Mock GPAT 3
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Graduate Pharmacy Aptitude Test The test has 100 question & 85 minutes. Each correct answer has 3 points There is 1 negative point for each incorrect answer. ALL THE BEST
- 1.Distribution of drug in human body is depends on its
- A.
Dissociation constant
- B.
Type of dosage form in which it dispensed
- C.
Route of drug administration
- D.
All of these
- 2.Uitraviolet-Visible spectroscopy is a type of
- A.
Emission spectroscopy
- B.
Absorption spectroscopy
- C.
Vibrational spectroscopy
- D.
None of these
- 3.Which of the following in a chromatographic separation is a measure of its capacity to remain unaffected by small, but deliberate variations in method parameters and provides an indication of its reliability during normal usage?
- A.
Ruggedness
- B.
Accuracy/Precision
- C.
Range/Linearity
- D.
Robustness
- 4.An example of Thermal Conductivity Detector is
- A.
Katharometer
- B.
Flame ionization detector
- C.
Electron capture detector
- D.
Bolometer
- 5.Which of the following is an antiparasitic compound obtained from Marine sources?
- A.
Bryostatin-1
- B.
Dolastatin-10
- C.
Alpha-kainic acid
- D.
Ecteinascidin 74
- 6.Stomatal Index(SI) is used as analytical constant for identification and authentification of
- A.
Bark drug
- B.
Volatile oil
- C.
Leaf drug
- D.
Fixed oil
- 7.Which one of the following adverse effect of the drugs is very common among persons having similar genetic make-up
- A.
Intolerance
- B.
Photosensitivity
- C.
Idiosyncrasy
- D.
Mutagenicity
- 8.Select the wrong statement from the following
- A.
Boswellia serrata, Pinaceae, Sesquiterpenes
- B.
Cassia angustifolia, Leguminoseae, Anthraquinones
- C.
Terminalia chebula, Combretaceae, Tannins
- D.
Butea monosperma, Papillioonaceae, Flavones
- 9.Which one of the drug acts directly to alter fungal cell membrane permeability
- A.
Ampicillin
- B.
Polymixin B
- C.
Amphotericin B
- D.
Streptomycin
- 10.All of the following agents consisting dibenz[b,f]azepine ring system except
- A.
Carbamazepine
- B.
Imipramine
- C.
Trimipramine
- D.
Amitryptyline
- 11.Where is National Institute of Virology (NIV) located?
- A.
Delhi
- B.
Pune
- C.
Kolkata
- D.
Hyderabad
- 12.Central Drugs Standard Control Organization is a regulatory authority of which country?
- A.
Japan
- B.
India
- C.
South Africa
- D.
Australia
- 13.
![]()
Identify the drug molecule- A.
Domperidone
- B.
Haloperidol
- C.
Clofribate
- D.
Droperidol
- 14."List of minimum equipments required for efficient running of pharmacy" is given in
- A.
Schedule M
- B.
Schedule N
- C.
Schedule R
- D.
Schedule Y
- 15.Over use of which of the following drug may cause Parkinsonism?
- A.
Levodopa
- B.
Domperidone
- C.
Imipramine
- D.
Chlorpromazine
- 16.Which one of the following is the most suitable Diluent for directly compressible tablet?
- A.
Polyvinyl Pyrrolidine
- B.
Hydroxy propyl methyl Cellulose
- C.
Carboxy Methyl Cellulose
- D.
MicroCrystalline Cellulose
- 17.Which of the following test of significance compares two experimental means, an experimental mean with a known value or sets of pairs of experimental values?
- A.
F test
- B.
T test
- C.
Analysis of Variance
- D.
Q test
- 18.Anti-hyperlipidemic which improves glucose tolerence?
- A.
Clofibrates
- B.
Atorvastatin
- C.
Fish oil
- D.
Bile acid sequestrants
- 19.Karplus curve is associated with which spectroscopy?
- A.
UV
- B.
Mass
- C.
FTIR
- D.
NMR
- 20.Esophageal ulceration is a side effect of which drug?
- A.
