Pharmacokinetics Ppt: Slides 64-95, Megan's Portion

41 Questions | Total Attempts: 109

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Pharmacokinetics Quizzes & Trivia

Questions and Answers
  • 1. 
    In a _______________, all drug administration occurs directly into the central compartment and distribution of drug is instantaneous throughout the volume.
    • A. 

      One compartment model

    • B. 

      Multiple compartment model

  • 2. 
    Clearance from this compartment in a one compartment model is a _____-order process: the amount of drug eliminated per unit of time depends on the amount (concentration) of drug in the body compartment.
    • A. 

      Second

    • B. 

      First

    • C. 

      Zero

  • 3. 
    After drugs are distributed, they are: 1.Redistributed (away from or towards)the tissues   2.Eliminated through Metabolism(aka biotransformation) and elimination
    • A. 

      Towards;metabolism, elimination

    • B. 

      Away from;elimination, metabolism

    • C. 

      Away from ;metabolism, elimination

    • D. 

      Away from;metabolism, absorption

  • 4. 
      A drug that makes an inactive drug active is called a _______  
    • A. 

      Activator

    • B. 

      Prodrome

    • C. 

      Prodrug

    • D. 

      Proformer

  • 5. 
    Through metabolism, an active drug may become inactive, which is an abnormal process of elimination.
    • A. 

      True

    • B. 

      False

  • 6. 
    Which is NOT an effect of metabolism?
    • A. 

      Make an active drug inactive:

    • B. 

      Make a toxic drug non-toxic

    • C. 

      Make an inactive drug active

    • D. 

      Make a drug toxic

  • 7. 
    The _is the main metabolic organ.
    • A. 

      Thyroid

    • B. 

      Kidneys

    • C. 

      Spleen

    • D. 

      Liver

  • 8. 
    What type of drug metabolism is important for activation or break down of a drug, and will help determine the dosage you'll give the patient?
    • A. 

      Second-pass metabolism

    • B. 

      First-pass metabolism

    • C. 

      Zero-order metabolism

    • D. 

      First-order metabolism

  • 9. 
    Following Phase I metabolism, a drug is MOST often: 
    • A. 

      Activated

    • B. 

      Inactivated

    • C. 

      Unchanged

    • D. 

      Changed

  • 10. 
    A conjugated drug is usually:
    • A. 

      Inactive

    • B. 

      Active

  • 11. 
    What event (according to her notes) will NOT happen to a drug after Phase I metabolism?
    • A. 

      Oxidation

    • B. 

      Hydrolysis

    • C. 

      Reduction

    • D. 

      Protonation

  • 12. 
     Phase I reactions do NOT  utilize P450 system at all. 
    • A. 

      True

    • B. 

      False

  • 13. 
    True or false: Phase I and Phase II drug metabolism both make hydrophobic drugs more polar to promote their elimination.
    • A. 

      True

    • B. 

      False

  • 14. 
    Phase I reactions generally add a___________ on the drug to slightly increase water solubility.
    • A. 

      Hydroxyl group

    • B. 

      Amine group

    • C. 

      Large polar group

  • 15. 
    Phase II reactions generally add ___________ to the hydroxyl group on the drug to greatly  increase water solubility.
    • A. 

      A large polar group

    • B. 

      Another hydroxyl group

    • C. 

      An amine group

    • D. 

      A fat soluble group

  • 16. 
    The consequence of Phase I reaction is a _______ in the drug's activity.
    • A. 

      Increase

    • B. 

      Inactivation

    • C. 

      Decrease

    • D. 

      Change

  • 17. 
    The consequence of Phase II reaction is  _______ in the drug's elimination.
    • A. 

      A decrease

    • B. 

      An increase

    • C. 

      A change

    • D. 

      No effect

  • 18. 
    What does DMMS stand for?
    • A. 

      Drug minimizing metabolic stereoisomer

    • B. 

      Drug microsomal metabolizing system

    • C. 

      Drug minimizing metabolizing stereoisomer

  • 19. 
    When a parent drug is metabolized by a DMMS enzyme, the oxidized metabolite gives off _____ and ______
    • A. 

      H20, NADP+

    • B. 

      NADP+, OH-

    • C. 

      H+, NADP+

    • D. 

      ADP+, H20

  • 20. 
    Fill in blanks regarding the nomenclature of CYP enzymes:  CYP+ number (_______)+ capital letter (_________)+ number (_____________)   example:  CYP3A4
    • A. 

      Subfamily,family, specific isozyme

    • B. 

      Family, subfamily,specific isozyme

    • C. 

      Phase reaction, family, subfamily

    • D. 

      Family, subfamily, phase reaction

  • 21. 
    Fill in blanks: -The Cytochrome P450 system is made of Microsomal mixed-function _________. -It metabolizes  many ________compounds (steroids, lipids, etc) and biotransforms  _________substances (xenobiotics).   -It is a superfamily of _____-containing isozymes located in most cells but primarily in liver and GI tract
    • A. 

      Oxidases, endogenous, exogenous, heme

    • B. 

      Proteases,endogenous, exogenous, hydroxyl

    • C. 

      Hydroxylases, exogenous, endogenous,protein

  • 22. 
    What CYP enzyme is found in high concentrations in the intestinal mucosa, and participates in  first-pass metabolism of chlorpromazine and clonazepam?
    • A. 

      CYP637

    • B. 

      CYP3B4

    • C. 

      CYP3A4

  • 23. 
    Activation of ________, a prodrug,  requires both metabolism by CYP2C19 and CYP3A4
    • A. 

      Clonazepam

    • B. 

      Clopidogrel

    • C. 

