Heme Metabolism - 20 Questions
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- 1.Predominant form of bilirubin seen in obstructive jaundice is
- A.
Bilirubin monoglucuronide
- B.
Bilirubin diglucuronide
- C.
Delta bilirubin
- D.
None
- 2.UDP-glucuronate is added to
- A.
Methyl group of bilirubin
- B.
Vinyl group of bilirubin
- C.
Propionate group of bilirubin
- D.
None
- 3.Which is not inherited in autosomal dominant mode
- A.
ALA synthase defeciency
- B.
Congenital erythropoietic porphyria
- C.
Both
- D.
None
- 4.Which is NOT a hemoprotein
- A.
Catalase
- B.
Tryptophan pyrrolase
- C.
Neuroglobin
- D.
Adenylate kinase
- 5.Acquired porphyria is due to
- A.
Hg
- B.
Pb
- C.
Cu
- D.
Sn
- 6.Deta bilirubin is ______ bilirubin _____ bound to albumin
- A.
Conjugated, covalently
- B.
Unconugated, non covalently
- C.
Conjugated, noncovalently
- D.
Unconjugated, covalently
- 7.Soret band is seen around the wavelength of
- A.
200 nm
- B.
300 nm
- C.
400 nm
- D.
500 nm
- 8.Biochemical basis of precipitation of porphyria by barbiturates is
- A.
Repression of ALA synthase
- B.
Derepression of ALA synthase
- C.
Rerepression of ALA synthase
- D.
MiRNA mediated
- 9.Choluric jaundice is/are
- A.
Hepatic
- B.
Post hepatic
- C.
Both
- D.
Hemolytic
- 10.Which is not produced by heme oxygenase
- A.
CO
- B.
CO2
- C.
Fe
- D.
H2o
- 11.Which is not seen in acute intermittent porphyria
- A.
Abdominal pain
- B.
Photosensitivity
- C.
Seizures
- D.
Constipation
- 12.Heme synthesis happens in
- A.
Cytoplasm
- B.
Mitochondria
- C.
Both
- D.
None
- 13.Porphyrin ring consists of 4 pyrrole rings linked by
- A.
Methylene bridges
- B.
Methine bridges
- C.
Methoxy bridges
- D.
Methyl bridges
- 14.Most common porphyria is due to defeciency of
- A.
PBG deaminase
- B.
Uroporphyrinogen decarboxylase
- C.
Ferrocheletase
- D.
Coproporphyrinogen oxidase
- 15.Which is not a hepatic porphyria
- A.
Variegate
- B.
AIP
- C.
PCT
- D.
Protoporphyria
- 16.Lead inhibits
- A.
ALA dehydratase
- B.
Ferrochelatase
- C.
Both
- D.
None
- 17.Which is not seen in plumbism
- A.
Raised RBC free protoporphyrin IX
- B.
Raises urinary ALA
- C.
Basophilic stippling of RBC
- D.
None
- 18.Number of bilirubin molecule(s) that can bind to high affinity binding site of albumin
- A.
1
- B.
2
- C.
3
- D.
4
- 19.True about Gilbert syndrome
- A.
Fatal
- B.
Conjugated Hyperbilirubinemia
- C.
Promoter defect of transferase enzyme
- D.
Missense mutation of transferase enzyme
- 20.Which is not a treatment modality of porphyria
- A.
Avoid fasting and alcohol
- B.
Glucose loading
- C.
Beta carotene and sunscreen
- D.
Phenobarbitone
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