Histones - High Yield Topic Series - Quiz, Trivia & Questions

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| By Kar

Kar, Assistant Professor (Biochemistry)

Karthikeyan Pethusamy is an assistant professor in the Department of Biochemistry at the All India Institute of Medical Sciences in New Delhi

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1/5 Questions

Histone acetylation leads to
- Euchromatin
- Heterochromatin
- Both of the above
- None of the above

About This Quiz

Explore the role of histones in gene regulation with our 'Histones - High Yield Topic Series'. This quiz covers anti-histone antibodies in drug-induced lupus, histone acetylation, and unique mRNA structures in histones. Ideal for students and professionals enhancing their understanding of DNA and genetics.

Histones - High Yield Topic Series - Quiz

2.

Poly A tail is usually present in 3' end of all pre-mRNA. But it is not present in the pre-mRNA of histone.
- True
- False
Correct Answer

A. True

Explanation

The poly A tail is a sequence of adenine nucleotides that is usually added to the 3' end of pre-mRNA molecules during RNA processing. However, in the case of histone pre-mRNA, this poly A tail is not present. This is because histone genes have a different mechanism of mRNA processing that involves cleavage and polyadenylation at a specific site within the coding region, rather than at the 3' end. Therefore, the statement that the poly A tail is not present in the pre-mRNA of histone is true.

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3.

Select the wrong statement ?
- Histone methylation is in general associated with transcriptional repression
- Histone acetylation tends to destabilize chromatin structure
- Histone is rich in basic amino acids.
- H1 is a component of Histone octamer.
Correct Answer

A. H1 is a component of Histone octamer.

Explanation

H1 histone is a linker.

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4.

Anti histone antibodies are seen in
- Drug induced lupus
- SLE
- Primary biliary Cirrhosis
- Dermatomyositis
Correct Answer

A. Drug induced lupus

Explanation

Anti-histone antibodies are antibodies that target histones, which are proteins involved in packaging DNA in the nucleus of cells. These antibodies are commonly seen in drug-induced lupus, a condition where certain medications can cause lupus-like symptoms in individuals who are susceptible. Drug-induced lupus is different from systemic lupus erythematosus (SLE), which is an autoimmune disease where the body's immune system mistakenly attacks healthy tissues and organs. While anti-histone antibodies can also be found in SLE, their presence is more strongly associated with drug-induced lupus. Therefore, the correct answer is drug-induced lupus.

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5.

Instead of poly A tail, which structure is present in the 3' end of the pre-mRNA of histone ?
- Stem loop
- Zinc finger
- Leucine zipper
- None of the above
Correct Answer

A. Stem loop

Explanation

In the 3' end of the pre-mRNA of histone, a structure called a stem loop is present instead of a poly A tail. A stem loop is a secondary structure formed when a sequence of nucleotides in the mRNA folds back on itself, creating a stem and a loop. This structure is important for the stability and regulation of the mRNA molecule.

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Quiz Edited by
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May 07, 2012

Quiz Created by
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Histones - High Yield Topic Series

Histone acetylation leads to

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Poly A tail is usually present in 3' end of all pre-mRNA. But it is not present in the pre-mRNA of histone.

Select the wrong statement ?

Anti histone antibodies are seen in

Instead of poly A tail, which structure is present in the 3' end of the pre-mRNA of histone ?