Mock GPAT 3

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Mock GPAT 3

Graduate Pharmacy Aptitude Test The test has 100 question & 85 minutes. Each correct answer has 3 points There is 1 negative point for each incorrect answer. ALL THE BEST


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Questions and Answers
  • 1. 
    Distribution of drug in human body is depends on its
    • A. 

      Dissociation constant

    • B. 

      Type of dosage form in which it dispensed

    • C. 

      Route of drug administration

    • D. 

      All of these

  • 2. 
    Uitraviolet-Visible spectroscopy is a type of    
    • A. 

      Emission spectroscopy

    • B. 

      Absorption spectroscopy

    • C. 

      Vibrational spectroscopy

    • D. 

      None of these

  • 3. 
    Which of the following in a chromatographic separation is  a measure of its capacity to remain unaffected by small, but deliberate variations in method parameters and provides an indication of its reliability during normal usage?
    • A. 

      Ruggedness

    • B. 

      Accuracy/Precision

    • C. 

      Range/Linearity

    • D. 

      Robustness

  • 4. 
    An example of Thermal Conductivity Detector is
    • A. 

      Katharometer

    • B. 

      Flame ionization detector

    • C. 

      Electron capture detector

    • D. 

      Bolometer

  • 5. 
    Which of the following is an antiparasitic compound obtained from Marine sources?  
    • A. 

      Bryostatin-1

    • B. 

      Dolastatin-10

    • C. 

      Alpha-kainic acid

    • D. 

      Ecteinascidin 74

  • 6. 
    Stomatal Index(SI) is used as analytical constant for identification and authentification of
    • A. 

      Bark drug

    • B. 

      Volatile oil

    • C. 

      Leaf drug

    • D. 

      Fixed oil

  • 7. 
    Which one of the following adverse effect of the drugs is very common among persons having similar genetic make-up
    • A. 

      Intolerance

    • B. 

      Photosensitivity

    • C. 

      Idiosyncrasy

    • D. 

      Mutagenicity

  • 8. 
    Select the wrong statement from the following
    • A. 

      Boswellia serrata, Pinaceae, Sesquiterpenes

    • B. 

      Cassia angustifolia, Leguminoseae, Anthraquinones

    • C. 

      Terminalia chebula, Combretaceae, Tannins

    • D. 

      Butea monosperma, Papillioonaceae, Flavones

  • 9. 
    Which one of the drug acts directly to alter fungal cell membrane permeability 
    • A. 

      Ampicillin

    • B. 

      Polymixin B

    • C. 

      Amphotericin B

    • D. 

      Streptomycin

  • 10. 
    All of the following agents consisting dibenz[b,f]azepine ring system except  
    • A. 

      Carbamazepine

    • B. 

      Imipramine

    • C. 

      Trimipramine

    • D. 

      Amitryptyline

  • 11. 
    Where is National Institute of Virology (NIV) located?
    • A. 

      Delhi

    • B. 

      Pune

    • C. 

      Kolkata

    • D. 

      Hyderabad

  • 12. 
    Central Drugs Standard Control Organization is a regulatory authority of which country?
    • A. 

      Japan

    • B. 

      India

    • C. 

      South Africa

    • D. 

      Australia

  • 13. 
    Identify the drug molecule
    • A. 

      Domperidone

    • B. 

      Haloperidol

    • C. 

      Clofribate

    • D. 

      Droperidol

  • 14. 
    "List of minimum equipments required for efficient running of pharmacy" is given in
    • A. 

      Schedule M

    • B. 

      Schedule N

    • C. 

      Schedule R

    • D. 

      Schedule Y

  • 15. 
    Over use of which of the following drug may cause Parkinsonism?  
    • A. 

      Levodopa

    • B. 

      Domperidone

    • C. 

      Imipramine

    • D. 

      Chlorpromazine

  • 16. 
    Which one of the following is the most suitable Diluent for directly compressible tablet?
    • A. 

      Polyvinyl Pyrrolidine

    • B. 

      Hydroxy propyl methyl Cellulose

    • C. 

