Diseases Of Immunity

66 Questions | Total Attempts: 834

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Immunity Quizzes & Trivia

Questions are based on Chapter 6 of Robbins and Cotran Pathologic Basis of Disease 7th edition.


Questions and Answers
  • 1. 
    Which of the following exhibit Toll like receptors? (6)
    • A. 

      Macrophages

    • B. 

      Erythrocytes

    • C. 

      Neutrophils

    • D. 

      Basophils

    • E. 

      T cells

    • F. 

      B cells

    • G. 

      Plasma cells

    • H. 

      Dendritic cells

    • I. 

      Mucosal epithelial cells

    • J. 

      Endothelial cells

    • K. 

      Natural killer cells

  • 2. 
    The Gram Negative LPS/LBP complex facilitates LPS binding to which molecule? _ _ _ _
  • 3. 
    Which is the most significant of the transcription factors activated by signalling from toll like receptors?
    • A. 

      MECP2

    • B. 

      NF-κB

    • C. 

      FOXP3

  • 4. 
    T_  _l l_ _e r_ _ _ _ _ _r activation ultimately results in synthesis of many different components of the innate immune response including cytokines, endothelial adhesion molecules and nitric oxide synthase.
  • 5. 
    Mannose binding lectin and C-reactive protein are circulating plasma proteins, both of which coat microbes for _ _ _ _ _ _ _ _ _ _ _ _ and complement activation.
  • 6. 
    Cell mediated (or cellular) immunity is responsible for defence against _ _ _ _ _ _ _ _ _ _ _ _ microbes.
  • 7. 
    Humoral immunity protects against _ _ _ _ _ _ _ _ _ _ _ _ microbes and their _ _ _ _ _ _. (separate answers with a comma)
  • 8. 
    T lymphocytes mediate _ _ _ _ _ _ _ _ immunity.
  • 9. 
    B lymphocytes mediate _ _ _ _ _ _ _ immunity.
  • 10. 
    As well as being found in the blood, naive T cells are found in the _ _ _ _ _ _ _ _ _ _ _ _ areas of lymph modes and _ _ _ _ _ _ _ _ _ _ _ _ _ _ sheaths of the spleen. (separate answers with a comma)
  • 11. 
    What does CD in CD4 stand for? (3 words)
  • 12. 
    T cells need 2 signals for activation.
    • A. 

      True

    • B. 

      False

  • 13. 
    Under the influence of IL-2, T cells proliferate, generating a large number of antigen-specific lymphocytes.  They differentiate into _ _ _ _ _ _ _ _ cells and _ _ _ _ _ _ cells. (separate answers with a comma)
  • 14. 
    T-helper -1 cells are CD4+ T cells that secrete which cytokines? (2 most important)
    • A. 

      IL-1

    • B. 

      IL-2

    • C. 

      IL-4

    • D. 

      IL-5

    • E. 

      TNF

    • F. 

      IFN-γ

  • 15. 
    T-helper -2 cells are CD4+ T cells that secrete which cytokines? (3 most important)
    • A. 

      IL-1

    • B. 

      IL-2

    • C. 

      IL-4

    • D. 

      IL-5

    • E. 

      IL-13

    • F. 

      IFN-γ

    • G. 

      TNF

  • 16. 
    CD8+ T cells act mainly as _ _ _ _ _ _ _ _ _ cells.
  • 17. 
    In the spleen, B lymphocytes are found in the _ _ _ _ _    _ _ _ _, in the lymph nodes they are found in the _ _ _ _ _ _ _ _ _ _ _   _ _ _ _ _ _.  At both sites they aggregate to form lyphoid follicles. (separate answers with a comma)
  • 18. 
    Where do plasma cells mainly reside? (3)
    • A. 

      Bone marrow

    • B. 

      Glandular tissue

    • C. 

      Mucosal tissue

    • D. 

      Lymphoid tissue

    • E. 

      Neural tissue

    • F. 

      Circulating blood

  • 19. 
    CD56 and which other CD molecule are the 2 cell surface molecules generally used to identify natural killer cells?
    • A. 

      CD3

    • B. 

      CD4

    • C. 

      CD8

    • D. 

      CD16

    • E. 

      CD40

    • F. 

      CD56

  • 20. 
    X-linked hyper-IgM syndrome is an immunodeficiency disease cause by a mutation in the gene for which ligand? _ _ _ _
  • 21. 
    Expression of class I MHC molecules _ _ _ _ _ _ _ s killing by natural killer cells.
  • 22. 
    What is type I hypersensitivity is also known as?
    • A. 

      Cell-mediated hypersensitivity

    • B. 

      Immediate hypersensitivity

    • C. 

      Antibody mediated hypersensitivity

    • D. 

      Immune complex hypersensitivity

  • 23. 
    What is type II hypersensitivity is also known as?
    • A. 

      Cell-mediated hypersensitivity

    • B. 

      Immediate hypersensitivity

    • C. 

      Antibody mediated hypersensitivity

    • D. 

      Immune complex hypersensitivity

  • 24. 
    What is type III hypersensitivity is also known as?
    • A. 

      Cell-mediated hypersensitivity

    • B. 

      Immediate hypersensitivity

    • C. 

      Antibody-mediated hypersensitivity

    • D. 

      Immune complex hypersensitivity

  • 25. 
    What is type IV hypersensitivity is also known as?
    • A. 

      Cell-mediated hypersensitivity

    • B. 

      Immediate hypersensitivity

    • C. 

      Antibody-mediated hypersensitivity

    • D. 

      Immune complex hypersensitivity

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