Pharmacokinetics Trivia Questions

78 Questions | Total Attempts: 216

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Pharmacokinetics Quizzes & Trivia

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Questions and Answers
  • 1. 
    Which of the following are true.  Select all that apply.
    • A. 

      Pharmacokinetics relates dosage regimen and plasma concentration.

    • B. 

      Pharmacodynamics relates plasma concentration and the effect.

    • C. 

      Vd, Cl, and t1/2 are all pharmacodynamic properties.

  • 2. 
    Select all of the following that are true regarding tylenol use in alcoholics.
    • A. 

      Alcoholics have overexpression of 1A2.

    • B. 

      Alcoholics have overexpression of 2E1.

    • C. 

      In non-drinkers APAP is metabolized by Phase II.

    • D. 

      NAPQI is a very reactive intermediate that covalently binds to proteins in the liver.

  • 3. 
    Compartmental analysis allows for a mathmatical description of plasma concentration vs ______.
    • A. 

      Dose

    • B. 

      Volume of distribution

    • C. 

      Time

    • D. 

      Absorption

    • E. 

      Elimination

  • 4. 
    Which is true about men (select all that apply).
    • A. 

      They have more intestinal CYP.

    • B. 

      They have more Pgp.

    • C. 

      They have more TBW, vascular volume, and muscle mass.

    • D. 

      They have higher Vds for hydrophilic drugs.

    • E. 

      They have lower Vds for lipophilic drugs.

  • 5. 
    Who has more albumin...men or women?
    • A. 

      Men

    • B. 

      Women

    • C. 

      We're the same

  • 6. 
    Compartmental analysis refers to true physiologic compartments.
    • A. 

      True

    • B. 

      False

  • 7. 
    On a log graph, a 1st order elimination would be linear.
    • A. 

      True

    • B. 

      False

  • 8. 
    Men generally have greater Cl and a decreased t1/2 for drugs they take compared to women.
    • A. 

      True

    • B. 

      False

  • 9. 
    On a non-log graph, zero order elimination would be linear.
    • A. 

      True

    • B. 

      False

  • 10. 
    Recent analysis of data from bioequivilence trials submitted to the FDA show that gender differences could occur in approximately 28% of all drugs.  In some cases, drug exposure was 50% greater in women, even when correcting for weight differences.
    • A. 

      True

    • B. 

      False

  • 11. 
    Which of the following are true about zero order elimination.  Select all that apply.
    • A. 

      The zero order rate constant units are AMOUNT/TIME

    • B. 

      It is dependent of drug concentration.

    • C. 

      The zero order rate constant is -k^t

    • D. 

      The zero order rate constant units are ONE/TIME

  • 12. 
    Which is true regarding the elderly?
    • A. 

      Absorption is generally delayed

    • B. 

      Gastric emptying rate decreases

    • C. 

      Intestinal blood flow AND intestinal surface area decreases

    • D. 

      Phase II conjugation stays the same, but Phase I decreases

    • E. 

      Total body water and muscle mass decrease, while fat increases

  • 13. 
    Phenytoin is an example of zero order elimination.
    • A. 

      True

    • B. 

      False

  • 14. 
    Albumin does not change in the elderly.
    • A. 

      True, it doesn't.

    • B. 

      False, it increases.

    • C. 

      False, it decreases

  • 15. 
    Which is true regarding first order elimination?
    • A. 

      The elimination rate increases with increasing drug plasma levels.

    • B. 

      The units are ONE/TIME

  • 16. 
    Saturable kinetics are often associated with metabolizing enzymes.
    • A. 

      True

    • B. 

      False

  • 17. 
    If an elderly person was to take a basic drug PO...what would happen to it?
    • A. 

      The dissolution rate would increase because gasric pH decreases as you age (gets more acidic)

    • B. 

      The dissolution rate would decrease because gastric pH increases as you age (gets more basic)

  • 18. 
    What is the "biggest and most important change in the elderly?"
    • A. 

      Liver blood flow decreases

    • B. 

      Fat increases

    • C. 

      Glomeular filtration rate and renal tubular secretion decreases

  • 19. 
    A drug that has entered the extracellular space would most likely have a volume of distribution of...
    • A. 

      5-6 L

    • B. 

      10-20 L

    • C. 

      25-30 L

    • D. 

      40 L

    • E. 

      >200 L

  • 20. 
    If the Vd is very small (5 to 6 L), the drug... (select all that apply)
    • A. 

      Is in the extracellular space.

    • B. 

      Is very lipophilic

    • C. 

      Is strongly bound in peripheral tissues

    • D. 

      Is very hydrophilic

  • 21. 
    A drug that has reached the intracellular space would have a Vd about...
    • A. 

      5-6 L

    • B. 

      10-20 L

    • C. 

      25-30L

    • D. 

      40L

  • 22. 
    A drug that has a very large Vd may be strongly bound to peripheral proteins or be very...
    • A. 

      Hydrophilic

    • B. 

      Lipophilic

  • 23. 
    For drugs administered by IV infusion, the time to reach steady state is directly related to ______.
    • A. 

      Absorption

    • B. 

      Dissolution

    • C. 

      Volume of distribution

    • D. 

      Clearance

    • E. 

      Half life

  • 24. 
    Total clearance is defined as the fraction of the volume of distribution (Vd) completely cleared of drug per unit time by a process of metabolism and/or excretion.
    • A. 

      True

    • B. 

      False

  • 25. 
    Clearance is a constant for drugs with linear elimination.
    • A. 

      True

    • B. 

      False