Pharmacokinetics Trivia Questions

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    Who has more albumin...men or women?

    • Men
    • Women
    • We're the same
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About This Quiz

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Pharmacokinetics Quizzes & Trivia

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  • 2. 

    Saturable kinetics are often associated with metabolizing enzymes.

    • True

    • False

    Correct Answer
    A. True
  • 3. 

    Recent analysis of data from bioequivilence trials submitted to the FDA show that gender differences could occur in approximately 28% of all drugs.  In some cases, drug exposure was 50% greater in women, even when correcting for weight differences.

    • True

    • False

    Correct Answer
    A. True
  • 4. 

    Recent analysis of data from bioequivilence trials submitted to the FDA show that gender differences could occur in approximately 28% of all drugs.  In some cases, drug exposure was 50% greater in women, even when correcting for weight differences.

    • True

    • False

    Correct Answer
    A. True
  • 5. 

    Total clearance is defined as the fraction of the volume of distribution (Vd) completely cleared of drug per unit time by a process of metabolism and/or excretion.

    • True

    • False

    Correct Answer
    A. True
  • 6. 

    Clearance is a constant for drugs with linear elimination.

    • True

    • False

    Correct Answer
    A. True
  • 7. 

    A drug, given as a solid, encounters several barriers and sites of loss in its sequential moevment during GI asborption.  Dissolution, a prerequisite to movement across the gut wall, is the first step.

    • True

    • False

    Correct Answer
    A. True
  • 8. 

    Increasing temperature and increasing fluid volume can both accelerate the absorption of drugs because of INCREASING DISSOLUTION RATE and INCREASING GASTRIC EMPTYING.

    • True

    • False

    Correct Answer
    A. True
  • 9. 

    Charbroiled foods, high protein diets, and cruciferous vegetables all increase oxidative metbaolism.

    • True

    • False

    Correct Answer
    A. True
  • 10. 

    Albumin does not change in the elderly.

    • True, it doesn't.

    • False, it increases.

    • False, it decreases

    Correct Answer
    A. False, it decreases
  • 11. 

    Warm foods and drinks help increase gastric emptying which accelerates absorption.

    • True

    • False

    Correct Answer
    A. True
  • 12. 

    Most metabolism occurs in the _______.

    • Gut

    • Kidney

    • Liver

    • Periphery

    Correct Answer
    A. Liver
  • 13. 

    Men generally have greater Cl and a decreased t1/2 for drugs they take compared to women.

    • True

    • False

    Correct Answer
    A. True
  • 14. 

    Solid meals ________ viscosity.

    • Increase

    • Decrease

    Correct Answer
    A. Increase
  • 15. 

    On a non-log graph, zero order elimination would be linear.

    • True

    • False

    Correct Answer
    A. True
  • 16. 

    Green tea and rosemary extract inhibit Pgp.

    • True

    • False

    Correct Answer
    A. True
  • 17. 

    On a log graph, a 1st order elimination would be linear.

    • True

    • False

    Correct Answer
    A. True
  • 18. 

    Albumin does not change in the elderly.

    • True, it doesn't.

    • False, it increases.

    • False, it decreases

    Correct Answer
    A. False, it decreases
  • 19. 

    Eating certain foods can decrease the number of efflux transporters and also compete for transport with drugs.

    • True

    • False

    Correct Answer
    A. True
  • 20. 

    If an elderly person was to take a basic drug PO...what would happen to it?

    • The dissolution rate would increase because gasric pH decreases as you age (gets more acidic)

    • The dissolution rate would decrease because gastric pH increases as you age (gets more basic)

    Correct Answer
    A. The dissolution rate would decrease because gastric pH increases as you age (gets more basic)
  • 21. 

    The overall effect of delaying drug absorption never has a clinically significant effect.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    It does with verapamil

    Rate this question:

  • 22. 

    Food and drink can influence viscosity.  When we increase viscosity, we increase dissolution.

    • True

    • False

    Correct Answer
    A. False
  • 23. 

    Foods and Drugs that slow gastric emptying are types of physiological reasons of gastric emptying rate decrease, while solubility and dissolution reasons are a physiochemical reason.

    • True

    • False

    Correct Answer
    A. True
  • 24. 

    A drug that has a very large Vd may be strongly bound to peripheral proteins or be very...

    • Hydrophilic

    • Lipophilic

    Correct Answer
    A. Lipophilic
  • 25. 

    Drug in solution stays very low in dissolution rate limited absorption.

    • True

    • False

    Correct Answer
    A. True
  • 26. 

    If a patient ingests a toxic amount of a basic drug, what would you do to the pH of the urine to excrete the drug quickly?

    • Decrease the pH

    • Increase the pH

    Correct Answer
    A. Decrease the pH
  • 27. 

    What is the "biggest and most important change in the elderly?"

    • Liver blood flow decreases

    • Fat increases

    • Glomeular filtration rate and renal tubular secretion decreases

    Correct Answer
    A. Glomeular filtration rate and renal tubular secretion decreases
  • 28. 

