Immunology General

1. A specific antibody binds to a specific binding site on an antigen, this area on the antigen where the antibody binds is called __________

Immunogenicity

Haptope

Eptitope

Immunoglobulins

immunoglobulin is another word for antibody so that aint right.

Explanation

immunoglobulin is another word for antibody so that aint right.

2. Which compliment pathway involves the C1 protein and is activated by the antigen-antibody complexes?

Alternative

MBL

Classical

MAC

3. Humoral immunity is associated with which type of cell?

Natural Killer Cells

T Cells

B Cells

Innate Cells

Humoral is associated with B cells. Cellular immunity is associated with T cells. Both are adaptive defence mechanisms.

Explanation

Humoral is associated with B cells. Cellular immunity is associated with T cells. Both are adaptive defence mechanisms.

4. Haptens alone can trigger an immune response

True

False

Hapens need to be attached to a body protein or to an antibody molecule already formed in order to illicit an immune response.

Explanation

Hapens need to be attached to a body protein or to an antibody molecule already formed in order to illicit an immune response.

5. The alternative pathway is usually triggered without anitbody involvement

True

False

Slide 18

Explanation

Slide 18

6. Which class of antibody has 10 binding sites?

IgM

IgE

IgA

IgD

IgG

7. A patient is sick and their blood levels indicate higher amounts of IgM compared with IgG, this is most likely

The patients first exposure to the antigen

The patients second exposure to the antigen

Going to be associated with a long lived response

A secondary immune response

This is characteristic of a primary immune response. All the others are characteristics of a secondary immune response.

Explanation

This is characteristic of a primary immune response. All the others are characteristics of a secondary immune response.

8. An Anaphylactic reaction is associated with abnormal production of which antibody?

IgD

IgE

All Antibodies

No Antibodies

9. Shortly after birth and before a newborn can produce its own antibodies, what is the only antibody class protecting the newborn?

IgA

IgM

IgG

All of the options

IgG is the only antibody class that can pass the placental barrier and so this is the only class that the baby will have in its body.

Explanation

IgG is the only antibody class that can pass the placental barrier and so this is the only class that the baby will have in its body.

10. Which of the following is an example of naturally acquired specific immunity?

Vaccination

Placental transfer of anitbodies

Administration of anitoxin

Interferons

Placental transfer is naturally acquired (passive) specific immunity. Vaccination (active) and administration of antitoxin (passive) are examples of artificially acquired specific immunity. Interferons are not specific immunity but rather innate immunity.

Explanation

Placental transfer is naturally acquired (passive) specific immunity. Vaccination (active) and administration of antitoxin (passive) are examples of artificially acquired specific immunity. Interferons are not specific immunity but rather innate immunity.

11. Helper T cells recognize antigen fragments associated with ____ where as Cytotoxic T cells recognize fragments associated with .

MHC-2 molecules, MHC-1 molecules

MHC-1 molecules, MHC-2 molecules

MHC-1 molecules, MHC-1 molecules

MHC-2 molecules, MHC-2 molecules

Slide 42

Explanation

Slide 42

12. Match the macrophage with its specific tissue

Histiocytes

Kupffer cells

Microglia

These are fixed macrophages and do not leave their specified tissue.

Explanation

These are fixed macrophages and do not leave their specified tissue.

Submit

13. Where would you find low levels of IgA?

Mucosal surfaces

General blood circulation

Breast Milk

Saliva

Slide 22

Explanation

Slide 22

14. T lymphocytes are more abundant in circulating blood than B lymphocytes

True

False

T lymphocytes = 70%. B lymphocytes = 15%

Explanation

T lymphocytes = 70%. B lymphocytes = 15%

15. If a person was diagnosed with AIDS, which of the following would you expect to see from their blood results?

CD4+ T Cells outnumbering the CD8+ T cells

Cytotoxic T cells outnumbering the Helper T cells

A ration of 1:1 between CD4 and CD8 T cells

No abnormality in blood lymphocyte make up

The normal ration between CD4 (Helper T cells) and CD8 (Cytotoxic T cells) is 2:1. In AIDS, it is 0.5:1

Explanation

The normal ration between CD4 (Helper T cells) and CD8 (Cytotoxic T cells) is 2:1. In AIDS, it is 0.5:1

16. Which of the following compliment pathways is the final pathway?

Classical Pathway

Alternative Pathway

MBL

MAC

MAC (Membrane attack complex) is what kills the cell by puncturing its membrane and destroying the pathogens internal stasis.