      Ativan

  • 24. 
    Inducers of CYPs cause ___________in drug metabolism.
    • A. 

      An increase

    • B. 

      A decrease

    • C. 

      No effect

  • 25. 
    Inducers of CYPs, which cause an increase in drug metabolism,  have consequences. What choice below is NOT one such consequence?  
    • A. 

      Decreased plasma drug concentrations ●

    • B. 

      Increased drug activity if metabolite is active

    • C. 

      Decreased drug activity if the metabolite is inactive

    • D. 

      Increased drug activity if the metabolite is inactive

    • E. 

      Decreased therapeutic drug effect

  • 26. 
    What are two common inducers for Warfarin, Ibuprofen,Tolbutamide, and Phenytoin?
    • A. 

      Phenobarbital, Rifampin

    • B. 

      Rifampin, Warfarin

    • C. 

      Warfarin, Phenobarbital

  • 27. 
    Desipramine, Imipramine,Haloperidol,propanolol are VERY susceptible to enzyme induction.
    • A. 

      True

    • B. 

      False

  • 28. 
    Inhibitors of CYPs cause __________ in drug metabolism.
    • A. 

      A decrease

    • B. 

      An increase

    • C. 

      No effect

  • 29. 
    Inhibitors of CYPs cause a decrease in drug metabolism, of which there are consequences. Of the choices below, which is NOT a consequence of CYP inhibitors? : 1.Increased plasma drug concentrations ● 2.Increased drug activity if the metabolite is inactive ● 3.Decreased drug activity if metabolite is active ● 4.Increased therapeutic drug effect
    • A. 

      Increased plasma drug concentrations

    • B. 

      Increased drug activity if the metabolite is inactive

    • C. 

      Decreased drug activity if metabolite is active

    • D. 

      Increased therapeutic drug effect

    • E. 

      Decreased therapeutic drug effect

  • 30. 
    The oxidation reactions NOT catalyzed by Cytochrome P450 include: 1) Flavin containing monoxygenase system 2) Alcohol dehydrogenase  3) Aldehyde oxidation  4) Xanthine oxidase 5) Amine oxidases 6) Flavin oxidases  
    • A. 

      1-4

    • B. 

      1,3,5

    • C. 

      1-5

    • D. 

      1-4, 6

  • 31. 
    The Flavin containing monoxygenase system, an oxidation rxn that is not catalyzed by CYP450. Fill in the blanks regarding this system below: –Present mainly in ______but some is expressed in gut and lung –Located in ____________ –_________compounds containing sulfur and nitrogen –Uses ____________ as cofactors
    • A. 

      Liver, smooth ER, oxidizes, NAD/NADPH

    • B. 

      Brain, golgi, reduces, NAD/NADPH

    • C. 

      Kidneys, smooth ER, oxidizes, NAD/NADPH

  • 32. 
    What two oxidation rxns that are not catalyzed by CYP450 take place in cellular cytosol? Alcohol dehydrogenase  Aldehyde oxidation •Xanthine oxidase •Amine oxidases
    • A. 

      Alcohol dehydrogenase, Amine oxidases

    • B. 

      Aldehyde oxidation, Xanthine oxidase

    • C. 

      Aldehyde oxidation, Amine oxidases

    • D. 

      Alcohol dehydrogenase, Aldehyde oxidation

  • 33. 
    Of the amine oxidases, (oxidation rxns not catalyzed by CYP450):  Monoamine oxidase is found in ________________, while Diamine oxidase found in _____________ and have  __________metabolism.
    • A. 

      Kidneys, brain, endogenous

    • B. 

      Liver microsomes, nerve terminals/mitochondria, exogenous

    • C. 

      Nerve terminals/mitochondria, liver microsomes, endogenous

  • 34. 
    The most important Phase II conjugation reaction according to her ppt, is :
    • A. 

      Sulfation by Sulfotransferase

    • B. 

      Glucuronidation by UDP-Glucuronosyltransferase

    • C. 

      Amino acid conjugation

    • D. 

      Fatty acid conjugation

  • 35. 
    A drug like Diazepam would reive a _____  from ______ in a Phase ____ reaction.  In a Phase ____ reaction, Diazepam would receive a ________ from ___________.
    • A. 

      Hydroxyl group, DMMP, II

    • B. 

      Hydroxyl group, CYP450, II, I, sugar group, glucoronidation

    • C. 

      Hydroxyl group, CYP450, I, II, sugar group, glucoronidation

  • 36. 
    A drug is eliminated by metabolism and excretion, or by _______only .
    • A. 

      Excretion

    • B. 

      Absorption

    • C. 

      Metabolism

  • 37. 
    In most clinical situations, the drug concentration [C] <<< Km. This represents the _________.
    • A. 

      I JUST DONT CARE SERIOUSLY

    • B. 

      Michaelis constant

    • C. 

      I NEED DRUGS

  • 38. 
    The rate of drug metabolism and elimination is directly proportional to the concentration of free drug, known as __________.
    • A. 

      First order kinetics

    • B. 

      Zero order kinetics

    • C. 

      Second order kinetics

    • D. 

      I still have to write my PD write up! >:0

  • 39. 
    The statement below represents what type of kinetics? The enzyme is saturated by a high free-drug concentration and the rate of metabolism remains constant over time.
    • A. 

      Zero order

    • B. 

      First order

    • C. 

      Second order

  • 40. 
    What are some common drugs that are zero order kinetics?aspirin, ethanol, phenytoin)
    • A. 

      Aspirin

    • B. 

      Phenytoin

    • C. 

      Ethanol

    • D. 

      Timbits!

    • E. 

      All of the above, minus Timbits!