    Men generally have greater Cl and a decreased t1/2 for drugs they take compared to women.

    • True

    • False

    Correct Answer
    A. True
  • 29. 

    When is the rate in GREATER than the rate out?

    • Pre-steady state

    • At steady state

    • Post-steady state

    Correct Answer
    A. Pre-steady state
  • 30. 

    St Johns Wart ______ Pgp.

    • Induces

    • Inhibits

    Correct Answer
    A. Induces
  • 31. 

    When we stir, we wipe off the diffusion layer.

    • True

    • False

    Correct Answer
    A. True
  • 32. 

    When pH >>pKa (for acids)...

    • Unionized

    • Ionized

    Correct Answer
    A. Ionized
  • 33. 

    A drug needs to be ionized for solubility and permeation through a membrane.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    UNIONIZED for permeation

    Rate this question:

  • 34. 

    If dissolution occurs much faster than permeation then the overall absorption is considered to be _________.

    • Permeation rate limited

    • Dissolution rate limited

    Correct Answer
    A. Permeation rate limited
  • 35. 

    Compartmental analysis refers to true physiologic compartments.

    • True

    • False

    Correct Answer
    A. False
  • 36. 

    The degree of ionization of a drug molecule can influence many properties including... (Select all that apply)

    • Solubility

    • Dissolution rate

    Correct Answer(s)
    A. Solubility
    A. Dissolution rate
  • 37. 

    Food can increase tablet erosion by increasing surface area.

    • True

    • False

    Correct Answer
    A. True
  • 38. 

    The intrinsic solubility of BH+ is greater at...

    • A low pH

    • A high pH

    Correct Answer
    A. A low pH
  • 39. 

    What is the "biggest and most important change in the elderly?"

    • Liver blood flow decreases

    • Fat increases

    • Glomeular filtration rate and renal tubular secretion decreases

    Correct Answer
    A. Glomeular filtration rate and renal tubular secretion decreases
  • 40. 

    A drug does not have to be in solution prior to absorption.

    • True

    • False

    Correct Answer
    A. False
  • 41. 

    Not getting enough protein does what to your renal blood flow?

    • Decrease blood flow, decreasing clearance

    • Increase blood flow, increasing clearance

    • Decrease blood flow, increasing clearance

    • Increase blood flow, decreasing clearance

    Correct Answer
    A. Decrease blood flow, decreasing clearance
  • 42. 

    Which is true regarding the elderly?

    • Absorption is generally delayed

    • Gastric emptying rate decreases

    • Intestinal blood flow AND intestinal surface area decreases

    • Phase II conjugation stays the same, but Phase I decreases

    • Total body water and muscle mass decrease, while fat increases

    Correct Answer(s)
    A. Absorption is generally delayed
    A. Gastric emptying rate decreases
    A. Intestinal blood flow AND intestinal surface area decreases
    A. Phase II conjugation stays the same, but Phase I decreases
    A. Total body water and muscle mass decrease, while fat increases
  • 43. 

    Compartmental analysis allows for a mathmatical description of plasma concentration vs ______.

    • Dose

    • Volume of distribution

    • Time

    • Absorption

    • Elimination

    Correct Answer
    A. Time
  • 44. 

    If an elderly person was to take a basic drug PO...what would happen to it?

    • The dissolution rate would increase because gasric pH decreases as you age (gets more acidic)

    • The dissolution rate would decrease because gastric pH increases as you age (gets more basic)

    Correct Answer
    A. The dissolution rate would decrease because gastric pH increases as you age (gets more basic)
  • 45. 

    Which is more common?

    • Permeation rate limited absorption

    • Dissolution rate limited absorption

    Correct Answer
    A. Dissolution rate limited absorption
  • 46. 

    Albumin generally binds basic drugs.

    • True

    • False

    Correct Answer
    A. False
  • 47. 

    Which of the following are true.  Select all that apply.

    • Pharmacokinetics relates dosage regimen and plasma concentration.

    • Pharmacodynamics relates plasma concentration and the effect.

    • Vd, Cl, and t1/2 are all pharmacodynamic properties.

    Correct Answer(s)
    A. Pharmacokinetics relates dosage regimen and plasma concentration.
    A. Pharmacodynamics relates plasma concentration and the effect.
  • 48. 

    To convert amount (X) to concentration (Cp) one uses the ___?

    • T1/2

    • Log p

    • Dose

    • Vd

    • Clearance

    Correct Answer
    A. Vd
    Explanation
    Cp = X / Vd

    Rate this question:

  • 49. 

    If you just took a basic drug and then take a few Tums shortly after that...what will happen to the drug...

    • The dissolution will be decreased

    • The dissolution will be increased

    • Nothing will happen unless the drug is one that complexes with calcium

    Correct Answer
    A. The dissolution will be decreased

Quiz Review Timeline (Updated): Jul 10, 2018 +

Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.

  • Current Version
  • Jul 10, 2018
    Quiz Edited by
    ProProfs Editorial Team
  • Sep 20, 2010
    Quiz Created by
    Caitlinb
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