Basic Immunology And Serology

60 Questions | Total Attempts: 3590

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Immunology Quizzes & Trivia

Clinical Laboratory Technician, Basic Immunology and Serology Exam. Instructional Materials: Clinical Immunology and Serology, A laboratory Perspective, 3rd Ed. 2009 Christine Dorresteyn Steven, McGraw-Hill Course ID: CL 1110 National American University


Questions and Answers
  • 1. 
    1. Acute phase reactants have been determined to be elevated in a patient. What does this result on its own indicate about the patient?
    • A. 

      Inflammation of unknown cause is present.

    • B. 

      Patient has a leukemia but not a lymphoma.

    • C. 

      This is a normal result.

    • D. 

      There is a parasitic infection and not a viral infection.

  • 2. 
    1. Which is characteristic of natural immunity?
    • A. 

      Memory is involved.

    • B. 

      Lymphocytes play a major role.

    • C. 

      It is very specific.

    • D. 

      It depends on normally present body functions.

  • 3. 
    What is the major function of C-reactive protein (CRP)?
    • A. 

      Acts as an opsonin

    • B. 

      Binds hemoglobin

    • C. 

      Causes vasodilation

    • D. 

      Helps to form clots

  • 4. 
    Which of the following acute phase reactants is an important clotting factor?
    • A. 

      Haptoglobin

    • B. 

      Ceruloplasmin

    • C. 

      Fibrinogen

    • D. 

      Alpha-2 macroglobulin

  • 5. 
    In 1796, Edward Jenner's discovery that cowpox generated immunity against smallpox is based on the princple of?
    • A. 

      Attenuation of a harmful substance

    • B. 

      Natural immunity

    • C. 

      Passive immunity

    • D. 

      Cross-immunity

  • 6. 
    All of the following are characteristics of acute phase reactants EXCEPT:
    • A. 

      Increase rapidly in response to infection

    • B. 

      Used to diagnose a specific disease

    • C. 

      Enhanced phagocytosis

    • D. 

      Promote inflammation

  • 7. 
    What is the function of the acute phase protein haptoglobin?
    • A. 

      Acts as an opsonin

    • B. 

      Forms clots

    • C. 

      Binds hemoglobin

    • D. 

      Acts as a chemotaxin

  • 8. 
    Measurement of CRP levels could be useful for which of the following?
    • A. 

      To determine risk of a heart attack

    • B. 

      To determine flare up of rheumatoid arthritis

    • C. 

      To detect an inflammatory process

    • D. 

      All of the above

  • 9. 
    Acquired immunity can be characterized by which of the following?
    • A. 

      Nonspecific

    • B. 

      Immediate response

    • C. 

      Depends on neutrophils and macrophages

    • D. 

      Involves memory

  • 10. 
    Which of the following best explains the reaction that takes place in the latex agglutination slide test for CRP?
    • A. 

      Latex particles are coated with anti-CRP

    • B. 

      Latex particles are coated with CRP

    • C. 

      Latex particles are nonspecifically bound

    • D. 

      CRP is acting as an antibody

  • 11. 
    The ability to resist infection through normally present body functions best characterizes:
    • A. 

      Autoimmunity

    • B. 

      Natural immunity

    • C. 

      Acquired immunity

    • D. 

      Alloimmunity

  • 12. 
    Antigen-independent differentiation of B cells occurs in the:
    • A. 

      Bone marrow

    • B. 

      Spleen

    • C. 

      Lymph node

    • D. 

      Peyer's patches

  • 13. 
    When IgM on the surface of an immature B cell binds to a self-antigen, which of the following processes can occur?
    • A. 

      Class switch

    • B. 

      Affinity maturation

    • C. 

      Apoptosis

    • D. 

      Differentiation

  • 14. 
    The receptor for antigen on a mature B cell and first immunoglobulin to appear in immune response is:
    • A. 

      MHC class I

    • B. 

      IgG

    • C. 

      IgM

    • D. 

      MHC class II

  • 15. 
    T lymphocytes undergo antigen-independent maturation in the:
    • A. 

      Thymus

    • B. 

      Bone marrow

    • C. 

      Lymph node

    • D. 

      Spleen

  • 16. 
    An immature T cell differs from a mature T cell because an immature T cell:
    • A. 

      Expresses beta chains and pre Ta

    • B. 

      Does not express T-cell receptor or CD3

    • C. 

      Co-expresses CD4 and CD8

    • D. 

      Is normally found in lymph nodes

  • 17. 
    In antiboy-dependent cell-mediated cytotoxicity, target cells are recognized by which of the following?
    • A. 

      T-cell receptor on the effector cell binding to Fab of IgG bound to the target cell

    • B. 

      C-type lectin inhibitory receptors on effector cell binding to class I on target cell

    • C. 

      CD16 on the effector cell binding to Fc of IgG to the target cell

    • D. 

      CD154 on the effector cell binding to CD40 on the target cell

  • 18. 
    Which of the following best descibes HLA class II molecules?
    • A. 

      They interact with CD8 and T cells

    • B. 

      They have an alpha chain and beta-2 microglobulin

    • C. 

      They have alpha and beta chains of equal size

    • D. 

      They combine with antigen made inside the cell

  • 19. 
    Which of the following is true of HLA (MHC) class I antigens?
    • A. 

      They are recognized by helper T cells.

    • B. 

      They are found on all nucleated cells

    • C. 

      They combine with exogenous antigen

    • D. 

      They are coded for on chromosome 9

  • 20. 
    Heterophile antigens are characterized as:
    • A. 

      Found in unrelated plants or animals but cross-react with the same antibody

    • B. 

      One's own self-antigens

    • C. 

      Any antigen used for immunization

    • D. 

      All of the above

  • 21. 
    HLA (MHC) class I protein is found on:
    • A. 

      RBCs

    • B. 

      All nucleated cells

    • C. 

      B cells and macrophages

    • D. 

      Stem cells only

  • 22. 
    Which MHC class of antigens is necessary for antigen recognition by CD4-positive T-cells?
    • A. 

      Class I

    • B. 

      Class II

    • C. 

      Class III

    • D. 

      No MHC molecule is necessary for antigen recognition

  • 23. 
    All of the following are characteristics of both MHC class I and class II molecules EXCEPT:
    • A. 

      Expressed codominantly

    • B. 

      Involved in antigen recognition

    • C. 

      Members of the immunoglobulin superfamily

    • D. 

      Expressed constitutively on all nucleated cells

  • 24. 
    Which complement component is found in both the classic and alternative pathways?
    • A. 

      C1

    • B. 

      C2

    • C. 

      Factor B

    • D. 

      C3

  • 25. 
    Which of the following can activate the alternative complement pathways?
    • A. 

      IgG

    • B. 

      Mannose-Binding Lectin

    • C. 

      C3b

    • D. 

      C1q

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