Immunology Exam (Ch.5-7)
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Antigen Recognition by T Lymphocytes, The Development of B Lymphocytes, The development of T Lymphocytes.
- 1.What are the two types of T-cells?
- A.
A:B T cells and y:S T cells
- B.
A:B T cells and D:Z T cells
- C.
Y:S T cells and a:L T cells
- D.
None of the Above
- 2.What are immature T cells called?
- A.
Thymocytes
- B.
Stromal cells
- C.
Lymphocytes
- D.
Plasma cells
- E.
Cytokines
- 3.The thymic stroma houses what kinds of cells?
- A.
Thymocytes
- B.
B cells
- C.
Plasma cells
- D.
Double-negative thymocytes
- E.
Double-positive thymocytes
- 4.How do lymphocytes enter and leave the thymus?
- 5.What two parts create the thymus?
- 6.What cells are responsible for the development of the cortex in the thymus?
- A.
Ectodermal cells
- B.
Endodermal cells
- C.
Mesodermal cells
- D.
Exodermal cells
- E.
Psuedodermal cells
- 7.In what syndrome does the thymus fail to develop?
- A.
DiGeroge's syndrome
- B.
Bare lymphocyte syndrome
- C.
Follicular center cell lymphoma
- D.
Hodgkin's Disease
- E.
Lupus
- 8.The process of fat claiming areas of thymocytes after a year birth in the thymus causing it to degenerate is called?
- 9.The involution of the thymus affects T-cell count.
- A.
True
- B.
False
- 10.What complement is a characteristic of a stem cell?
- A.
CD34
- B.
CD7
- C.
CD4
- D.
CD8
- E.
CD24
- 11.When a stem cell expresses ____ and _____ it becomes a T cell.
- A.
CD2 and CD5
- B.
CD4 and CD8
- C.
CD34 and CD2
- D.
CD34 and CD5
- E.
CD12 and CD21
- 12.A double-negative thymocyte does not express...
- A.
CD4 and CD8
- B.
CD34 and CD21
- C.
CD7 and CD11
- D.
CD14 and CD21
- E.
CD4 and CD9
- 13.Thymocytes are considered to be double-negative cells. This is possible because...
- A.
Thymocytes are in the process of rearranging their genes
- B.
Thymocytes are unable to express the required complements to divide
- C.
Thymocytes lack CD4 and CD8
- D.
None of the above
- E.
A and C
- 14.Cytokine ______ is critical in the development of T-cells.
- 15.What cells secrete cytokine 7?
- A.
Stromal cells
- B.
Goblet cells
- C.
B lymphocytes
- D.
T lymphocytes
- E.
Follicular cells
- 16.What complement does IL-7 bind to?
- A.
CD34
- B.
CD21
- C.
CD4
- D.
CD5
- E.
CD8
- 17.The cell receptor on a thymocyte is called...
- 18.Notch 1 interacts with transmembrane ligands on thymic epithelial cells which initiates a proteolytic cleavage. The process that follows the proteolytic cleavage which involves an intracellular domain of Notch 1 affects the thymocyte in what particular way?
- A.
Notch 1 sends signals that controls the pathway of T-cell differentiation and keeps it away from the B-cell
- B.
Notch 1 does not allow the binding of MHC I molecules to the thymocyte
- C.
CD8 is allowed to bind to the thymocyte receptor
- D.
CD4 is not allowed to bind to the thymocyte
- E.
Notch 1 sends signals that allow the thymocyte to differentiate into a B-cell
- 19.A double negative thymocyte precursor creates:
- A.
A:B and y:D T cells
- B.
A:B and y:G T cells
- C.
L:a and Z:y T cells
- D.
All of the above
- E.
None of the above
- 20.Rearrangement of double-negative thymocytes begins with...
- A.
Rearrangement at the y, D, and B loci at the same time
- B.
Rearrangement at the y, D, and B loci at a different time
- C.
Rearrangement at the a, B, and y loci at the same time
- D.
Rearrangement at the D, S, and y loci at the same time
- E.
Rearrangement at the a, B, and D loci at the same time
- 21.Which two loci compete with the B locus on a double-negative thymocyte during rearrangement?
- A.
Y and D
- B.
B and a
- C.
Y and a
- D.
D and a
- E.
S and z
- 22.What percentage of thymocytes survive positive selection?
- 23.Which TCR does not undergo positive and negative selection?
- A.
Y:D TCR
- B.
A:B TCR
- C.
D:a TCR
- D.
Y:B TCR
- E.
L:T TCR
- 24.What is the B-chain of the thymocyte test for when translocated to the ER after double-negative rearrangement?
- A.
The capacity to bind to pTa
- B.
The capacity to bind to y:D chain
- C.
The capacity to bind to self-antigens
- D.
The capacity to bind to CD3
- E.
The capacity to bind to CD34
- 25.PTa is an invariant polypeptide that acts as a _________ __________.
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