Pharmacokinetics Trivia Questions

78 Questions | Total Attempts: 174

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Pharmacokinetics Quizzes & Trivia

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Questions and Answers
  • 1. 
    Which of the following are true.  Select all that apply.
    • A. 

      Pharmacokinetics relates dosage regimen and plasma concentration.

    • B. 

      Pharmacodynamics relates plasma concentration and the effect.

    • C. 

      Vd, Cl, and t1/2 are all pharmacodynamic properties.

  • 2. 
    Select all of the following that are true regarding tylenol use in alcoholics.
    • A. 

      Alcoholics have overexpression of 1A2.

    • B. 

      Alcoholics have overexpression of 2E1.

    • C. 

      In non-drinkers APAP is metabolized by Phase II.

    • D. 

      NAPQI is a very reactive intermediate that covalently binds to proteins in the liver.

  • 3. 
    Compartmental analysis allows for a mathmatical description of plasma concentration vs ______.
    • A. 

      Dose

    • B. 

      Volume of distribution

    • C. 

      Time

    • D. 

      Absorption

    • E. 

      Elimination

  • 4. 
    Which is true about men (select all that apply).
    • A. 

      They have more intestinal CYP.

    • B. 

      They have more Pgp.

    • C. 

      They have more TBW, vascular volume, and muscle mass.

    • D. 

      They have higher Vds for hydrophilic drugs.

    • E. 

      They have lower Vds for lipophilic drugs.

  • 5. 
    Who has more albumin...men or women?
    • A. 

      Men

    • B. 

      Women

    • C. 

      We're the same

  • 6. 
    Compartmental analysis refers to true physiologic compartments.
    • A. 

      True

    • B. 

      False

  • 7. 
    On a log graph, a 1st order elimination would be linear.
    • A. 

      True

    • B. 

      False

  • 8. 
    Men generally have greater Cl and a decreased t1/2 for drugs they take compared to women.
    • A. 

      True

    • B. 

      False

  • 9. 
    On a non-log graph, zero order elimination would be linear.
    • A. 

      True

    • B. 

      False

  • 10. 
    Recent analysis of data from bioequivilence trials submitted to the FDA show that gender differences could occur in approximately 28% of all drugs.  In some cases, drug exposure was 50% greater in women, even when correcting for weight differences.
    • A. 

      True

    • B. 

      False

  • 11. 
    Which of the following are true about zero order elimination.  Select all that apply.
    • A. 

      The zero order rate constant units are AMOUNT/TIME

    • B. 

      It is dependent of drug concentration.

    • C. 

      The zero order rate constant is -k^t

    • D. 

      The zero order rate constant units are ONE/TIME

  • 12. 
    Which is true regarding the elderly?
    • A. 

      Absorption is generally delayed

    • B. 

      Gastric emptying rate decreases

    • C. 

      Intestinal blood flow AND intestinal surface area decreases

    • D. 

      Phase II conjugation stays the same, but Phase I decreases

    • E. 

      Total body water and muscle mass decrease, while fat increases

  • 13. 
    Phenytoin is an example of zero order elimination.
    • A. 

      True

    • B. 

      False

  • 14. 
    Albumin does not change in the elderly.
    • A. 

      True, it doesn't.

    • B. 

      False, it increases.

    • C. 

      False, it decreases

  • 15. 
    Which is true regarding first order elimination?
    • A. 

      The elimination rate increases with increasing drug plasma levels.

    • B. 

      The units are ONE/TIME

  • 16. 
    Saturable kinetics are often associated with metabolizing enzymes.
    • A. 

      True

    • B. 

      False

  • 17. 
    If an elderly person was to take a basic drug PO...what would happen to it?
    • A. 

      The dissolution rate would increase because gasric pH decreases as you age (gets more acidic)

    • B. 

      The dissolution rate would decrease because gastric pH increases as you age (gets more basic)

  • 18. 
    What is the "biggest and most important change in the elderly?"
    • A. 

      Liver blood flow decreases

    • B. 

      Fat increases

    • C. 