Doxycycline
- B.
Clarithromycin
- C.
Cinnarizine
- D.
Olapatidine
- 21.The most commonly used vector in r-DNA technology is
- A.
Pseudomonas aeruginosa B.megaterium
- B.
E.coli
- C.
B.subtilis
- D.
B.megaterium
- 22.Which of the following drug is used in SLE(Systemic Lupus Erythromatus)?
- A.
Hydralazine
- B.
Primaquine
- C.
Chloroquine
- D.
Artemisine
- 23.Which of the following nuclei has Odd Atomic mass & Atomic number and spin number(I) of 1/2.
- A.
1H
- B.
17O
- C.
13C
- D.
29Si
- 24.Intravaginal drug Delivery is categorized under which route of drug administration?
- A.
Parenteral
- B.
Topical
- C.
Enteral
- D.
Pre-oral
- 25.Absorption of cardiac glycoside and insulin is via which transport route?
- A.
Intracellular
- B.
Intercellular
- C.
Vesicular
- D.
None of above
- 26.In which of the following transport mechanism compound does not have to be in an aqueous solution in order to be absorbed?
- A.
Passive difusion
- B.
Vesicular
- C.
Carrier mediated
- D.
ABC
- 27.Which of the following factors would be Rate Limiting step for dissolution of a drug candidate classified under BCS class I ?
- A.
Solubility
- B.
Permeability
- C.
Gastric emptying time
- D.
It varies case by case
- 28.Danckwert's model proposed for dissolution of solid dosage form in physiological fluid is based on which theory?
- A.
Film theory
- B.
Surface Renewal Theory
- C.
Double barrier
- D.
Limited solvation theory
- 29.Cortisone acetate exists in how many polymorphic forms?
- A.
5
- B.
6
- C.
7
- D.
8
- 30.Select inappropriate statement with respect to the Lipinski's rule of Five.
- A.
Molecular weight of drug must be less than 500
- B.
Log P must be less than 5
- C.
Number of H-bond donor must be less than 5
- D.
Number of H-bond acceptor must be less than 5
- 31."Frontal headache" is side effect of which NSAID?
- A.
Aspirin
- B.
Indomethacin
- C.
Analgin
- D.
Phenylbutazone
- 32.Which of the ommited schedule includes calculation of poisons in certain cases?
- A.
Sch I
- B.
Sch B
- C.
Sch L
- D.
Sch Z
- 33.Standards for opthalmic preparation is included in which of the schedule of Drug & Cosmetic Act?
- A.
Sch F(I)
- B.
Sch FF
- C.
Sch F(II)
- D.
Sch (III)
- 34.Configuration of cardiac glycoside between A-B,B-C,C-D ring is?
- A.
Cis-cis-cis
- B.
Trans-cis-trans
- C.
Cis-trans-cis
- D.
Trans-trans-trans
- 35.EXAMPLE OF DRUG WHOSE DISSOLUTION IN CRYSTALLINE FORM IS HIGHER THAN ITS AMORPHOUS FORM?
- A.
Erythromycin
- B.
Streptomycin
- C.
Ketoconazole
- D.
Pyrazinamide
- 36.Which non essential amino acid has two chiral centre?
- A.
Lysine
- B.
Isoleucine
- C.
Threonine
- D.
Isoleucine and threonine
- E.
None
- 37.Carnauba wax is used in the following step of Sugar Coating of tablet:
- A.
Seal coating
- B.
Syrup coating
- C.
Polishing
- D.
Sub coating
- 38.Which of the following antibiotic is known to cause Hyperkalemia?
- A.
Tetracycline
- B.
Amphotericin B
- C.
Penicillin
- D.
Streptomycin
- 39._____ is having a furan moeity and also CYP450 inhibitory activity?
- A.
Cimetidine
- B.
Ranitidine
- C.
Nizatidine
- D.
Famotidine
- E.
None of the above
- 40.The duration of action of sublingual NG is...?
- A.
3-5 sec
- B.
10-30mins
- C.
3-5 mins
- D.