      Carboxy Methyl Cellulose

    • D. 

      MicroCrystalline Cellulose

  • 17. 
    Which of the following test of significance compares two experimental means, an experimental mean with a known value or sets of pairs of experimental values?
    • A. 

      F test

    • B. 

      T test

    • C. 

      Analysis of Variance

    • D. 

      Q test

  • 18. 
    Anti-hyperlipidemic which improves glucose tolerence?
    • A. 

      Clofibrates

    • B. 

      Atorvastatin

    • C. 

      Fish oil

    • D. 

      Bile acid sequestrants

  • 19. 
    Karplus curve is associated with which spectroscopy?
    • A. 

      UV

    • B. 

      Mass

    • C. 

      FTIR

    • D. 

      NMR

  • 20. 
    Esophageal ulceration is a side effect of which drug?
    • A. 

      Doxycycline

    • B. 

      Clarithromycin

    • C. 

      Cinnarizine

    • D. 

      Olapatidine

  • 21. 
    The most commonly used vector in r-DNA technology is
    • A. 

      Pseudomonas aeruginosa B.megaterium

    • B. 

      E.coli

    • C. 

      B.subtilis

    • D. 

      B.megaterium

  • 22. 
    Which of the following drug is used in SLE(Systemic Lupus Erythromatus)?
    • A. 

      Hydralazine

    • B. 

      Primaquine

    • C. 

      Chloroquine

    • D. 

      Artemisine

  • 23. 
    Which of the following nuclei has Odd Atomic mass & Atomic number  and spin number(I) of 1/2.
    • A. 

      1H

    • B. 

      17O

    • C. 

      13C

    • D. 

      29Si

  • 24. 
    Intravaginal drug Delivery is categorized under which route of drug administration?
    • A. 

      Parenteral

    • B. 

      Topical

    • C. 

      Enteral

    • D. 

      Pre-oral

  • 25. 
    Absorption of cardiac glycoside and insulin is via which transport route?
    • A. 

      Intracellular

    • B. 

      Intercellular

    • C. 

      Vesicular

    • D. 

      None of above

  • 26. 
    In which of the following transport mechanism compound does not have to be in an aqueous solution in order to be absorbed?
    • A. 

      Passive difusion

    • B. 

      Vesicular

    • C. 

      Carrier mediated

    • D. 

      ABC

  • 27. 
    Which of the following factors would be Rate Limiting step for dissolution of a drug candidate classified under BCS class I ?
    • A. 

      Solubility

    • B. 

      Permeability

    • C. 

      Gastric emptying time

    • D. 

      It varies case by case

  • 28. 
    Danckwert's model proposed for dissolution of solid dosage form in physiological fluid is based on which theory?
    • A. 

      Film theory

    • B. 

      Surface Renewal Theory

    • C. 

      Double barrier

    • D. 

      Limited solvation theory

  • 29. 
    Cortisone acetate exists in how many polymorphic forms?
    • A. 

      5

    • B. 

      6

    • C. 

      7

    • D. 

      8

  • 30. 
    Select inappropriate statement with respect to the  Lipinski's rule of Five.
    • A. 

      Molecular weight of drug must be less than 500

    • B. 

      Log P must be less than 5

    • C. 

      Number of H-bond donor must be less than 5

    • D. 

      Number of H-bond acceptor must be less than 5

  • 31. 
    "Frontal headache" is side effect of which NSAID?
    • A. 

      Aspirin

    • B. 

      Indomethacin

    • C. 

      Analgin

    • D. 

      Phenylbutazone

  • 32. 
    Which of the ommited schedule includes calculation of poisons in certain cases?
    • A. 

      Sch I

    • B. 

      Sch B

    • C. 

      Sch L

    • D. 

      Sch Z

  • 33. 
    Standards for opthalmic preparation is included in which of the schedule of Drug & Cosmetic Act?
    • A. 

      Sch F(I)

    • B. 

      Sch FF

    • C. 

      Sch F(II)

    • D. 

      Sch (III)

  • 34. 
    Configuration of cardiac glycoside between A-B,B-C,C-D ring is?
    • A. 

