Heme Metabolism - 20 Questions

20 Questions | Total Attempts: 2334

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Metabolism Quizzes & Trivia

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Questions and Answers
  • 1. 
    Acquired porphyria is due to 
    • A. 

      Hg

    • B. 

      Pb

    • C. 

      Cu

    • D. 

      Sn

  • 2. 
    Biochemical basis of precipitation of porphyria by barbiturates is 
    • A. 

      Repression of ALA synthase

    • B. 

      Derepression of ALA synthase

    • C. 

      Rerepression of ALA synthase

    • D. 

      MiRNA mediated

  • 3. 
    Choluric jaundice is/are
    • A. 

      Hepatic

    • B. 

      Post hepatic

    • C. 

      Both

    • D. 

      Hemolytic

  • 4. 
    Deta bilirubin is ______ bilirubin _____ bound to albumin
    • A. 

      Conjugated, covalently

    • B. 

      Unconugated, non covalently

    • C. 

      Conjugated, noncovalently

    • D. 

      Unconjugated, covalently

  • 5. 
    Heme synthesis happens in
    • A. 

      Cytoplasm

    • B. 

      Mitochondria

    • C. 

      Both

    • D. 

      None

  • 6. 
    Lead inhibits
    • A. 

      ALA dehydratase

    • B. 

      Ferrochelatase

    • C. 

      Both

    • D. 

      None

  • 7. 
    Most common porphyria is due to defeciency of
    • A. 

      PBG deaminase

    • B. 

      Uroporphyrinogen decarboxylase

    • C. 

      Ferrocheletase

    • D. 

      Coproporphyrinogen oxidase

  • 8. 
    Number of bilirubin molecule(s) that can bind to high affinity binding site of albumin
    • A. 

      1

    • B. 

      2

    • C. 

      3

    • D. 

      4

  • 9. 
    • A. 

      Methylene bridges

    • B. 

      Methine bridges

    • C. 

      Methoxy bridges

    • D. 

      Methyl bridges

  • 10. 
    Predominant form of bilirubin seen in obstructive jaundice is
    • A. 

      Bilirubin monoglucuronide

    • B. 

      Bilirubin diglucuronide

    • C. 

      Delta bilirubin

    • D. 

      None

  • 11. 
    Soret band is seen around the wavelength of 
    • A. 

      200 nm

    • B. 

      300 nm

    • C. 

      400 nm

    • D. 

      500 nm

  • 12. 
    UDP-glucuronate is added to 
    • A. 

      Methyl group of bilirubin

    • B. 

      Vinyl group of bilirubin

    • C. 

      Propionate group of bilirubin

    • D. 

      None

  • 13. 
    Which is NOT a hemoprotein
    • A. 

      Catalase

    • B. 

      Tryptophan pyrrolase

    • C. 

      Neuroglobin

    • D. 

      Adenylate kinase

  • 14. 
    Which is not a hepatic porphyria
    • A. 

      Variegate

    • B. 

      AIP

    • C. 

      PCT

    • D. 

      Protoporphyria

  • 15. 
    Which is not inherited in autosomal dominant mode
    • A. 

      ALA synthase defeciency

    • B. 

      Congenital erythropoietic porphyria

    • C. 

      Both

    • D. 

      None

  • 16. 
    Which is not produced by heme oxygenase
    • A. 

      CO

    • B. 

      CO2

    • C. 

      Fe

    • D. 

      H2o

  • 17. 
    Which is not seen in acute intermittent porphyria
    • A. 

      Abdominal pain

    • B. 

      Photosensitivity

    • C. 

      Seizures

    • D. 

      Constipation

  • 18. 
    Which is not seen in plumbism
    • A. 

      Raised RBC free protoporphyrin IX

    • B. 

      Raises urinary ALA

    • C. 

      Basophilic stippling of RBC

    • D. 

      None

  • 19. 
    True about Gilbert syndrome 
    • A. 

      Fatal

    • B. 

      Conjugated Hyperbilirubinemia

    • C. 

      Promoter defect of transferase enzyme

    • D. 

      Missense mutation of transferase enzyme

  • 20. 
    Which is not a treatment modality of porphyria 
    • A. 

      Avoid fasting and alcohol

    • B. 

      Glucose loading

    • C. 

      Beta carotene and sunscreen

    • D. 

      Phenobarbitone