Quiz On Bone Pathology

28 Questions | By Sowmya520 | Updated: Mar 22, 2022 | Attempts: 3244

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Many diseases that affect the whole body affect the bones in our bodies. Over the past few days in our classes we have been able to cover some of this topic. Take up the quiz below on bone pathology and see how much you understand about the features and diagnosis for the said diseases.

Questions and Answers

1.

A 56 year old post-menopausal woman complains of bone fractures. A gross image of her bones shows decreased size of the trebculae and loss of apposition. What molecule is increased in her disease?
- A.
  
  RANK
- B.
  
  OPG
- C.
  
  Monocytes
- D.
  
  Antibodies
- E.
  
  IFNg
2.

A blood test is performed on a patient with chronic renal failure and it seem that the levels of phosphate and calcium are lowered. There also appears to be iron and aluminum deposition in the bones. What is a common complication of his condition?
- A.
  
  Osteopetrosis
- B.
  
  Osteoporosis
- C.
  
  Scurvy
- D.
  
  Osteomalacia
- E.
  
  Diabetes Mellitus
3.

A 5 year old child has a GI tract problem that causes malabsorption of a certain substance. The same disease seen is adults is known as osteomalacia. What condition is also associated with the deficiency?
- A.
  
  Osteoporosis
- B.
  
  Osteopetrosis
- C.
  
  Scurvy
- D.
  
  Cushing's syndrome
- E.
  
  Pneumonia of the Lung
4.

A 40 year old white male from Germany complains of pain in certain areas of the body. He is also discovered to be hypertensive. It is said that he has a problem wearing shoes and hats since they don't fit him properly anymore, he has outgrown them. What is the most common etiologic factor of his disease?
- A.
  
  HIV
- B.
  
  Smoking
- C.
  
  It's hereditary
- D.
  
  Polyoma virus
- E.
  
  Paramyxovirus
5.

A 15 year old boy has shortened limbs and ribs, frontal bossing of the forehead, bowing of the limbs, his IQ however is normal. The cells that are affected in his disorder are:
- A.
  
  Osteoclasts
- B.
  
  Chondrocytes
- C.
  
  Osteoblasts
- D.
  
  Macrophages
- E.
  
  Osteocytes
6.

A patient presents with multiple fractures and blue sclera of the eye. The same disease in infants would result in:
- A.
  
  Death
- B.
  
  Tumor of the bone
- C.
  
  Fractures
- D.
  
  Blue sclera
- E.
  
  A C and D
7.

A patient presents with hypermobile joints, easy bruising, hyperextensible skin and kyphoscoliosis. He is also seen with a blue sclera. The diseases that could cause some of the same symptoms listed above are:
- A.
  
  SIADH secretion and Hoshimotos
- B.
  
  Osteogenesis imperfecta and Cushing's syndrome
- C.
  
  Adenoma of the adrenal gland and pheochromocytoma
- D.
  
  Subdural hematoma and Epidural Hematoma
- E.
  
  Conn's syndrome and Cushing's syndrome
8.

A patient presents to be the office with extremely long extremities, long tapering fingers, hyperflexible joints and pigeon chested. The pathogenesis of his disease is_ and the tissue involved is also observed in _ disease:
- A.
  
  Mutation of elastin gene, Ehlers-Danlos Syndrome
- B.
  
  Mutation of fibrillin gene, Osteogenesis Imperfecta
- C.
  
  Mutation of fibrillin gene, Ehlers-Danlos Syndrome
- D.
  
  Mutation of collagen type 1, Osteogenesis Imperfecta
- E.
  
  None of the above.
9.

A patient presents with bleeding in the gums and microfractures. There also appears to be increased parathyroid hormone levels due to a decrease in calcium. The pathogenesis association with this disease is:
- A.
  
  Defective crosslinking of collagen
- B.
  
  Failed hydroxylation
- C.
  
  Gene deletion
- D.
  
  Failure to cleave
- E.
  
  None of the above
10.

Upon performing a radiological examination of a patient's bone, there appears to be increased density and mineralization of the bone due to dysfunction in osteoclasts. The disease is also known as brittle bone disease. The enzyme that is not functioning properly in this disease is:
- A.
  
  Carbonic anhydrase
- B.
  
  Phosphatase
- C.
  
  Creatine kinase
- D.
  
  Phosphorylase
- E.
  
  None of the above
11.

A woman presents with fever, headache and malaise, symptoms of an infection. She received catheterization recently. Bone radiology studies reveals laying down of new bone. The disease she has can also be cause by a viral agent. Which of the following disease has a viral etiology?
- A.
  
  Chondrocytoma
- B.
  
  Progressive multifocal leukoencephalopathy
- C.
  
