Block 2 Pace Quiz Sem 1 Biochem
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- 1.Which of the following substances, produced by platelets, is responsible for the activation of platelets?
- A.
Serotonin
- B.
Phosphatidyl inositol
- C.
Thromboxane
- D.
Prostaglandins
- E.
Leukotrienes
- 2.Patients with vitamin K deficiency are most likely to have prolonged coagulation time because of problems associated with :
- A.
Factor V
- B.
Factor VIII
- C.
Factor II
- D.
High molecular weight kin inogen
- E.
Von Willebrand factor
- 3.Plate let adhesion, the process of platelets binding to exposed subendothelial tissue after vascular injury, is primarily mediated by?
- A.
Endothelial cells
- B.
Subendothelial cells
- C.
Platelets
- D.
Clotting factors
- E.
Von Willebrand Factor
- 4.Which vasopermeability factor is secreted by activated platelets?
- A.
Bradykinin
- B.
Histamine
- C.
Thrombin
- D.
Thromboxane
- E.
Serotonin
- 5.Von Willebrand Disease (vWD) is due to an inherited deficiency in von Willebrand Factor (vWF). Which of the following factors are also affected as a result of deficiency of vWF?
- A.
Factor VII
- B.
Factor VIII
- C.
Factor IX
- D.
Factor X
- E.
Factor Xa
- 6.Which of the following works with thrombin in aiding the degradation of clotting factors?
- A.
Thrombomodulin
- B.
Protein C
- C.
Protein S
- D.
All of the above
- E.
None of the above
- 7.A mother finds her 4-year-old daughter with a bag of rat poison . The child has already eaten almost the whole amount in the bag. It turns out that the active ingredient of the rat poison is warfarin. On seeing this child in the emergency room one hour later, what should you do?
- A.
Tell the mother that the child is going to die in a few hours
- B.
Inject a high dose of tissue-type plasminogen activator, then keep monitoring the prothrombin time over the next days
- C.
Make an excha ng-e transfusion immedlately, then keep monitoring the activated partial thromboplastin time over the next days
- D.
Transfuse fresh frozen plasma Immediately, to replace the defective clotting factors
- E.
Gastric lavage and injection of a high dose of vitamin K, and keep monitoring the prothrombin time over the next days
- 8.A 2-year-old boy has a bleeding disorder that is clinically indistinguishable from classical hemophilia (hemophilia A). However, tests for factor VIII activity show a normal protein with normal biological properties. Which of the following observations would suggest that the boy has hemophilia B?
- A.
The plasma level of von Willebrand factor is reduced to 10% of normal
- B.
Injected heparin has a paradoxical pro-coagulant effect
- C.
The amino acid hydrolyxate of a plasma sample contains an abnormally large quantity of y-carboxyglutamate
- D.
The boy's blood clots when mixed with the blood of a patient with hemophilia A, but not when mixed with blood from a patient with hemophilia B
- E.
The prothrombin time is normal, but the activated partial thromboplastin time is greatly reduced
- 9.Antithrombin III is a circulating protease inhibitor that becomes active in the presence of :
- A.
Thromboplastin
- B.
Thrombomodulin
- C.
Heparin
- D.
Vitamin K
- E.
Urokinase
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