Otterbein/Grant CRNA A&p Hemostasis/Coagulation Quick Review

27 Questions | Total Attempts: 49

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Coagulation Quizzes & Trivia

Questions and Answers
  • 1. 
    The major function of this cell type is to transport hemoglobin:
    • A. 

      Erythrocytes

    • B. 

      Lymphocytes

    • C. 

      Thrombocytes

    • D. 

      Basophils

  • 2. 
    Erythropoetin is a glycoprotein produced in response to arterial hypoxemia, it is released from the _______ and stimulated RBC production in the bone marrow, peaking after 5 days but will continue until hypoxemia is resolved.
  • 3. 
    The average lifespan of a RBC is _____ days.
    • A. 

      120

    • B. 

      90

    • C. 

      60

    • D. 

      30

  • 4. 
    Platelets are formed in the megakaryocytes, have a 8-12 day lifespan and a normal platelet count is 150-300,000/mm3.
    • A. 

      True

    • B. 

      False

  • 5. 
    Aged platelets are removed by the reticuloendothelial system and spleen.
    • A. 

      True

    • B. 

      False

  • 6. 
    Nitric oxide is produced by endothelial cells, potentiating prostacyclin effects.  NO _______ platelet adhesion, as well as the aggregation and binding of fibrinogen between GPIIb/IIIa complexes.
    • A. 

      Inhibits

    • B. 

      Causes

  • 7. 
    Prostacycling is a powerful ________, derived from arachadonic acid and synthesized by endothelial cells.
    • A. 

      Vasodilator

    • B. 

      Vasoconstrictor

  • 8. 
    Thromboxane A2 is a potent vasoconstrictor that causes potent stimulus for platelet aggregation by _________ adenylyl cyclase and cAMP.
    • A. 

      Inhibiting

    • B. 

      Stimulating

  • 9. 
    VWF is necessary for primary hemostasis to occur.
    • A. 

      True

    • B. 

      False

  • 10. 
    Factors II, VII, IX, and X are:
    • A. 

      Vitamin K dependent

    • B. 

      Not synthesized in the liver

  • 11. 
    Tissue factor is considered the trigger for coagulation to occur.
    • A. 

      True

    • B. 

      False

  • 12. 
    The final common pathway occurs when factor ___ is activated by either the intrinsic or extrinsic pathway.
  • 13. 
    The bleeding related to NSAIDs is related to the inhibition of thromboxane synthesis, leading to platelet inhibition.
    • A. 

      True

    • B. 

      False

  • 14. 
    Cryo contains all of the following except:
    • A. 

      Tissue factor

    • B. 

      Factors I, VIII, XIII

    • C. 

      VWF

    • D. 

      Protein C and fibrinogen

  • 15. 
    __________ is activated by tPA, urokinase, streptokinase, becoming plasmin.  After it's activated it acts on fibrin, degrading it into fibrin degradation products.
  • 16. 
    During the amplification/propagation phase of the cell based theory, all factors are influencing each other to create a burst of _______ to convert fibrinogen into fibrin.
  • 17. 
    ATIII, protein C, protein S, and tissue factor pathway inhibitor are all internal:
    • A. 

      Anticoagulants

    • B. 

      Procoagulants

  • 18. 
    Prostacyclin and thromboxane are both derived from arachadonic acid.  One is synthesized due to vascular damage while the other is produced under normal conditions.  Which one is produced under normal conditions?
  • 19. 
    The __________ pathway is activated by release of factor III when injury occurs outside the vessel wall or blood.
  • 20. 
    The presence of factor IV (calcium) is necessary for both the intrinsic and extrinsic pathways to proceed.
    • A. 

      True

    • B. 

      False

  • 21. 
    This process involves the conversion of plasminogen to plasmin, leading to the dissolution of clots, restoring normal flow through blood vessels.
    • A. 

      Fibrinolysis

    • B. 

      Clot formation

    • C. 

      Gluconeogenesis

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