      Glomeular filtration rate and renal tubular secretion decreases

  • 19. 
    A drug that has entered the extracellular space would most likely have a volume of distribution of...
    • A. 

      5-6 L

    • B. 

      10-20 L

    • C. 

      25-30 L

    • D. 

      40 L

    • E. 

      >200 L

  • 20. 
    If the Vd is very small (5 to 6 L), the drug... (select all that apply)
    • A. 

      Is in the extracellular space.

    • B. 

      Is very lipophilic

    • C. 

      Is strongly bound in peripheral tissues

    • D. 

      Is very hydrophilic

  • 21. 
    A drug that has reached the intracellular space would have a Vd about...
    • A. 

      5-6 L

    • B. 

      10-20 L

    • C. 

      25-30L

    • D. 

      40L

  • 22. 
    A drug that has a very large Vd may be strongly bound to peripheral proteins or be very...
    • A. 

      Hydrophilic

    • B. 

      Lipophilic

  • 23. 
    For drugs administered by IV infusion, the time to reach steady state is directly related to ______.
    • A. 

      Absorption

    • B. 

      Dissolution

    • C. 

      Volume of distribution

    • D. 

      Clearance

    • E. 

      Half life

  • 24. 
    Total clearance is defined as the fraction of the volume of distribution (Vd) completely cleared of drug per unit time by a process of metabolism and/or excretion.
    • A. 

      True

    • B. 

      False

  • 25. 
    Clearance is a constant for drugs with linear elimination.
    • A. 

      True

    • B. 

      False

  • 26. 
    When is the rate in GREATER than the rate out?
    • A. 

      Pre-steady state

    • B. 

      At steady state

    • C. 

      Post-steady state

  • 27. 
    To convert amount (X) to concentration (Cp) one uses the ___?
    • A. 

      T1/2

    • B. 

      Log p

    • C. 

      Dose

    • D. 

      Vd

    • E. 

      Clearance

  • 28. 
    A drug does not have to be in solution prior to absorption.
    • A. 

      True

    • B. 

      False

  • 29. 
    Most metabolism occurs in the _______.
    • A. 

      Gut

    • B. 

      Kidney

    • C. 

      Liver

    • D. 

      Periphery

  • 30. 
    A drug, given as a solid, encounters several barriers and sites of loss in its sequential moevment during GI asborption.  Dissolution, a prerequisite to movement across the gut wall, is the first step.
    • A. 

      True

    • B. 

      False

  • 31. 
    When pH >>pKa (for acids)...
    • A. 

      Unionized

    • B. 

      Ionized

  • 32. 
    A drug needs to be ionized for solubility and permeation through a membrane.
    • A. 

      True

    • B. 

      False

  • 33. 
    The degree of ionization of a drug molecule can influence many properties including... (Select all that apply)
    • A. 

      Solubility

    • B. 

      Dissolution rate

  • 34. 
    The intrinsic solubility of BH+ is greater at...
    • A. 

      A low pH

    • B. 

      A high pH

  • 35. 
    When we take meds with a full glass of water, we increase the dissolution by changing what part of the Noyes-Whitney equation?
    • A. 

      D

    • B. 

      S

    • C. 

      C

    • D. 

      Cs

    • E. 

      H

  • 36. 
    Which part of the Noyes Whitney equation explains why when we take a tablet with warm water we increase the dissolution?
    • A. 

      D

    • B. 

      S

    • C. 

      Cs

    • D. 

      C

    • E. 

      H

  • 37. 
    Which factor in the Noyes Whitney equation can be influenced by pH?
    • A. 

      D

    • B. 

      C

    • C. 

      Cs

    • D. 

      S

    • E. 

      H

  • 38. 
    When we stir, we wipe off the diffusion layer.
    • A. 

      True

    • B. 

      False

  • 39. 
    Food and drink can influence viscosity.  When we increase viscosity, we increase dissolution.
    • A. 

      True

    • B. 

      False

  • 40. 
    Cs stands for...
    • A. 

      The concentration of the solute in the bulk solution at time t

    • B. 

