Pharmacokinetics Ppt Slides 1-31- Shannon

16 Questions | Total Attempts: 633

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Pharmacokinetics Quizzes & Trivia

Questions and Answers
  • 1. 
    Which does the term pharmacokinetics not include? (what the body does to the drug or how the drug gets in, around and out of the body)
    • A. 

      Clinical response to a drug ie; toxicity & efficacy

    • B. 

      Drug concentration at site of action

    • C. 

      Dose of drug administered

    • D. 

      Drug metabolized or excreted

  • 2. 
    Balance between what 4 processes of pharmacokinetics determines magnitude & duration of drug effects?
    • A. 

      Route of administration, dosage formulation, first pass effect, total surface area for absorption

    • B. 

      ROME

    • C. 

      Absorption, distribution, metabolism, elimination/excretion

    • D. 

      Physiochemical properties, chemical properties, expression of P-glycoprotein, route of administration

  • 3. 
    Most drugs enter the venous side of circulation; which route is the exception?
    • A. 

      IV injection

    • B. 

      IM injection

    • C. 

      Suppository

    • D. 

      Inhalation

  • 4. 
    A drug that might cause an upset stomach if taken orally can alternatively be administered via which route?
    • A. 

      Injection into the gut

    • B. 

      Sublingual route

    • C. 

      Topical patch

    • D. 

      Rectal suppository

  • 5. 
    Little Billy has accidentally ingested a toxic chemical which has made him unconscious  and will soon kill him.  Which route of administration will ER physicians and PA's most likely use to administer an antidote for this toxin?
    • A. 

      IV

    • B. 

      Oral

    • C. 

      Topical

    • D. 

      Rectal

  • 6. 
    The primary route of excretion route for drugs from the body is?
    • A. 

      Liver

    • B. 

      Kidneys

    • C. 

      Lungs

    • D. 

      Intestines

  • 7. 
    The primary organ that metabolizes drugs in the body is?
    • A. 

      Liver

    • B. 

      Lungs

    • C. 

      Kidneys

    • D. 

      Intestines

  • 8. 
    Which route allows cocaine to get into the brain fastest (another one is a very close second)?
    • A. 

      IV injection

    • B. 

      Inhalation

    • C. 

      Oral

    • D. 

      Rectal

  • 9. 
    Which route(s) of administration completely bypass the first pass effect?
    • A. 

      Transdermal & sublingual

    • B. 

      Rectal and oral

    • C. 

      Rectal, transdermal & sublingual

    • D. 

      Oral

  • 10. 
    Which route of administration is safest, most economical & most common?
    • A. 

      Transdermal

    • B. 

      Intravenous

    • C. 

      Oral

    • D. 

      Inhalation

  • 11. 
    What factors associated with the route of administration affect drug absorption?
    • A. 

      Blood flow to the absorption site

    • B. 

      Total surface area available for absorption

    • C. 

      Contact time at the absorption surface

    • D. 

      All of the above

  • 12. 
    When no facilitating factor is involved in the net movement of molecules in the direction of lower concentration; this is known as what?
    • A. 

      Facilitated diffusion

    • B. 

      Passive diffusion

    • C. 

      Active transport

    • D. 

      Endocytosis

  • 13. 
    When morphine is administered orally, only 40-50% reaches the CNS... why does this happen?
    • A. 

      Drugs administered orally are exposed to the liver and may be extensively metabolized before reaching the rest of the body (first pass effect)

    • B. 

      Drugs administered orally enter directly into systemic circulation and because of highly fenestrated endothelial capillary cells make it to the brain quickly

    • C. 

      Rectally is always the answer

    • D. 

      Less contact time at the absorption site

  • 14. 
    Which of the following is NOT a parenteral route of administration?
    • A. 

      IV

    • B. 

      IM

    • C. 

      Subcutaneous

    • D. 

      Sublingual

  • 15. 
    This mode of drug entry involves specific carrier proteins; energy dependent form is driven by the hydrolysis of ATP & it is capable of moving drugs across a concentration gradient....
    • A. 

      Facilitated Diffusion

    • B. 

      Active Transport

    • C. 

      Passive Diffusion

    • D. 

      Endocytosis

  • 16. 
    Bioavailability is known as the extent to which a drug reaches the systemic circulation (% of drug administered that reaches the blood stream).  In the book it is initially defined as: Bioavailability = AUC oral/ AUC injected x 100
    • A. 

      True

    • B. 

      False