Review In Clinical Immunology & Serology
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This examination covers the basics of Immunology and Serology that a Medical Technology student must know. This 70-item exam has a time limit of 60 minutes only. Please enter your name in the required field.
- 1.Which of the following is not true?
- A.
A hapten when combined with a carrier can elicit the formation of antibodies.
- B.
Complete Freund's Adjuvant can stimulate cellular immunity.
- C.
IgG is the best complement fixing immunoglobulin.
- D.
Anaphylaxis is an immediate hypersensitivity reaction that causes bronchoconstriction.
- 2.Which of the following domains is considered to be the foot of IgE?
- A.
CH1
- B.
CH2
- C.
CH3
- D.
CH4
- 3.What type of immunity develops during convalescence from an infection?
- A.
Natural active immunity
- B.
Natural passive immunity
- C.
Artificial active immunity
- D.
Artificial passive immunity
- 4.The coating of particulate antigen by antibody and/or complement components that allows them to be more phagocytized readily is called:
- A.
Immune adherence
- B.
Complement fixation
- C.
Opsonization
- D.
Immune complex formation
- 5.Which of the following is correct?
- A.
The method of complement assay that involves the measurement of precipiting ring diameter after 48 hours is Fahey McKelvey.
- B.
Type I hypersensitivity is known as the "cytotoxic type".
- C.
CD19, CD20, and CD21 are subtypes of B cells.
- D.
The C5 convertase in the Classical Pathway of complement activation is C4b2b3b.
- 6.Which of the following plays an important role as an external defense mechanism?
- A.
Phagocytosis
- B.
CRP
- C.
Lysozyme
- D.
Complement
- 7.MHC molecules are associated with which of the following?
- A.
Graft rejection
- B.
Autoimmune diseases
- C.
Determining to which agents an individual responds
- D.
All of the above
- 8.All of the following are characteristic of a good immunogen except
- A.
Internal complexity
- B.
Large molecular weight
- C.
The presence of numerous epitopes
- D.
Found on host cells
- 9.Which of the following is characteristic of the endpoint method of RID?
- A.
Readings are taken before equivalence is reached.
- B.
Concentration is directly proportional to the square of the diameter.
- C.
The diameter is plotted against the log of the concentration.
- D.
It is primarily a qualitative rather than a quantitative method.
- 10.Agglutination of dyed bacterial cells represents which type of reaction?
- A.
Direct agglutination
- B.
Passive agglutination
- C.
Reverse passive agglutination
- D.
Agglutination inhibition
- 11.A positive direct Coomb's test would occur under which circumstances?
- A.
Hemolytic disease of the newborn
- B.
Autoimmune hemolytic anemia
- C.
Antibodies to drugs that bind to red cells
- D.
Any of the above
- 12.How much diluent needs to be added to 0.2mL of serum to make a 1:20 dilution?
- A.
19.8 mL
- B.
4.0 mL
- C.
3.8 mL
- D.
10.0 mL
- 13.All of the following are true of IgM except that it
- A.
Can cross the placenta
- B.
Fixes complement
- C.
Has a J chain
- D.
Is a primary response antibody
- 14.If cells of an individual are not agglutinated by serum from anyone else, this represents which Lansteiner blood type?
- A.
Type A
- B.
Type B
- C.
Type O
- D.
Type AB
- 15.Metchnikoff first described which of the following?
- A.
Phagocytosis
- B.
Variolation
- C.
Humoral immunity
- D.
Opsonization
- 16.The inflammatory process is characterized by all of the following except
- A.
Increased blood supply to the area
- B.
Migration of white blood cells
- C.
Decreased capillary permeability
- D.
Appearance of acute phase reactants
- 17.In an agglutination reaction, if cells are not centrifuged long enough, which of the following might occur?
- A.
False-negative result
- B.
False-positive result
- C.
No effect
- D.
Slight but can be ignored
- 18.The density gradient solution used for the separation of lymphocytes
- A.
Roswell Park Memorial Institute
- B.
Ficolle medium
- C.
Phosphate buffered saline
- D.
Normal saline solution (0.9% NaCl)
- 19.The purpose of serum inactivation is/are
- A.
To destory the native complement
- B.
To remove heat labile anti-complementary substances
- C.
To stabilize the serologic properties of the serum
- D.
All of the above
- 20.Inactivation of serum is done by heating at ____ for ____.
- A.
56 degrees Celsius, 30 minutes
- B.
56 degrees Celsius, 10 minutes
- C.
65 degrees Celsius, 20 minutes
- D.
65 degrees Celsius, 10 minutes
- 21.Which of the following reagents is used to cleave a polymeric antibody at the J chain resulting to monomers?
- A.
Papain
- B.
Pepsin
- C.
Sodium polyanethol
- D.
Dithiothreitol
- 22.Diabetes mellitus can be detected by typing HLA of class
- A.
I
- B.
II
- C.
III
- D.
IV
- 23.The exact binding site of an antigen is called its
- A.
Epitope.
- B.
Paratope.
- C.
Valence.
- D.
Any of the above
- 24.Which of the following is true about RPR and VDRL?
- A.
Serum inactivation is required.
- B.
These are examples of indirect agglutination tests.
- C.
Both are classified as TTT.
- D.
These are non-specific for syphilis.
- 25.Skin, lactic acid secretions, stomach acidity, and the motion of cilia represent which type of immunity?
- A.
Natural
- B.
Acquired
- C.
Adaptive
- D.
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