Pharmacokinetics Trivia Questions
.
- 1.
Which of the following are true. Select all that apply.
- A.
Pharmacokinetics relates dosage regimen and plasma concentration.
- B.
Pharmacodynamics relates plasma concentration and the effect.
- C.
Vd, Cl, and t1/2 are all pharmacodynamic properties.
Correct Answer(s)
A. Pharmacokinetics relates dosage regimen and plasma concentration.
B. Pharmacodynamics relates plasma concentration and the effect. -
- 2.
Select all of the following that are true regarding tylenol use in alcoholics.
- A.
Alcoholics have overexpression of 1A2.
- B.
Alcoholics have overexpression of 2E1.
- C.
In non-drinkers APAP is metabolized by Phase II.
- D.
NAPQI is a very reactive intermediate that covalently binds to proteins in the liver.
Correct Answer(s)
B. Alcoholics have overexpression of 2E1.
C. In non-drinkers APAP is metabolized by Phase II.
D. NAPQI is a very reactive intermediate that covalently binds to proteins in the liver. -
- 3.
Compartmental analysis allows for a mathmatical description of plasma concentration vs ______.
- A.
Dose
- B.
Volume of distribution
- C.
Time
- D.
Absorption
- E.
Elimination
Correct Answer
C. Time -
- 4.
Which is true about men (select all that apply).
- A.
They have more intestinal CYP.
- B.
They have more Pgp.
- C.
They have more TBW, vascular volume, and muscle mass.
- D.
They have higher Vds for hydrophilic drugs.
- E.
They have lower Vds for lipophilic drugs.
Correct Answer(s)
A. They have more intestinal CYP.
B. They have more Pgp.
C. They have more TBW, vascular volume, and muscle mass.
D. They have higher Vds for hydrophilic drugs.
E. They have lower Vds for lipophilic drugs. -
- 5.
Who has more albumin...men or women?
- A.
Men
- B.
Women
- C.
We're the same
Correct Answer
C. We're the same -
- 6.
Compartmental analysis refers to true physiologic compartments.
- A.
True
- B.
False
Correct Answer
B. False -
- 7.
On a log graph, a 1st order elimination would be linear.
- A.
True
- B.
False
Correct Answer
A. True -
- 8.
Men generally have greater Cl and a decreased t1/2 for drugs they take compared to women.
- A.
True
- B.
False
Correct Answer
A. True -
- 9.
On a non-log graph, zero order elimination would be linear.
- A.
True
- B.
False
Correct Answer
A. True -
- 10.
Recent analysis of data from bioequivilence trials submitted to the FDA show that gender differences could occur in approximately 28% of all drugs. In some cases, drug exposure was 50% greater in women, even when correcting for weight differences.
- A.
True
- B.
False
Correct Answer
A. True -
- 11.
Which of the following are true about zero order elimination. Select all that apply.
- A.
The zero order rate constant units are AMOUNT/TIME
- B.
It is dependent of drug concentration.
- C.
The zero order rate constant is -k^t
- D.
The zero order rate constant units are ONE/TIME
Correct Answer(s)
A. The zero order rate constant units are AMOUNT/TIME
C. The zero order rate constant is -k^t -
- 12.
Which is true regarding the elderly?
- A.
Absorption is generally delayed
- B.
Gastric emptying rate decreases
- C.
Intestinal blood flow AND intestinal surface area decreases
- D.
Phase II conjugation stays the same, but Phase I decreases
- E.
Total body water and muscle mass decrease, while fat increases
Correct Answer(s)
A. Absorption is generally delayed
B. Gastric emptying rate decreases
C. Intestinal blood flow AND intestinal surface area decreases
D. Phase II conjugation stays the same, but Phase I decreases
E. Total body water and muscle mass decrease, while fat increases -
- 13.
Phenytoin is an example of zero order elimination.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
Phenytoin is Michaelis Menten. Alcohol is an example of zero order kinetics.Rate this question:
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- 14.
