Trivia Quiz On Immunology And Behavioral Science

20 Questions

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Trivia Quiz On Immunology And Behavioral Science

Jan 2012


Questions and Answers
  • 1. 
    Microbiology Dr Ber 1) Associate these characteristics with the appropriate MHC: (I) MHC class I (II) MHC class II  (a) Generally only expressed by some leukocytes (b) Generally expressed by all nucleated cells (c) Signal for CD8 T lymphocytes (d) Signal for CD4 T lymphocytes (e) Binds peptides 8 to 12 amino acids long (f) Binds peptides 13 to 21 amino acids long (g) Antigenic peptides are derived from the phagolysosome (h) Requires a functional ubiquitin/proteasome
    • A. 

      I-b, I-c, I-e, I-h, II-a, II-d, II-f, II-g

    • B. 

      I-b, I-d, I-e, I-g, II-a, II-c, II-f, II-h

    • C. 

      I-a, I-c, I-f, I-h, II-b, II-d, II-e, II-g

    • D. 

      I-a, I-d, I-e, I-h, II-b, II-c, II-f, II-g

    • E. 

      I-b, I-c, I-f, I-g, II-a, II-d, II-e, II-h

  • 2. 
    (Micro Dr D)   In May 2011, an outbreak of foodborne illness, complicated in many cases by hemolytic uremic syndrome, was seen in Germany. In thousands of patients, the causative agent was identified as a Shiga-toxin producing, Gram-negative, oxidase-negative rod that fermented lactose. A novel finding was that the isolates had the serotype O104:H4:K9, indicating that there was a common source for the infection and that it was a pathogen that had not previously been seen. What bacterial structures/components were useful in determining the serotype of this organism?
    • A. 

      Flagella, lipid A, pili

    • B. 

      Histones, peptidoglycan, teichoic acid

    • C. 

      LPS, flagella, capsule

    • D. 

      OMPs, haptens, kinetoplasts

    • E. 

      Pili, transpeptidases, hemolysins

  • 3. 
    A researcher is testing the importance of various virulence factors in a bacterial pathogen using site-directed mutagenesis. He converts a codon near the 5’ end of a gene to a stop codon, and notes that the resulting mutants are less able to adhere to mammalian cells in culture. What is the most likely product of the gene he mutated?
    • A. 

      16S ribosomal RNA

    • B. 

      Transpeptidase

    • C. 

      Flagellin

    • D. 

      Pilin

    • E. 

      Type III secretion system component

  • 4. 
    • A. 

      Complement activation via the classical pathway

    • B. 

      Memory response to the common cold

    • C. 

      Antigen clearance by cilia in the respiratory tract

    • D. 

      Antibody production by plasma cells

    • E. 

      The effector function of cytotoxic T lymphocytes

  • 5. 
    Which of the following actions is most characteristic of cytokines produced by Th1 cells?
    • A. 

      Inhibition of inflammatory signals

    • B. 

      Stimulation of the proliferation of Th2 cells

    • C. 

      Promotion of allergic reactions

    • D. 

      Activation of macrophage function

    • E. 

      Inhibition of natural killer cell function

  • 6. 
    Micro Dr Sch   After plating 0.1 ml of a 10-5 dilution of bacteria, you get 60 colonies. In order to calculate the cfu/ml you’ll have to multiply the count of a plate with the dilution and the plating factor. The cfu/ml results in 6.0 x 105. Which of the following sections of the picture pertains to the plating factor?
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 7. 
    The important virulence factor of H. pylori, CagA, is encoded the on a pathogenicity island. Which of the following facilitates the transfer of the CagA protein into the host epithelial cells?
    • A. 

      Type I secretion system

    • B. 

      Type II secretion system

    • C. 

      Type III secretion system

    • D. 

      Type IV secretion system

    • E. 

      Type V secretion system

  • 8. 
    Immunno Dr S   If a patient had a defect in expression of the IL-2 receptor, what step in the T cell life cycle would be affected?
    • A. 

      Rearrangement of the T cell receptor (TCR) B chain

    • B. 

      Rearrangement of the TCR a chain

    • C. 

      Proliferation of an activated a mature, naïve T cell

    • D. 

      Transduction of signals coming from the TCR on a mature, naïve T cell

    • E. 

      Differentiation into an effector T cell

  • 9. 
    • A. 

      Type III Hypersensitivity

    • B. 

      Type I Hypersensitivity

    • C. 

      Type II Hypersensitivity

    • D. 

      Type IV Hypersensitivity

    • E. 

      Direct activation of mast cells by the anesthetic gas

  • 10. 
    Your area technologist in the Micro lab.  You are looking at a culture of pus collected from an abscess (see image below).  You perform a Gram stain on the isolate (see image).  What is the next step that you should do in order to determine the identity of the organism?
    • A. 

      Subculture the isolate to MacConky agar

    • B. 

      Perform a catalase test

    • C. 

      Subculture the isolate to Mannitol Salt agar

    • D. 

      Perform an oxidase test

    • E. 

