MHC & AG Processing Presentation Quiz

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  • 1/12 Questions

    To what type of pathogen are patients with bare lymphocyte syndrome most likely to be vulnerable?

    • Viruses
    • Intracellular bacteria
    • Extracellular protozoans
    • Extracellular bacteria
    • Intracellular protozoans
    • All of the Above
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Immunology Quizzes & Trivia
About This Quiz

This MHC & AG Processing Presentation Quiz assesses understanding of MHC-I and MHC-II pathways, focusing on their roles in antigen presentation and immune cell targeting. It evaluates knowledge critical for diagnosing and understanding immune deficiencies and cellular immune responses.

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  • 2. 

    To what type of pathogen are patients with HLA class I deficiency (bare lymphocyte syndrome type I) most likely to be vulnerable?

    • Viruses

    • Intracellular bacteria

    • Extracellular protozoans

    • Extracellular bacteria

    • Intracellular protozoans

    • None of the Above

    Correct Answer
    A. None of the Above
    Explanation
    Surprisingly, people with MHC-I deficiency are not abnormally affected by viral and other intracellular infections. This is because MHC-I deficiency is mainly due to mutations in TAP-1/TAP-2, and that there probably exist compensatory pathways for peptide transport.

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  • 3. 

    What is the minimum number of different MHC-I alleles that can be present on the cell surface of a normal, healthy, individuals?

    • 1

    • 2

    • 3

    • 4

    • 5

    • 6

    Correct Answer
    A. 3
    Explanation
    The minimum number of different MHC-I alleles that can be present on the cell surface of a normal, healthy individual is 3. MHC-I molecules are highly polymorphic, meaning they have many different alleles. Each individual inherits two sets of MHC-I genes, one from each parent. Since each parent can contribute a maximum of three different alleles, the minimum number of different MHC-I alleles that can be present is 3.

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  • 4. 

    What is the maximum number of different MHC-I alleles that can be present on the cell surface of a normal, healthy, individuals?

    • 1

    • 2

    • 3

    • 4

    • 5

    • 6

    Correct Answer
    A. 6
    Explanation
    There are six possible MHC-I alleles that can be present on the cell surface of a normal, healthy individual.

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  • 5. 

    Which cell is the target of MHC-I-restricted antigen presentation?

    • B lymphocyte

    • Macrophage

    • CD4 T lymphocyte

    • Dendritic cell

    • CD8 T lymphocyte

    Correct Answer
    A. CD8 T lymphocyte
    Explanation
    CD8 T lymphocytes are the target of MHC-I-restricted antigen presentation. MHC-I molecules present antigens derived from intracellular pathogens or abnormal self-proteins to CD8 T cells. This interaction triggers the activation of CD8 T cells, leading to the elimination of infected or abnormal cells. CD8 T lymphocytes play a crucial role in cell-mediated immunity and are responsible for killing virus-infected cells, tumor cells, and cells expressing foreign antigens.

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  • 6. 

    Which cell is the target of MHC-II-restricted antigen presentation?

    • B lymphocyte

    • Macrophage

    • CD4 T lymphocyte

    • Dendritic cell

    • CD8 T lymphocyte

    Correct Answer
    A. CD4 T lymphocyte
    Explanation
    MHC-II molecules are found on the surface of antigen-presenting cells (APCs) such as macrophages, dendritic cells, and B lymphocytes. These cells are responsible for presenting antigens to CD4 T lymphocytes. CD4 T lymphocytes recognize antigens that are presented by MHC-II molecules, and they play a critical role in coordinating the immune response by activating other immune cells. Therefore, CD4 T lymphocytes are the target of MHC-II-restricted antigen presentation. CD8 T lymphocytes, on the other hand, recognize antigens presented by MHC-I molecules.

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  • 7. 

    What is(are) the antigen presenting cell(s) involved in MHC-II-restricted antigen presentation?

    • B lymphocyte

    • Macrophage

    • CD4 T lymphocyte

    • Dendritic cell

    • CD8 T lymphocyte

    Correct Answer(s)
    A. B lymphocyte
    A. Macrophage
    A. Dendritic cell
    Explanation
    B lymphocytes, macrophages, and dendritic cells are all antigen presenting cells involved in MHC-II-restricted antigen presentation. These cells play a crucial role in the immune response by capturing, processing, and presenting antigens to CD4 T lymphocytes. B lymphocytes present antigens to CD4 T lymphocytes through MHC-II molecules, while macrophages and dendritic cells also express MHC-II molecules and present antigens to CD4 T lymphocytes. This process is essential for the activation of CD4 T lymphocytes and the initiation of an effective immune response against pathogens.

