Day 4: Dry Eye, Sjogren's Syndrome, And Sjo

39 Questions

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Syndrome Quizzes & Trivia

This quiz has been designed to test your knowledge of dry eye, Sjögren's syndrome, and the new LDT Sjö. You have 1 hour to complete the quiz. A passing grade is a 90% or above.


Questions and Answers
  • 1. 
    True or False:  Only 25% of the patients with Sjögren's syndrome are women.
    • A. 

      True

    • B. 

      False

  • 2. 
    Which of the following is a specific antibody to salivary gland proteins?
    • A. 

      CA-6

    • B. 

      SS-A (Ro)

    • C. 

      SS-B (La)

    • D. 

      ANA

  • 3. 
    Which of the following is an abnormal antibody found in patients with systemic lupus erythematosus?
    • A. 

      SS-B (La)

    • B. 

      Anti-dsDNA

    • C. 

      SP-1

    • D. 

      SS-A (Ro)

  • 4. 
    How many cases of Sjögren's syndrome are thought to be undiagnosed?
    • A. 

      500,000

    • B. 

      1.5 million

    • C. 

      3 million

    • D. 

      6 million

  • 5. 
    Which of the following is NOT considered a traditional biomarker for detecting Sjögren's syndrome?
    • A. 

      ANA

    • B. 

      SP-1

    • C. 

      SS-A (Ro)

    • D. 

      SS-B (La)

  • 6. 
    All of the following are considered proprietary biomarkers for detecting Sjögren's syndrome, except for:
    • A. 

      SP-1

    • B. 

      RF

    • C. 

      PSP

    • D. 

      CA-6

  • 7. 
    Which of the following is NOT an advantage of diagnosing Sjögren's syndrome in the early stages of the disease?
    • A. 

      Increases patients' chances for avoiding many serious complications

    • B. 

      Helps patients receive proper treatment

    • C. 

      Increases patients' chance for a cure

    • D. 

      Helps patients improve their quality of life

  • 8. 
    Which of the following is considered a serious complication of Sjögren's syndrome?
    • A. 

      Neurological problems

    • B. 

      Heart disease

    • C. 

      Diabetes

    • D. 

      Low blood counts

  • 9. 
    What is the rate of sensitivity and specificity for traditional tests for Sjögren's syndrome?
    • A. 

      20%-40%

    • B. 

      40%-60%

    • C. 

      60%-80%

    • D. 

      80%-100%

  • 10. 
    When a patient goes to a third-party lab to have a Sjö test run, who provides the physician with the test results?
    • A. 

      Third-party lab

    • B. 

      RPS

    • C. 

      IMMCO Diagnostics

    • D. 

      LabCorp

  • 11. 
    Who is responsible for billing the patient's insurance company if the blood sample is collected at a third-party lab?
    • A. 

      ECP

    • B. 

      Third-party lab

    • C. 

      IMMCO Diagnostics

    • D. 

      Patient

  • 12. 
    In which journal was the retrospective study by Akpek et al published?
    • A. 

      Clincial Immunology

    • B. 

      British Journal of Ophthalmology

    • C. 

      Cornea

    • D. 

      Clinical Immunology

  • 13. 
    True or False:  The authors of the Shen et al paper concluded that SS-A (Ro), SS-B (La), RF, and ANA are useful markers for identifying patients with Sjögren's syndrome at early stages of the disease.
    • A. 

      True

    • B. 

      False

  • 14. 
    How many patients were included in the study by Akpek et al which evaluated the rate of Sjögren's syndrome in patients with dry eye syndrome?
    • A. 

      186

    • B. 

      220

    • C. 

      362

    • D. 

      414

  • 15. 
    In the study conducted by Akpek et al, what percentage of patients had a combined aqueous and evaporative type of dry eye?
    • A. 

      52.9%

    • B. 

      67.5%

    • C. 

      75.2%

    • D. 

      86.9%

  • 16. 
    In the study conducted by Akpek et al, what percentage of patients with primary Sjögren's syndrome were diagnosed as a result of the initial evaluation?
    • A. 

      50%

    • B. 

      62%

    • C. 

      77%

    • D. 

      83%

  • 17. 
    Of the patients that were diagnosed with Sjögren's syndrome as a result of the initial evaluation during the study conducted by Akpek et al, what percentage tested positive for SS-A (Ro) and SS-B (La) antibodies?
    • A. 

      33.3%

    • B. 

      66.6%

    • C. 

      75.5%

    • D. 

      81.8%

  • 18. 
    Multiple sclerosis is an inflammatory disease that destroys _____.
    • A. 

      Cartilage

    • B. 

      Liver function

    • C. 

      WBCs

    • D. 

