2012 Pharm II- Quiz 3

110 Questions | Attempts: 202
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  • 1/110 Questions

    What could you give to treat a patient with post dural puncture headache?

    • Ritalin
    • Doxipram
    • Dantrolene
    • Caffeine
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About This Quiz

A review of the material for second semester pharmacology, test #1.

2012 Pharm II- Quiz 3 - Quiz

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  • 2. 

    Which of the following is used to treat tuberculosis?

    • Isoniazide & Rifampin

    • Amoxicillin & Clavulanic Acid

    • Ampicillin & Sulbactam

    • Metronidazole & Vancomycin

    Correct Answer
    A. Isoniazide & Rifampin
  • 3. 

    Seizure disorders are most likely caused by:

    • A focus of hyperexcitable neurons that fire in the absence of appropriate stimuli

    • Too little dopaminergic input from the substantia nigra into the striam

    • 5 HT serotonin in excess in the synaptic cleft.

    • Spending too much time standing under strobe lights

    Correct Answer
    A. A focus of hyperexcitable neurons that fire in the absence of appropriate stimuli
  • 4. 

    Tricyclic antidepressants have a  wide therapeutic index and are relatively safe when taken in overdose when compared to SSRI’s which produce life threatening overdose symptoms. 

    • True

    • False

    Correct Answer
    A. False
  • 5. 

    Peniciilin G may cause what electrolyte imbalance when given to patients with renal failure?

    • Hyperkalemia

    • Hypernatremia

    • Hypercalcemia

    • Hypermagnesemia

    Correct Answer
    A. Hyperkalemia
  • 6. 

    What is the mechanism of action of Dantrolene?

    • Centrally acting analeptic that selectively increases minute ventilation by activating the carotid bodies

    • Causes cortical arousal and delay of fatigue.

    • Direct action on excitation-contraction coupling, presumably by decreasing the amount of calcium released from the sarcoplasmic reticulum

    • None of above

    Correct Answer
    A. Direct action on excitation-contraction coupling, presumably by decreasing the amount of calcium released from the sarcoplasmic reticulum
  • 7. 

    What is the primary glucocorticoid released by the body?

    • Aldosterone

    • Cortisol

    • Prednisolone

    • ACTH

    Correct Answer
    A. Cortisol
  • 8. 

    You are the SRNA for Mr. Guther who is having a right lobectomy today. He has no history of drug allergies, which of the following would be the most appropriate pre-op antibiotic?

    • Ampicillin

    • Cefoxitin

    • Clindamycin

    • Cefazolin

    Correct Answer
    A. Cefazolin
  • 9. 

    Lithium is most consistently used to treat…

    • Bipolar Disorder

    • Schizophrenia

    • Epilepsy

    • Parkinsons

    Correct Answer
    A. Bipolar Disorder
  • 10. 

    In order to prevent histamine release and hypotension, what dose of vancomycin should be given?

    • 1 gm PO

    • 10 mg/kg IV over 20 minutes

    • 10 mg/kg IV over 60 minutes

    • 15 mg/kg over 24 hours

    Correct Answer
    A. 10 mg/kg IV over 60 minutes
  • 11. 

    Which of the following contains a Beta-Lactam ring?

    • Tetracycline

    • Macrolides

    • Fluoroquinolones

    • Penicillins

    Correct Answer
    A. Penicillins
  • 12. 

    What is the Mechanism of Action of antipsychotic drugs (like phenothiazides and butyrophenones)?

    • Potentiate effects biogenic amines by inhibiting reuptake of norepi and serotonin thus making more available in the synaptic space

    • Blockade of dopamine D2 receptors in the basal ganglia and the limbic portions of the forebrain.

    • Selectively block the reuptake of serotonin and thus enhance serotogenic activity.

    • Converts to dopamine by dopa decarboxylase enzyme to replenish stores in the basal ganglia

    Correct Answer
    A. Blockade of dopamine D2 receptors in the basal ganglia and the limbic portions of the forebrain.
  • 13. 

    Which of the following is not a known side effect of Aminoglycosides?

    • Peptic Ulcer Disease

    • Ototoxicity

    • Nephrotoxicity

    • Skeletal Muscle Weakness

    Correct Answer
    A. Peptic Ulcer Disease
  • 14. 

    Which anti-emetic would be best to give near the end of the case to prevent PONV?

    • Dexamethasone

    • Famotidine

    • Metaclopromide

    • Odansetron

    Correct Answer
    A. Odansetron
  • 15. 

    For which patient would it be appropriate to give a test dose of Ancef?

    • Those with Renal Failure

    • Those with a PCN allergy

    • Those with history of PONV

    • Those with a Fish allergy

    Correct Answer
    A. Those with a PCN allergy
  • 16. 

    Why is Cefoxitin, a second generation cephalosporin, commonly used for GI cases?

    • Increased acitivity against gram negative bacteria

    • Broad spectrum activity against gram positive bacteria

    • Due to high resistance against beta lactamases

    • Due to inhibition of bacterial protein synthesis

    Correct Answer
    A. Increased acitivity against gram negative bacteria
  • 17. 