  Osteogenesis imperfecta
- D.
  
  Subdural hematoma
- E.
  
  None of the above
12.

A patient presents with fever, night sweats, and bloody sputum. There appear to be abscesses with calcification in his spine. The most likely outcome of his disease is:
- A.
  
  Good prognosis
- B.
  
  Malignancy
- C.
  
  Spread to IV disc
- D.
  
  Endocarditis
- E.
  
  Pneumonia
13.

A 70 year old obese male complains of pain in the joints, and morning stiffness that worsens with movement. He presents with bumps on his hand. Upon taking a radiological image of his bones, there appears to bone growth known as osteophytes and subchondral cysts. Which of the following disease is also associated with a decreased amount of substance associated with this patients disease:
- A.
  
  Osteogenesis Imperfecta
- B.
  
  Osteopetrosis
- C.
  
  Osteoporosis
- D.
  
  Rheumatoid arthritis
- E.
  
  Rickets
14.

A patient presents with pain in the joints of the hands and feet, morning stiffness that gets better with movement, subcutaneous nodules on the ulnar aspect of the hand. Which of the following is also has a similar pathogenesis as his disease?
- A.
  
  Myasthenia gravis
- B.
  
  Osteomyelitis
- C.
  
  Osteogenesis Imperfecta
- D.
  
  Osteosarcoma
- E.
  
  Hashimoto's Thyroiditis
15.

A blood sample of a patient is taken and there appears to be high levels of uric acid. A feature/s commonly associated with this patient is:
- A.
  
  Tophi
- B.
  
  Calcium pyrophosphate
- C.
  
  Heberden's node
- D.
  
  Pannus
- E.
  
  A and D
16.

A patient presents with severe joint disease and symptoms that mimic rheumatoid arthritis and osteoarthritis. There appears to be calcium pyrophosphate crystals in his joint. Which of the following gene is affected in the hereditary version of the disease?
- A.
  
  HNPCC
- B.
  
  ANKH
- C.
  
  Gene for collage Type1
- D.
  
  Gene for collagen Type 2
- E.
  
  None of the above
17.

A 70 year old with long standing hypertension and increasing shoe size and cap size comes into your office. Her condition has progressed a tumor. Radiological examination reveals sunburst effect and Codman's triangle. What is the most common location of her tumor?
- A.
  
  Metaphysis
- B.
  
  Diaphysis
- C.
  
  Epiphysis
- D.
  
  Metaphysis and Diaphysis
- E.
  
  Diaphysis and Epiphysis
18.

A 70 year old man presents with a tumor that has metastasized to different parts of the body. The tumor associated is known to sometimes recur and dedifferentiate. It arises from cartilage producing cells. What is/are a common site of this tumor?
- A.
  
  Pelvis and proximal femur
- B.
  
  Distal femur
- C.
  
  Pelvis and humerus
- D.
  
  Epiphysis
- E.
  
  A and C
19.

A 25 year old man presents with benign tumor of the bone. The tumor is associated with macrophages and upon radiological examination of the bone, there appears to be a soap bubble like lesion. What is main location of the tumor?
- A.
  
  Metaphysis
- B.
  
  Diaphysis
- C.
  
  Epiphysis
- D.
  
  Humerus
- E.
  
  Pelvis
20.

The most common tumor of the bone occurs via _
21.

A patient presents to your office with pathological fractures. It is determined that the patient has a tumor with hyaline cartilage. There also appears to be vascular tumors. What is a common feature of this disease?
- A.
  
  Possible osteosarcoma
- B.
  
  Possible Ewing's disease
- C.
  
  Possible Breast Cancer
- D.
  
  Possible Osteomyelitis
- E.
  
  Possible pneumonia
22.

A 16 year old boy presents with a tumor of the long bones. Upon histological examination, there appears to be small blue cells. What is the prime location of the tumor?
- A.
  
  Epiphysis
- B.
  
  Metaphysis
- C.
  
  Diaphysis
- D.
  
  Epiphysis and diaphysis
- E.
  
  None of the above.
23.

_ also has a similar location.
24.

A patient presents with a benign tumor of the mature bone in the face. There appears to be bone islands. What is associated with this tumor?
- A.
  
  Maffuci' syndrome
- B.
  
  Gardner's syndrome
- C.
  
  Ollier's disease
- D.
  
  Rheumatoid arthritis
- E.
  
  None of the above are associated
25.

A young male of the age 24 presents with a benign tumor of the appendicular skeleton. Which of the following tumors has a similar prognosis?
- A.
  
  Chondrosarcoma
- B.
  
  Osteosarcoma
- C.
  
  Osteoma
- D.
  
  Ewing's sarcoma
- E.
  
  None of the above