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Neurobiology of Synaptic Plasticity: Understanding Protein Synthesis and LTP

Neurobiology Of Synaptic Plasticity: Understanding Protein Synthesis And Ltp

Explore the critical role of protein synthesis in strengthening synapses in neurobiology. This educational resource focuses on enhancing your understanding of synaptic mechanisms and their implications for neural function and...

Questions: 26 | Attempts: 10 | Last updated: Aug 4, 2025

Sample Question 1
What are the differences between short-lasting LTP (S-LTP or early LTP) and long-lasting LTP (L-LTP or late LTP)?

Early LTP is induced by low-frequency stimulation and involves new protein synthesis. Late LTP is induced by high-frequency stimulation and is solely dependent on post-translational modifications.

Early LTP is induced by weak high-frequency stimulation and is caused by post-translational modifications (e.g. AMPA receptor trafficking). Late LTP is induced by strong high-frequency stimulation and involves new protein synthesis.

Early LTP is induced by strong high-frequency stimulation and involves new protein synthesis. Late LTP is induced by weak high-frequency stimulation and is caused by post-translational modifications.

Early LTP is induced by a single pulse of electrical stimulation and is caused by gene mutations. Late LTP is induced by multiple pulses of electrical stimulation and involves DNA repair mechanisms.

Sample Question 2
What are the processes involved in gene expression including transcription, translation, and post-translation?

Transcription: copying mRNA to DNA; Translation: rearranging amino acids in proteins; Post-translation: forming mRNA molecules

Transcription: breaking down proteins into amino acids; Translation: merging DNA and RNA sequences; Post-translation: duplicating the genetic code

Transcription: creating new mRNAs from DNATranslation: ribosomes read the mRNAs and form a polypeptide chain that folds into proteinsPost-translation: modifications that occur after the protein is made (e.g. phosphorylation, ubiquitination, methylation)

Transcription: converting RNA to DNA; Translation: converting proteins to mRNA; Post-translation: editing DNA sequences

Sample Question 3
What is the genomic signaling hypothesis?

Synaptic activity from the high-frequency stimulation will activate signaling molecules that move to the nucleus and phosphorylate transcription factors (CREB), resulting in new protein synthesis.

High-frequency stimulation only results in temporary changes at the synapse.

DNA is directly altered by synaptic activity to produce new proteins.

The genomic signaling hypothesis only involves protein degradation, not synthesis.

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