manufacture. This allows for any potential loss or variation in the manufacturing process, ensuring that the final product meets the required specifications and quantities. By adding extra materials, the manufacturer can account for any potential losses and maintain the desired quantity and quality of the pharmaceutical preparation.

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  • 40. 

    This type of coating imparts the same general characteristics as sugar coating with the added advantage of greatly reduced time period required for the coating operation.I. Enteric coatingII. Single-layer coatingIII. Film coating 

    • I only

    • I and II

    • III only

    • I and III

    Correct Answer
    A. III only
    Explanation
    Film coating is the correct answer because it imparts the same general characteristics as sugar coating, such as improving the appearance, taste, and odor of the coated material. Additionally, film coating has the added advantage of reducing the time required for the coating operation compared to sugar coating. This makes film coating a more efficient and time-saving option.

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  • 41. 

    Which of the following excipients increase the likelihood of settling in suspensions?

    • Thickening agent

    • Suspending agent

    • Flocculating agent

    • Wetting agents

    Correct Answer
    A. Flocculating agent
    Explanation
    Flocculating agents cause the solid particles to aggregate, which encourages settling of particles in suspension.

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  • 42. 

    Which of the following is a broad-spectrum preservative effective against bacteria and molds?

    • Parabens

    • Sodium benzoate

    • Alcohol

    • Glycerin

    Correct Answer
    A. Parabens
    Explanation
    Parabens are a type of preservative commonly used in cosmetic and personal care products. They are considered broad-spectrum, meaning they are effective against a wide range of microorganisms, including bacteria and molds. Parabens work by inhibiting the growth and reproduction of these microorganisms, helping to extend the shelf life of products and prevent spoilage. However, it is important to note that there has been some controversy surrounding the safety of parabens, as studies have suggested a possible link to hormone disruption.

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  • 43. 

    This phenomenon is the taking up of liquid by a gel without measurable increase in volume.

    • Swelling

    • Imbibition

    • Syneresis

    • Xerogel

    Correct Answer
    A. Imbibition
    Explanation
    Imbibition refers to the process in which a gel absorbs liquid without any significant change in its volume. This phenomenon occurs due to the capillary action, where the liquid is drawn into the gel's network of pores or spaces between its particles. As a result, the gel swells and takes up the liquid, but the overall volume remains relatively unchanged. This process is commonly observed in various natural and synthetic gels, such as hydrogels, where they can absorb large amounts of water without expanding significantly.

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  • 44. 

    Silica-containing materials are excipients which are employed as:

    • Granulating agents

    • Lubricants

    • Diluents

    • Disintegrants

    Correct Answer
    A. Lubricants
    Explanation
    Silica-containing materials are used as lubricants in pharmaceutical formulations. Lubricants are substances that are added to improve the flowability of the powders during the manufacturing process. They reduce friction between particles and equipment surfaces, preventing sticking or clumping. Silica-containing materials have excellent lubricating properties and are commonly used in tablet and capsule formulations. They help in the smooth and efficient production of pharmaceutical products by ensuring uniform mixing and easy tablet compression.

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  • 45. 

    Regarding the preparation of ointments and creams by fusion, which of the following is false?

    • Solids may be levigated with a portion of the base before adding to melted components.

    • Heat-labile and volatile substances are added first immediately after fusion.

    • During cooling, the rest of the components are added until congealed.

    • Ingredients with the highest melting points are melted at the lowest required temperature.

    Correct Answer
    A. Heat-labile and volatile substances are added first immediately after fusion.
    Explanation
    Heat-labile and volatile substances are added later, after the preparation has cooled, to avoid thermolysis or evaporation of substances.

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  • 46. 

    Which of the following excipients can be added to a tablet formulation to prevent sticking of powder particles on the surface of processing equipment?

    • Gelatin

    • Magnesium stearate

    • Sodium starch glycolate

    • Talc

    Correct Answer
    A. Magnesium stearate
    Explanation
    Magnesium stearate is a lubricant, which prevents sticking of powder particles on processing equipment. Gelatin acts as a binder. Talc is a glidant. Sodium starch glycolate is a disintegrant.

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  • 47. 

    Which of the following raw materials can be used as tablet diluent, disintegrant, and binder?

    • Avicel

    • Lactose

    • Celutab

    • Cornstarch

    Correct Answer
    A. Cornstarch
    Explanation
    Cornstarch can be used as a tablet diluent, disintegrant, and binder. As a diluent, it helps to increase the bulk of the tablet and facilitate the manufacturing process. As a disintegrant, it promotes the breakup of the tablet in the gastrointestinal tract, allowing for better absorption of the active ingredients. And as a binder, it helps to hold the tablet together and ensure its structural integrity. Avicel, lactose, and celutab may also be used as tablet diluents, but they do not serve as both disintegrants and binders.

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  • 48. 

    The following are agents used in tablet and capsule formulations to improve flow properties of the powder mix, EXCEPT:

    • Lactose

    • Talc

    • Cornstarch

    • Colloidal silica

    Correct Answer
    A. Lactose
    Explanation
    As an excipient, lactose functions as a diluent or filler. Talc, starches, and silicious materials are all glidants. Starch, in particular, is a popular choice as it has the additional value of disintegrant.

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  • 49. 

    Class 100 environment can be defined as:

    • Total particles do not exceed 100 per cubic foot of air of 0.5 µm at normal condition.

    • Total particles do not exceed 100 per cubic meter of air of 0.5 µm at rest.

    • Total particles do not exceed 100 per cubic meter of air of 0.5 µm at normal condition.

    • Total particles do not exceed 100 per cubic meter of air of 0.5 µm at rest.

    Correct Answer
    A. Total particles do not exceed 100 per cubic foot of air of 0.5 µm at normal condition.
    Explanation
    < 100 per cubic foot of air of 0.5 µm at normal condition.

    When a room is at rest (i.e. no movement, production, personnel, etc.), there is definitively lesser amount of particles in circulation in the air. It would not accurately reflect contamination in a working environment.

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  • Feb 25, 2024
    Quiz Edited by
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  • Apr 20, 2017
    Quiz Created by
    Mikhaelajuntado

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