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  • 8. 

    What is(are) the antigen presenting cell(s) involved in MHC-I-restricted antigen presentation?

    • B lymphocyte

    • Macrophage

    • CD4 T lymphocyte

    • Dendritic cell

    • CD8 T lymphocyte

    Correct Answer(s)
    A. B lymphocyte
    A. Macrophage
    A. Dendritic cell
    Explanation
    B lymphocytes, macrophages, and dendritic cells are all antigen presenting cells (APCs) involved in MHC-I-restricted antigen presentation. These cells play a crucial role in the immune response by capturing, processing, and presenting antigens to CD8 T lymphocytes. B lymphocytes are responsible for producing antibodies and presenting antigens to helper T cells. Macrophages are phagocytic cells that engulf and present antigens to T cells. Dendritic cells are specialized APCs that capture and present antigens to both CD4 and CD8 T cells, initiating an immune response. CD4 and CD8 T lymphocytes are not antigen presenting cells, but rather recognize antigens presented by APCs.

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  • 9. 

    What is the source of peptides involved in MHC-II-restricted antigen presentation?

    • Proteasome

    • Phagolysosome

    • Golgi

    • Peptidase

    • Nuclease

    Correct Answer
    A. Phagolysosome
    Explanation
    Phagolysosomes are the source of peptides involved in MHC-II-restricted antigen presentation. Phagolysosomes are formed when phagosomes, which are membrane-bound vesicles containing engulfed pathogens or particles, fuse with lysosomes. Within the phagolysosome, the engulfed material is degraded by various enzymes, including proteases, resulting in the generation of peptides. These peptides are then loaded onto MHC-II molecules and presented on the cell surface to activate immune responses. Therefore, the correct answer is Phagolysosome.

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  • 10. 

    What is the source of peptides involved in MHC-I-restricted antigen presentation?

    • Proteasome

    • Phagolysosome

    • Golgi

    • Peptidase

    • Nuclease

    Correct Answer
    A. Proteasome
    Explanation
    The correct answer is Proteasome. Proteasomes are responsible for degrading proteins into peptides. These peptides are then transported into the endoplasmic reticulum, where they bind to MHC-I molecules and are presented on the cell surface for recognition by cytotoxic T cells. This process is known as MHC-I-restricted antigen presentation. Phagolysosomes, Golgi, peptidase, and nuclease are not directly involved in this process.

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  • 11. 

    Activation of CD8 T lymphocytes requires which elements?

    • MHC class I antigen presentation, CD86 co-stimulation and IL-12

    • MHC class II antigen presentation, CD86 co-stimulation and IL-12

    • MHC class I antigen presentation, CD86 co-stimulation and IL-4

    • MHC class II antigen presentation, CD86 co-stimulation and IL-4

    • MHC class I antigen presentation, CD40 co-stimulation and IL-12

    • MHC class II antigen presentation, CD40 co-stimulation and IL-12

    • MHC class I antigen presentation, CD40 co-stimulation and IL-4

    • MHC class II antigen presentation, CD40 co-stimulation and IL-4

    Correct Answer
    A. MHC class I antigen presentation, CD86 co-stimulation and IL-12
    Explanation
    The activation of CD8 T lymphocytes requires MHC class I antigen presentation, CD86 co-stimulation, and IL-12. MHC class I molecules present antigens to CD8 T cells, CD86 provides a co-stimulatory signal to enhance T cell activation, and IL-12 is a cytokine that promotes the differentiation and activation of CD8 T cells. This combination of elements is necessary for the activation of CD8 T lymphocytes.

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  • 12. 

    Activation of CD4 T lymphocytes requires which elements?

    • MHC class I antigen presentation, CD86 co-stimulation and IL-12

    • MHC class II antigen presentation, CD86 co-stimulation and IL-12

    • MHC class I antigen presentation, CD86 co-stimulation and IL-4

    • MHC class II antigen presentation, CD86 co-stimulation and IL-4

    • MHC class I antigen presentation, CD40 co-stimulation and IL-12

    • MHC class II antigen presentation, CD40 co-stimulation and IL-12

    • MHC class I antigen presentation, CD40 co-stimulation and IL-4

    • MHC class II antigen presentation, CD40 co-stimulation and IL-4

    Correct Answer
    A. MHC class II antigen presentation, CD86 co-stimulation and IL-12
    Explanation
    Depending if you have a TH1, TH2 or a TH17 response., D and F could also be correct answers

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  • Current Version
  • Mar 21, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • Jun 07, 2012
    Quiz Created by
    Rosssweetie

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