Quiz For Lecture 2 - Components Of The Innate Immune System

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  • 1/20 Questions

    The Eosinophil is a granulocyte whose main function is to combat parasitic infection, especially by helminth worms.

    • True
    • False
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About This Quiz

Quiz to consolidate learning from Lecture 2 - Components of the Innate Immune Sytem As ever dont worry if you get the wrong answer, simply revisit the Lecture and see if you can improve youre knowledge Take the quiz as many times as you like Good luck

Innate Immunity Quizzes & Trivia

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  • 2. 

    System of over 20 blood proteins that form an enzymatic cascade to attack extracellular forms of infectious agents.

    • The Explosive system

    • The Myeloid lineage

    • The Complement system

    • The Lymphoid lineage

    Correct Answer
    A. The Complement system
    Explanation
    The Complement system is a system of over 20 blood proteins that work together in a cascade to attack extracellular forms of infectious agents. This system plays a crucial role in the immune response by enhancing the ability of antibodies and phagocytic cells to clear pathogens. It can also directly lyse certain pathogens, recruit inflammatory cells to the site of infection, and help in the removal of immune complexes. Overall, the Complement system is an important component of the innate immune system and helps in the defense against infections.

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  • 3. 

    The Complement system of proteins is an effector mechanism of the innate immune system.

    • True

    • False

    Correct Answer
    A. True
    Explanation
    The complement system of proteins is indeed an effector mechanism of the innate immune system. This system consists of a group of proteins that work together to enhance the immune response against pathogens. It plays a crucial role in inflammation, opsonization (marking pathogens for destruction), and lysis of foreign cells. Therefore, the statement "The Complement system of proteins is an effector mechanism of the innate immune system" is true.

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  • 4. 

    The Granulocyte Neutrophil forms the major constituent of pus.

    • True

    • False

    Correct Answer
    A. True
    Explanation
    The Granulocyte Neutrophil is a type of white blood cell that plays a key role in the immune response to bacterial infections. When there is an infection, neutrophils are recruited to the site and release enzymes and chemicals to destroy the invading bacteria. This process leads to the formation of pus, which is made up of dead neutrophils, bacteria, and tissue debris. Therefore, it is true that the Granulocyte Neutrophil forms the major constituent of pus.

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  • 5. 

    The myeloid lineage forms the major effector for the innate immune system.

    • True

    • False

    Correct Answer
    A. True
    Explanation
    The myeloid lineage includes the granulocytes and agranulocytes, and the Natural Killer Cell which is the only cell of the Lymphoid lineage to play a direct role in the innate immune response.

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  • 6. 

    The Eosinophil is the tissue based form of the Basophil.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    The tissue based form of the Basophil is the Mast Cell.

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  • 7. 

    A Basophil is a type of agranulocyte.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    A basophil is a type of granulocyte – it has granules within its cytoplasm.
    The other granulocytes include the eosinophil, neutrophil and Natural Killer Cell.

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  • 8. 

    The Natural Killer Cell (NKC) is the only cell of the lymphoid lineage that plays a prominent role in the adaptive immune system.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    The Natural Killer Cell (NKC) is the only cell of the lymphoid lineage that plays a prominent role in the innate immune system.
    The other cells in the lymphoid lineage, so the B & T cells are the effectors of the adaptive immune system.

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  • 9. 

    A Monocyte is a type of granulocyte.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    Remember a monocyte is an agranulocyte as it contains few or no granules.
    The other agranulocytes are the macrophage and the dendritic cell.

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  • 10. 

    A tissue based, agranulocyte that is a potent phagocyte; called a Kupffer cell when found in the liver.

    • Basophil

    • Dendritic Cell

    • Neutrophil

    • Macrophage

    Correct Answer
    A. Macrophage
    Explanation
    Macrophages are found in tissues and phagocytose dead/malfunctioning cells and foreign material.
    Also named according to the organ that they are in; microglial cells in the brain, osteoclasts within bone, and kupffer cells when found in the liver.

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  • 11. 

    Activation pathway of the complement cascade that is initiated by recognition of non-self components on the surface of a pathogen.

    • Alternative Pathway

    • Classical

    • Lectin-Mannose Pathway

    Correct Answer
    A. Alternative Pathway
    Explanation
    The alternative pathway is the correct answer because it is one of the three activation pathways of the complement cascade. It is initiated by the recognition of non-self components on the surface of a pathogen, leading to the activation of complement proteins and the subsequent immune response. The alternative pathway is unique because it can be activated independently of antibodies, unlike the classical pathway.

