Pharmacokinetics Questions Quiz! Trivia Test

20 Questions | Total Attempts: 546

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Pharmacokinetics Questions Quiz! Trivia Test


Questions and Answers
  • 1. 
    What does ADME stand for? A___ D___ M___ E___
  • 2. 
    Which of the following are parenteral methods of  administration (the others being enteral)?
    • A. 

      Oral

    • B. 

      Subcutaneous

    • C. 

      Sublingual

    • D. 

      Buccal

    • E. 

      Intramuscular

    • F. 

      Rectal

    • G. 

      Intravenous

    • H. 

      Intrathecal

  • 3. 
    By definition, when a medication is administered _______, its bioavailability is 100%.
  • 4. 
    Which of the following can be absorbed dermally?
    • A. 

      Nicotine

    • B. 

      Testosterone

    • C. 

      Oestrogen

    • D. 

      Insulin

    • E. 

      Fentanyl (a strong opiate to control pain in the terminally ill)

    • F. 

      Nitroglycerine (releases NO to treat angina)

    • G. 

      Lidocaine (local anesthetic which blocks Na+ channels)

    • H. 

      Morphine

    • I. 

      Clonidine (high blood pressure treatment)

  • 5. 
    The partition coefficient logP=____
    • A. 

      Log([solute in octanol]/[solute in unionised water])

    • B. 

      Log([solute in unionised water]/[solute in octanol])

    • C. 

      Log([solute in hexane]/[solute in unionised water])

    • D. 

      Log([solute in unionised water]/[solute in hexane])

  • 6. 
    Drugs with a higher partition coefficient...
    • A. 

      Are better orally absorbed

    • B. 

      May be less likely to partition out of the bilayer again

    • C. 

      Are always more selective

    • D. 

      Are retained in the body for longer

    • E. 

      Are less toxic

    • F. 

      Are often extensively metabolised

  • 7. 
    What is the advantage of prodrugs?
    • A. 

      Greater oral bioavailability

    • B. 

      Lower toxicity

    • C. 

      Greater specificity

    • D. 

      Higher potency

  • 8. 
    Why is the bioavailability of valaciclovir greater than aciclovir?
    • A. 

      Greater partition coefficient

    • B. 

      Can be transported by branched chain amino acid carriers

    • C. 

      It is a prodrug

  • 9. 
    Which one of the following Phase I reactions are most commonly carried out by Cytochrome P450 enzymes?
    • A. 

      Oxidation/hydroxylation

    • B. 

      Dealkylation

    • C. 

      Deamination

    • D. 

      Hydrolysis

    • E. 

      Reduction

  • 10. 
    Which of the following groups are drugs often conjugated to in Phase II metabolism?
    • A. 

      Glucuronyl

    • B. 

      Sulphate

    • C. 

      Hydroxyl

    • D. 

      Methyl

    • E. 

      Acetyl

    • F. 

      Amine

    • G. 

      Glycyl

    • H. 

      Glutathione

  • 11. 
    How is caffiene metabolised?
    • A. 

      1-N demethyation

    • B. 

      3-N demethylation

    • C. 

      5-N demethylation

    • D. 

      7-N demethylation

    • E. 

      Hydroxylation

    • F. 

      Conjugation

  • 12. 
    The drug C____ is a prodrug that forms an active metabolite with an exposed ___ group which covalently modifies a purinergic GPCR to prevent blood clots.
  • 13. 
    Tyrosine is ____ to give tyramine, noradrenaline and 5-HT, the amino groups on which can be removed by _____ ____ to give an aldehyde which can then be oxidised to an ___. Blocking of this pathway can lead to cheese syndrome by activating the ____ pathway. 
  • 14. 
    Alcohol levels decrease:
    • A. 

      Linearly

    • B. 

      Exponentially

    • C. 

      Parabolically