Immunology & Serology

125 Questions | Total Attempts: 424

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Immunology & Serology

Immunology & Serology 


Questions and Answers
  • 1. 
    One reason that pathogenic microorganisms have an advantage in the host they infect is because they 
    • A. 

      Have previously been encountered through natural exposure

    • B. 

      Reproduce and evolve more rapidly than the host can eliminate them

    • C. 

      Strengthen the hosts immune response

    • D. 

      Reproduce and evolve more slowly than the host can eliminate them

    • E. 

      Have previously been encountered through vaccination

  • 2. 
    Which of the following is NOT a characteristic of inflammation
    • A. 

      Pain

    • B. 

      Increased vascular permeability and edema

    • C. 

      Inactivation of macrophages

    • D. 

      Influx of leukocytes

    • E. 

      Vasodilation

  • 3. 
    Which of the following is NOT associated with mucosal surfaces
    • A. 

      White pulp

    • B. 

      M cells

    • C. 

      Lysozyme

    • D. 

      Beating cilia

    • E. 

      Mucus=secreting goblet cells

  • 4. 
    Which of the following pairs is mismatched 
    • A. 

      Erythrocyte: oxygen transport

    • B. 

      Natural killer cell: kills virus-infected cells

    • C. 

      Macrophage: phagocytosis and killing of microorganisms

    • D. 

      Eosinophil: defense against parasites

    • E. 

      Lymphocytes: innate immune response

  • 5. 
    Examples of granulocytes include all of the following except 
    • A. 

      Neutrophil

    • B. 

      Monocyte

    • C. 

      Basophil

    • D. 

      Eosinophil

    • E. 

      All of the above are examples of granulocytes

  • 6. 
    The most abundant type of leukocyte in human peripheral blood is 
    • A. 

      Eosinophil

    • B. 

      Basophil

    • C. 

      Monocyte

    • D. 

      Neutrophil

    • E. 

      Lymphocyte

  • 7. 
    Which of the following pairs of association is mismatched 
    • A. 

      Monocyte: macrophages

    • B. 

      B cell: plasma cell

    • C. 

      Myeloid progenitor: neutrophil

    • D. 

      Large granular lymphocyte: T cell

    • E. 

      Megakaryocyte: platelet

  • 8. 
    Which of the following statements is false 
    • A. 

      Megakaryocytes do not circulate and reside only in the bone marrow

    • B. 

      The hematopoietic stem cell gives rise to white blood cells but a different stem cell is the progenitor of red blood cells

    • C. 

      Platelets participate in clotting reactions to prevent blood loss

    • D. 

      During human development, hemotopoiesis takes place a different anatomical locations

    • E. 

      Hematopoeitic stem cells are self-renewing

  • 9. 
    Which of the following describes the flow of lymph through a lymph node draining an infected tissue 
    • A. 

      Artery to lymph node to efferent lymphatic vessel

    • B. 

      Afferent lymphatic vessel to lymph node to efferent lymphatic vessel

    • C. 

      Efferent lymphatic vessel to lymph node to afferent lymphatic vessel

    • D. 

      Venule to lymph node to efferent lymphatic vessel

    • E. 

      Afferent lymphatic vessel to lymph node to artery

  • 10. 
    Which of the following is the predominant route by which pathogens are brought from a site of infection into a lymph node. 
    • A. 

      Efferent lymphatics

    • B. 

      Vein

    • C. 

      Artery

    • D. 

      High endothelial venule

    • E. 

      Afferent lymphatics

  • 11. 
    Which of the following does NOT accuratley describe complement components 
    • A. 

      Soluble proteins

    • B. 

      Made by the spleen

    • C. 

      Located in extracellular spaces

    • D. 

      Some function as proteases once activated

    • E. 

      Activated by a cascade of enzymatic reactions

  • 12. 
    Which of the following is the membrane-bound form of C3 convertase of the alternative pathway of complement activation 
    • A. 

      IC3

    • B. 

      C3a

    • C. 

      C3b

    • D. 

      IC3Bb

    • E. 

      C3bBb

  • 13. 
    The plasma proteins that counteract the activity of factor P by inactivating C3 convertase through the cleavage of C3b are 
    • A. 

      Factor B and factor H

    • B. 

      Factor H and factor I

    • C. 

      Factor B and factor I

    • D. 

      Decay-accelerating factor and factor H

    • E. 