10-60 mins
- 41.Mescaline is synthesized from which amino acid?
- A.
Ornithine
- B.
Phenylalanine
- C.
Tryptophan
- D.
None
- 42.PEMATREXED IS...
- A.
Inhibit Thymidylate Transferase
- B.
Inhibit Thymidylate Synthetase
- C.
Inhibit Adenylate Transferase
- D.
Inhibit Adenylate Synthetase
- 43.Which of the following is NOT a drug exhibiting zero-order elimination kinetics?
- A.
Ethanol
- B.
Aspirin
- C.
Morphine
- D.
Phentoin
- 44.106 mg of compound A (dissolved in 100 ml ethanol) in a 1 cm long cell has a lambda max 295 nm and absorbance is 0.28. then value of A1%1 cm is...?
- A.
2.64
- B.
264
- C.
190
- D.
640
- 45.Which of the following coenzyme is required in phospholipid synthesis?
- A.
CDP
- B.
ADP
- C.
SAM
- D.
PLP
- 46.Which of the following is anti-expectorant?
- A.
Ergot
- B.
Atropine
- C.
Reserpine
- D.
Veratrum
- 47.A sheath of crystal formed around sclerenchyma is identifying characteristic of which drug?
- A.
Digitalis
- B.
Datura
- C.
Senna
- D.
Belladona
- 48.Which of the following herbal drug is an example of warty outgrowth from micropyle?
- A.
Croton
- B.
Cardamom
- C.
Nutmeg
- D.
Datura
- 49.Which of the following plant hormone inhibit root growth?
- A.
IAA
- B.
GA3
- C.
Zeatin
- D.
ABA
- 50.Central Institute of Medicinal and Aromatic Plants is located at ?
- A.
Dehradun
- B.
Lucknow
- C.
Pune
- D.
Kolkata
- E.
Delhi
- 51."knee shaped trichome" is characteristic of which of the following plant drug?
- A.
Ephedra equisetina
- B.
Lobelia inflata
- C.
Adhatoda vasaka
- D.
Ocimum sanctum
- 52.Which of the following method is used for assay of Myrh and Asafoetida?
- A.
Water soluble extractive
- B.
Alcohol soluble extractive
- C.
Ether soluble extractive
- D.
Volatile oil content
- 53.Influenza virus belongs to which of the following morphological categories?
- A.
Helical Viruses
- B.
Complex Viruses
- C.
Enveloped Helical Viruses
- D.
Icosahedral Viruses
- 54.First Amino acid in protein synthesis in case of Archaea,Bacteria & Eukarya is?`
- A.
Methionine,Formylmethionine & Methionine respectively
- B.
Alanine,Glycine & Methionine respectively
- C.
Lysine,Isoleucine & Arginine respectively
- D.
Tryptophan,Tyrosine & Histidine respectively
- 55.Which of the following group is electron withdrawing & meta director?
- A.
-CN
- B.
-CF3
- C.
-SO3H
- D.
All of the above
- 56.
- A.
P-nitroanoline is less basic due electron release & p-methoxyaniline is more basic due to electron withdrawal
- B.
P-nitroanoline is less basic due electron withdrawal & p-methoxyaniline is more basic due to electron release
- C.
P-nitroanoline is more basic due electron withdrawal & p-methoxyaniline is less basic due to electron release
- D.
Electron release & withdrawal does not affect basicity
- 57.Energetic Photons are used as ionizing agent in which of the following mode of ionization for Mass spectroscopy?
- A.
Chemical Ionization
- B.
Desorption Ionization(DI)
- C.
Fast Atom Bombardment(FAB)
- D.
Electron Ionization
- 58.Volume in millilitres occupied by 1 gram of a drug, including any adhering mucilage, after it has swollen in an aqueous liquid for 4 hour is
- A.
Water number
- B.
Swelling Index
- C.
Tannin Content
- D.
Bitterness value
- 59.Corticosteroids act on which type of receptors?
- A.
Intermembrane receptors
- B.
Surface receptors
- C.
Nuclear receptors
- D.