    Which of the following is an inhibitory neurotransmitter which is stimulated by many sedative drugs?

    • Gamma-amino butyric acid

    • Acetycholine

    • Glutamate

    • Dopamine

    Correct Answer
    A. Gamma-amino butyric acid
  • 18. 

    Which of the following should not be administered concurrently with and MAO inhibitor?

    • Fluoxetine

    • Sertraline

    • Nefazodone

    • All the above

    Correct Answer
    A. All the above
  • 19. 

    What is a severe adverse effect associated with antipsychotics, particularly Haldol?

    • Neuroleptic malignant syndrome

    • Malignant Hyperthermia

    • Status Epilepticus

    • All the Above

    Correct Answer
    A. Neuroleptic malignant syndrome
  • 20. 

    COMIC RELIEF: If you don't like to click here, then here is the link.http://www.youtube.com/watch?v=E9UXVgmbBrI

    • Ooooh, Holy niiiight..... Sweet!

    • Ya think our preceptors will start doing that to US soon?

    • Funny stuff.

    • All The Above

    Correct Answer
    A. All The Above
  • 21. 

    You are doing an outpatient pre-op assessment for a patient who is taking a tricyclic antidepressant. What pre-op instructions would you give to this patient regarding their antidepressant medication?

    • Discontinue medication 5 weeks prior to surgery

    • Continue to take medication as normal, but you will make sure to be aware of possible interactions.

    • Discontinue drug 4-6 days prior to surgery.

    • They should increase the dosage to relieve anxiety related to surgery.

    Correct Answer
    A. Continue to take medication as normal, but you will make sure to be aware of possible interactions.
  • 22. 

    You are caring for Mr. Press who is admitted to ER after having overdosed Amitriptyline. The patient appears to be suffering from psychosis due to the overdose. What medication should you administer to help treat this?

    • Naloxone 1-4 mcg/kg IV

    • Diazepam 0.1 mg/kg

    • IV infusion of Lidocaine at 1mg/min

    • Physostigmine 0.5-2 mg IV

    Correct Answer
    A. Physostigmine 0.5-2 mg IV
  • 23. 

    Antipsychotic drugs should not be administered to patients with which medical condition?

    • Asthma

    • Renal Insufficiency

    • Parkinsons

    • Schizophrenia

    Correct Answer
    A. Parkinsons
  • 24. 

    WHY does someone on steroid therapy need steroid replacement prior to surgery?

    • Because of Increase susceptibility to bacterial and fungal infections

    • Because of susceptibility to electrolyte imbalances

    • Because of the CRNA that tells me to

    • Because of Suppression of the hypothalamic-pituitary axis

    Correct Answer
    A. Because of Suppression of the hypothalamic-pituitary axis
  • 25. 

    You are the SRNA for 26 yr old Mr. Kearn who has testicular CA. He has been treated with bleomycin and today is having removal of the mass done. Will the Bleomycin affect your plan of care?

    • This drug will prolong action of succinylcholine due to depletion of pseudocholinesterase

    • This drug may cause myocardial ischemia in patients, especially if they have CAD

    • This drug may cause cardiomyopathy that is unresponsive to intotropic drugs or mechanical ventricular devices

    • This drug may cause pulmonary toxicity, you should keep your FiO2 at 30% or less.

    Correct Answer
    A. This drug may cause pulmonary toxicity, you should keep your FiO2 at 30% or less.
  • 26. 

    You are the SRNA for Mrs. Alder who is having a prosthetic heart valve placed today. She is allergic to PCN, Cephalosporins, and Sulfa drugs. Which of the following would be an appropriate pre-op antibiotic to give this patient?

    • Tetracycline

    • Cefoxitin

    • Vancomycin

    • Ciprofloxacin

    Correct Answer
    A. Vancomycin
  • 27. 

    What is the mechanism of action of Heparin?

    • Activates antithrombin III to inhibit coagulation cascade

    • Inhibits Vit K dependent reactions in Factors II, VII, X

    • Inhibition of cycloxygenase to inhibit production of thromboxane

    • Highly selective for degredation of fibrin in clots

    Correct Answer
    A. Activates antithrombin III to inhibit coagulation cascade
  • 28. 

    What is mechanism of action of Aspirin?

    • Activates antithrombin III to inhibit coagulation cascade

    • Inhibits Vit K dependent reactions in Factors II, VII, X

    • Inhibition of cycloxygenase to inhibit production of thromboxane

    • Highly selective for degredation of fibrin in clots

    Correct Answer
    A. Inhibition of cycloxygenase to inhibit production of thromboxane
  • 29. 

    If protamine is given too fast IV it may cause…

    • Anaphylaxis

    • Anticoagulation

    • Vomitting

    • Hypotension

    Correct Answer
    A. Hypotension
  • 30. 

    What is the Mechanism of Action of SSRI’s?

    • Potentiate effects biogenic amines by inhibiting reuptake of norepi and serotonin thus making more available in the synaptic space

    • Forms a stabe, irreversible complex with MAO to prevent demaination of monoamines.

