Review In Clinical Immunology & Serology

68 Questions | Total Attempts: 3010

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Review In Clinical Immunology & Serology

This examination covers the basics of Immunology and Serology that a Medical Technology student must know. This 70-item exam has a time limit of 60 minutes only. Please enter your name in the required field.


Questions and Answers
  • 1. 
    Which of the following is not true?
    • A. 

      A hapten when combined with a carrier can elicit the formation of antibodies.

    • B. 

      Complete Freund's Adjuvant can stimulate cellular immunity.

    • C. 

      IgG is the best complement fixing immunoglobulin.

    • D. 

      Anaphylaxis is an immediate hypersensitivity reaction that causes bronchoconstriction.

  • 2. 
    Which of the following domains is considered to be the foot of IgE?
    • A. 

      CH1

    • B. 

      CH2

    • C. 

      CH3

    • D. 

      CH4

  • 3. 
    • A. 

      Natural active immunity

    • B. 

      Natural passive immunity

    • C. 

      Artificial active immunity

    • D. 

      Artificial passive immunity

  • 4. 
    The coating of particulate antigen by antibody and/or complement components that allows them to be more phagocytized readily is called:
    • A. 

      Immune adherence

    • B. 

      Complement fixation

    • C. 

      Opsonization

    • D. 

      Immune complex formation

  • 5. 
    Which of the following is correct?
    • A. 

      The method of complement assay that involves the measurement of precipiting ring diameter after 48 hours is Fahey McKelvey.

    • B. 

      Type I hypersensitivity is known as the "cytotoxic type".

    • C. 

      CD19, CD20, and CD21 are subtypes of B cells.

    • D. 

      The C5 convertase in the Classical Pathway of complement activation is C4b2b3b.

  • 6. 
    Which of the following plays an important role as an external defense mechanism?
    • A. 

      Phagocytosis

    • B. 

      CRP

    • C. 

      Lysozyme

    • D. 

      Complement

  • 7. 
    • A. 

      Graft rejection

    • B. 

      Autoimmune diseases

    • C. 

      Determining to which agents an individual responds

    • D. 

      All of the above

  • 8. 
    • A. 

      Internal complexity

    • B. 

      Large molecular weight

    • C. 

      The presence of numerous epitopes

    • D. 

      Found on host cells

  • 9. 
    • A. 

      Readings are taken before equivalence is reached.

    • B. 

      Concentration is directly proportional to the square of the diameter.

    • C. 

      The diameter is plotted against the log of the concentration.

    • D. 

      It is primarily a qualitative rather than a quantitative method.

  • 10. 
    • A. 

      Direct agglutination

    • B. 

      Passive agglutination

    • C. 

      Reverse passive agglutination

    • D. 

      Agglutination inhibition

  • 11. 
    A positive direct Coomb's test would occur under which circumstances?
    • A. 

      Hemolytic disease of the newborn

    • B. 

      Autoimmune hemolytic anemia

    • C. 

      Antibodies to drugs that bind to red cells

    • D. 

      Any of the above

  • 12. 
    • A. 

      19.8 mL

    • B. 

      4.0 mL

    • C. 

      3.8 mL

    • D. 

      10.0 mL

  • 13. 
    All of the following are true of IgM except that it
    • A. 

      Can cross the placenta

    • B. 

      Fixes complement

    • C. 

      Has a J chain

    • D. 

      Is a primary response antibody

  • 14. 
    If cells of an individual are not agglutinated by serum from anyone else, this represents which Lansteiner blood type?
    • A. 

      Type A

    • B. 

      Type B

    • C. 

      Type O

    • D. 

      Type AB

  • 15. 
    Metchnikoff first described which of the following?
    • A. 

      Phagocytosis

    • B. 

      Variolation

    • C. 

      Humoral immunity

    • D. 

      Opsonization

  • 16. 
    The inflammatory process is characterized by all of the following except
    • A. 

      Increased blood supply to the area

    • B. 

      Migration of white blood cells

    • C. 

      Decreased capillary permeability

    • D. 

      Appearance of acute phase reactants

  • 17. 
    In an agglutination reaction, if cells are not centrifuged long enough, which of the following might occur?
    • A. 

      False-negative result

    • B. 

      False-positive result

    • C. 

      No effect

    • D. 

      Slight but can be ignored

  • 18. 
    The density gradient solution used for the separation of lymphocytes
    • A. 

      Roswell Park Memorial Institute

    • B. 

      Ficolle medium

    • C. 

      Phosphate buffered saline

    • D. 

      Normal saline solution (0.9% NaCl)

  • 19. 
    The purpose of serum inactivation is/are
    • A. 

      To destory the native complement

    • B. 

      To remove heat labile anti-complementary substances

    • C. 

      To stabilize the serologic properties of the serum

    • D. 

      All of the above

  • 20. 
    • A. 

      56 degrees Celsius, 30 minutes

    • B. 

      56 degrees Celsius, 10 minutes

    • C. 

      65 degrees Celsius, 20 minutes

    • D. 

      65 degrees Celsius, 10 minutes

  • 21. 
    Which of the following reagents is used to cleave a polymeric antibody at the J chain resulting to monomers?
    • A. 

      Papain

    • B. 

      Pepsin

    • C. 

      Sodium polyanethol

    • D. 

      Dithiothreitol

  • 22. 
    Diabetes mellitus can be detected by typing HLA of class
    • A. 

      I

    • B. 

      II

    • C. 

      III

    • D. 

      IV

  • 23. 
    • A. 

      Epitope.

    • B. 

      Paratope.

    • C. 

      Valence.

    • D. 

      Any of the above

  • 24. 
    Which of the following is true about RPR and VDRL?
    • A. 

      Serum inactivation is required.

    • B. 

      These are examples of indirect agglutination tests.

    • C. 

      Both are classified as TTT.

    • D. 

      These are non-specific for syphilis.

  • 25. 
    Skin, lactic acid secretions, stomach acidity, and the motion of cilia represent which type of immunity?
    • A. 

      Natural

    • B. 

      Acquired

    • C. 

      Adaptive

    • D. 

      Auto