Enzymes
- 60.GABA transport is inhibited by which of the following drugs?
- A.
Vigabatrine
- B.
Guvacine
- C.
Gabapentin
- D.
None of the above
- 61.First choice antibiotic for vancomycin resistant streptococcus is
- A.
Amoxicillin
- B.
Quinupristin
- C.
Azithromycin
- D.
Clindamycin
- 62.Which of the followingchemotherapeutic drugs double the distance between adjacent base pairs of DNA?
- A.
Cytarabine
- B.
Gatifloxacin
- C.
Bleomycin
- D.
Acriflavin
- 63.Which of the following peptide antibiotic is used in the treatment of TB?
- A.
Clarithromycin
- B.
Capreomycin
- C.
Cycloserine
- D.
Chlormycetin
- 64.Which of the following antitubercular drugs penetrates Necrotic tuberculous lesions?
- A.
Isoniazid
- B.
Rifampicin
- C.
Cyclosrine
- D.
Ethambutol
- 65.Which of the following cells are the first to enter an inflammed area?
- A.
Mast cells
- B.
Monocytes
- C.
Eosinophills
- D.
Neutrophills
- 66.Which of the following statement is not true for Atracurium?
- A.
It undergoes spontaneous non-enzymatic chemical degradation in plasma
- B.
Its action becomes briefer during respiratory alkalosis caused by hyperventillation
- C.
It is a steroid based compound
- D.
It is a bis-quaternary compound
- 67.Which of the following is released as a co-transmitter with noradrenaline(NA) at many sympathetic nerve endings?
- A.
VIP
- B.
Angiotensin
- C.
Neuropeptide Y
- D.
Acetylcholine
- 68.Which of the following drug is used in the treatment of the symptoms of carcinoid tumours?
- A.
Ergometrine
- B.
Cyproheptadine
- C.
Methysergide
- D.
Pizotifen
- 69.Which of the following drug reduces the positive free water clearance,but does not affect the negative free water clearnce?
- A.
Furosemide
- B.
Hydrochlorthiazide
- C.
Spironolactone
- D.
Acetazolamide
- 70.Which of the following drug shows Bimodal distribution in the population?
- A.
Hydralazine
- B.
Sodium nitroprusside
- C.
Clonidine
- D.
Pethidine
- 71.Which of the following antianginal drug reduces fatty acid metabolism and increases glucose metabolism in myocardium?
- A.
Triamterene
- B.
Dipyridamole
- C.
Trimetazidine
- D.
Nimodipine
- 72.Which one of the following drugs belonging to Cephalosporinclass of antibiotics exist in Zwiiter ionic form?
- A.
Cefixime
- B.
Cefpodoxime Axetil
- C.
Cefpirome
- D.
Ceftrioxone
- 73.Which of the following antiarrhythmetic drugs has direct membrane stabilizing action at high doses?
- A.
Propafenone
- B.
Amiodarone
- C.
Propranolol
- D.
Verapamil
- 74.Which of the following drug decreases the absorption of Digoxin?
- A.
Erythromycin
- B.
Omeprazole
- C.
Metoclopramide
- D.
Tetracycline
- 75.Which of the following chemotherapeutic agents inhibits DNA synthesis?
- A.
Amphotericin
- B.
Griseofulvin
- C.
Capsofungin
- D.
Flucytosine
- 76.For Acetic acid (CH3COOH) if the pH of the environment is less than its pKa,according to HENDERSON-HESSELBACH EQUATION
- A.
Cojugate base (anion)CH3COO- will predominate
- B.
Acidic (neutral) form CH3COOH will predominate
- C.
Both species will be in equal proportioons
- D.
Can't be infferred from given information
- 77.In IR sharp,medium intensity peak at 2250 cm-1 is due to which fumctional group?
- A.
C triple bond N
- B.
C=C
- C.
C triple bond C
- D.
C-O
- 78.Woodward-Fieser rules can be applied upto how many bonds?
- A.
4
- B.
5
- C.
6
- D.
No such limits are there
- 79.
![]()
Identify this anti-convulsant-- A.
