Immunology Quiz- Antigen And Antibody Structure

27 Questions
Immunology Quiz- Antigen And Antibody Structure

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Questions and Answers
  • 1. 
    Which of the following differentiates an antigen from an immunogen?
    • A. 

      An antigen is a foreign molecule

    • B. 

      An antigen can cause the production of antibodies

    • C. 

      An antigen does not always elicit an immune response

    • D. 

      Antigens are usually proteins or polysaccharides

    • E. 

      Antigens are capable of being bound by immunologic receptors

  • 2. 
    Which of the following is NOT true regarding effective immunogens?
    • A. 

      Foreign to the host

    • B. 

      Fairly large (molecular weight > 6000)

    • C. 

      Chemically complex (e.g. proteins made of many nucleotide bases)

    • D. 

      Requires a carrier-conjugate to cause the generation of antibodies

  • 3. 
    • A. 

      Large in size and can induce an immune response alone

    • B. 

      Large in size and needs to be coupled to induce an immune response

    • C. 

      Small in size and can induce an immune response alone

    • D. 

      Small in size and needs to be coupled to induce an immune response

  • 4. 
    An epitope is generally used to refer to an area on a much larger molecule (e.g., a viral protein) with which an antibody can react.
    • A. 

      True

    • B. 

      False

  • 5. 
    Which of the following is NOT true?
    • A. 

      The term epitope is not synonymous with antigen

    • B. 

      A viral protein may contain a large number of epitopes that are capable of interacting with many different specific antibodies

    • C. 

      Immunologic receptors on T cells recognize continuous (linear) epitopes

    • D. 

      Immunologic receptors on T cells recognize discontinuous (conformational) epitopes

    • E. 

      Antibodies can recognize both continuous and discontinuous epitopes

  • 6. 
    • A. 

      Antigen

    • B. 

      Epitope

    • C. 

      Immunogen

    • D. 

      Stimulant

    • E. 

      Adjuvant

  • 7. 
    What fraction of serum are the antibodies (immunoglobulins) initially found when using lytical techniques (e.g. electrophoresis)?
    • A. 

      Albumin

    • B. 

      Gamma (!) globulin

    • C. 

      Beta (") globulin

    • D. 

      Alpha (#) globulin

  • 8. 
     In the electrophoresis of human serum, which of the following is the most electronegative and thus migrates farthest toward the positive electrode?
    • A. 

      Albumin

    • B. 

      Gamma (!) globulin

    • C. 

      Beta (") globulin

    • D. 

      Alpha (#) globulin

  • 9. 
    Gamma (!) globulin serum fraction contains predominantly which immunoglobulin?
    • A. 

      IgA

    • B. 

      IgD

    • C. 

      IgE

    • D. 

      IgG

    • E. 

      IgM

  • 10. 
    • A. 

      Active immunity

    • B. 

      Passive immunity

  • 11. 
    • A. 

      Immunize a mouse with antigen of choice then remove the spleen when the mouse is making an antibody response

    • B. 

      Fuse the immune spleen cells with a myeloma tumor cell

    • C. 

      The cells are cultured in a selective medium allowing fused and non-fused cells to survive

    • D. 

      Cells are grown in individual culture plate wells, and culture supernatants from wells contains growing hybrid cells are screened for presence of desired antibody by an enzyme-linked immunosorbent assay (ELISA)

    • E. 

      This clone (hybridoma) is an immortal producer of the desired monoclonal antibody

  • 12. 
    Match the following descriptions with their term: Allows for flexibility
    • A. 

      Light chain

    • B. 

      Heavy chain

    • C. 

      Fab region

    • D. 

      Fc region

    • E. 

      Hinge region

  • 13. 
    Match the following descriptions with their term: Binds antigen
    • A. 

      Light chain

    • B. 

      Heavy chain

    • C. 

      Fab region

    • D. 

      Fc region

    • E. 

      Hinge region

  • 14. 
    Match the following descriptions with their term: Binds to various cellular receptors and to complement
    • A. 

      Light chain

    • B. 

      Heavy chain

    • C. 

      Fab region

    • D. 

      Fc region

    • E. 

      Hinge region

  • 15. 
    Match the following descriptions with their term: Binds to various cellular receptors and to complement
    • A. 

      Light chain

    • B. 

      Heavy chain

    • C. 

      Fab region

    • D. 

      Fc region

    • E. 

      Hinge region

  • 16. 
    Match the following descriptions with their term:  Has an fragment crystallizable (Fc) and Fab region
    • A. 

      Light chain

    • B. 

      Heavy chain

    • C. 

      Fab region

    • D. 

      Fc region

    • E. 

      Hinge region

  • 17. 
    Match the immunoglobulin(s) with the functional description: Activates the complement system
    • A. 

      IgG

    • B. 

      IgE

    • C. 

      IgM

    • D. 

      IgG & IgM

    • E. 

      IgG & IgA

  • 18. 
    Match the immunoglobulin(s) with the functional description: Involved in allergic responses
    • A. 

      IgG

    • B. 

      IgE

    • C. 

      IgM

    • D. 

      IgG & IgM

    • E. 

      IgG & IgA

  • 19. 
    Match the immunoglobulin(s) with the functional description: Predominant in the primary (early) immune response
    • A. 

      IgG

    • B. 

      IgE

    • C. 

      IgM

    • D. 

      IgG & IgM

    • E. 

      IgG & IgA

  • 20. 
    Match the immunoglobulin(s) with the functional description: Has different subtypes
    • A. 

      IgG

    • B. 

      IgE

    • C. 

      IgM

    • D. 

      IgG & IgM

    • E. 

      IgG & IgA

  • 21. 
    Match the immunoglobulin(s) with the functional description: Can transfer across the placental (maternal protection)
    • A. 

      IgG

    • B. 

      IgE

    • C. 

      IgM

    • D. 

      IgG & IgM

    • E. 

      IgG & IgA

  • 22. 
    Papain cleaves what region of immunoglobulin?
    • A. 

      Heavy chain

    • B. 

      Light chain

    • C. 

      Hinge region

  • 23. 
    Pepsin cleaves what region of immunoglobulin?
    • A. 

      Heavy chain

    • B. 

      Light chain

    • C. 

      Hinge region

  • 24. 
    IgM is structurally characterized as:
    • A. 

      Monometric

    • B. 

      Bimetric

    • C. 

      Trimetric

    • D. 

      Tetrametric

    • E. 

      Pentametric

  • 25. 
    Which of the following is the main immunoglobulin in the gut and secretions (saliva, milk, tears) and is important in mucosal immunity?
    • A. 

      IgA

    • B. 

      IgD

    • C. 

      IgE

    • D. 

      IgG

    • E. 

      IgM

  • 26. 
    Which of the following binds to an Fc receptor on mast cells and basophils?
    • A. 

      IgA

    • B. 

      IgD

    • C. 

      IgE

    • D. 

      IgG

    • E. 

      IgM

  • 27. 
    Which of the following is chiefly found on the surface of B cells as a receptor molecule and is involved in cell activation?
    • A. 

      IgA

    • B. 

      IgD

    • C. 

      IgE

    • D. 

      IgG

    • E. 

      IgM