Pharmacokinetics Questions Quiz! Trivia Test
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- 1.What does ADME stand for? A___ D___ M___ E___
- 2.Which of the following are parenteral methods of administration (the others being enteral)?
- A.
Oral
- B.
Subcutaneous
- C.
Sublingual
- D.
Buccal
- E.
Intramuscular
- F.
Rectal
- G.
Intravenous
- H.
Intrathecal
- 3.By definition, when a medication is administered _______, its bioavailability is 100%.
- 4.Which of the following can be absorbed dermally?
- A.
Nicotine
- B.
Testosterone
- C.
Oestrogen
- D.
Insulin
- E.
Fentanyl (a strong opiate to control pain in the terminally ill)
- F.
Nitroglycerine (releases NO to treat angina)
- G.
Lidocaine (local anesthetic which blocks Na+ channels)
- H.
Morphine
- I.
Clonidine (high blood pressure treatment)
- 5.The partition coefficient logP=____
- A.
Log([solute in octanol]/[solute in unionised water])
- B.
Log([solute in unionised water]/[solute in octanol])
- C.
Log([solute in hexane]/[solute in unionised water])
- D.
Log([solute in unionised water]/[solute in hexane])
- 6.Drugs with a higher partition coefficient...
- A.
Are better orally absorbed
- B.
May be less likely to partition out of the bilayer again
- C.
Are always more selective
- D.
Are retained in the body for longer
- E.
Are less toxic
- F.
Are often extensively metabolised
- 7.What is the advantage of prodrugs?
- A.
Greater oral bioavailability
- B.
Lower toxicity
- C.
Greater specificity
- D.
Higher potency
- 8.Why is the bioavailability of valaciclovir greater than aciclovir?
- A.
Greater partition coefficient
- B.
Can be transported by branched chain amino acid carriers
- C.
It is a prodrug
- 9.Which one of the following Phase I reactions are most commonly carried out by Cytochrome P450 enzymes?
- A.
Oxidation/hydroxylation
- B.
Dealkylation
- C.
Deamination
- D.
Hydrolysis
- E.
Reduction
- 10.Which of the following groups are drugs often conjugated to in Phase II metabolism?
- A.
Glucuronyl
- B.
Sulphate
- C.
Hydroxyl
- D.
Methyl
- E.
Acetyl
- F.
Amine
- G.
Glycyl
- H.
Glutathione
- 11.How is caffiene metabolised?
- A.
1-N demethyation
- B.
3-N demethylation
- C.
5-N demethylation
- D.
7-N demethylation
- E.
Hydroxylation
- F.
Conjugation
- 12.The drug C____ is a prodrug that forms an active metabolite with an exposed ___ group which covalently modifies a purinergic GPCR to prevent blood clots.
- 13.Tyrosine is ____ to give tyramine, noradrenaline and 5-HT, the amino groups on which can be removed by _____ ____ to give an aldehyde which can then be oxidised to an ___. Blocking of this pathway can lead to cheese syndrome by activating the ____ pathway.
- 14.Alcohol levels decrease:
- A.
Linearly
- B.
Exponentially
- C.
Parabolically
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