      The concentration of the drug in the diffusion layer (saturated solubility)

    • C. 

      The diffusion coefficient of the solute in solution

  • 41. 
    If dissolution occurs much faster than permeation then the overall absorption is considered to be _________.
    • A. 

      Permeation rate limited

    • B. 

      Dissolution rate limited

  • 42. 
    Which is more common?
    • A. 

      Permeation rate limited absorption

    • B. 

      Dissolution rate limited absorption

  • 43. 
    Drug in solution stays very low in dissolution rate limited absorption.
    • A. 

      True

    • B. 

      False

  • 44. 
    Effects of delayed drug absoprtion include... (select all that apply)
    • A. 

      Increase AUC

    • B. 

      Decrease AUC

    • C. 

      Increase Cmax

    • D. 

      Decrease Cmax

    • E. 

      Increase Tmax

    • F. 

      Decrease Tmax

  • 45. 
    High energy foods, hypertonic solutions, and low pH solutions increase gastric emptying rate.
    • A. 

      True

    • B. 

      False

  • 46. 
    Which drugs slow gastric emptying rate (select all that apply)?
    • A. 

      Cholinergics

    • B. 

      Atropine

    • C. 

      Narcotics

    • D. 

      Aspirin

  • 47. 
    Foods and Drugs that slow gastric emptying are types of physiological reasons of gastric emptying rate decrease, while solubility and dissolution reasons are a physiochemical reason.
    • A. 

      True

    • B. 

      False

  • 48. 
    If you just took a basic drug and then take a few Tums shortly after that...what will happen to the drug...
    • A. 

      The dissolution will be decreased

    • B. 

      The dissolution will be increased

    • C. 

      Nothing will happen unless the drug is one that complexes with calcium

  • 49. 
    The overall effect of delaying drug absorption never has a clinically significant effect.
    • A. 

      True

    • B. 

      False

  • 50. 
    3 reasons for reduced drug absorption are...
    • A. 

      Drug instability

    • B. 

      Drugs such as anticholingerics and narcotics

    • C. 

      Drug complexation interactions

    • D. 

      Increased viscosity

    • E. 

      Bile acid secretion

  • 51. 
    Solid meals ________ viscosity.
    • A. 

      Increase

    • B. 

      Decrease

  • 52. 
    Drugs that are typically affected by increased absorption are drugs that have ______.
    • A. 

      Poor bioavailability

    • B. 

      Good bioavailability

  • 53. 
    Which of the following statements are true?  (Select all that apply)
    • A. 

      You secrete more bile acid in the fasted state than the fed.

    • B. 

      You secrete more bile acid in the fed state than the fasted.

    • C. 

      Bile acid helps solubilize insoluble drugs

    • D. 

      Bile acids help accelerate absorption of cyclosporine.

    • E. 

      Bile acids help solublize hydrophilic drugs.

  • 54. 
    Food can increase tablet erosion by increasing surface area.
    • A. 

      True

    • B. 

      False

  • 55. 
    Warm foods and drinks help increase gastric emptying which accelerates absorption.
    • A. 

      True

    • B. 

      False

  • 56. 
    Increasing temperature and increasing fluid volume can both accelerate the absorption of drugs because of INCREASING DISSOLUTION RATE and INCREASING GASTRIC EMPTYING.
    • A. 

      True

    • B. 

      False

  • 57. 
    ______ hepatic blood flow decreases first pass metabolism.
    • A. 

      Increasing

    • B. 

      Decreasing

  • 58. 
    Eating certain foods can decrease the number of efflux transporters and also compete for transport with drugs.
    • A. 

      True

    • B. 

      False

  • 59. 
    Green tea and rosemary extract inhibit Pgp.
    • A. 

      True

    • B. 

      False

  • 60. 
    St Johns Wart ______ Pgp.
    • A. 

      Induces

    • B. 

      Inhibits

  • 61. 
    Albumin generally binds basic drugs.
    • A. 

      True

    • B. 

      False

  • 62. 
    Fatty meals can ______ the concentration of free drugs in the plasma (increasing the Vd).
    • A. 