      Decay-accelerating factor and membrane cofactor protein

  • 14. 
    Which of the following polymerizes to form a transmembrane channel that compromises the integrity of cell membranes 
    • A. 

      C5

    • B. 

      C6

    • C. 

      C7

    • D. 

      C8

    • E. 

      C9

  • 15. 
    The ligand for CR3 and CR4 formed by the cleavage of C3b by the combined action of factors H and I is called
    • A. 

      C3bBb

    • B. 

      C3a

    • C. 

      C3b2Bb

    • D. 

      IC3b

    • E. 

      C5b

  • 16. 
    Which of the following does NOT describe the actions of the coagulation system 
    • A. 

      Blood clot formation

    • B. 

      Enhancement of dissemination of microbes into lymphatics and bloodstream

    • C. 

      Decrease in blood loss and fluid into interstitial spaces in tissue

    • D. 

      Release of infammatory mediators by platelets

    • E. 

      Wound healing

  • 17. 
    Which of the following is NOT a characteristic of C-reactive protein 
    • A. 

      Acts as an opsonin by binding to phosphocholine of pathogens

    • B. 

      Synthesized by spleen

    • C. 

      Induced by elevated IL-6

    • D. 

      A member of the pentraxin family

    • E. 

      Triggers the classical pathway of complement activation

  • 18. 
    Which of the following TLR3 and TLR4 adaptor proteins participates in the activation pathway that culminates iin the synthesis of type1 interferons 
    • A. 

      C-reactive protein

    • B. 

      MyD88

    • C. 

      LPS-binding protein

    • D. 

      TRIF and TRAM

    • E. 

      NFKappaB

  • 19. 
    Which of the following is NOT a charactersitc of septic shock
    • A. 

      Organ failure

    • B. 

      High mortality rate

    • C. 

      Compromised blood supply to vital organs

    • D. 

      Blood vessel constriction

    • E. 

      Disseminated intravascular coagulation

  • 20. 
    Which of the following best describes an endogenous pyrogen 
    • A. 

      Cytokines made by pathogens that decrease body temperature

    • B. 

      Pathogen products that decrease body temperature

    • C. 

      Pathogen products that increase body temperature

    • D. 

      Cytokines made by the host that decrease body temperature

    • E. 

      Cytokines made by the host that increase body temperature

  • 21. 
    Which of the following is mismatched 
    • A. 

      Immunoglobin light chain: VJ

    • B. 

      T-cell receptor alpha chain: VJ

    • C. 

      Immunoglobin heavy chain: VJ

    • D. 

      T-cell recepot beta chain:VDJ

    • E. 

      None of the above is mismatched

  • 22. 
    In most cases, adaptive immune responses rely on the initial activation of ________ in secondary lymphoid tissue 
    • A. 

      Macrophages

    • B. 

      T cells

    • C. 

      B cells

    • D. 

      Dendritic cells

    • E. 

      Epithelium

  • 23. 
    Which of the following is NOT a characteristic of native antigen recognized by T cells 
    • A. 

      Peptides ranging between 8 and 25 amino acids in length

    • B. 

      Not requiring degradation for recognition

    • C. 

      Amino acid sequences not found in host proteins

    • D. 

      Primary, and not secondary, structure of protein

    • E. 

      Binding to major histocompatibility complex molecules on the surface of antigen-presenting cells

  • 24. 
    Which of the following statements regarding CD8 T cells is incorrect 
    • A. 

      When activated, CD8 T cells in turn activate B cells

    • B. 

      CD8 is also known as the CD8 T-cell co-receptor

    • C. 

      CD8 binds to MHC molecules at a site distinct from that bound by the T-cell receptor

    • D. 

      CD8 cells kill pathogen-infected cells by inducing apoptosis

    • E. 

      CD8 T cells are MHC class I-restricted

  • 25. 
    Which of the following characteristics permits activated CD8 T cells to destroy any cell type harboring viable and replicating pathogens such as viruses 
    • A. 

      The pathogen is located in extracellular pathogens

    • B. 

      CD8 T cells enable macrophages to kill intracellular pathogens

    • C. 

      Pathogen-derived peptides bind MHC Class I molecules in endocytic vesicles found ubiquitously in most cell types

    • D. 

      MHC class II molecules are expressed ubiquitoously by most nucleated cells

    • E. 

      MHC class I molecules are expressed ubiquitously by most nucleated cells