      Cis-cis-cis

    • B. 

      Trans-cis-trans

    • C. 

      Cis-trans-cis

    • D. 

      Trans-trans-trans

  • 35. 
    EXAMPLE OF DRUG WHOSE DISSOLUTION IN CRYSTALLINE FORM IS HIGHER THAN ITS AMORPHOUS FORM?
    • A. 

      Erythromycin

    • B. 

      Streptomycin

    • C. 

      Ketoconazole

    • D. 

      Pyrazinamide

  • 36. 
    Which non essential amino acid has two chiral centre?
    • A. 

      Lysine

    • B. 

      Isoleucine

    • C. 

      Threonine

    • D. 

      Isoleucine and threonine

    • E. 

      None

  • 37. 
    Carnauba wax is used in the following step of Sugar Coating of tablet:  
    • A. 

      Seal coating

    • B. 

      Syrup coating

    • C. 

      Polishing

    • D. 

      Sub coating

  • 38. 
    Which of the following antibiotic is known to cause Hyperkalemia?
    • A. 

      Tetracycline

    • B. 

      Amphotericin B

    • C. 

      Penicillin

    • D. 

      Streptomycin

  • 39. 
    ‎_____ is having a furan moeity and also CYP450 inhibitory activity?
    • A. 

      Cimetidine

    • B. 

      Ranitidine

    • C. 

      Nizatidine

    • D. 

      Famotidine

    • E. 

      None of the above

  • 40. 
    The duration of action of sublingual NG is...?
    • A. 

      3-5 sec

    • B. 

      10-30mins

    • C. 

      3-5 mins

    • D. 

      10-60 mins

  • 41. 
    Mescaline is synthesized from which amino acid?
    • A. 

      Ornithine

    • B. 

      Phenylalanine

    • C. 

      Tryptophan

    • D. 

      None

  • 42. 
             PEMATREXED IS...
    • A. 

      Inhibit Thymidylate Transferase

    • B. 

      Inhibit Thymidylate Synthetase

    • C. 

      Inhibit Adenylate Transferase

    • D. 

      Inhibit Adenylate Synthetase

  • 43. 
    Which of the following is NOT a drug exhibiting zero-order elimination kinetics?
    • A. 

      Ethanol

    • B. 

      Aspirin

    • C. 

      Morphine

    • D. 

      Phentoin

  • 44. 
    ‎106 mg of compound A (dissolved in 100 ml ethanol) in a 1 cm long cell has a lambda max 295 nm and absorbance is 0.28. then value of A1%1 cm is...?
    • A. 

      2.64

    • B. 

      264

    • C. 

      190

    • D. 

      640

  • 45. 
    Which of the following coenzyme is required in phospholipid synthesis? 
    • A. 

      CDP

    • B. 

      ADP

    • C. 

      SAM

    • D. 

      PLP

  • 46. 
    Which of the following is anti-expectorant?
    • A. 

      Ergot

    • B. 

      Atropine

    • C. 

      Reserpine

    • D. 

      Veratrum

  • 47. 
    A sheath of crystal formed around sclerenchyma is identifying characteristic of which drug?
    • A. 

      Digitalis

    • B. 

      Datura

    • C. 

      Senna

    • D. 

      Belladona

  • 48. 
    Which of the following herbal drug is an example of warty outgrowth from micropyle?
    • A. 

      Croton

    • B. 

      Cardamom

    • C. 

      Nutmeg

    • D. 

      Datura

  • 49. 
    Which of the following plant hormone inhibit root growth?
    • A. 

      IAA

    • B. 

      GA3

    • C. 

      Zeatin

    • D. 

      ABA

  • 50. 
    Central Institute of Medicinal and Aromatic Plants is located at ?
    • A. 

      Dehradun

    • B. 

      Lucknow

    • C. 

      Pune

    • D. 

      Kolkata

    • E. 

      Delhi

  • 51. 
    "knee shaped trichome" is characteristic of which of the following plant drug?
    • A. 

      Ephedra equisetina

    • B. 

