Pharmacology(5) Hypertension, Angina And Heart Failure

11 Questions | Total Attempts: 122

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Heart Failure Quizzes & Trivia

Questions and Answers
  • 1. 
    Stable angina is characterized by
    • A. 

      Attacks which occur at rest

    • B. 

      Is relieved by glyceryl trinitrate

    • C. 

      Is often a prelude to myocardial infarction

    • D. 

      Attacks that occur with increasing frequency and intensity

    • E. 

      Attacks that occur on less and less exertion

  • 2. 
    Besides atheroma other factors which can contribute to cardiac ischemia are:
    • A. 

      White thrombus (platelet/fibrinogen/fibrin aggregates)

    • B. 

      Spasm of the smooth muscle of the coronary arteries

    • C. 

      A presence of endothelium-derived vasodilators

    • D. 

      Smoking

    • E. 

      A relative deficiency of endothelium-derived vasodilators

  • 3. 
    Patients with unstable angina:
    • A. 

      Need not stop smoking

    • B. 

      Require urgent antiplatelet therapy

    • C. 

      If treated with glyceryl trinitrate then a constant i.v. infusion should be used

    • D. 

      Pain should be easily relieved by glyceryl trinitrate sublingually

    • E. 

      Are treated by i.v. heparin and beta-blockers

  • 4. 
    Glyceryl trinitrate (nitroglycerin) A. is used for..B. is
    • A. 

      A... acute prophylaxis

    • B. 

      A... longer prophylaxis

    • C. 

      B... volatile

    • D. 

      B... not volatile

    • E. 

      B... to be stored in a cool place in a tightly capped dark container

  • 5. 
    For acute prophylaxis glyceryl trinitrate can be administered
    • A. 

      Orally

    • B. 

      Sublingually

    • C. 

      Transdermally

    • D. 

      In a spray

    • E. 

      Immediately before undertaking strenuous activity

  • 6. 
    Stable angina is managed using:
    • A. 

      Glyceryl trinitrate for pain relief

    • B. 

      Acute prophylaxis by sublingual buccal administration of organic nitrates

    • C. 

      Longer prophylaxis by oral organic nitrates

    • D. 

      Beta-adrenoceptor blockers

    • E. 

      Calcium channel blockers

  • 7. 
    After organic nitrates administration:
    • A. 

      Nitric oxide is generated

    • B. 

      The vascular smooth muscle is contracted

    • C. 

      Platelet function is inhibited

    • D. 

      Chest pain is relieved

    • E. 

      Non-vascular smooth muscles are not influenced

  • 8. 
    Organic nitrates A. are selective for... B. can...
    • A. 

      A...arteriolar rather than venous smooth muscle

    • B. 

      A...venous rather than arteriolar smooth muscle

    • C. 

      B...reduce cardiac preload

    • D. 

      B...increase cardiac work and oxygen demand

    • E. 

      B...improve coronary blood flow

  • 9. 
    Tolerance to organic nitrates A. is... B. can be avoided
    • A. 

      A...loss of efficacy of the drugs

    • B. 

      A...due to exhaustion of sulfydryl-containing intermediary

    • C. 

      A...a long-term event

    • D. 

      B...by intermittent dosage

    • E. 

      B...by omitting the evening dose in patients who do not experience angina at night

  • 10. 
    Nitrovasodilators A. provide NO... B.can be active...
    • A. 

      A...as an endothelium-derived relaxing factor

    • B. 

      A...in an endothelium-independent manner

    • C. 

      B...only if endothelial function is normal

    • D. 

      B...also if endothelial function is severely impaired

    • E. 

      B...in many patients with coronary artery disease

  • 11. 
    Systemic bioavailability of glyceryl trinitrate from the gut
    • A. 

      Is determined by presystemic drug biotransformation

    • B. 

      Is higher as opposed to that from the sublingual space

    • C. 

      Is higher as opposed to that from the buccal mucosa

    • D. 

      Is useful for minimizing adverse effects of the sublingual tablets if they are swallowed

    • E. 

      Can be influenced by molecule modification

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