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  • 12. 

    Cell type which belongs to both the adaptive and innate immune system, main function is as an antigen presenting cell.

    • T-lymphocyte

    • Plasma cell

    • Dendritic cell

    • Natural Killer cell

    Correct Answer
    A. Dendritic cell
    Explanation
    Dendritic cells function as an antigen presenting cell, phagocytosing infectious agents and traveling to secondary lymphoid organs; and present the antigens of their phagocytosed infectious agents to cells of the adaptive immune system; B & T cells.

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  • 13. 

    Activation pathway of the complement cascade that is initiated by either the binding of antibody or an innate immune system protein called C-reactive protein to the pathogens surface.

    • Alternative Pathway

    • Classical

    • Lectin-Mannose Pathway

    Correct Answer
    A. Classical
    Explanation
    The classical pathway is the activation pathway of the complement cascade that is initiated by the binding of antibody to the pathogen's surface. This pathway is specific to adaptive immunity and requires the presence of antibodies. When antibodies bind to the pathogen, they activate complement proteins, leading to a series of reactions that ultimately result in the destruction of the pathogen.

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  • 14. 

    Process by which the Dendritic cell takes up extracellular fluid by endocytosis.

    • Phagocytosis

    • Macropinocytosis

    Correct Answer
    A. Macropinocytosis
    Explanation
    Macropinocytosis is the process by which the dendritic cell takes up extracellular fluid by endocytosis. This process involves the formation of large, membrane-bound vesicles called macropinosomes, which engulf the fluid and its contents. Macropinocytosis is a non-selective process that allows the cell to sample its environment and capture antigens for presentation to the immune system. Unlike phagocytosis, which involves the ingestion of large particles, macropinocytosis is characterized by the uptake of fluid and small solutes.

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  • 15. 

    The basophil is a potent phagocyte; engulfing target cells and destroying them with intracellular vesicles which use degradative enzymes and other antimicrobial substances stored in their granules.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    The Basophil plays a prominent role in mediating the inflammatory response.
    It has cytoplasmic granules which contain inflammatory mediators such as histamine and vasodilators such as prostaglandins.

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  • 16. 

    Resultant protein from the splitting of complement protein C3 that acts as a chemoattractant; recruiting other cells of the immune system to the site of infection; notably macrophages and neutrophils.

    • C3a

    • C3b

    • C5a

    • C5b

    Correct Answer
    A. C3a
    Explanation
    C3a is the correct answer because it is the resultant protein from the splitting of complement protein C3. It acts as a chemoattractant, which means it attracts other cells of the immune system to the site of infection. This includes macrophages and neutrophils, which are important for fighting off infections. C3a plays a crucial role in the immune response and helps to recruit the necessary immune cells to the site of infection.

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  • 17. 

    Cell type whose cytoplasm contains large Birbeck granules, and are similar in function to the Dendritic cell.

    • Basophils

    • Neutrophils

    • Monocyte

    • Langerhans cells

    Correct Answer
    A. Langerhans cells
    Explanation
    Langerhans cells are a type of cell whose cytoplasm contains large Birbeck granules and they are similar in function to dendritic cells. Basophils, neutrophils, and monocytes do not have these characteristics and functions.

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  • 18. 

    The cytokine IL-10, produced by the Cytotoxic (CD8+) T-cell increases the killing ability of the NKC.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    IL-10 actually switches off NKC activity .
    The cytokine IL-2, produced by the T-helper 1 cell, increases the killing ability of the NKC.

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  • 19. 

    Cytokine produced by the mighty Macrophage that activates Natural Killer Cells.

    • IL-8

    • IL-12

    • IFN-γ

    Correct Answer
    A. IL-12
    Explanation
    IL-8 Also produced by the macrophage, this cytokine acts as a chemotracttant, drawing in Neutrophils to the site of infection.
    IFN-γ This cytokine is produced by NKC’s and T cells, serving to further activate the mighty macrophage.

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  • 20. 

    Precurser (undifferentiated form) of a Macrophage.

    • T-lymphocyte

    • Monocyte

    • Neutrophil

    • Mast cell

    Correct Answer
    A. Mast cell
    Explanation
    A monocyte circulates in blood, however on leaving blood it is called a macrophage.

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  • Current Version
  • Mar 20, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • Dec 01, 2011
    Quiz Created by
    SwanseaGEMStuden
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