Immunology & Serology
Settings
Immunology & Serology
- 1.One reason that pathogenic microorganisms have an advantage in the host they infect is because they
- A.
Have previously been encountered through natural exposure
- B.
Reproduce and evolve more rapidly than the host can eliminate them
- C.
Strengthen the hosts immune response
- D.
Reproduce and evolve more slowly than the host can eliminate them
- E.
Have previously been encountered through vaccination
- 2.Which of the following is NOT a characteristic of inflammation
- A.
Pain
- B.
Increased vascular permeability and edema
- C.
Inactivation of macrophages
- D.
Influx of leukocytes
- E.
Vasodilation
- 3.Which of the following is NOT associated with mucosal surfaces
- A.
White pulp
- B.
M cells
- C.
Lysozyme
- D.
Beating cilia
- E.
Mucus=secreting goblet cells
- 4.Which of the following pairs is mismatched
- A.
Erythrocyte: oxygen transport
- B.
Natural killer cell: kills virus-infected cells
- C.
Macrophage: phagocytosis and killing of microorganisms
- D.
Eosinophil: defense against parasites
- E.
Lymphocytes: innate immune response
- 5.Examples of granulocytes include all of the following except
- A.
Neutrophil
- B.
Monocyte
- C.
Basophil
- D.
Eosinophil
- E.
All of the above are examples of granulocytes
- 6.The most abundant type of leukocyte in human peripheral blood is
- A.
Eosinophil
- B.
Basophil
- C.
Monocyte
- D.
Neutrophil
- E.
Lymphocyte
- 7.Which of the following pairs of association is mismatched
- A.
Monocyte: macrophages
- B.
B cell: plasma cell
- C.
Myeloid progenitor: neutrophil
- D.
Large granular lymphocyte: T cell
- E.
Megakaryocyte: platelet
- 8.Which of the following statements is false
- A.
Megakaryocytes do not circulate and reside only in the bone marrow
- B.
The hematopoietic stem cell gives rise to white blood cells but a different stem cell is the progenitor of red blood cells
- C.
Platelets participate in clotting reactions to prevent blood loss
- D.
During human development, hemotopoiesis takes place a different anatomical locations
- E.
Hematopoeitic stem cells are self-renewing
- 9.Which of the following describes the flow of lymph through a lymph node draining an infected tissue
- A.
Artery to lymph node to efferent lymphatic vessel
- B.
Afferent lymphatic vessel to lymph node to efferent lymphatic vessel
- C.
Efferent lymphatic vessel to lymph node to afferent lymphatic vessel
- D.
Venule to lymph node to efferent lymphatic vessel
- E.
Afferent lymphatic vessel to lymph node to artery
- 10.Which of the following is the predominant route by which pathogens are brought from a site of infection into a lymph node.
- A.
Efferent lymphatics
- B.
Vein
- C.
Artery
- D.
High endothelial venule
- E.
Afferent lymphatics
- 11.Which of the following does NOT accuratley describe complement components
- A.
Soluble proteins
- B.
Made by the spleen
- C.
Located in extracellular spaces
- D.
Some function as proteases once activated
- E.
Activated by a cascade of enzymatic reactions
- 12.Which of the following is the membrane-bound form of C3 convertase of the alternative pathway of complement activation
- A.
IC3
- B.
C3a
- C.
C3b
- D.
IC3Bb
- E.
C3bBb
- 13.The plasma proteins that counteract the activity of factor P by inactivating C3 convertase through the cleavage of C3b are
- A.
Factor B and factor H
- B.
Factor H and factor I
- C.
Factor B and factor I
- D.
Decay-accelerating factor and factor H
- E.
Decay-accelerating factor and membrane cofactor protein
- 14.Which of the following polymerizes to form a transmembrane channel that compromises the integrity of cell membranes
- A.
C5
- B.
C6
- C.
C7
- D.
C8
- E.
C9
- 15.The ligand for CR3 and CR4 formed by the cleavage of C3b by the combined action of factors H and I is called
- A.
C3bBb
- B.
C3a
- C.
C3b2Bb
- D.
IC3b
- E.
C5b
- 16.Which of the following does NOT describe the actions of the coagulation system
- A.
Blood clot formation
- B.
Enhancement of dissemination of microbes into lymphatics and bloodstream
- C.
Decrease in blood loss and fluid into interstitial spaces in tissue
- D.
Release of infammatory mediators by platelets
- E.
Wound healing
- 17.Which of the following is NOT a characteristic of C-reactive protein
- A.
Acts as an opsonin by binding to phosphocholine of pathogens
- B.
Synthesized by spleen
- C.
Induced by elevated IL-6
- D.
A member of the pentraxin family
- E.
Triggers the classical pathway of complement activation
- 18.Which of the following TLR3 and TLR4 adaptor proteins participates in the activation pathway that culminates iin the synthesis of type1 interferons
- A.
C-reactive protein
- B.
MyD88
- C.
LPS-binding protein
- D.
TRIF and TRAM
- E.
NFKappaB
- 19.Which of the following is NOT a charactersitc of septic shock
- A.
Organ failure
- B.
High mortality rate
- C.
Compromised blood supply to vital organs
- D.
Blood vessel constriction
- E.
Disseminated intravascular coagulation
- 20.Which of the following best describes an endogenous pyrogen
- A.
Cytokines made by pathogens that decrease body temperature
- B.
Pathogen products that decrease body temperature
- C.
Pathogen products that increase body temperature
- D.
Cytokines made by the host that decrease body temperature
- E.
Cytokines made by the host that increase body temperature
- 21.Which of the following is mismatched
- A.
Immunoglobin light chain: VJ
- B.
T-cell receptor alpha chain: VJ
- C.
Immunoglobin heavy chain: VJ
- D.
T-cell recepot beta chain:VDJ
- E.
None of the above is mismatched
- 22.In most cases, adaptive immune responses rely on the initial activation of ________ in secondary lymphoid tissue
- A.
Macrophages
- B.
T cells
- C.
B cells
- D.
Dendritic cells
- E.
Epithelium
- 23.Which of the following is NOT a characteristic of native antigen recognized by T cells
- A.
Peptides ranging between 8 and 25 amino acids in length
- B.
Not requiring degradation for recognition
- C.
Amino acid sequences not found in host proteins
- D.
Primary, and not secondary, structure of protein
- E.
Binding to major histocompatibility complex molecules on the surface of antigen-presenting cells
- 24.Which of the following statements regarding CD8 T cells is incorrect
- A.
When activated, CD8 T cells in turn activate B cells
- B.
CD8 is also known as the CD8 T-cell co-receptor
- C.
CD8 binds to MHC molecules at a site distinct from that bound by the T-cell receptor
- D.
CD8 cells kill pathogen-infected cells by inducing apoptosis
- E.
CD8 T cells are MHC class I-restricted
- 25.Which of the following characteristics permits activated CD8 T cells to destroy any cell type harboring viable and replicating pathogens such as viruses
- A.
The pathogen is located in extracellular pathogens
- B.
CD8 T cells enable macrophages to kill intracellular pathogens
- C.
Pathogen-derived peptides bind MHC Class I molecules in endocytic vesicles found ubiquitously in most cell types
- D.
MHC class II molecules are expressed ubiquitoously by most nucleated cells
- E.
MHC class I molecules are expressed ubiquitously by most nucleated cells
Back to top