      Perform a coagulase test

  • 11. 
    Pharmacology (Dr B)   The pharmacokinetics of a new drug was studied in a healthy subject. The drug followed first-order elimination kinetics and had a volume of distribution of 50 liters. A dose of 5 mg was given IV. Ten hours later the plasma concentration of the drug was 25 mcg/L. Which of the following was most likely the half-life of the drug (in hours)?  
    • A. 

      1

    • B. 

      2

    • C. 

      3

    • D. 

      4

    • E. 

      5

  • 12. 
    A 56-year-old man, admitted to the coronary unit with a myocardial infarction, developed an episode of ventricular tachycardia and the cardiologist ordered a therapy with lidocaine. The drug has a volume of distribution of about 77 L and a half life of about 2 hours. An IV infusion of lidocaine was started and two hours later a blood sample indicated a drug plasma concentration of 2 mg/L. The IV infusion was then continued for other 8 hours. Which of the following was most likely the steady state plasma concentration of the drug (in mg/L)?
    • A. 

      1

    • B. 

      4

    • C. 

      6

    • D. 

      8

    • E. 

      12

  • 13. 
    Five new antihypertensive drugs have been tested on hypertensive patients. Each drug has a unique overdose toxicity. The results are reported here:   Drug   Median effective dose   TD1 / ED99   A   3 mg   2.9   B   10 mg   3.4   C   24 mg   2.2   D   35 mg   4.5   E   50 mg   3.1   TD1  = toxic dose in 1% of patients ED99 = effective dose in 99% of patients Which of the following drugs has the highest risk of overdose toxicity?  
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 14. 
    • A. 

      Drug A and B

    • B. 

      Drug B and C

    • C. 

      Drug D and E

    • D. 

      Drug A and D

    • E. 

      Drug A and C

  • 15. 
    The therapeutic Index of a drug may be quite variable from drug to drug. Which of the following best indicates the range of variability of that index in humans? (Assume the index is defined as the estimated lethal dose over the standard therapeutic dose)
    • A. 

      3-100

    • B. 

      1.5- >10000

    • C. 

      10- >10000

    • D. 

      1.5-30

    • E. 

      0.5-100

  • 16. 
    Pathology Dr C  A pathologist receives a surgical specimen taken from a 12-year-old boy.  The submitted history is not helpful. The specimen is processed for histopathology and the pathologist submits the following report.  “The specimen was one cm in diameter and nodular.  The cut surface revealed a central region of white creamy material surrounded by a rim of firm tissue. Microscopically, the central region consisted of neutrophils, some of which were apoptotic.  The neutrophils were surrounded by a capsule of proliferating granulation tissue.” What is your diagnosis?
    • A. 

      Benign neoplasm

    • B. 

      Abscess

    • C. 

      Cellulitis

    • D. 

      Granuloma

    • E. 

      Infarct

  • 17. 
    A 62-year-old medical missionary has recently returned to the US from a tour in an emerging nation.  She presents to her family physician with a complaint of a productive cough and some dyspnea.  She says that this has been going on for some time, but she wanted to wait for medical care in the states.  She has a history of smoking one pack of cigarettes per day and has 1-2 beers per day.  Physical exam reveals some lung consolidation on auscultation and a low grade fever.  A chest x-ray reveals multifocal 1-3 cm nodules, a few being cavitated.  The lesions are cultured and the results are pending. Lung biopsies are taken and image 1 is representative of the biopsy results.   Which of the following is the best diagnosis?
    • A. 

      Acute purulent pneumonitis

    • B. 

      Bronchogenic carcinoma

    • C. 

      Parasitic migration tracts

    • D. 

      Pulmonary abscesses

    • E. 

      Granulomatous pneumonitis

  • 18. 
    A 70-year-old man has been smoking cigarettes since he was 19-years-old.  While he has had a relatively persistent cough for a number of years, recently it has gotten worse.  He has a complete workup including a lung biopsy and he is diagnosed with squamous metaplasia of his bronchial mucosa.  Which of the following best describes the mechanism by which the metaplastic lesions occur?
    • A. 

      Re-programming of stem cells from adjacent normal tissues

    • B. 

      Decreases in protein synthesis and activation of ubiquitin pathways

    • C. 

      Remodeling of the bronchi

    • D. 

      Sequential mutations in proliferating cellular populations

    • E. 

      Stimulation of resting G0 cells to enter the cell cycle to become G1 cells

  • 19. 
    You are asked to review some biopsies of kidneys that are to be used for transplantation.  The major concern is that the tissue is viable.  Which of the following findings would indicate that the tissue was still viable?
    • A. 

      Cells without nuclei

    • B. 

      Karyolysis

    • C. 

      Karyorrhexis

    • D. 

      Steatosis

    • E. 

      Pyknosis

  • 20. 
    Behavioral Science (Dr A)   Dr. Welby learned during the interview from his patient, Ms. Only, that her father had recently passed away. His immediate urge was to say, “I so sorry”, yet he chose to respond by asking her, “How are you managing your loss?” Dr. Welby’s response is an example of which of the following communication micro-skills?
    • A. 

      Empathy

    • B. 

      Respect and warmth

    • C. 

      Non-judgmental attitude

    • D. 

      Immediacy

    • E. 

      Authenticity or congruence