      Lobelia inflata

    • C. 

      Adhatoda vasaka

    • D. 

      Ocimum sanctum

  • 52. 
    Which of the following method is used for assay of Myrh and Asafoetida?
    • A. 

      Water soluble extractive

    • B. 

      Alcohol soluble extractive

    • C. 

      Ether soluble extractive

    • D. 

      Volatile oil content

  • 53. 
    Influenza virus belongs to which of the following morphological categories?
    • A. 

      Helical Viruses

    • B. 

      Complex Viruses

    • C. 

      Enveloped Helical Viruses

    • D. 

      Icosahedral Viruses

  • 54. 
    First Amino acid in protein synthesis in case of Archaea,Bacteria & Eukarya is?`
    • A. 

      Methionine,Formylmethionine & Methionine respectively

    • B. 

      Alanine,Glycine & Methionine respectively

    • C. 

      Lysine,Isoleucine & Arginine respectively

    • D. 

      Tryptophan,Tyrosine & Histidine respectively

  • 55. 
    Which of the following group is electron withdrawing & meta director?
    • A. 

      -CN

    • B. 

      -CF3

    • C. 

      -SO3H

    • D. 

      All of the above

  • 56. 
    • A. 

      P-nitroanoline is less basic due electron release & p-methoxyaniline is more basic due to electron withdrawal

    • B. 

      P-nitroanoline is less basic due electron withdrawal & p-methoxyaniline is more basic due to electron release

    • C. 

      P-nitroanoline is more basic due electron withdrawal & p-methoxyaniline is less basic due to electron release

    • D. 

      Electron release & withdrawal does not affect basicity

  • 57. 
    Energetic Photons are used as ionizing agent in which of the following mode of ionization for Mass spectroscopy?
    • A. 

      Chemical Ionization

    • B. 

      Desorption Ionization(DI)

    • C. 

      Fast Atom Bombardment(FAB)

    • D. 

      Electron Ionization

  • 58. 
    Volume in millilitres occupied by 1 gram of a drug, including any adhering mucilage, after it has swollen in an aqueous liquid for 4 hour is
    • A. 

      Water number

    • B. 

      Swelling Index

    • C. 

      Tannin Content

    • D. 

      Bitterness value

  • 59. 
    Corticosteroids act on which type of receptors?
    • A. 

      Intermembrane receptors

    • B. 

      Surface receptors

    • C. 

      Nuclear receptors

    • D. 

      Enzymes

  • 60. 
    GABA transport is inhibited by which of the following drugs?
    • A. 

      Vigabatrine

    • B. 

      Guvacine

    • C. 

      Gabapentin

    • D. 

      None of the above

  • 61. 
    First choice antibiotic for vancomycin resistant streptococcus is
    • A. 

      Amoxicillin

    • B. 

      Quinupristin

    • C. 

      Azithromycin

    • D. 

      Clindamycin

  • 62. 
    Which of the followingchemotherapeutic drugs  double the distance between adjacent base pairs of DNA?
    • A. 

      Cytarabine

    • B. 

      Gatifloxacin

    • C. 

      Bleomycin

    • D. 

      Acriflavin

  • 63. 
    Which of the following peptide antibiotic is used in the treatment of TB?
    • A. 

      Clarithromycin

    • B. 

      Capreomycin

    • C. 

      Cycloserine

    • D. 

      Chlormycetin

  • 64. 
    Which of the following  antitubercular drugs penetrates Necrotic tuberculous lesions?
    • A. 

      Isoniazid

    • B. 

      Rifampicin

    • C. 

      Cyclosrine

    • D. 

      Ethambutol

  • 65. 
    Which of the following cells are the first to enter an inflammed area?
    • A. 

      Mast cells

    • B. 

      Monocytes

    • C. 

      Eosinophills

    • D. 

      Neutrophills

  • 66. 
    Which of the following statement is not true for Atracurium?
    • A. 

      It undergoes spontaneous non-enzymatic chemical degradation in plasma

    • B. 

      Its action becomes briefer during respiratory alkalosis caused by hyperventillation

    • C. 

