Pmc 1 Exam 3

114 Questions | Total Attempts: 54

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Androgens & Estrogens (Cox & Sumanasekera), Adrenocorticosteroids (Cox & Sumanasekera) and Antihistamines (Cox & McCune)


Questions and Answers
  • 1. 
    A substituent attached to the 10 Carbon on the steroid nucleus shown here would have what numbering?
    • A. 

      18

    • B. 

      19

    • C. 

      20

    • D. 

      21

  • 2. 
    Steroids bind receptors ____
    • A. 

      Inside the cell membrane

    • B. 

      Extracellularly

    • C. 

      Intracellularly

  • 3. 
    Steroids act by binding intracellular receptors; the steroid-receptor complex then enters the nucleus and changes levels of proteins by altering the rate of DNA replication.
    • A. 

      True

    • B. 

      False

  • 4. 
    Testosterone exhibits poor bioavailability due to extensive 1st pass metabolism.
    • A. 

      True

    • B. 

      False

  • 5. 
    The steroid molecule shown here is transformed by which of the following enzymes?
    • A. 

      Gyrases

    • B. 

      Esterases

    • C. 

      Deaminases

    • D. 

      Phosphatases

  • 6. 
    Esterases metabolize lipophilic esters found at C17 on steroid molecules. Where in the body can these enzymes be found?
    • A. 

      Liver only

    • B. 

      Lung and skin only

    • C. 

      Fat tissues only

    • D. 

      Throughout the body

  • 7. 
    The purpose of esterification of steroid molecules with long carbon chains at C17 is to
    • A. 

      Reduce drug half-lfie

    • B. 

      Make the molecule more hydrophilic

    • C. 

      Extend drug half-life in the blood

    • D. 

      Minimize the lipophilicity of the molecule

  • 8. 
    Finasteride and Dutasteride act by which of the following mechanisms?
    • A. 

      5a Reductase inhibition

    • B. 

      5a Reductase induction

    • C. 

      11b Hydroxysteroid dehydrogenase inhibition

    • D. 

      11b Hydroxysteroid dehydrogenase induction

  • 9. 
    5-alpha Reductase inhibitors, such as Dutasteride, are irreversible modifiers.
    • A. 

      True

    • B. 

      False

  • 10. 
    The antiandrogens Bicalutamide, Flutamide and Nilutamide act by blocking the effects of testosterone and DHT on androgen receptors in the treatment of advanced prostate cancer.
    • A. 

      True

    • B. 

      False

  • 11. 
    Which feature of the molecule shown here is very rarely found in drug molecules today?
    • A. 

      Tri-fluoro group

    • B. 

      Nitro group

    • C. 

      Amide group

    • D. 

      Cyano group

  • 12. 
    Why is the nitro group found in antiandrogens such as Nilutamide and Flutamide so unusual in modern drugs?
    • A. 

      Highly nephrotoxic

    • B. 

      Highly hepatotoxic

    • C. 

      Highly neurotoxic

    • D. 

      Highly cardiotoxic

  • 13. 
    Estrogens have an aromatic A ring, 18 Carbons and a 3-OH group. Which of the following is the most potent estrogen?
    • A. 

      Option 1

    • B. 

      Option 2

    • C. 

      Option 3

    • D. 

      Option 4

  • 14. 
    The rightward reaction shown in this pictures is what type of reaction?
    • A. 

      Oxidation

    • B. 

      Reduction

    • C. 

      Amination

    • D. 

      Esterification

  • 15. 
    What type of reaction is shown here?
    • A. 

      Reduction

    • B. 

      Dehydroxylation

    • C. 

      Oxidation

    • D. 

      Dehydration

  • 16. 
    Which of the following are Phase 2 reactions undergone by Estrogens?
    • A. 

      Sulfation

    • B. 

      Glucuronidation

    • C. 

      Hydroxylation

    • D. 

      Esterification

  • 17. 
    The enzyme which catalyzes the Phase 2 reaction of estradiol shown here is which of the following?
    • A. 

      UDP-glucuronosyltransferase

    • B. 

      Methyltransferase

    • C. 

      Thioesterase

    • D. 

      Sulfotransferase

  • 18. 
    The reaction shown here occurs in Phase ___ and is catalyzed by the enzyme ______.
    • A. 

      2; dehydrogenase

    • B. 

      1; UGT

    • C. 

      2; UGT

    • D. 

      1; dehydrogenase

  • 19. 
    Which of the following enzymes is responsible for enterohepatic cycling?
    • A. 

      Beta-glucuronidase

    • B. 

      Estrogen 2/4-hydroxylase

    • C. 

      COMT

    • D. 

      UGT

  • 20. 
    The enzyme responsible for enterohepatic cycling, Beta-glucuronidase, can be found where?
    • A. 

      Bacteria in the liver

    • B. 

      Bacteria in the large intestine

    • C. 

      Liver cell membranes

    • D. 

      Intestinal cell membranes

  • 21. 
    The drug-drug interaction between antibiotics and estrogens is due to the lack of Beta-glucuronidase that occurs after antibiotics kill intestinal bacteria. Estrogen levels decrease because estrogen can no longer undergo enterohepatic cycling.
    • A. 

      True

    • B. 

      False

  • 22. 
    Another name for the enzyme Estrogen 2/4-hydroxylase is
    • A. 

      CYP2D6

    • B. 

      CYP2C9

    • C. 

      CYP3A4

    • D. 

      CYP6D9

  • 23. 
    The structure shown here is produced by metabolism of Estrogen by Estrogen 2-hydroxylase enzyme. This molecule is further metabolized by which of the following enzymes?
    • A. 

      UGT

    • B. 

      Estrogen 4-hydroxylase

    • C. 

      COMT

    • D. 

      Aromatase

  • 24. 
    The purpose of the addition of the 17-alpha alkyne group to this estrogen molecule is to
    • A. 

      Increase molecular size

    • B. 

      Decrease oral bioavailability

    • C. 

      Increase oral bioavailability

    • D. 

      Make the molecule ionic

  • 25. 
    Which of the following classes of drugs are estrogen antagonists?
    • A. 

      Aromatase Inhibitors

    • B. 

      Phenylethanolamines

    • C. 

      PDE5 Inhibitiors

    • D. 

      Triphenylethylenes

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