Pharmacokinetics (Some From Middle Of Lecture)

21 Questions | Total Attempts: 329

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Pharmacokinetics Quizzes & Trivia

About slides 32-65


Questions and Answers
  • 1. 
    Why can't we give insulin orally?
    • A. 

      Volume is too large

    • B. 

      PH of stomach is too high

    • C. 

      PH of stomach is too low

    • D. 

      Volume is too small

  • 2. 
    Which one of the following is NOT a chemical property that affects the transport route of a drug?
    • A. 

      Temperature

    • B. 

      Molecular size

    • C. 

      Polarity

    • D. 

      Charge

  • 3. 
    Most drugs are 
    • A. 

      Strong acids or strong bases

    • B. 

      Weak acids or weak bases

    • C. 

      Strong acids or weak bases

    • D. 

      Strong bases or weak acid

  • 4. 
    What dictates a drug charge?
  • 5. 
    What chemical property is described by the following?  nonpolar molecule (HA) reversibly dissociates into a polar ion (A-) and a protin (H+)?  
    • A. 

      Strong acid

    • B. 

      Strong base

    • C. 

      Weak acid

    • D. 

      Weak base

  • 6. 
    What form of weak acids and bases passively diffuses through membranes?
    • A. 

      Charged

    • B. 

      Uncharged

  • 7. 
    Term for the measure of strength of the interaction of a compound with a proton.  CONSTANT of a drug. 
  • 8. 
    The lower the pKa the more _____ a drug
    • A. 

      Acidic

    • B. 

      Basic

  • 9. 
    In areas of high expression P glycoprotein does what to drug absorption and thus more is transported out of cells?
    • A. 

      Reduces

    • B. 

      Increases

    • C. 

      Don't know

    • D. 

      Stays the same

  • 10. 
    Expression of P glycoprotein is associated with what?
    • A. 

      Risk of malignancy

    • B. 

      Allergies

    • C. 

      Multidrug resistance

    • D. 

      Anemia

  • 11. 
    Term for the extent to which a drug reaches systemic circulation (bloodstream)
  • 12. 
    If two drugs have comparable bioavailabilities and similar times to achieve peak blood concentrations they are said to be 
    • A. 

      Don't know

    • B. 

      Biodynamic

    • C. 

      Bioequivalent

    • D. 

      Bioavailability

  • 13. 
    Distribution of blood flow is faster to skeletal muscle than to the brain or liver. 
    • A. 

      True

    • B. 

      False

  • 14. 
    Tissue permeability affects distribution.  Many drugs can enter portal system.  In the liver this is because the basement membrane has...
    • A. 

      No fenestrations

    • B. 

      Fenestrations

    • C. 

    • D. 

  • 15. 
    What is the major drug binding protein that can act as a drug reservoir?
    • A. 

      Plasma albumin

    • B. 

      Fibrinogen

    • C. 

      Globulin

  • 16. 
    Hydrophobic drugs diffuse more readily across a membrane than hydrophilic.
    • A. 

      True

    • B. 

      False

  • 17. 
    Blood flow to an area is NOT a major factor influencing hydrophobicity. 
    • A. 

      True

    • B. 

      False

  • 18. 
    Theoretical volume that a drug would have to occupy (if it were uniformly distributed) to provide the same concentration in all organs or compartments as it currently is providing in blood plasma
    • A. 

      Volume of equivalency

    • B. 

      Volume of Bioavailability

    • C. 

      Volume of Drug Concentration

    • D. 

      Volume of Distribution

  • 19. 
    With regards to volume of distribution the plasma compartment contains drug with what type of molecular weight?
    • A. 

      Very large molecular weight

    • B. 

      Very small molecular weight

  • 20. 
    With regards to extracellular fluid and distribution this compartment would refer to drugs that are what molecular weight as well as hydrophobic/hydrophilic?
    • A. 

      Low molecular weight, hydrophilic

    • B. 

      Low molecular weight, hydrophobic

    • C. 

      High molecular weight, hydrophilic

    • D. 

      High molecular weight, hydrophobic

  • 21. 
    With regards to distribution and total body water this would refer to which type of drug
    • A. 

      High molecular weight and hydrophobic

    • B. 

      High molecular weight and hydrophilic

    • C. 

      Low molecular weight and hydrophobic

    • D. 

      Low molecular weight and hydrophilic