Pmc 1 Exam 3
Androgens & Estrogens (Cox & Sumanasekera), Adrenocorticosteroids (Cox & Sumanasekera) and Antihistamines (Cox & McCune)
- 1.
![A substituent attached to the 10 Carbon on the steroid nucleus shown here would have what numbering? - ProProfs]( "A substituent attached to the 10 Carbon on the steroid nucleus shown here would have what numbering?")
A substituent attached to the 10 Carbon on the steroid nucleus shown here would have what numbering?- A.
18
- B.
19
- C.
20
- D.
21
- 2.Steroids bind receptors ____
- A.
Inside the cell membrane
- B.
Extracellularly
- C.
Intracellularly
- 3.Steroids act by binding intracellular receptors; the steroid-receptor complex then enters the nucleus and changes levels of proteins by altering the rate of DNA replication.
- A.
True
- B.
False
- 4.Testosterone exhibits poor bioavailability due to extensive 1st pass metabolism.
- A.
True
- B.
False
- 5.
![The steroid molecule shown here is transformed by which of the following enzymes? - ProProfs]( "The steroid molecule shown here is transformed by which of the following enzymes?")
The steroid molecule shown here is transformed by which of the following enzymes?- A.
Gyrases
- B.
Esterases
- C.
Deaminases
- D.
Phosphatases
- 6.Esterases metabolize lipophilic esters found at C17 on steroid molecules. Where in the body can these enzymes be found?
- A.
Liver only
- B.
Lung and skin only
- C.
Fat tissues only
- D.
Throughout the body
- 7.The purpose of esterification of steroid molecules with long carbon chains at C17 is to
- A.
Reduce drug half-lfie
- B.
Make the molecule more hydrophilic
- C.
Extend drug half-life in the blood
- D.
Minimize the lipophilicity of the molecule
- 8.Finasteride and Dutasteride act by which of the following mechanisms?
- A.
5a Reductase inhibition
- B.
5a Reductase induction
- C.
11b Hydroxysteroid dehydrogenase inhibition
- D.
11b Hydroxysteroid dehydrogenase induction
- 9.5-alpha Reductase inhibitors, such as Dutasteride, are irreversible modifiers.
- A.
True
- B.
False
- 10.The antiandrogens Bicalutamide, Flutamide and Nilutamide act by blocking the effects of testosterone and DHT on androgen receptors in the treatment of advanced prostate cancer.
- A.
True
- B.
False
- 11.
![Which feature of the molecule shown here is very rarely found in drug molecules today? - ProProfs]( "Which feature of the molecule shown here is very rarely found in drug molecules today?")
Which feature of the molecule shown here is very rarely found in drug molecules today?- A.
Tri-fluoro group
- B.
Nitro group
- C.
Amide group
- D.
Cyano group
- 12.Why is the nitro group found in antiandrogens such as Nilutamide and Flutamide so unusual in modern drugs?
- A.
Highly nephrotoxic
- B.
Highly hepatotoxic
- C.
Highly neurotoxic
- D.
Highly cardiotoxic
- 13.Estrogens have an aromatic A ring, 18 Carbons and a 3-OH group. Which of the following is the most potent estrogen?
- A.
Option 1
- B.
Option 2
- C.
Option 3
- D.
Option 4
- 14.
![The rightward reaction shown in this pictures is what type of reaction? - ProProfs]( "The rightward reaction shown in this pictures is what type of reaction?")
The rightward reaction shown in this pictures is what type of reaction?- A.
Oxidation
- B.
Reduction
- C.
Amination
- D.
Esterification
- 15.
![What type of reaction is shown here? - ProProfs]( "What type of reaction is shown here?")
What type of reaction is shown here?- A.
Reduction
- B.
Dehydroxylation
- C.
Oxidation
- D.
Dehydration
- 16.Which of the following are Phase 2 reactions undergone by Estrogens?
- A.
Sulfation
- B.
Glucuronidation
- C.
Hydroxylation
- D.
Esterification
- 17.
![The enzyme which catalyzes the Phase 2 reaction of estradiol shown here is which of the following? - ProProfs]( "The enzyme which catalyzes the Phase 2 reaction of estradiol shown here is which of the following?")
The enzyme which catalyzes the Phase 2 reaction of estradiol shown here is which of the following?- A.
UDP-glucuronosyltransferase
- B.
Methyltransferase
- C.
Thioesterase
- D.
Sulfotransferase
- 18.
![The reaction shown here occurs in Phase ___ and is catalyzed by the enzyme ______. - ProProfs]( "The reaction shown here occurs in Phase ___ and is catalyzed by the enzyme ______.")
The reaction shown here occurs in Phase ___ and is catalyzed by the enzyme ______.- A.
2; dehydrogenase
- B.
1; UGT
- C.
2; UGT
- D.
1; dehydrogenase
- 19.Which of the following enzymes is responsible for enterohepatic cycling?
- A.
Beta-glucuronidase
- B.
Estrogen 2/4-hydroxylase
- C.
COMT
- D.
UGT
- 20.The enzyme responsible for enterohepatic cycling, Beta-glucuronidase, can be found where?
- A.
Bacteria in the liver
- B.
Bacteria in the large intestine
- C.
Liver cell membranes
- D.
Intestinal cell membranes
- 21.The drug-drug interaction between antibiotics and estrogens is due to the lack of Beta-glucuronidase that occurs after antibiotics kill intestinal bacteria. Estrogen levels decrease because estrogen can no longer undergo enterohepatic cycling.
- A.
True
- B.
False
- 22.Another name for the enzyme Estrogen 2/4-hydroxylase is
- A.
CYP2D6
- B.
CYP2C9
- C.
CYP3A4
- D.
CYP6D9
- 23.
![The structure shown here is produced by metabolism of Estrogen by Estrogen 2-hydroxylase enzyme. This molecule is further metabolized by which of the following enzymes? - ProProfs]( "The structure shown here is produced by metabolism of Estrogen by Estrogen 2-hydroxylase enzyme. This molecule is further metabolized by which of the following enzymes?")
The structure shown here is produced by metabolism of Estrogen by Estrogen 2-hydroxylase enzyme. This molecule is further metabolized by which of the following enzymes?- A.
UGT
- B.
Estrogen 4-hydroxylase
- C.
COMT
- D.
Aromatase
- 24.
![The purpose of the addition of the 17-alpha alkyne group to this estrogen molecule is to - ProProfs]( "The purpose of the addition of the 17-alpha alkyne group to this estrogen molecule is to")
The purpose of the addition of the 17-alpha alkyne group to this estrogen molecule is to- A.
Increase molecular size
- B.
Decrease oral bioavailability
- C.
Increase oral bioavailability
- D.
Make the molecule ionic
- 25.Which of the following classes of drugs are estrogen antagonists?
- A.
Aromatase Inhibitors
- B.
Phenylethanolamines
- C.
PDE5 Inhibitiors
- D.
Triphenylethylenes
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