Felbamate
- B.
Tiagabine
- C.
Zonisamide
- D.
Topiramate
- 80.
![]()
Identify the category of this drug:- A.
Neuroleptic
- B.
Thymoleptic
- C.
Analeptic
- D.
Minor tranquilizer
- 81.(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one is IUPAC name of which anti-hyperlipidemic agent?
- A.
Simvastatin
- B.
Ezetimibe
- C.
Probucol
- D.
Mipomerosen
- 82.
- A.
(3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-isoquinoline-3-carboxylic acid
- B.
(3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroquinoline-3-carboxylic acid
- C.
(3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-quinoline-3-carboxylic acid
- D.
(3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
- 83.which drug is effective in both short-term and long-term treatment of Mania and Hypomania with addition of MgO?
- A.
Nifedipine
- B.
Verapamil
- C.
Diltiazem
- D.
Hydralazine
- 84.Which of the following is unique as a non-opioid, non-NSAID, non-steroidal analgesic?
- A.
Femipezole
- B.
Flupirtine
- C.
Olapatidine
- D.
Morphazinamide
- 85.Which of the following is appropriate mechanism of action of Sematilide ?
- A.
K+ channel blocker
- B.
K+ channel opener
- C.
Ca+ channel opener
- D.
Ca+ channel blocker
- 86.In case of chewable tablet which tooling is used generally?
- A.
B tooling
- B.
BB tooling
- C.
D tooling
- D.
None
- 87.In newer tablet machine Antiturning device is used for which of the following purposes?
- A.
To avoid double impression
- B.
To avoid cone formation
- C.
To avoid rat-holing
- D.
To avoid weight variation
- 88.Which of the following is not the content of "NU-Tab"?
- A.
Sucrose
- B.
Corn starch
- C.
Modified dextrin
- D.
Mg stearate
- 89.Which company has made first film coating tablet?
- A.
Pfizer
- B.
Abbott
- C.
GSK
- D.
Johnson & johnson
- 90.Which of the following has pH-independent solubility?
- A.
PVAP
- B.
PVA
- C.
HPMC
- D.
HPMCP
- 91.Largest capsule size for human use is...?
- A.
0
- B.
000
- C.
1
- D.
5
- 92.Which of the following film former is soluble below 40 C and insoluble above 45 C in water?
- A.
HPMC
- B.
HPC
- C.
HPMCP
- D.
Povidone
- 93.In spraying process which of the following step eliminated in sugar coating?
- A.
Seal coating
- B.
Subcoating
- C.
Polishing
- D.
Smoothing
- 94.
- A.
Only P and Q are true
- B.
Only Q and r true
- C.
Only P,Q,R are true
- D.
All are true
- 95.S.rimosus is a biological source of which of the following antibiotic?
- A.
Oxytetracycline
- B.
Chlortetracycline
- C.
Tobramycin
- D.
Bleomycin
- 96.
![]()
Identify this reaction:- A.
Vilsmeier haack reaction
- B.
Ullmann reaction
- C.
Forvski reaction
- D.
None
- 97.In Proton NMR spectra of an organic compound,peak IS obtained at around 7 ppm and it is singlet. That infers the compound is...
- A.
Ortho substituted
- B.
Meta substituted
- C.
Para substituted
- D.
Mono substituted
- 98.PH of 0.02 normal Hydrochloric acid will be
- A.
Less than 1
- B.
Between 1-2
- C.
Between 2-3
- D.
Greater than 3
- 99.What is the correct order for unsaturation present in following fatty acids
- Polmitoleic Acid
- Linolenic
- Alpha linolenic
- Arachidonic acid
- A.
1>2>3>4
- B.
3>4=2>1
- C.
4>3>2>1
- D.
4>3=2>1
- 100.Select inappropriate statement
- A.
Neostigmine, Physostigmine, cough suppressant
- B.
Etoposide, Podophyllotoxin ,Anticancer
- C.
Dextromethorphan, Morphin, Analgesic
- D.
Sodium cromoglycate, Khellin, Anti asthmatic
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