      Myelin

  • 19. 
    Anti-Sm is an abnormal antibody found in which of the following diseases?
    • A. 

      Sjögren's syndrome

    • B. 

      Systemic lupus erythematosus

    • C. 

      Rheumatoid arthritis

    • D. 

      Multiple sclerosis

  • 20. 
    Which of the following is NOT a feature of dry eye?
    • A. 

      Inflammation

    • B. 

      Hyperosmolarity

    • C. 

      High TBUT

    • D. 

      Abnormalities of the ocular surface

  • 21. 
    Approximately how many people over age 40 does dry eye affect in the United States?
    • A. 

      4 million

    • B. 

      11 million

    • C. 

      20 million

    • D. 

      40 million

  • 22. 
    If you were suffering with aqueous-deficient dry eye, which of the following might be useful?
    • A. 

      Plaquenil

    • B. 

      Restasis

    • C. 

      Doxycycline

    • D. 

      Voltaren

  • 23. 
    Sjögren's syndrome dry eye and non-Sjögren's syndrome dry eye are subclasses of __________.
    • A. 

      Age-related dry eye

    • B. 

      Evaporative dry eye

    • C. 

      Tear-defective dry eye

    • D. 

      Aqueous-deficient dry eye

  • 24. 
    Which of the following is the most common cause of evaporative dry eye?
    • A. 

      Diabetes

    • B. 

      Aging

    • C. 

      Inflammation

    • D. 

      Meibomian gland dysfunction

  • 25. 
    Which of the following tests can be used for detecting Sjögren's syndrome?
    • A. 

      Lactoferrin

    • B. 

      Sjö

    • C. 

      Ap4A

    • D. 

      Lysozyme

  • 26. 
    Which of the following is considered the mainstay of dry eye treatment?
    • A. 

      Corticosteroids

    • B. 

      Omega-3 fatty acids

    • C. 

      Artificial tears

    • D. 

      Punctal plugs

  • 27. 
    Which of the following is NOT thought to be a contributor to autoimmune disease?
    • A. 

      Heredity

    • B. 

      Normal immune cell function

    • C. 

      Ethnicity

    • D. 

      Gender

  • 28. 
    True or False:  A healthy person may have an antibody seen in an autoimmune disease.
    • A. 

      True

    • B. 

      False

  • 29. 
    Which of the following joints does rheumatoid arthritis most commonly affect?
    • A. 

      Hips

    • B. 

      Shoulders

    • C. 

      Fingers

    • D. 

      Knees

  • 30. 
    Which of the following is NOT a way in which a physician may receive the results of the Sjö test?
    • A. 

      Email/IMMCO online

    • B. 

      Phone

    • C. 

      Fax

    • D. 

      Mail

  • 31. 
    What is the cumulative rate of sensitivity for Sjö?
    • A. 

      67%

    • B. 

      78%

    • C. 

      89%

    • D. 

      95%

  • 32. 
    True or False:  The authors of the Akpek et al study concluded that primary Sjögren's syndrome seems to be underdiagnosed in patients with dry eye syndrome and should be the focus of diagnostic evaluations.
    • A. 

      True

    • B. 

      False

  • 33. 
    True or False:  Primary Sjögren's syndrome accounts for half of all cases of Sjögren's syndrome.
    • A. 

      True

    • B. 

      False

  • 34. 
    True or False:  A patient with an autoimmune disease will always have an antibody to the affected organ.
    • A. 

      True

    • B. 

      False

  • 35. 
    What is the cumulative rate of specificity for Sjö? 
    • A. 

      66%

    • B. 

      78%

    • C. 

      89%

    • D. 

      95%

  • 36. 
    In Akpek et al, how many patients that were identified during the initial evaluation as having primary Sjögren's syndrome tested positive for SS-A (Ro) or SS-B (La) antibodies?
    • A. 

      2

    • B. 

      4

    • C. 

      6

    • D. 

      8

  • 37. 
    True or False:  Sjö is the only available test that identifies both organ-specific and non-organ-specific autoantibodies in Sjögren's syndrome.
    • A. 

      True

    • B. 

      False

  • 38. 
    Which of the following is considered a key advantage of Sjo as compared to traditional testing methods?
    • A. 

      In-office testing

    • B. 

      6 novel biomarkers

    • C. 

      Identifies non-organ-specific autoantibodies

    • D. 

      Earlier detection

  • 39. 
    Which of the following circumstances may result in a Sjö test receiving a QNS result?
    • A. 

      Blood spots were considered layered

    • B. 

      Blood spots exceeded the circles on the Whatman card

    • C. 

      Blood spots saturated through to the back of the Whatman card

    • D. 

      Blood specimen was contaminated