Review In Clinical Immunology & Serology

68 Questions | By Mmtech_18 | Updated: Mar 22, 2022 | Attempts: 7043

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Review In Clinical Immunology & Serology - Quiz

This examination covers the basics of Immunology and Serology that a Medical Technology student must know. This 70-item exam has a time limit of 60 minutes only. Please enter your name in the required field.

Questions and Answers

1.

Which of the following is not true?
- A.
  
  A hapten when combined with a carrier can elicit the formation of antibodies.
- B.
  
  Complete Freund's Adjuvant can stimulate cellular immunity.
- C.
  
  IgG is the best complement fixing immunoglobulin.
- D.
  
  Anaphylaxis is an immediate hypersensitivity reaction that causes bronchoconstriction.
2.

Which of the following domains is considered to be the foot of IgE?
- A.
  
  CH1
- B.
  
  CH2
- C.
  
  CH3
- D.
  
  CH4
3.

What type of immunity develops during convalescence from an infection?
- A.
  
  Natural active immunity
- B.
  
  Natural passive immunity
- C.
  
  Artificial active immunity
- D.
  
  Artificial passive immunity
4.

The coating of particulate antigen by antibody and/or complement components that allows them to be more phagocytized readily is called:
- A.
  
  Immune adherence
- B.
  
  Complement fixation
- C.
  
  Opsonization
- D.
  
  Immune complex formation
5.

Which of the following is correct?
- A.
  
  The method of complement assay that involves the measurement of precipiting ring diameter after 48 hours is Fahey McKelvey.
- B.
  
  Type I hypersensitivity is known as the "cytotoxic type".
- C.
  
  CD19, CD20, and CD21 are subtypes of B cells.
- D.
  
  The C5 convertase in the Classical Pathway of complement activation is C4b2b3b.
6.

Which of the following plays an important role as an external defense mechanism?
- A.
  
  Phagocytosis
- B.
  
  CRP
- C.
  
  Lysozyme
- D.
  
  Complement
7.

MHC molecules are associated with which of the following?
- A.
  
  Graft rejection
- B.
  
  Autoimmune diseases
- C.
  
  Determining to which agents an individual responds
- D.
  
  All of the above
8.

All of the following are characteristic of a good immunogen except
- A.
  
  Internal complexity
- B.
  
  Large molecular weight
- C.
  
  The presence of numerous epitopes
- D.
  
  Found on host cells
9.

Which of the following is characteristic of the endpoint method of RID?
- A.
  
  Readings are taken before equivalence is reached.
- B.
  
  Concentration is directly proportional to the square of the diameter.
- C.
  
  The diameter is plotted against the log of the concentration.
- D.
  
  It is primarily a qualitative rather than a quantitative method.
10.

Agglutination of dyed bacterial cells represents which type of reaction?
- A.
  
  Direct agglutination
- B.
  
  Passive agglutination
- C.
  
  Reverse passive agglutination
- D.
  
  Agglutination inhibition
11.

A positive direct Coomb's test would occur under which circumstances?
- A.
  
  Hemolytic disease of the newborn
- B.
  
  Autoimmune hemolytic anemia
- C.
  
  Antibodies to drugs that bind to red cells
- D.
  
  Any of the above
12.

How much diluent needs to be added to 0.2mL of serum to make a 1:20 dilution?
- A.
  
  19.8 mL
- B.
  
  4.0 mL
- C.
  
  3.8 mL
- D.
  
  10.0 mL
13.

All of the following are true of IgM except that it
- A.
  
  Can cross the placenta
- B.
  
  Fixes complement
- C.
  
  Has a J chain
- D.
  
  Is a primary response antibody
14.

If cells of an individual are not agglutinated by serum from anyone else, this represents which Lansteiner blood type?
- A.
  
  Type A
- B.
  
  Type B
- C.
  
  Type O
- D.
  
  Type AB
15.

Metchnikoff first described which of the following?
- A.
  
  Phagocytosis
- B.
  
  Variolation
- C.
  
  Humoral immunity
- D.
  
  Opsonization
16.

The inflammatory process is characterized by all of the following except
- A.
  
  Increased blood supply to the area
- B.
  
  Migration of white blood cells
- C.
  
  Decreased capillary permeability
- D.
  
  Appearance of acute phase reactants
17.

In an agglutination reaction, if cells are not centrifuged long enough, which of the following might occur?
- A.
  
  False-negative result
- B.
  
  False-positive result
- C.
  
  No effect
- D.
  
  Slight but can be ignored
18.

The density gradient solution used for the separation of lymphocytes
- A.
  
  Roswell Park Memorial Institute
- B.
  
  Ficolle medium
- C.
  
  Phosphate buffered saline
- D.
  
  Normal saline solution (0.9% NaCl)
19.

The purpose of serum inactivation is/are
- A.
  
  To destory the native complement
- B.
  
  To remove heat labile anti-complementary substances
- C.
  
  To stabilize the serologic properties of the serum
- D.
  
  All of the above
20.

Inactivation of serum is done by heating at ____ for ____.
- A.
  
  56 degrees Celsius, 30 minutes
- B.
  
  56 degrees Celsius, 10 minutes
- C.
  
  65 degrees Celsius, 20 minutes
- D.
  
  65 degrees Celsius, 10 minutes
21.

Which of the following reagents is used to cleave a polymeric antibody at the J chain resulting to monomers?
- A.
  
  Papain
- B.
  
  Pepsin
- C.
  
  Sodium polyanethol
- D.
  
  Dithiothreitol
22.

Diabetes mellitus can be detected by typing HLA of class
- A.
  
  I
- B.
  
  II
- C.
  
  III
- D.
  
  IV
23.

The exact binding site of an antigen is called its
- A.
  
  Epitope.
- B.
  
  Paratope.
- C.
  
  Valence.
- D.
  
  Any of the above
24.

Which of the following is true about RPR and VDRL?
- A.
  
  Serum inactivation is required.
- B.
  
  These are examples of indirect agglutination tests.
- C.
  
  Both are classified as TTT.
- D.
  
  These are non-specific for syphilis.
25.

Skin, lactic acid secretions, stomach acidity, and the motion of cilia represent which type of immunity?
- A.
  
  Natural
- B.
  
  Acquired
- C.
  
  Adaptive
- D.
  
  Auto