Histones - High Yield Topic Series

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| By Kar
Kar, Assistant Professor (Biochemistry)
Karthikeyan Pethusamy is an assistant professor in the Department of Biochemistry at the All India Institute of Medical Sciences in New Delhi
Quizzes Created: 33 | Total Attempts: 50,084
| Attempts: 114
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  • 1/5 Questions

    Histone acetylation leads to 

    • Euchromatin
    • Heterochromatin
    • Both of the above
    • None of the above
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About This Quiz

Explore the role of histones in gene regulation with our 'Histones - High Yield Topic Series'. This quiz covers anti-histone antibodies in drug-induced lupus, histone acetylation, and unique mRNA structures in histones. Ideal for students and professionals enhancing their understanding of DNA and genetics.

Histones - High Yield Topic Series - Quiz

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  • 2. 

    Poly A tail is usually present in 3' end of all pre-mRNA. But it is not present in the pre-mRNA of histone.

    • True

    • False

    Correct Answer
    A. True
    Explanation
    The poly A tail is a sequence of adenine nucleotides that is usually added to the 3' end of pre-mRNA molecules during RNA processing. However, in the case of histone pre-mRNA, this poly A tail is not present. This is because histone genes have a different mechanism of mRNA processing that involves cleavage and polyadenylation at a specific site within the coding region, rather than at the 3' end. Therefore, the statement that the poly A tail is not present in the pre-mRNA of histone is true.

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  • 3. 

    Select the wrong statement ?

    • Histone methylation is in general associated with transcriptional repression

    • Histone acetylation tends to destabilize chromatin structure

    • Histone is rich in basic amino acids.

    • H1 is a component of Histone octamer.

    Correct Answer
    A. H1 is a component of Histone octamer.
    Explanation
    H1 histone is a linker.

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  • 4. 

    Anti histone antibodies are seen in

    • Drug induced lupus

    • SLE

    • Primary biliary Cirrhosis

    • Dermatomyositis

    Correct Answer
    A. Drug induced lupus
    Explanation
    Anti-histone antibodies are antibodies that target histones, which are proteins involved in packaging DNA in the nucleus of cells. These antibodies are commonly seen in drug-induced lupus, a condition where certain medications can cause lupus-like symptoms in individuals who are susceptible. Drug-induced lupus is different from systemic lupus erythematosus (SLE), which is an autoimmune disease where the body's immune system mistakenly attacks healthy tissues and organs. While anti-histone antibodies can also be found in SLE, their presence is more strongly associated with drug-induced lupus. Therefore, the correct answer is drug-induced lupus.

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  • 5. 

    Instead of poly A tail, which structure is present in the 3' end of the pre-mRNA of histone ?

    • Stem loop

    • Zinc finger

    • Leucine zipper

    • None of the above

    Correct Answer
    A. Stem loop
    Explanation
    In the 3' end of the pre-mRNA of histone, a structure called a stem loop is present instead of a poly A tail. A stem loop is a secondary structure formed when a sequence of nucleotides in the mRNA folds back on itself, creating a stem and a loop. This structure is important for the stability and regulation of the mRNA molecule.

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