Immunology Exam (Ch.5-7)

184 Questions | Total Attempts: 209

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Immunology Quizzes & Trivia

Antigen Recognition by T Lymphocytes, The Development of B Lymphocytes, The development of T Lymphocytes.


Questions and Answers
  • 1. 
    What are the two types of T-cells?
    • A. 

      A:B T cells and y:S T cells

    • B. 

      A:B T cells and D:Z T cells

    • C. 

      Y:S T cells and a:L T cells

    • D. 

      None of the Above

  • 2. 
    What are immature T cells called?
    • A. 

      Thymocytes

    • B. 

      Stromal cells

    • C. 

      Lymphocytes

    • D. 

      Plasma cells

    • E. 

      Cytokines

  • 3. 
    The thymic stroma houses what kinds of cells?
    • A. 

      Thymocytes

    • B. 

      B cells

    • C. 

      Plasma cells

    • D. 

      Double-negative thymocytes

    • E. 

      Double-positive thymocytes

  • 4. 
    How do lymphocytes enter and leave the thymus?
  • 5. 
    What two parts create the thymus?
  • 6. 
    What cells are responsible for the development of the cortex in the thymus?
    • A. 

      Ectodermal cells

    • B. 

      Endodermal cells

    • C. 

      Mesodermal cells

    • D. 

      Exodermal cells

    • E. 

      Psuedodermal cells

  • 7. 
     In what syndrome does the thymus fail to develop?
    • A. 

      DiGeroge's syndrome

    • B. 

      Bare lymphocyte syndrome

    • C. 

      Follicular center cell lymphoma

    • D. 

      Hodgkin's Disease

    • E. 

      Lupus

  • 8. 
    The process of fat claiming areas of thymocytes after a year birth in the thymus causing it to degenerate is called?
  • 9. 
    The involution of the thymus affects T-cell count.
    • A. 

      True

    • B. 

      False

  • 10. 
    What complement is a characteristic of a stem cell?
    • A. 

      CD34

    • B. 

      CD7

    • C. 

      CD4

    • D. 

      CD8

    • E. 

      CD24

  • 11. 
    When a stem cell expresses ____ and _____ it becomes a T cell.
    • A. 

      CD2 and CD5

    • B. 

      CD4 and CD8

    • C. 

      CD34 and CD2

    • D. 

      CD34 and CD5

    • E. 

      CD12 and CD21

  • 12. 
    A double-negative thymocyte does not express...
    • A. 

      CD4 and CD8

    • B. 

      CD34 and CD21

    • C. 

      CD7 and CD11

    • D. 

      CD14 and CD21

    • E. 

      CD4 and CD9

  • 13. 
    Thymocytes are considered to be double-negative cells. This is possible because...
    • A. 

      Thymocytes are in the process of rearranging their genes

    • B. 

      Thymocytes are unable to express the required complements to divide

    • C. 

      Thymocytes lack CD4 and CD8

    • D. 

      None of the above

    • E. 

      A and C

  • 14. 
    Cytokine ______ is critical in the development of T-cells.
  • 15. 
    What cells secrete cytokine 7?
    • A. 

      Stromal cells

    • B. 

      Goblet cells

    • C. 

      B lymphocytes

    • D. 

      T lymphocytes

    • E. 

      Follicular cells

  • 16. 
    What complement does IL-7 bind to?
    • A. 

      CD34

    • B. 

      CD21

    • C. 

      CD4

    • D. 

      CD5

    • E. 

      CD8

  • 17. 
    The cell receptor on a thymocyte is called...
  • 18. 
    Notch 1 interacts with transmembrane ligands on thymic epithelial cells which initiates a proteolytic cleavage. The process that follows the proteolytic cleavage which involves an intracellular domain of Notch 1 affects the thymocyte in what particular way?
    • A. 

      Notch 1 sends signals that controls the pathway of T-cell differentiation and keeps it away from the B-cell

    • B. 

      Notch 1 does not allow the binding of MHC I molecules to the thymocyte

    • C. 

      CD8 is allowed to bind to the thymocyte receptor

    • D. 

      CD4 is not allowed to bind to the thymocyte

    • E. 

      Notch 1 sends signals that allow the thymocyte to differentiate into a B-cell

  • 19. 
    A double negative thymocyte precursor creates:
    • A. 

      A:B and y:D T cells

    • B. 

      A:B and y:G T cells

    • C. 

      L:a and Z:y T cells

    • D. 

      All of the above

    • E. 

      None of the above

  • 20. 
    Rearrangement of double-negative thymocytes begins with...
    • A. 

      Rearrangement at the y, D, and B loci at the same time

    • B. 

      Rearrangement at the y, D, and B loci at a different time

    • C. 

      Rearrangement at the a, B, and y loci at the same time

    • D. 

      Rearrangement at the D, S, and y loci at the same time

    • E. 

      Rearrangement at the a, B, and D loci at the same time

  • 21. 
    Which two loci compete with the B locus on a double-negative thymocyte during rearrangement?
    • A. 

      Y and D

    • B. 

      B and a

    • C. 

      Y and a

    • D. 

      D and a

    • E. 

      S and z

  • 22. 
    What percentage of thymocytes survive positive selection?
  • 23. 
    Which TCR does not undergo positive and negative selection?
    • A. 

      Y:D TCR

    • B. 

      A:B TCR

    • C. 

      D:a TCR

    • D. 

      Y:B TCR

    • E. 

      L:T TCR

  • 24. 
    What is the B-chain of the thymocyte test for when translocated to the ER after double-negative rearrangement?
    • A. 

      The capacity to bind to pTa

    • B. 

      The capacity to bind to y:D chain

    • C. 

      The capacity to bind to self-antigens

    • D. 

      The capacity to bind to CD3

    • E. 

      The capacity to bind to CD34

  • 25. 
    PTa is an invariant polypeptide that acts as a _________ __________.