Albumin does not change in the elderly.
- A.
True, it doesn't.
- B.
False, it increases.
- C.
False, it decreases
Correct Answer
C. False, it decreases -
- 15.
Which is true regarding first order elimination?
- A.
The elimination rate increases with increasing drug plasma levels.
- B.
The units are ONE/TIME
Correct Answer(s)
A. The elimination rate increases with increasing drug plasma levels.
B. The units are ONE/TIME -
- 16.
Saturable kinetics are often associated with metabolizing enzymes.
- A.
True
- B.
False
Correct Answer
A. True -
- 17.
If an elderly person was to take a basic drug PO...what would happen to it?
- A.
The dissolution rate would increase because gasric pH decreases as you age (gets more acidic)
- B.
The dissolution rate would decrease because gastric pH increases as you age (gets more basic)
Correct Answer
B. The dissolution rate would decrease because gastric pH increases as you age (gets more basic) -
- 18.
What is the "biggest and most important change in the elderly?"
- A.
Liver blood flow decreases
- B.
Fat increases
- C.
Glomeular filtration rate and renal tubular secretion decreases
Correct Answer
C. Glomeular filtration rate and renal tubular secretion decreases -
- 19.
A drug that has entered the extracellular space would most likely have a volume of distribution of...
- A.
5-6 L
- B.
10-20 L
- C.
25-30 L
- D.
40 L
- E.
>200 L
Correct Answer
B. 10-20 L -
- 20.
If the Vd is very small (5 to 6 L), the drug... (select all that apply)
- A.
Is in the extracellular space.
- B.
Is very lipophilic
- C.
Is strongly bound in peripheral tissues
- D.
Is very hydrophilic
Correct Answer
D. Is very hydrophilic -
- 21.
A drug that has reached the intracellular space would have a Vd about...
- A.
5-6 L
- B.
10-20 L
- C.
25-30L
- D.
40L
Correct Answer
C. 25-30L -
- 22.
A drug that has a very large Vd may be strongly bound to peripheral proteins or be very...
- A.
Hydrophilic
- B.
Lipophilic
Correct Answer
B. Lipophilic -
- 23.
For drugs administered by IV infusion, the time to reach steady state is directly related to ______.
- A.
Absorption
- B.
Dissolution
- C.
Volume of distribution
- D.
Clearance
- E.
Half life
Correct Answer
E. Half life -
- 24.
Total clearance is defined as the fraction of the volume of distribution (Vd) completely cleared of drug per unit time by a process of metabolism and/or excretion.
- A.
True
- B.
False
Correct Answer
A. True -
- 25.
Clearance is a constant for drugs with linear elimination.
- A.
True
- B.
False
Correct Answer
A. True -
- 26.
When is the rate in GREATER than the rate out?
- A.
Pre-steady state
- B.
At steady state
- C.
Post-steady state
Correct Answer
A. Pre-steady state -
- 27.
To convert amount (X) to concentration (Cp) one uses the ___?
- A.
T1/2
- B.
Log p
- C.
Dose
- D.
Vd
- E.
Clearance
Correct Answer
D. VdExplanation
Cp = X / VdRate this question:
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- 28.
A drug does not have to be in solution prior to absorption.
- A.
True
- B.
False
Correct Answer
B. False -
- 29.
Most metabolism occurs in the _______.
- A.
Gut
- B.
Kidney
- C.
Liver
- D.
Periphery
Correct Answer
C. Liver -
- 30.
A drug, given as a solid, encounters several barriers and sites of loss in its sequential moevment during GI asborption. Dissolution, a prerequisite to movement across the gut wall, is the first step.
- A.
True
- B.
False
Correct Answer
A. True -
- 31.
When pH >>pKa (for acids)...
- A.
Unionized
- B.
Ionized
Correct Answer
B. Ionized -
- 32.
A drug needs to be ionized for solubility and permeation through a membrane.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
UNIONIZED for permeationRate this question:
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- 33.
