Pathology Exam Quiz Trivia: MCQ!

40 Questions | Total Attempts: 650

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Pathology Exam Quiz Trivia: MCQ! - Quiz

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Questions and Answers
  • 1. 
    One of the following is not affected in cancer development?
    • A. 

      DNA repair gene

    • B. 

      Activation of growth promoting oncogenes 

    • C. 

      Genes that regulate apoptosis 

    • D. 

      Activation of tumor suppressor genes 

  • 2. 
    Insensitivity to growth-inhibiting signals is one of the cancer hallmarks, one of the following is false about it.
    • A. 

      Tumor suppressor genes are recessive genes 

    • B. 

      In sporadic cases, one mutated allele is inherited

    • C. 

      Both alleles have to be mutated to express neoplastic transformation

    • D. 

      In familial cases, the person needs only one more somatic mutation in order to develop cancer 

  • 3. 
    What is the checkpoint in the cell cycle that is regulated by the RB gene?
    • A. 

      G2 to M

    • B. 

      M to G1 

    • C. 

      G1 to S

    • D. 

      S to G2 

  • 4. 
    TP-53 is one of the genes that is playing a role in cancer development, one of the following is true about it.
    • A. 

      P53 is active when it’s bound to its negative regulator MDM2

    • B. 

      It is called governor of the genome

    • C. 

      When it is activated it will arrest the cell cycle in M phase results in more time for repair

    • D. 

      A mutation in the TP-53 gene can be acquired or inherited

  • 5. 
    Mutant APC gene will release the amount of one of the following:
    • A. 

      B-catenin

    • B. 

      TGF-B 

    • C. 

      P53 

    • D. 

      MDM2 complex 

  • 6. 
    One of the following is not a hallmark of cancer.
    • A. 

      Evasion of Apoptosis

    • B. 

      Programmed cell death 

    • C. 

      Limitless replicative potential

    • D. 

      Development of Sustained Angiogenesis

  • 7. 
    Translocation in Follicular B cell Lymphoma is:
    • A. 

      T(18;14) 

    • B. 

      T(11;22) 

    • C. 

      T(12;21)

    • D. 

      T(4;4) 

  • 8. 
    What are the genes responsible for xeroderma pigmentosum disorder?
    • A. 

      K-RAS

    • B. 

      Mismatch repair genes

    • C. 

      Nucleotide excision repair genes

    • D. 

      BRCA-1 & BRCA-2

  • 9. 
    True about BRCA-1 & BRCA-2 genes:
    • A. 

      Tumor suppressor genes

    • B. 

      Found in 50% of familial breast cancers & ovarian cancer

    • C. 

      The BRCA gene is rarely inactivated in sporadic cases

    • D. 

      All of the following are correct 

  • 10. 
    One of the following is not a positive angiogenic factor.
    • A. 

      Thrombospondin1 (TSP-1)

    • B. 

      HIF-1a

    • C. 

      VEGF

    • D. 

      TGF

  • 11. 
    Accumulate mutations in tumor cells leads to:
    • A. 

      A more aggressive nature of tumor 

    • B. 

      Non antigenic growth

    • C. 

      All of them are correct 

    • D. 

      Invasion and Metastases

  • 12. 
    Which of the following is responsible for the attachment of tumor cells to matrix components in the metastasis process?
    • A. 

      Matrix Metalloproteinase

    • B. 

      Laminin & integrin receptors

    • C. 

      E-Cadherin

    • D. 

      Autocrine motility factor

  • 13. 
    One of the following doesn't influence the site of metastasis?
    • A. 

      Anatomical location of the primary tumor.

    • B. 

      Size of the tumor

    • C. 

      Complimentary adhesion molecule between tumor cells and target organs

    • D. 

      Chemoatractants liberated by target organs

    • E. 

      Protease inhibitors present in certain tissues

  • 14. 
    The least common site for a lung tumor to spread to is:
    • A. 

      Ovaries

    • B. 

      Brain 

    • C. 

      Adrenal glands 

    • D. 

      Liver 

  • 15. 
    One of the following is false about chemical carcinogens.
    • A. 

      They are electrophilic and cause DNA damage 

    • B. 

      Initiator (Mutagen) is a chemical inducing irreversible DNA damage

    • C. 

      They can't be natural substances 

    • D. 

      Some examples on them are nitrosamines and alkylating agents

  • 16. 
    Which of the following is not a skin cancer?
    • A. 

      Neuroblastoma 

    • B. 

      Squamous Cell Carcinoma 

    • C. 

      Basal Cell Carcinoma 

    • D. 

      Melanoma 

  • 17. 
    Which HPV strains have a high risk of developing Squamous cell CA in the cervix?
    • A. 

      HPV 4 & 7

    • B. 

      HPV 1  

    • C. 

      HPV 16 & 18 

    • D. 

      HPV 6 & 11

  • 18. 
    Burkitt lymphoma is mostly related to which virus?
    • A. 

      HPV

    • B. 

      HIV

    • C. 

      HCV

    • D. 

      EBV 

  • 19. 
    One of the following is false about microbial carcinogens?
    • A. 

      HTLV-1 TAX gene attaches to T cells induces Leukemia /Lymphoma 

    • B. 

      EBV playing a role in developing of hepatocellular carcinoma 

    • C. 

      Hepatitis B & C viruses are oncogeneic viruses 

    • D. 

      H.pylori may cause gastric carcinoma 

  • 20. 
    Regarding tumor immunology, one of the following is false.
    • A. 

      Tumors become more aggressive they distort their antigens

    • B. 

      Patients with congenital immune deficiency have 200 times higher ­risk of cancer

    • C. 

      Normal immunity present to protect against development of tumors

    • D. 

      All tumors cells have no specific antigens 

  • 21. 
    The most important Immune cells involved in fighting against tumors are:
    • A. 

      NK cells 

    • B. 

      CD8+ T-cells

    • C. 

      Macrophages 

    • D. 

      Adipocyets 

  • 22. 
    Which of the following antigens are seen in melanoma?
    • A. 

      Bcr/abl 

    • B. 

      HER-2

    • C. 

      HER-1

    • D. 

      Tyrosinase

  • 23. 
    Tumor cells escape immune surveillance by one of the following.
    • A. 

      Upregulation of co-stimulatory molecules.

    • B. 

      Apoptosis of  macrophages 

    • C. 

      Antigen masking

    • D. 

      Increase MHC molecules on tumor cell surface 

  • 24. 
    Cushing's syndrome as a paraneoplastic syndrome is mainly related to: 
    • A. 

      Squamous cell carcinoma 

    • B. 

      Hepatic carcinoma 

    • C. 

      Fibrosarcoma 

    • D. 

      Small cell carcinoma 

  • 25. 
    Tumor markers are used for?
    • A. 

      Confirm diagnosis

    • B. 

      Determine the response to treatment

    • C. 

      Detect early relapse

    • D. 

      All of them are correct 

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