      It is a steroid based compound

    • D. 

      It is a bis-quaternary compound

  • 67. 
    Which of the following is released as a co-transmitter with noradrenaline(NA) at many sympathetic nerve endings?
    • A. 

      VIP

    • B. 

      Angiotensin

    • C. 

      Neuropeptide Y

    • D. 

      Acetylcholine

  • 68. 
    Which of the following drug is used in the treatment of the symptoms of carcinoid tumours?
    • A. 

      Ergometrine

    • B. 

      Cyproheptadine

    • C. 

      Methysergide

    • D. 

      Pizotifen

  • 69. 
    Which of the following drug reduces the positive free water clearance,but does not affect the negative free water clearnce?
    • A. 

      Furosemide

    • B. 

      Hydrochlorthiazide

    • C. 

      Spironolactone

    • D. 

      Acetazolamide

  • 70. 
    Which of the following drug shows Bimodal distribution in the population?
    • A. 

      Hydralazine

    • B. 

      Sodium nitroprusside

    • C. 

      Clonidine

    • D. 

      Pethidine

  • 71. 
    Which of the following antianginal drug reduces fatty acid metabolism and increases glucose metabolism in myocardium?
    • A. 

      Triamterene

    • B. 

      Dipyridamole

    • C. 

      Trimetazidine

    • D. 

      Nimodipine

  • 72. 
    Which one of the following drugs belonging to Cephalosporinclass of antibiotics exist in Zwiiter ionic form?
    • A. 

      Cefixime

    • B. 

      Cefpodoxime Axetil

    • C. 

      Cefpirome

    • D. 

      Ceftrioxone

  • 73. 
    Which of the following antiarrhythmetic drugs has direct membrane stabilizing action at high doses?
    • A. 

      Propafenone

    • B. 

      Amiodarone

    • C. 

      Propranolol

    • D. 

      Verapamil

  • 74. 
    Which of the following drug decreases the absorption of Digoxin?
    • A. 

      Erythromycin

    • B. 

      Omeprazole

    • C. 

      Metoclopramide

    • D. 

      Tetracycline

  • 75. 
    Which of the following chemotherapeutic agents inhibits DNA synthesis?
    • A. 

      Amphotericin

    • B. 

      Griseofulvin

    • C. 

      Capsofungin

    • D. 

      Flucytosine

  • 76. 
    For Acetic acid (CH3COOH) if the pH of the environment is less than its pKa,according to HENDERSON-HESSELBACH EQUATION
    • A. 

      Cojugate base (anion)CH3COO- will predominate

    • B. 

      Acidic (neutral) form CH3COOH will predominate

    • C. 

      Both species will be in equal proportioons

    • D. 

      Can't be infferred from given information

  • 77. 
    In IR sharp,medium intensity peak at 2250 cm-1 is due to which fumctional group?
    • A. 

      C triple bond N

    • B. 

      C=C

    • C. 

      C triple bond C

    • D. 

      C-O

  • 78. 
    Woodward-Fieser rules  can be applied upto how many bonds?
    • A. 

      4

    • B. 

      5

    • C. 

      6

    • D. 

      No such limits are there

  • 79. 
    Identify this anti-convulsant-
    • A. 

      Felbamate

    • B. 

      Tiagabine

    • C. 

      Zonisamide

    • D. 

      Topiramate

  • 80. 
    Identify the category of this drug:
    • A. 

      Neuroleptic

    • B. 

      Thymoleptic

    • C. 

      Analeptic

    • D. 

      Minor tranquilizer

  • 81. 
    (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one is IUPAC name of which anti-hyperlipidemic agent?
    • A. 

      Simvastatin

    • B. 

      Ezetimibe

    • C. 

      Probucol

    • D. 

      Mipomerosen

  • 82. 
    • A. 

      (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-isoquinoline-3-carboxylic acid

    • B. 

      (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroquinoline-3-carboxylic acid

    • C. 

      (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-quinoline-3-carboxylic acid

    • D. 

