Dive into the fundamentals of pharmacokinetics with this trivia quiz! Test your knowledge on ADME, drug administration routes, and bioavailability. Perfect for students and professionals in the medical field to assess and enhance their understanding.
Oxidation/hydroxylation
Dealkylation
Deamination
Hydrolysis
Reduction
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Greater oral bioavailability
Lower toxicity
Greater specificity
Higher potency
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Linearly
Exponentially
Parabolically
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Log([solute in octanol]/[solute in unionised water])
Log([solute in unionised water]/[solute in octanol])
Log([solute in hexane]/[solute in unionised water])
Log([solute in unionised water]/[solute in hexane])
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Oral
Subcutaneous
Sublingual
Buccal
Intramuscular
Rectal
Intravenous
Intrathecal
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Greater partition coefficient
Can be transported by branched chain amino acid carriers
It is a prodrug
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Nicotine
Testosterone
Oestrogen
Insulin
Fentanyl (a strong opiate to control pain in the terminally ill)
Nitroglycerine (releases NO to treat angina)
Lidocaine (local anesthetic which blocks Na+ channels)
Morphine
Clonidine (high blood pressure treatment)
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Are better orally absorbed
May be less likely to partition out of the bilayer again
Are always more selective
Are retained in the body for longer
Are less toxic
Are often extensively metabolised
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Glucuronyl
Sulphate
Hydroxyl
Methyl
Acetyl
Amine
Glycyl
Glutathione
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1-N demethyation
3-N demethylation
5-N demethylation
7-N demethylation
Hydroxylation
Conjugation
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