      Increase

    • B. 

      Decrease

  • 63. 
    Malnutrition can ___ the Vd for some drugs.
    • A. 

      Increase

    • B. 

      Decrease

  • 64. 
    Charbroiled foods, high protein diets, and cruciferous vegetables all increase oxidative metbaolism.
    • A. 

      True

    • B. 

      False

  • 65. 
    Charbroiled foods induce CYP_____.
    • A. 

      1A4

    • B. 

      2E1

    • C. 

      1A2

  • 66. 
    If a patient ingests a toxic amount of a basic drug, what would you do to the pH of the urine to excrete the drug quickly?
    • A. 

      Decrease the pH

    • B. 

      Increase the pH

  • 67. 
    Regarding foods that affect urinary pH, select all of the following that are true...
    • A. 

      Vegetables increase pH.

    • B. 

      Vegetables decrease pH.

    • C. 

      Milk increases pH.

    • D. 

      Milk decreases pH.

    • E. 

      Meat and fish increase pH.

    • F. 

      Meat and fish decrease pH.

  • 68. 
    Not getting enough protein does what to your renal blood flow?
    • A. 

      Decrease blood flow, decreasing clearance

    • B. 

      Increase blood flow, increasing clearance

    • C. 

      Decrease blood flow, increasing clearance

    • D. 

      Increase blood flow, decreasing clearance

  • 69. 
    A patient is taking an antibiotic that is excreted renally.  She wants to know if she can wash it down with alcohol.  You tell her.
    • A. 

      Yes, because alcohol decreases renal elimination.

    • B. 

      No, because alcohol decreases elimination.

    • C. 

      Yes, because alcohol increases renal elimination.

    • D. 

      No, because alcohol increases renal elimination.

  • 70. 
    Select all of the following that are true regarding tylenol use in alcoholics.
    • A. 

      Alcoholics have overexpression of 1A2.

    • B. 

      Alcoholics have overexpression of 2E1.

    • C. 

      In non-drinkers APAP is metabolized by Phase II.

    • D. 

      NAPQI is a very reactive intermediate that covalently binds to proteins in the liver.

  • 71. 
    Which is true about men (select all that apply).
    • A. 

      They have more intestinal CYP.

    • B. 

      They have more Pgp.

    • C. 

      They have more TBW, vascular volume, and muscle mass.

    • D. 

      They have higher Vds for hydrophilic drugs.

    • E. 

      They have lower Vds for lipophilic drugs.

  • 72. 
    Who has more albumin...men or women?
    • A. 

      Men

    • B. 

      Women

    • C. 

      We're the same

  • 73. 
    Men generally have greater Cl and a decreased t1/2 for drugs they take compared to women.
    • A. 

      True

    • B. 

      False

  • 74. 
    Recent analysis of data from bioequivilence trials submitted to the FDA show that gender differences could occur in approximately 28% of all drugs.  In some cases, drug exposure was 50% greater in women, even when correcting for weight differences.
    • A. 

      True

    • B. 

      False

  • 75. 
    Which is true regarding the elderly?
    • A. 

      Absorption is generally delayed

    • B. 

      Gastric emptying rate decreases

    • C. 

      Intestinal blood flow AND intestinal surface area decreases

    • D. 

      Phase II conjugation stays the same, but Phase I decreases

    • E. 

      Total body water and muscle mass decrease, while fat increases

  • 76. 
    Albumin does not change in the elderly.
    • A. 

      True, it doesn't.

    • B. 

      False, it increases.

    • C. 

      False, it decreases

  • 77. 
    If an elderly person was to take a basic drug PO...what would happen to it?
    • A. 

      The dissolution rate would increase because gasric pH decreases as you age (gets more acidic)

    • B. 

      The dissolution rate would decrease because gastric pH increases as you age (gets more basic)

  • 78. 
    What is the "biggest and most important change in the elderly?"
    • A. 

      Liver blood flow decreases

    • B. 

      Fat increases

    • C. 

      Glomeular filtration rate and renal tubular secretion decreases