Pmc 1 Exam 3

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Quizzes Created: 1 | Total Attempts: 76

Questions: 114 | Attempts: 76 | Updated: Mar 20, 2023

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Androgens & Estrogens (Cox & Sumanasekera), Adrenocorticosteroids (Cox & Sumanasekera) and Antihistamines (Cox & McCune)

Questions and Answers

Pmc 1 Exam 3

A substituent attached to the 10 Carbon on the steroid nucleus shown here would have what numbering?

Steroids bind receptors ____

Steroids act by binding intracellular receptors; the steroid-receptor complex then enters the nucleus and changes levels of proteins by altering the rate of DNA replication.

Testosterone exhibits poor bioavailability due to extensive 1st pass metabolism.

The steroid molecule shown here is transformed by which of the following enzymes?

Esterases metabolize lipophilic esters found at C17 on steroid molecules. Where in the body can these enzymes be found?

The purpose of esterification of steroid molecules with long carbon chains at C17 is to

Finasteride and Dutasteride act by which of the following mechanisms?

5-alpha Reductase inhibitors, such as Dutasteride, are irreversible modifiers.

The antiandrogens Bicalutamide, Flutamide and Nilutamide act by blocking the effects of testosterone and DHT on androgen receptors in the treatment of advanced prostate cancer.

Which feature of the molecule shown here is very rarely found in drug molecules today?

Why is the nitro group found in antiandrogens such as Nilutamide and Flutamide so unusual in modern drugs?

Estrogens have an aromatic A ring, 18 Carbons and a 3-OH group. Which of the following is the most potent estrogen?

The rightward reaction shown in this pictures is what type of reaction?

What type of reaction is shown here?

Which of the following are Phase 2 reactions undergone by Estrogens?

The enzyme which catalyzes the Phase 2 reaction of estradiol shown here is which of the following?

The reaction shown here occurs in Phase ___ and is catalyzed by the enzyme ______.

Which of the following enzymes is responsible for enterohepatic cycling?

The enzyme responsible for enterohepatic cycling, Beta-glucuronidase, can be found where?

The drug-drug interaction between antibiotics and estrogens is due to the lack of Beta-glucuronidase that occurs after antibiotics kill intestinal bacteria. Estrogen levels decrease because estrogen can no longer undergo enterohepatic cycling.

Another name for the enzyme Estrogen 2/4-hydroxylase is

The structure shown here is produced by metabolism of Estrogen by Estrogen 2-hydroxylase enzyme. This molecule is further metabolized by which of the following enzymes?

The purpose of the addition of the 17-alpha alkyne group to this estrogen molecule is to

Which of the following classes of drugs are estrogen antagonists?

Selective Estrogen Receptor Modulators, or SERMs, act as agonists for estrogen in bone tissue (not marrow) and antagonists in breast tissue.

SERMs, such as Clomifene and Tamoxifen, act by which of the following mechanisms?

Which of the following antiestrogens is NOT an aromatase inhibitor?

The function of the enzyme Aromatase is to de-aromatize the A ring of androgen molecules.

The enzyme Aromatase can produce Estrone from which of the following androgens?

Identify this drug.

Suicide inhibition is another name for which type of binding, exhibited by steroid binding to aromatase?

Which of the following are structural features of progestins, which promote gestation and relax the uterus?

Progesterone is converted to 6-alpha-hydroxyprogesterone by the addition of a hydroxy group at the 6 position. This reaction is a(n)

5-beta-pregnanediol is produced by changing the 3-keto group of progesterone to a 3-OH and saturating the double bond at the 4 position. This reaction is a(n)

The follicular phase of menstruation involves the conversion of pregnenolone to DHEA. The luteal phase involves the conversion of pregnenolone to which of the following?

11-deoxycorticosterone is converted to Aldosterone in the Zona Glomerulosa via which of the following enzymes?

The enzyme Aromatase produces 17b-estradiol from which of the following androgens?

Estradiol enhances protein synthesis by altering the rate of transcription. Which of the following are functions of estradiol in the body?

Are you going to read Dr. S's research paper in sharepoint?

Progestins reduce the risk of cancer from estrogen therapy and decrease water retention by competing with aldosterone.

Dutasteride blocks the conversion of Testosterone to which of the following?

Steroids are transported in the blood via transport proteins. Which of the following is NOT a transport protein for steroids?

One example of a drug-drug interaction involving competition for steroid transport proteins is that between oral contraceptives and prednisolone.

Which of the following substituents (numbered) is CORRECTLY matched with its designation as alpha or beta?

The most potent endogenous glucocorticoid is _____ while the most potent endogenous mineralocorticoid is _____.

A 17-Beta Ketol group, which may or may not be esterified, is a MUST for which type of activity?

Which of the following enzymes catalyzes the reaction shown here?

Cortisone is a prodrug of Hydrocortisone. The conversion of cortisone to hydrocortisone requires converting the 11-keto group to an 11-OH. This conversion is which type of reaction?

This compound is hydrolyzed to a 17-beta ketol by which of the following enzymes?

The reaction shown here occurs in Phase _ and is catalyzed by the enzyme ____.

The most potent endogenous glucocorticoid is _ while the most potent endogenous mineralocorticoid is _.