Explanation

MAC (Membrane attack complex) is what kills the cell by puncturing its membrane and destroying the pathogens internal stasis.

17. A cell becomes infected with a virus and begins to produce proteins that signal nearby cells to produce antivirual proteins. What are the signal proteins called?

Cytokines

Interferons

Phagocytic proteins

Antigen presenting complex

18. Cell mediated immunity (Select 2)

Is carried out primarily by T cells

Is more effective against intracellular pathogens

Is carried out primarily by B cells

Is more effective against extracellular pathogens

B cells are responsible for the other 2 options.

Explanation

B cells are responsible for the other 2 options.

Submit

19. Which of the following is true regarding IgM? (Select 2)

It is the first antibody produced in response to infection

It requires class switching

It has 2 forms - surface form and secreted form

The compliment system is blind to IgM

IgM does not require class switching and this is partially why it is the first antibody in response (less processing time). It is not blind to the compliment system, it is actually a good stimulator of the compliment system.

Explanation

IgM does not require class switching and this is partially why it is the first antibody in response (less processing time). It is not blind to the compliment system, it is actually a good stimulator of the compliment system.

Submit

20. Which portion of the antibody binds with the antigen? (Select 2)

Fc

Crystallizable

Variable

FAB

Fc and Crystallizable are the same thing.

Explanation

Fc and Crystallizable are the same thing.

Submit

21. Nonspecific innate immunity is present shortly after birth (2-4 weeks)

True

False

It is present from birth

Explanation

It is present from birth

22. Which of the following are examples of first or second line of defences in the body? (select all that apply)

Mucous membranes

Enzymes in secretions

Interferon

Vaccinations

Vaccination is third line of defence (specific immunity) and is artificially acquired (active)

Explanation

Vaccination is third line of defence (specific immunity) and is artificially acquired (active)

Submit

23. Which of the following is true regarding the primary immune response?

It is carried out by innate cells

It is part of the specific immune response

It is the skin barrier preventing entry of a pathogen

It is the mucous barrier lining epithelial cells

Immunology General

1. A specific antibody binds to a specific binding site on an antigen, this area on the antigen where the antibody binds is called __________

2.

What first name or nickname would you like us to use?

2. Which compliment pathway involves the C1 protein and is activated by the antigen-antibody complexes?

3. Humoral immunity is associated with which type of cell?

4. Haptens alone can trigger an immune response

5. The alternative pathway is usually triggered without anitbody involvement

6. Which class of antibody has 10 binding sites?

7. A patient is sick and their blood levels indicate higher amounts of IgM compared with IgG, this is most likely

8. An Anaphylactic reaction is associated with abnormal production of which antibody?

9. Shortly after birth and before a newborn can produce its own antibodies, what is the only antibody class protecting the newborn?

10. Which of the following is an example of naturally acquired specific immunity?

11. Helper T cells recognize antigen fragments associated with __________ where as Cytotoxic T cells recognize fragments associated with ______.

12. Match the macrophage with its specific tissue

13. Where would you find low levels of IgA?

14. T lymphocytes are more abundant in circulating blood than B lymphocytes

15. If a person was diagnosed with AIDS, which of the following would you expect to see from their blood results?

16. Which of the following compliment pathways is the final pathway?

17. A cell becomes infected with a virus and begins to produce proteins that signal nearby cells to produce antivirual proteins. What are the signal proteins called?

18. Cell mediated immunity (Select 2)

19. Which of the following is true regarding IgM? (Select 2)

20. Which portion of the antibody binds with the antigen? (Select 2)

21. Nonspecific innate immunity is present shortly after birth (2-4 weeks)

22. Which of the following are examples of first or second line of defences in the body? (select all that apply)

23. Which of the following is true regarding the primary immune response?

11. Helper T cells recognize antigen fragments associated with ____ where as Cytotoxic T cells recognize fragments associated with .