Pharmacokinetics Slides 96-124, Teresa's Portion

29 Questions | Total Attempts: 156

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Pharmacokinetics Quizzes & Trivia

The last part of the Pharmacokinetics powerpoint


Questions and Answers
  • 1. 
    What is the process of expelling or removing, especially of waste products from the body? 
    • A. 

      Excretion

    • B. 

      Exoneration

    • C. 

      Elimination or clearance

    • D. 

      Eruption

  • 2. 
    Elimination or clearance is also the process by which the active form of a drug is removed from the bloodstream by either __________ or __________. 
    • A. 

      Excretion or diffusion

    • B. 

      Metabolism or excretion

    • C. 

      Metabolism or diffusion

  • 3. 
    Which of the following is NOT a process in which a drug is excreted? (According to her powerpoint)
    • A. 

      Sweat

    • B. 

      Urine

    • C. 

      Breast milk

    • D. 

      Defecation

    • E. 

      Tears

    • F. 

      Exhaled air

  • 4. 
    The formula for excretion is: Excretion = ________ + _________ - __________
    • A. 

      Reabsorption; Secretion; Filtration

    • B. 

      Reabsorption; Filtration; Secretion

    • C. 

      Secretion; Filtration; Reabsorption

  • 5. 
    What the term that describes the amount of plasma that the drug can be totally removed from per unit time?
    • A. 

      Plasma filtration rate

    • B. 

      Drug removal rate

    • C. 

      Clearance

  • 6. 
    What is the benefit of the enterohepatic cycle?
    • A. 

      Drugs MW> 300. This process is not beneficial to the body at all.

    • B. 

      Drugs MW> 300. This process eliminates and excretes the drug from your system.

    • C. 

      Drugs MW> 300. This process reduces the elimination of a drug and prolongs its half-life and duration of action in the body.

  • 7. 
    What is half-life?
    • A. 

      The time it takes your body to absorb a drug.

    • B. 

      Amount of time required to eliminate 50% of the drug existing in the body.

    • C. 

      50% of the dosage that you are required to take.

  • 8. 
    What component is not a consideration when clinicians design a Dose Regimen?
    • A. 

      Further refine or optimize this regimen to achieve maximum benefit with minimum adverse effects.

    • B. 

      Decide whether continuous administration or intervals of time and dose will be used.

    • C. 

      Take into account patient and drug factors and how rapidly the steady state must be achieved.

    • D. 

      The proportion of patients whom the Dose Regimen was successful.

  • 9. 
    Which is not one of the 3 Dosage Regimens mentioned her powerpoint?
    • A. 

      Continuous-infusion regimens

    • B. 

      Fixed-dose/fixed-time regimens

    • C. 

      Minimal risk regimens

    • D. 

      Optimization of dose

  • 10. 
    What is the goal of the continuous-infusion regimen?
    • A. 

      To eliminate as much of the drug out of the system by flushing it out.

    • B. 

      To increase the plasma concentration of a drug to reach Steady State, which is the time at which the rate of administration equals the rate of elimination.

    • C. 

      To keep the plasma concentration of a drug low in the system, so it does not have a huge effect.

  • 11. 
    Does a faster rate of infusion change the time needed to achieve steady state?
    • A. 

      Yes

    • B. 

      No

  • 12. 
    The shape of the graph of the time required to reach the steady-state drug concentration is a:
    • A. 

      Bell shaped curve

    • B. 

      Linear curve

    • C. 

      Parabola shaped curve

    • D. 

      Exponential curve

  • 13. 
    What is the main determinant of the rate approaching steady state?
    • A. 

      T1/2

    • B. 

      CL

    • C. 

      Concentration

  • 14. 
    When infusion is stopped, plasma concentration ______________ with the ________ time course observed in approaching the steady state.
    • A. 

      Declines to zero; different

    • B. 

      Declines to zero; same

    • C. 

      Increases to steady state; same

    • D. 

      Increases to steady state; different

  • 15. 
    Continuous-infusion regimens can be a:  in fixed-dose/fixed-time interval regimens (e.g., ‘one tablet every 4 hours’)
    • A. 

      Single administration of a drug (e.g., zolpidem, a sleep-inducing agent)

    • B. 

      Continued administration of a drug IV or orally

    • C. 

      Both

    • D. 

      Neither

  • 16. 
    Fixed-dose/fixed-time regimens consists of:
    • A. 

      Multiple IV injections

    • B. 

      Multiple oral administrations

    • C. 

      Neither

    • D. 

      Both

  • 17. 
    The goal of fixed-dose/fixed-time regimen is to:
    • A. 

      To increase the absorption of the drug due to a sudden decline in plasma concentration

    • B. 

      To prevent the plasma concentration of the drug from reaching steady state

    • C. 

      Give multiple administrations of a drug in short intervals to reach steady state

  • 18. 
    What is the "maintenance of dose" goal of Optimization of dose?
    • A. 

      Maintain a steady state concentration within the therapeutic window.

    • B. 

      Reach steady state as quickly and effectively as possible.

    • C. 

      Find the best dosage to have the maximum effect desired.

  • 19. 
    What is the goal of "loading dose" of the Optimization of dose regimen?
    • A. 

      To give the maximum dose possible to the patient.

    • B. 

      To achieve desired plasma levels of a drug faster (e.g., lidocaine for arrhythmias).

    • C. 

      To reduce the amount of drug in the plasma level.

  • 20. 
    Loading doses can be: 
    • A. 

      A single dose

    • B. 

      A series of doses

    • C. 

      Neither

    • D. 

      Both

  • 21. 
    Which is NOT a disadvantage of loading doses?
    • A. 

      Increase risk of drug toxicity

    • B. 

      Longer time for concentration to fall if excess drug level occurs

    • C. 

      Difficult to control the concentration once it reaches a certain point

  • 22. 
    What is the importance of dose adjustment?
    • A. 

      To monitor drug concentration and correlating it with therapeutic benefits can also be helpful to individualize therapy

    • B. 

      To have a fallback in case you overdose someone

    • C. 

      To monitor and assess the side effects of a dose at a certain point

  • 23. 
    When dosages are doubled, halved, or stopped during steady-state administration, the time required to achieve a new steady-state level is ___________ of the route of administration.
    • A. 

      Dependent

    • B. 

      Independent

    • C. 

      Neither