Pathoimmunology Of Airway Diseases (Knoell)

13 Questions | By Teatimebarbie | Last updated: Mar 20, 2022 | Total Attempts: 56

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Pathoimmunology of Airway Diseases (Knoell)

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1.

Which of the following cells of the innate immune system fits the following description: very potent granulocytes, persists in circulation for 8-12 hours, presence in lung, skin, or internal organs is indicative of disease?
- A.
  
  Neutrophils
- B.
  
  Eosinophils
- C.
  
  Mast cells
- D.
  
  Dendritic cell
- E.
  
  Phagocytes
2.

Which of the following cells are able to: recognize invaders with higher specificity, phagocytose the bacterium, process antigen, and mobilizes to regional lymph nodes to present Ag to lymphocytes?
- A.
  
  Neutrophils
- B.
  
  Eosinophils
- C.
  
  Mast cells
- D.
  
  Dendritic cells
- E.
  
  Phagocytes
3.

The hygiene theory attempts to explain the growing incidence of atopic diseases. Which the following CD4+ t-helper cells must predominate for an atopic disease to develop?
- A.
  
  TH1
- B.
  
  TH2
4.

Which of the following are NOT a major player in perpetuating tissue damage and inflammation related to asthma?
- A.
  
  Mast cells
- B.
  
  TH1 lymphocytes
- C.
  
  TH2 lymphocytes
- D.
  
  Eosinophils
- E.
  
  Neutrophils
5.

The release of chemotactic factors from mast cells is associated with which of the following?
- A.
  
  Early phase reaction (EPR) of mast cell activation
- B.
  
  Late phase reaction (LPR) of mast cell activation
6.

Which of the following is a correctly matched pair of disorder and chest condition?
- A.
  
  Asthma: restrictive chest condition
- B.
  
  Atelectasis: restrictive chest condition
- C.
  
  Pleural effusion: obstructive chest condition
- D.
  
  Pneumothorax: obstructive chest condition
- E.
  
  Emphysema: obstructive chest condition
7.

Gas exchange during respiration requires an even match between which TWO of the following parameters?
- A.
  
  Alveolar space
- B.
  
  Blood perfusion
- C.
  
  CO2 diffusion capacity
- D.
  
  Lung volume
- E.
  
  Ventilation (air movement)
8.

Bronchial morphology of an asthmatic includes all of the following except:
- A.
  
  Inflammation
- B.
  
  Eosinophils
- C.
  
  Gland hyperplasia --> mucus plug
- D.
  
  Hypertrophy of muscle layer
- E.
  
  Weakened or collapsed alveolar sacs
9.

The most common predisposing factors associated with asthma include all of the following except:
- A.
  
  History of atopy/exposure to airbourne allergens
- B.
  
  Initiation of asthma is early life
- C.
  
  Respiratory viral infections
- D.
  
  Positive family history
- E.
  
  All of the above are predisposing factors
10.

What is the primary cause of chronic obstructive pulmonary disease?
- A.
  
  History of atopy
- B.
  
  Chronic viral infection
- C.
  
  Cigarette smoking
- D.
  
  Alpha-1-amitrypsin deficiency
- E.
  
  Occupational exposure to chemicals
11.

True or False: COPD, like other diseases such as coronary heart disease and strokes, are on a death decline due to the development of effective treatment.
- A.
  
  True
- B.
  
  False
12.

The diagnostic definition of chronic bronchitis includes all of the following EXCEPT:
- A.
  
  Abnormal, permanent air space enlargement
- B.
  
  Chronic, productive cough for 3 months during each of the past 2 years
- C.
  
  Decline in FEV1
- D.
  
  Asymptomatic until pulmonary function is
- E.
  
  Classic symptoms: cough, dyspnea, wheezing, sputum production
13.

Using spirometry, which of the following values obtain after a bronchodilator challenge confirms the presence of airflow limitation that is NOT fully reversible?
- A.
  
  >12% improvement in FEV
- B.
  
  FEV1/FVC < 70%
- C.
  
  FEV1/FVC > 80%
- D.
  
  >200 ml change in spirometry
- E.
  
  All of the above are indicative of COPD's irreversible nature