The degree of ionization of a drug molecule can influence many properties including... (Select all that apply)
- A.
Solubility
- B.
Dissolution rate
Correct Answer(s)
A. Solubility
B. Dissolution rate -
- 34.
The intrinsic solubility of BH+ is greater at...
- A.
A low pH
- B.
A high pH
Correct Answer
A. A low pH -
- 35.
When we take meds with a full glass of water, we increase the dissolution by changing what part of the Noyes-Whitney equation?
- A.
D
- B.
S
- C.
C
- D.
Cs
- E.
H
Correct Answer
C. C -
- 36.
Which part of the Noyes Whitney equation explains why when we take a tablet with warm water we increase the dissolution?
- A.
D
- B.
S
- C.
Cs
- D.
C
- E.
H
Correct Answer
A. DExplanation
D = kT / 6*pi*n*aRate this question:
-
- 37.
Which factor in the Noyes Whitney equation can be influenced by pH?
- A.
D
- B.
C
- C.
Cs
- D.
S
- E.
H
Correct Answer
C. Cs -
- 38.
When we stir, we wipe off the diffusion layer.
- A.
True
- B.
False
Correct Answer
A. True -
- 39.
Food and drink can influence viscosity. When we increase viscosity, we increase dissolution.
- A.
True
- B.
False
Correct Answer
B. False -
- 40.
Cs stands for...
- A.
The concentration of the solute in the bulk solution at time t
- B.
The concentration of the drug in the diffusion layer (saturated solubility)
- C.
The diffusion coefficient of the solute in solution
Correct Answer
B. The concentration of the drug in the diffusion layer (saturated solubility) -
- 41.
If dissolution occurs much faster than permeation then the overall absorption is considered to be _________.
- A.
Permeation rate limited
- B.
Dissolution rate limited
Correct Answer
A. Permeation rate limited -
- 42.
Which is more common?
- A.
Permeation rate limited absorption
- B.
Dissolution rate limited absorption
Correct Answer
B. Dissolution rate limited absorption -
- 43.
Drug in solution stays very low in dissolution rate limited absorption.
- A.
True
- B.
False
Correct Answer
A. True -
- 44.
Effects of delayed drug absoprtion include... (select all that apply)
- A.
Increase AUC
- B.
Decrease AUC
- C.
Increase Cmax
- D.
Decrease Cmax
- E.
Increase Tmax
- F.
Decrease Tmax
Correct Answer(s)
D. Decrease Cmax
E. Increase Tmax -
- 45.
High energy foods, hypertonic solutions, and low pH solutions increase gastric emptying rate.
- A.
True
- B.
False
Correct Answer
B. False -
- 46.
Which drugs slow gastric emptying rate (select all that apply)?
- A.
Cholinergics
- B.
Atropine
- C.
Narcotics
- D.
Aspirin
Correct Answer(s)
B. Atropine
C. Narcotics
D. Aspirin -
- 47.
Foods and Drugs that slow gastric emptying are types of physiological reasons of gastric emptying rate decrease, while solubility and dissolution reasons are a physiochemical reason.
- A.
True
- B.
False
Correct Answer
A. True -
- 48.
If you just took a basic drug and then take a few Tums shortly after that...what will happen to the drug...
- A.
The dissolution will be decreased
- B.
The dissolution will be increased
- C.
Nothing will happen unless the drug is one that complexes with calcium
Correct Answer
A. The dissolution will be decreased -
- 49.
The overall effect of delaying drug absorption never has a clinically significant effect.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
It does with verapamilRate this question:
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- 50.
3 reasons for reduced drug absorption are...
- A.
Drug instability
- B.
Drugs such as anticholingerics and narcotics
- C.
Drug complexation interactions
- D.
Increased viscosity
- E.
Bile acid secretion
Correct Answer(s)
A. Drug instability
C. Drug complexation interactions
D. Increased viscosity -
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Jul 10, 2018Quiz Edited by
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Sep 20, 2010Quiz Created by
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