Pathoimmunology Of Airway Diseases (Knoell)

13 Questions | Total Attempts: 36

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Disease Quizzes & Trivia

Pathoimmunology of Airway Diseases (Knoell)


Questions and Answers
  • 1. 
    Which of the following cells of the innate immune system fits the following description: very potent granulocytes, persists in circulation for 8-12 hours, presence in lung, skin, or internal organs is indicative of disease? 
    • A. 

      Neutrophils

    • B. 

      Eosinophils

    • C. 

      Mast cells

    • D. 

      Dendritic cell

    • E. 

      Phagocytes

  • 2. 
    Which of the following cells are able to: recognize invaders with higher specificity, phagocytose the bacterium, process antigen, and mobilizes to regional lymph nodes to present Ag to lymphocytes?
    • A. 

      Neutrophils

    • B. 

      Eosinophils

    • C. 

      Mast cells

    • D. 

      Dendritic cells

    • E. 

      Phagocytes

  • 3. 
    The hygiene theory attempts to explain the growing incidence of atopic diseases. Which the following CD4+ t-helper cells must predominate for an atopic disease to develop?
    • A. 

      TH1

    • B. 

      TH2

  • 4. 
    Which of the following are NOT a major player in perpetuating tissue damage and inflammation related to asthma?
    • A. 

      Mast cells

    • B. 

      TH1 lymphocytes

    • C. 

      TH2 lymphocytes

    • D. 

      Eosinophils

    • E. 

      Neutrophils

  • 5. 
    The release of chemotactic factors from mast cells is associated with which of the following?
    • A. 

      Early phase reaction (EPR) of mast cell activation

    • B. 

      Late phase reaction (LPR) of mast cell activation

  • 6. 
    Which of the following is a correctly matched pair of disorder and chest condition?
    • A. 

      Asthma: restrictive chest condition

    • B. 

      Atelectasis: restrictive chest condition

    • C. 

      Pleural effusion: obstructive chest condition

    • D. 

      Pneumothorax: obstructive chest condition

    • E. 

      Emphysema: obstructive chest condition

  • 7. 
    Gas exchange during respiration requires an even match between which TWO of the following parameters?
    • A. 

      Alveolar space

    • B. 

      Blood perfusion

    • C. 

      CO2 diffusion capacity

    • D. 

      Lung volume

    • E. 

      Ventilation (air movement)

  • 8. 
    Bronchial morphology of an asthmatic includes all of the following except:
    • A. 

      Inflammation

    • B. 

      Eosinophils

    • C. 

      Gland hyperplasia --> mucus plug

    • D. 

      Hypertrophy of muscle layer

    • E. 

      Weakened or collapsed alveolar sacs

  • 9. 
    The most common predisposing factors associated with asthma include all of the following except:
    • A. 

      History of atopy/exposure to airbourne allergens

    • B. 

      Initiation of asthma is early life

    • C. 

      Respiratory viral infections

    • D. 

      Positive family history

    • E. 

      All of the above are predisposing factors

  • 10. 
    What is the primary cause of chronic obstructive pulmonary disease?
    • A. 

      History of atopy

    • B. 

      Chronic viral infection

    • C. 

      Cigarette smoking

    • D. 

      Alpha-1-amitrypsin deficiency

    • E. 

      Occupational exposure to chemicals

  • 11. 
    True or False: COPD, like other diseases such as coronary heart disease and strokes, are on a death decline due to the development of effective treatment.
    • A. 

      True

    • B. 

      False

  • 12. 
    The diagnostic definition of chronic bronchitis includes all of the following EXCEPT:
    • A. 

      Abnormal, permanent air space enlargement

    • B. 

      Chronic, productive cough for 3 months during each of the past 2 years

    • C. 

      Decline in FEV1

    • D. 

      Asymptomatic until pulmonary function is

    • E. 

      Classic symptoms: cough, dyspnea, wheezing, sputum production

  • 13. 
    Using spirometry, which of the following values obtain after a bronchodilator challenge confirms the presence of airflow limitation that is NOT fully reversible?
    • A. 

      >12% improvement in FEV

    • B. 

      FEV1/FVC < 70%

    • C. 

      FEV1/FVC > 80%

    • D. 

      >200 ml change in spirometry

    • E. 

      All of the above are indicative of COPD's irreversible nature