Explore the fundamentals of pharmacokinetics with this engaging quiz designed by Shannon, covering key concepts such as drug absorption, distribution, metabolism, and excretion. Understand how drugs interact with the body and the clinical implications of these processes.
Route of administration, dosage formulation, first pass effect, total surface area for absorption
ROME
Absorption, distribution, metabolism, elimination/excretion
Physiochemical properties, chemical properties, expression of P-glycoprotein, route of administration
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Transdermal
Intravenous
Oral
Inhalation
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Drugs administered orally are exposed to the liver and may be extensively metabolized before reaching the rest of the body (first pass effect)
Drugs administered orally enter directly into systemic circulation and because of highly fenestrated endothelial capillary cells make it to the brain quickly
Rectally is always the answer
Less contact time at the absorption site
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IV
Oral
Topical
Rectal
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Blood flow to the absorption site
Total surface area available for absorption
Contact time at the absorption surface
All of the above
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Liver
Kidneys
Lungs
Intestines
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IV
IM
Subcutaneous
Sublingual
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True
False
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Facilitated Diffusion
Active Transport
Passive Diffusion
Endocytosis
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Facilitated diffusion
Passive diffusion
Active transport
Endocytosis
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Clinical response to a drug ie; toxicity & efficacy
Drug concentration at site of action
Dose of drug administered
Drug metabolized or excreted
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IV injection
Inhalation
Oral
Rectal
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IV injection
IM injection
Suppository
Inhalation
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Injection into the gut
Sublingual route
Topical patch
Rectal suppository
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Transdermal & sublingual
Rectal and oral
Rectal, transdermal & sublingual
Oral
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