Immunology Quiz- Introduction To Antigen Recognition
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- 1.
- A.
They are serum proteins that form protein cascades, each activated component activating the next to generate a physiologic response
- B.
They can bind to bacteria, making holes in their membrane
- C.
They attract phagocytes to both foreign material and self cells
- D.
Binding of MBLs to a bacterial capsule triggers the complement cascade
- E.
They help to eliminate immune complexes (antibody-antigen) and prevent them from damaging the body
- 2.Which of the following key components of the complement pathway can be activated by the lectin, classical, and alternative pathways?
- A.
C1
- B.
C3
- C.
C5
- D.
C7
- E.
C9
- 3.Match the three types of molecules that recognize antigen with their description: Can create a soluble antigen receptor (antibody)
- A.
B cell receptor (BCR)
- B.
T cell receptor (TCR)
- C.
Major histocompatibility complex (MHC)
- 4.Match the three types of molecules that recognize antigen with their description: Recognize antigens bound to MHC
- A.
B cell receptor (BCR)
- B.
T cell receptor (TCR)
- C.
Major histocompatibility complex (MHC)
- 5.Match the three types of molecules that recognize antigen with their description: A cluster of genes that encode proteins
- A.
B cell receptor (BCR)
- B.
T cell receptor (TCR)
- C.
Major histocompatibility complex (MHC)
- 6.The genes encoding which of the following can undergo hypermutation to create receptors that are an even better fit for foreign antigens?
- A.
BCRs
- B.
TCRs
- C.
MHCs
- D.
BCRs & TCRs
- E.
BCRs, TCRs, & MHCs
- 7.Which of the following has an immunoglobulin fold?
- A.
BCRs
- B.
TCRs
- C.
MHCs
- D.
BCRs & TCRs
- E.
BCRs, TCRs, & MHCs
- 8.The genes encoding which of the following are extensively polymorphic (have multiple alleles or forms of the same gene)?
- A.
BCRs
- B.
TCRs
- C.
MHCs
- D.
BCRs & TCRs
- E.
BCRs, TCRs, & MHCs
- 9.What types of cell is class I MHC found on?
- A.
B cells
- B.
Macrophages
- C.
Dendritic cells
- D.
Essentially all cells
- E.
Mainly on A, B, & C
- 10.What types of cell is class II MHC found on?
- A.
B cells
- B.
Macrophages
- C.
Dendritic cells
- D.
Essentially all cells
- E.
Mainly on A, B, & C
- 11.What is the function of major histocompatibility complex (MHC) molecules?
- A.
Present sugars to T cells
- B.
Present peptides to T cells
- C.
Create holes in the membranes of bacteria
- D.
Lyse foreign antigens
- E.
Phagocytize foreign antigens
- 12.Unlike B cell receptors (BCRs), T cell receptors (TCRs) can only recognize foreign antigen if it is presented as a complex with a MHC molecule.
- A.
True
- B.
False
- 13.If the structure of an individuals MHC molecules makes it impossible for them to recognize and bind any peptide antigen from a given virus, that individual will still be able to activate a T cell response to cells infected with that virus.
- A.
True
- B.
False
- 14.Which of the following is NOT true about MHC molecules but true about B and T cells?
- A.
The genes that encode molecules are the most variable genes we know of in the human genome (polygenic)
- B.
They are extensively polymorphic (existence of multiple alleles or forms of the same gene)
- C.
Every cell in each individual expresses the same set of molecules
- D.
) Every cell expresses a different molecule created from multiple gene segments that undergo somatic rearrangement
- E.
Their diversity exists in the population as a whole, not in the individual
- 15.Given that an individual’s parents have completely different HLA genes, that individual will have about____ different class I and II MHC molecules on the surface of certain of their lymphoid cells.
- A.
3
- B.
6
- C.
9
- D.
12
- E.
15
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