Physio 2013: Inflammation And Immunity
- 1.Which of the following complement cascade pathways is usually triggered by IgG and IgM antibody-antigen complexes?
- A.
Lectin
- B.
Classical
- C.
Alternative
- D.
None of the above
- 2.Which cytokine is released by TH1 helper cells and sends signals to activate other helper T cells, cytotoxic T cells, NK cells, and macrophages and is required by cytotoxic T cells to perform their function? (Hint: CDR O said this one was important to remember)
- A.
IL-2
- B.
IL-4
- C.
INF-Beta
- D.
None of the above
- 3.Which clotting factor is considered the intersection of coagulation and immunity?
- A.
Tissue thromboplastin (Factor III)
- B.
Hageman factor (Factor XII)
- C.
Von Willebrand factor
- D.
None of the above
- 4.How does the coagulation cascade help the inflammatory response? (Check all that apply)
- A.
Entraps and localizes the agent using a fibrin meshwork
- B.
Also phagocytoses antigens
- C.
Release chemotaxins through fibrinolysis (the resulting particles) to attract neutrophils and macrophages
- D.
It does not aid in the inflammatory response
- 5.Antibodies are able to go into tissues.
- A.
True
- B.
False
- 6.Which is the most common antibody?
- A.
IgD
- B.
IgE
- C.
IgG
- D.
IgA
- 7.Where do antibodies come from?
- A.
When a mommy antibody and a daddy antibody love each other very much
- B.
Mast cells
- C.
B cells
- D.
T cells
- 8.What are the primary vasoactive chemicals during an inflammatory response released by mast cells? (Check all that apply)
- A.
Histamine
- B.
Prostaglandins
- C.
Lysosomal proteases
- D.
Leukotrienes
- 9.Which of the following are not receptors on a macrophage?
- A.
Fc receptors
- B.
Muscarinic receptors
- C.
Selectins and integrin receptors
- D.
Cytokine receptors
- 10.Which of the following cells are considered part of the innate immune response?
- A.
NK, macrophages, & neutrophils
- B.
B, T, & NK
- C.
Dendritic, B, & T
- D.
Neutrophils & T
- 11.Which is the most common leukocyte?
- A.
Neutrophils
- B.
Lymphocytes
- C.
Eosinophils
- D.
Macrophages
- 12.Where do the majority of cytokines come from?
- A.
Macrophages and T helper cells
- B.
Bob Saget
- C.
Macrophages and mast cells
- D.
Cytotoxic T cells and mast cells
- 13.Which leukocyte is the most important in the beginning of the healing process following an inflammatory response?
- A.
Eosinophils
- B.
Macrophages
- C.
B cells
- D.
NK cells
- 14.Which of the following components characterize the inflammatory response?
- A.
Decreased vascular permeability, recruitment and emigration of leukocytes, and phagocytosis of antigens and debris
- B.
Increased vascular permeability, recruitment and emigration of leukocytes, and phagocytosis of antigens and debris
- C.
Antigen presentation by B cells and macrophages, proliferation and cloning of T cells and T cells, and antibody production
- D.
None of the above
- 15.What are the benefits of vasodilation in the inflammatory response?
- A.
Increased blood flow leads to increased hydrostatic pressure and fluid leakage which dilutes toxic agents
- B.
Vasodilation decreases vascular permeability so that phagocytes can stay within the bloodstream
- C.
Increased blood flow facilitates margination (the process by which the neutrophils move to the sides of the vessel walls, stick, and squeeze through the spaces in order to get to the tissue)
- D.
Increased blood flow allows for better oxygenation of the tissues to promote ATP production
- 16.Class II Major Histocompatibility Complex (MHC) proteins are used for antigen presentation on which leukocytes?
- A.
Dendritic cells, macrophages and B cells
- B.
Eosinophils and neutrophils
- C.
B cells and T cells
- D.
None of the above
- 17.Phagocytic cells cannot display MHC I proteins.
- A.
True
- B.
False
- 18.When do B cells function independently of T cells?
- A.
Never
- B.
In response to nonprotein antigens
- C.
In response to protein antigens
- D.
When there are macrophages present
- 19.Which of the following are ways in which the cytotoxic T cell attacks a cell that presents an antigen on its MHC I peptide complex? (Check all that apply)
- A.
Perforins allow for granzymes to move into the cell to perform cellular lysis
- B.
The T cells engulfs the target cell to fuse it to lysosomes to be broken down by enzymes
- C.
T helper cells recognize the cell first and release cytokines to alert cytotoxic T cell to destroy the antigen
- D.
CD95 (FasL) binds with CD95 on target cell and initiates apoptosis
- 20.Naive B cells encounter an antigen for the first time and proliferate with the aid of T helper cells. Of the new colony of B cells, which type is the majority?
- A.
Memory
- B.
Plasma (effector)
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