Diseases Of Immunity
Questions are based on Chapter 6 of Robbins and Cotran Pathologic Basis of Disease 7th edition.
- 1.Which of the following exhibit Toll like receptors? (6)
- A.
Macrophages
- B.
Erythrocytes
- C.
Neutrophils
- D.
Basophils
- E.
T cells
- F.
B cells
- G.
Plasma cells
- H.
Dendritic cells
- I.
Mucosal epithelial cells
- J.
Endothelial cells
- K.
Natural killer cells
- 2.The Gram Negative LPS/LBP complex facilitates LPS binding to which molecule? _ _ _ _
- 3.Which is the most significant of the transcription factors activated by signalling from toll like receptors?
- A.
MECP2
- B.
NF-κB
- C.
FOXP3
- 4.T_ _l l_ _e r_ _ _ _ _ _r activation ultimately results in synthesis of many different components of the innate immune response including cytokines, endothelial adhesion molecules and nitric oxide synthase.
- 5.Mannose binding lectin and C-reactive protein are circulating plasma proteins, both of which coat microbes for _ _ _ _ _ _ _ _ _ _ _ _ and complement activation.
- 6.Cell mediated (or cellular) immunity is responsible for defence against _ _ _ _ _ _ _ _ _ _ _ _ microbes.
- 7.Humoral immunity protects against _ _ _ _ _ _ _ _ _ _ _ _ microbes and their _ _ _ _ _ _. (separate answers with a comma)
- 8.T lymphocytes mediate _ _ _ _ _ _ _ _ immunity.
- 9.B lymphocytes mediate _ _ _ _ _ _ _ immunity.
- 10.As well as being found in the blood, naive T cells are found in the _ _ _ _ _ _ _ _ _ _ _ _ areas of lymph modes and _ _ _ _ _ _ _ _ _ _ _ _ _ _ sheaths of the spleen. (separate answers with a comma)
- 11.What does CD in CD4 stand for? (3 words)
- 12.T cells need 2 signals for activation.
- A.
True
- B.
False
- 13.Under the influence of IL-2, T cells proliferate, generating a large number of antigen-specific lymphocytes. They differentiate into _ _ _ _ _ _ _ _ cells and _ _ _ _ _ _ cells. (separate answers with a comma)
- 14.T-helper -1 cells are CD4+ T cells that secrete which cytokines? (2 most important)
- A.
IL-1
- B.
IL-2
- C.
IL-4
- D.
IL-5
- E.
TNF
- F.
IFN-γ
- 15.T-helper -2 cells are CD4+ T cells that secrete which cytokines? (3 most important)
- A.
IL-1
- B.
IL-2
- C.
IL-4
- D.
IL-5
- E.
IL-13
- F.
IFN-γ
- G.
TNF
- 16.CD8+ T cells act mainly as _ _ _ _ _ _ _ _ _ cells.
- 17.In the spleen, B lymphocytes are found in the _ _ _ _ _ _ _ _ _, in the lymph nodes they are found in the _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _. At both sites they aggregate to form lyphoid follicles. (separate answers with a comma)
- 18.Where do plasma cells mainly reside? (3)
- A.
Bone marrow
- B.
Glandular tissue
- C.
Mucosal tissue
- D.
Lymphoid tissue
- E.
Neural tissue
- F.
Circulating blood
- 19.CD56 and which other CD molecule are the 2 cell surface molecules generally used to identify natural killer cells?
- A.
CD3
- B.
CD4
- C.
CD8
- D.
CD16
- E.
CD40
- F.
CD56
- 20.X-linked hyper-IgM syndrome is an immunodeficiency disease cause by a mutation in the gene for which ligand? _ _ _ _
- 21.Expression of class I MHC molecules _ _ _ _ _ _ _ s killing by natural killer cells.
- 22.What is type I hypersensitivity is also known as?
- A.
Cell-mediated hypersensitivity
- B.
Immediate hypersensitivity
- C.
Antibody mediated hypersensitivity
- D.
Immune complex hypersensitivity
- 23.What is type II hypersensitivity is also known as?
- A.
Cell-mediated hypersensitivity
- B.
Immediate hypersensitivity
- C.
Antibody mediated hypersensitivity
- D.
Immune complex hypersensitivity
- 24.What is type III hypersensitivity is also known as?
- A.
Cell-mediated hypersensitivity
- B.
Immediate hypersensitivity
- C.
Antibody-mediated hypersensitivity
- D.
Immune complex hypersensitivity
- 25.What is type IV hypersensitivity is also known as?
- A.
Cell-mediated hypersensitivity
- B.
Immediate hypersensitivity
- C.
Antibody-mediated hypersensitivity
- D.
Immune complex hypersensitivity
Questions: 15 | Attempts: 5536 | Last updated: Mar 22, 2022
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