Immunology- Antigen And Antibody Structure Quiz

22 Questions | By Smb6 | Updated: Mar 22, 2022 | Attempts: 23217

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Immunology- Antigen And Antibody Structure Quiz - Quiz

Take this immunology, antigen, and antibody structure quiz if you want to find out how much you can actually recall about this topic! Test your memory and your knowledge by taking this simple quiz that has been designed to quiz you on immunology and the structure of antigens and antibodies that have far-reaching repercussions on how exactly our body deals with any infection or foreign invasion. What are you waiting for? Let's begin!

Questions and Answers

1.

Which of the following is NOT true?
- A.
  
  The term epitope is not synonymous with antigen
- B.
  
  A viral protein may contain a large number of epitopes that are capable of interacting with many different specific antibodies
- C.
  
  Immunologic receptors on T cells recognize continuous (linear) epitopes
- D.
  
  Immunologic receptors on T cells recognize discontinuous (conformational) epitopes
- E.
  
  Antibodies can recognize both continuous and discontinuous epitopes
2.

Which of the following is an agent (e.g., aluminum salts, oil-based, virosomes) often used to modify or augment the effects of a vaccine by stimulating the immune system to respond to the vaccine more vigorously, and thus providing increased immunity to a particular disease?
- A.
  
  Antigen
- B.
  
  Epitope
- C.
  
  Immunogen
- D.
  
  Stimulant
- E.
  
  Adjuvant
3.

What fraction of serum are the antibodies (immunoglobulins) initially found when using lytical techniques (e.g., electrophoresis)?
- A.
  
  Albumin
- B.
  
  Gamma (!) globulin
- C.
  
  Beta (") globulin
- D.
  
  Alpha (#) globulin
4.

In the electrophoresis of human serum, which of the following is the most electronegative and thus migrates farthest toward the positive electrode?
- A.
  
  Albumin
- B.
  
  Gamma (!) globulin
- C.
  
  Beta (") globulin
- D.
  
  Alpha (#) globulin
5.

Gamma (!) globulin serum fraction contains predominantly which immunoglobulin?
- A.
  
  IgA
- B.
  
  IgD
- C.
  
  IgE
- D.
  
  IgG
- E.
  
  IgM
6.

On an early morning run near his home, a runner startled a group of dogs being exercised and was bitten on the leg. The runner was later unable to locate the dog and its owner to verify that the dog had an up-to-date rabies vaccination. Given that rabies is always fatal, and despite the very low incidence in domesticated dogs, prudence dictated that he undergo treatment. The runner was given human immunoglobulin G-containing antibodies to rabies virus (anti-rabies immunoglobulin) injected around the site of the wound and at several other intramuscular sites. This antibody preparation confers instant protection from the virus without requiring the body to develop a response. This is an example of:
- A.
  
  Active immunity
- B.
  
  Passive immunity
7.

The aim of monoclonal antibody production is to produce cells that only secrete immunoglobulin directed against the antigen used in immunization. Which of the following hybridoma production steps is NOT correct?
- A.
  
  Immunize a mouse with antigen of choice then remove the spleen when the mouse is making an antibody response
- B.
  
  Fuse the immune spleen cells with a myeloma tumor cell
- C.
  
  The cells are cultured in a selective medium allowing fused and non-fused cells to survive
- D.
  
  Cells are grown in individual culture plate wells, and culture supernatants from wells contains growing hybrid cells are screened for presence of desired antibody by an enzyme-linked immunosorbent assay (ELISA)
- E.
  
  This clone (hybridoma) is an immortal producer of the desired monoclonal antibody
8.

Match the following descriptions with their term: Allows for flexibility
- A.
  
  Light chain
- B.
  
  Heavy chain
- C.
  
  Fab region
- D.
  
  Fc region
- E.
  
  Hinge region
9.

Match the following descriptions with their term: Binds antigen
- A.
  
  Light chain
- B.
  
  Heavy chain
- C.
  
  Fab region
- D.
  
  Fc region
- E.
  
  Hinge region
10.

Match the following descriptions with their term: Binds to various cellular receptors and to complement
- A.
  
  Light chain
- B.
  
  Heavy chain
- C.
  
  Fab region
- D.
  
  Fc region
- E.
  
  Hinge region
11.

Match the following descriptions with their term: Binds to various cellular receptors and to complement
- A.
  
  Light chain
- B.
  
  Heavy chain
- C.
  
  Fab region
- D.
  
  Fc region
- E.
  
  Hinge region
12.

Match the following descriptions with their term: Has a fragment crystallizable (Fc) and Fab region
- A.
  
  Light chain
- B.
  
  Heavy chain
- C.
  
  Fab region
- D.
  
  Fc region
- E.
  
  Hinge region
13.

Match the immunoglobulin(s) with the functional description: Activates the complement system
- A.
  
  IgG
- B.
  
  IgE
- C.
  
  IgM
- D.
  
  IgG & IgM
- E.
  
  IgG & IgA
14.

Match the immunoglobulin(s) with the functional description: Involved in allergic responses
- A.
  
  IgG
- B.
  
  IgE
- C.
  
  IgM
- D.
  
  IgG & IgM
- E.
  
  IgG & IgA
15.

Match the immunoglobulin(s) with the functional description: Predominant in the primary (early) immune response
- A.
  
  IgG
- B.
  
  IgE
- C.
  
  IgM
- D.
  
  IgG & IgM
- E.
  
  IgG & IgA
16.

Match the immunoglobulin(s) with the functional description: Has different subtypes
- A.
  
  IgG
- B.
  
  IgE
- C.
  
  IgM
- D.
  
  IgG & IgM
- E.
  
  IgG & IgA
17.

Match the immunoglobulin(s) with the functional description: Can transfer across the placental (maternal protection)
- A.
  
  IgG
- B.
  
  IgE
- C.
  
  IgM
- D.
  
  IgG & IgM
- E.
  
  IgG & IgA
18.

Papain cleaves what region of immunoglobulin?
- A.
  
  Heavy chain
- B.
  
  Light chain
- C.
  
  Hinge region
19.

Pepsin cleaves what region of immunoglobulin?
- A.
  
  Heavy chain
- B.
  
  Light chain
- C.
  
  Hinge region
20.

IgM is structurally characterized as:
- A.
  
  Monometric
- B.
  
  Bimetric
- C.
  
  Trimetric
- D.
  
  Tetrametric
- E.
  
  Pentametric
21.

Which of the following is the main immunoglobulin in the gut and secretions (saliva, milk, tears) and is important in mucosal immunity?
- A.
  
  IgA
- B.
  
  IgD
- C.
  
  IgE
- D.
  
  IgG
- E.
  
  IgM
22.

Which of the following binds to an Fc receptor on mast cells and basophils?
- A.
  
  IgA
- B.
  
  IgD
- C.
  
  IgE
- D.
  
  IgG
- E.
  
  IgM