      (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

  • 83. 
     which drug is effective in both short-term and long-term treatment of Mania and Hypomania with addition of MgO?
    • A. 

      Nifedipine

    • B. 

      Verapamil

    • C. 

      Diltiazem

    • D. 

      Hydralazine

  • 84. 
    Which of the following is unique as a non-opioid, non-NSAID, non-steroidal analgesic?
    • A. 

      Femipezole

    • B. 

      Flupirtine

    • C. 

      Olapatidine

    • D. 

      Morphazinamide

  • 85. 
    Which of the following is appropriate mechanism of action of Sematilide ?
    • A. 

      K+ channel blocker

    • B. 

      K+ channel opener

    • C. 

      Ca+ channel opener

    • D. 

      Ca+ channel blocker

  • 86. 
    In case of chewable tablet which tooling is used generally?
    • A. 

      B tooling

    • B. 

      BB tooling

    • C. 

      D tooling

    • D. 

      None

  • 87. 
    In newer tablet machine Antiturning device is used for which of the following purposes?
    • A. 

      To avoid double impression

    • B. 

      To avoid cone formation

    • C. 

      To avoid rat-holing

    • D. 

      To avoid weight variation

  • 88. 
    Which of the following is not the content of "NU-Tab"?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
    • A. 

      Sucrose

    • B. 

      Corn starch

    • C. 

      Modified dextrin

    • D. 

      Mg stearate

  • 89. 
    Which company has made first film coating tablet?
    • A. 

      Pfizer

    • B. 

      Abbott

    • C. 

      GSK

    • D. 

      Johnson & johnson

  • 90. 
    Which of the following has pH-independent solubility?
    • A. 

      PVAP

    • B. 

      PVA

    • C. 

      HPMC

    • D. 

      HPMCP

  • 91. 
    Largest capsule size for human use is...?
    • A. 

      0

    • B. 

      000

    • C. 

      1

    • D. 

      5

  • 92. 
    Which of the following film former is soluble below 40 C and insoluble above 45 C in water?
    • A. 

      HPMC

    • B. 

      HPC

    • C. 

      HPMCP

    • D. 

      Povidone

  • 93. 
    In spraying process which of the following step eliminated in sugar coating?
    • A. 

      Seal coating

    • B. 

      Subcoating

    • C. 

      Polishing

    • D. 

      Smoothing

  • 94. 
    • A. 

      Only P and Q are true

    • B. 

      Only Q and r true

    • C. 

      Only P,Q,R are true

    • D. 

      All are true

  • 95. 
    S.rimosus is a biological source of which of the following antibiotic?
    • A. 

      Oxytetracycline

    • B. 

      Chlortetracycline

    • C. 

      Tobramycin

    • D. 

      Bleomycin

  • 96. 
    Identify this reaction:
    • A. 

      Vilsmeier haack reaction

    • B. 

      Ullmann reaction

    • C. 

      Forvski reaction

    • D. 

      None

  • 97. 
    In Proton NMR spectra of an organic compound,peak IS obtained at around 7 ppm and it is singlet. That infers the compound is...
    • A. 

      Ortho substituted

    • B. 

      Meta substituted

    • C. 

      Para substituted

    • D. 

      Mono substituted

  • 98. 
    PH of 0.02 normal Hydrochloric acid will be  
    • A. 

      Less than 1

    • B. 

      Between 1-2

    • C. 

      Between 2-3

    • D. 

      Greater than 3

  • 99. 
    What is the correct order for unsaturation present in following fatty acids
    1. Polmitoleic Acid
    2. Linolenic
    3. Alpha linolenic
    4. Arachidonic acid
    • A. 

      1>2>3>4

    • B. 

      3>4=2>1

    • C. 

      4>3>2>1

    • D. 

      4>3=2>1

  • 100. 
    Select inappropriate statement
    • A. 

      Neostigmine, Physostigmine, cough suppressant

    • B. 

      Etoposide, Podophyllotoxin ,Anticancer

    • C. 

      Dextromethorphan, Morphin, Analgesic

    • D. 

      Sodium cromoglycate, Khellin, Anti asthmatic