Immunology Quiz- Antigen And Antibody Structure
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- 1.Which of the following differentiates an antigen from an immunogen?
- A.
An antigen is a foreign molecule
- B.
An antigen can cause the production of antibodies
- C.
An antigen does not always elicit an immune response
- D.
Antigens are usually proteins or polysaccharides
- E.
Antigens are capable of being bound by immunologic receptors
- 2.Which of the following is NOT true regarding effective immunogens?
- A.
Foreign to the host
- B.
Fairly large (molecular weight > 6000)
- C.
Chemically complex (e.g. proteins made of many nucleotide bases)
- D.
Requires a carrier-conjugate to cause the generation of antibodies
- 3.
- A.
Large in size and can induce an immune response alone
- B.
Large in size and needs to be coupled to induce an immune response
- C.
Small in size and can induce an immune response alone
- D.
Small in size and needs to be coupled to induce an immune response
- 4.An epitope is generally used to refer to an area on a much larger molecule (e.g., a viral protein) with which an antibody can react.
- A.
True
- B.
False
- 5.Which of the following is NOT true?
- A.
The term epitope is not synonymous with antigen
- B.
A viral protein may contain a large number of epitopes that are capable of interacting with many different specific antibodies
- C.
Immunologic receptors on T cells recognize continuous (linear) epitopes
- D.
Immunologic receptors on T cells recognize discontinuous (conformational) epitopes
- E.
Antibodies can recognize both continuous and discontinuous epitopes
- 6.
- A.
Antigen
- B.
Epitope
- C.
Immunogen
- D.
Stimulant
- E.
Adjuvant
- 7.What fraction of serum are the antibodies (immunoglobulins) initially found when using lytical techniques (e.g. electrophoresis)?
- A.
Albumin
- B.
Gamma (!) globulin
- C.
Beta (") globulin
- D.
Alpha (#) globulin
- 8.In the electrophoresis of human serum, which of the following is the most electronegative and thus migrates farthest toward the positive electrode?
- A.
Albumin
- B.
Gamma (!) globulin
- C.
Beta (") globulin
- D.
Alpha (#) globulin
- 9.Gamma (!) globulin serum fraction contains predominantly which immunoglobulin?
- A.
IgA
- B.
IgD
- C.
IgE
- D.
IgG
- E.
IgM
- 10.
- A.
Active immunity
- B.
Passive immunity
- 11.
- A.
Immunize a mouse with antigen of choice then remove the spleen when the mouse is making an antibody response
- B.
Fuse the immune spleen cells with a myeloma tumor cell
- C.
The cells are cultured in a selective medium allowing fused and non-fused cells to survive
- D.
Cells are grown in individual culture plate wells, and culture supernatants from wells contains growing hybrid cells are screened for presence of desired antibody by an enzyme-linked immunosorbent assay (ELISA)
- E.
This clone (hybridoma) is an immortal producer of the desired monoclonal antibody
- 12.Match the following descriptions with their term: Allows for flexibility
- A.
Light chain
- B.
Heavy chain
- C.
Fab region
- D.
Fc region
- E.
Hinge region
- 13.Match the following descriptions with their term: Binds antigen
- A.
Light chain
- B.
Heavy chain
- C.
Fab region
- D.
Fc region
- E.
Hinge region
- 14.Match the following descriptions with their term: Binds to various cellular receptors and to complement
- A.
Light chain
- B.
Heavy chain
- C.
Fab region
- D.
Fc region
- E.
Hinge region
- 15.Match the following descriptions with their term: Binds to various cellular receptors and to complement
- A.
Light chain
- B.
Heavy chain
- C.
Fab region
- D.
Fc region
- E.
Hinge region
- 16.Match the following descriptions with their term: Has an fragment crystallizable (Fc) and Fab region
- A.
Light chain
- B.
Heavy chain
- C.
Fab region
- D.
Fc region
- E.
Hinge region
- 17.Match the immunoglobulin(s) with the functional description: Activates the complement system
- A.
IgG
- B.
IgE
- C.
IgM
- D.
IgG & IgM
- E.
IgG & IgA
- 18.Match the immunoglobulin(s) with the functional description: Involved in allergic responses
- A.
IgG
- B.
IgE
- C.
IgM
- D.
IgG & IgM
- E.
IgG & IgA
- 19.Match the immunoglobulin(s) with the functional description: Predominant in the primary (early) immune response
- A.
IgG
- B.
IgE
- C.
IgM
- D.
IgG & IgM
- E.
IgG & IgA
- 20.Match the immunoglobulin(s) with the functional description: Has different subtypes
- A.
IgG
- B.
IgE
- C.
IgM
- D.
IgG & IgM
- E.
IgG & IgA
- 21.Match the immunoglobulin(s) with the functional description: Can transfer across the placental (maternal protection)
- A.
IgG
- B.
IgE
- C.
IgM
- D.
IgG & IgM
- E.
IgG & IgA
- 22.Papain cleaves what region of immunoglobulin?
- A.
Heavy chain
- B.
Light chain
- C.
Hinge region
- 23.Pepsin cleaves what region of immunoglobulin?
- A.
Heavy chain
- B.
Light chain
- C.
Hinge region
- 24.IgM is structurally characterized as:
- A.
Monometric
- B.
Bimetric
- C.
Trimetric
- D.
Tetrametric
- E.
Pentametric
- 25.Which of the following is the main immunoglobulin in the gut and secretions (saliva, milk, tears) and is important in mucosal immunity?
- A.
IgA
- B.
IgD
- C.
IgE
- D.
IgG
- E.
IgM
- 26.Which of the following binds to an Fc receptor on mast cells and basophils?
- A.
IgA
- B.
IgD
- C.
IgE
- D.
IgG
- E.
IgM
- 27.Which of the following is chiefly found on the surface of B cells as a receptor molecule and is involved in cell activation?
- A.
IgA
- B.
IgD
- C.
IgE
- D.
IgG
- E.
IgM
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