1.
A patient was admitted to the hospital because of an acute episode of bronchial asthma. Theophylline was administered to the patient as an iv loading dose of 300 mg followed immediately by a constant rate iv infusion of 45 mg/hr. The theophylline steady state concentration achieved is 15 mg/L ( k is 0.1 hr-1)
the volume of distribution???
2.
The first-order elimination rate constant for penicillin G is 1.2 hr-1, for gentamicin is 0.35 hr-1, for flucytosine is 0.1 hr-1, and for rifampin is 0.2 hr-1. Which of these drugs will reach steady state faster during repeated administration?
3.
Digoxin is a drug used in the treatment of congestive heart failure. Its elimination rate constant is 0.4 day-1, and its volume of distribution is 7 L/kg. How long it will take to reach steady state if a patient started taking 0.25 mg digoxin every day ?
4.
A patient was admitted to the hospital because of acute myocardial infarction. After stabilizing his condition, he was given an iv loading dose of 150 mg propranolol followed immediately by a constant rate iv infusion of 3 mg/hr. What is the rate of propranolol elimination at steady state?
5.
Procainamide is a class Ia antiarrhythmic drug that alters conduction in normal and ischemic cardiac tissues by sodium-channel blockade. What is the steady state procainamide concentration achieved during constant rate iv infusion of 2 mg/min if procainamide volume of distribution is 120 liters and elimination rate constant is 0.2 hr-1 ?
6.
Procainamide was administered to a patient as a constant rate iv infusion of 2 mg/min to control his ventricular arrhythmia. The steady state procainamide concentration was found to be 4 mg/L. Because the patient condition was not controlled, the physician asked you to recommend an infusion rate that will increase the steady state plasma procainamide concentration in this patient to 6 mg/L. What will be your recommendation?
7.
Bretylium is an antiarrhythmic drug used in the treatment of ventricular arrhythmia. Its elimination rate constant in patients with renal insufficiency is 0.5 day-1, and its volume of distribution is 6 L/kg. How long it will take to reach steady state if a patient with renal insufficiency was started on a constant rate iv infusion of 90 mg/hr ?
8.
A patient is receiving a constant rate iv infusion of 60 mg/hr theophylline to control an acute episode of bronchial asthma. Theophylline steady state concentration during this infusion was 15 mg/L. Calculate the total body clearance of theophylline in this patient.
9.
Theophylline therapeutic range is between 10-20 mg/L. calculate theophylline steady state concentration during a constant rate IV infusion of 25 mg/hr? (Vd = 30 L, and K = 0.1155 hr-1)
please note will the concentration achieved reach the therapeutic range ???
10.
Theophylline therapeutic range is between 10-20 mg/L. what is the infusion rate required to achieve steady state concentration of 15 mg/L (Vd = 30 L, and K = 0.1155 hr-1)
11.
A patient is taking 200 mg quinidine sulfate tablet every 8 hours for the treatment of cardiac arrhythmia. His average plasma quinidine concentration at steady state was 2 mg/L. Because the patient condition was not controlled, the physician asked you to recommend a dosing regimen that will increase the average steady state plasma quinidine concentration in this patient to 6 mg/L. What will be your recommendation?
12.
A patient is taking 450 mg of an antibiotic every 12 h as IV bolus doses. At steady state, the maximum and minimum plasma antibiotic concentrations were 40 and 10 mg/L, respectively. the half life of this drug is
13.
A patient is taking a daily 25 mg prednisone tablet which is 100% bioavailable for the treatment of ulcerative colitis, and his condition is well under control. The patient is to start taking a new prednisone formulation which is known to have bioavailability of 80%. What will be the required dose from this new formulation to control the patient's condition ?
14.
During repeated administration of 40 mg ibuprufen tablet every 8 hours (F=1) for the treatment of rheumatoid arthritis the AUC during one dosing interval was 16 mg-hr/L. What is the average ibuprufen steady state plasma concentration during this dosing regimen (40 mg every 8 hours) ?
15.
A patient is taking procainamide 600 mg/ 6hrs to control cardiac arrhythemia. the average procainamide conc. at s.s was 4 mg/L. what will be the dose requiredto increase the average s.s. conc to 5 mg/L.
F= 1
K=0.231 hr-1
Vd=110 L
16.
After administration of a single 400 mg iv dose of ciprofloxacin 240 mg excreted unchanged in urine. If the TBC of ciprofloxacin is 0.45 L/hr/kg, what is the renal clearance of this drug ?
17.
A patient is taking 500 mg tetracycline tablet every 12 hours. Tetracycline is rapidly and completely absorbed after oral administration and its renal clearance represent 20% of its total body clearance. What is the amount of tetracycline eliminated unchanged in urine during one dosing interval at steady state ?
18.
A patient is receiving a constant rate IV infusion of 30 mg/hr propranolol to control an acute episode
of arrythemia. propranolol steady state concentration during this infusion was 10 mg/L. You
were asked to recommend an oral dosing regimen to achieve the same average steady state concentration. What will be your recommendation if the bioavailability of the oral preparation is 100%?
19.
A patient was taking his antihypertensive medication as 500 mg every 12 h. He was taking his medication
in the form of an oral tablet that is rapidly and completely absorbed. After administration of a single oral
500 mg dose, 375 mg is excreted unchanged in urine and the drug half-life is 8 h. The average plasma
concentration of this antihypertensive drug in this patient while taking 500 mg every 12 h was 20 mg/L.
Calculate the volume of distribution of this drug in this patient
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20.
This patient developed acute renal failure and his creatinine clearance decreased from the normal value of 120 to 30 mL/min. Calculate the new total body clearance for this drug in this patient after developing the renal failure assuming that the deterioration in the kidney function does not affect the drug distribution characteristics.