    • Selectively block the reuptake of serotonin and thus enhance serotogenic activity.

    • Converts to dopamine by dopa decarboxylase enzyme to replenish stores in the basal ganglia

    Correct Answer
    A. Selectively block the reuptake of serotonin and thus enhance serotogenic activity.
  • 31. 

    What is the Mechanism of Action of tricyclic antidepressants?

    • Potentiate effects biogenic amines by inhibiting reuptake of norepi and serotonin thus making more available in the synaptic space

    • Forms a stabe, irreversible complex with MAO to prevent demaination of monoamines.

    • Selectively block the reuptake of serotonin and thus enhance serotogenic activity.

    • Converts to dopamine by dopa decarboxylase enzyme to replenish stores in the basal ganglia

    Correct Answer
    A. Potentiate effects biogenic amines by inhibiting reuptake of norepi and serotonin thus making more available in the synaptic space
  • 32. 

    You are caring for Mrs. Noopy who is having a Left BKA today. Her medication list includes Amitriptyline, Insulin, Avandia & Nexium. During surgery Mrs. Noopy becomes hypotensive and requires pharmacologic intervention. Which drug would be the best choice for this patient?

    • Ephedrine, full dose since only indirect acting sympathomimetics are safe.

    • Levophed drip, you can not use either of your standard drugs on this patient.

    • Neosynephrine, but cut dose to 1/3 due to possibility of pronounced response.

    • Just keep giving fluid boluses to control the hypotension.

    Correct Answer
    A. Neosynephrine, but cut dose to 1/3 due to possibility of pronounced response.
  • 33. 

    You are the SRNA for Hannibal Lector.  He has recently been placed on an MAO inhibitor. You ask about his diet and he tells you this about his favorite foods: Liver, fava beans, & chianti. He has a really creepy grin on his face.... What do you tell Mr. Lector?

    • Ummm, pardon me but I have to leave. (Then, RUN LIKE HELL!!)

    • That sounds very nutritionally balanced! It sounds like you are properly adhering to all dietary restrictions.

    • You need to try to cut out the wine, but your other food choices are just fine.

    • Mr. Lector I am afraid you may not eat any of those foods anymore, they are all listed as very unsafe for you.

    Correct Answer
    A. Mr. Lector I am afraid you may not eat any of those foods anymore, they are all listed as very unsafe for you.
  • 34. 

    Which of the following corticosteroids lacks mineralcorticoid properties and would be appropriate to give during neurosurgery?

    • Methylprednisolone

    • Aldosterone

    • Dexamethasone

    • Prednisolone

    Correct Answer
    A. Dexamethasone
  • 35. 

    What is an appropriate dose of protamine for a patient who has received 2,000 units of heparin?

    • 10 mg

    • 5 mg

    • 20 mg

    • 30 mg

    Correct Answer
    A. 20 mg
  • 36. 

    You are going up to the floor to do a pre-op assessment on a patient who is having wound debridement in the AM. You review the MAR and find the patient has been taking: Insulin, Gentamicin, Lansoprazole, and Lovenox (On hold this evening). Do you have any concerns regarding these medications?

    • Lovenox will still increase the risk of bleeding significantly. You should have FFP ready.

    • Gentamicin will increase the duration of nondepolarizing neuromuscular blockers.

    • Pre-op Cefazolin will cause hyperglycemia.

    • None of the above, these meds are fine.

    Correct Answer
    A. Gentamicin will increase the duration of nondepolarizing neuromuscular blockers.
  • 37. 

    What would be an appropriate starting dose of dantrolene to give to a patient weighing 56 kg to treat malignant hyperthermia?

    • 14 mg

    • 140 mg

    • 35 mg

    • 280 mg

    Correct Answer
    A. 140 mg
  • 38. 

    What is mechanism is action of Coumadin?

    • Activates antithrombin III to inhibit coagulation cascade

    • Inhibits Vit K dependent reactions in Factors II, VII, X

    • Inhibition of cycloxygenase to inhibit production of thromboxane

    • Highly selective for degredation of fibrin in clots

    Correct Answer
    A. Inhibits Vit K dependent reactions in Factors II, VII, X
  • 39. 

    Which of the following carries the risk of causing pseudomembranous colitis?

    • Cefazolin

    • Clindamycin

    • Ketonazole

    • Acyclovir

    Correct Answer
    A. Clindamycin
  • 40. 

    When should prophylocatic antibiotic be administered in relation to surgery?

    • Ideally, 3-4 hours prior to incision

    • At the same time incision is made antibiotics should be given IV

    • Immediately after surgery antibiotics are given

    • Shortly before incision is made and completed before induction

    Correct Answer
    A. Shortly before incision is made and completed before induction
  • 41. 

    What is mechanism of action of tPA?

    • Activates antithrombin III to inhibit coagulation cascade

    • Inhibits Vit K dependent reactions in Factors II, VII, X

    • Inhibition of cycloxygenase to inhibit production of thromboxane

    • Highly selective for degredation of fibrin in clots

    Correct Answer
    A. Highly selective for degredation of fibrin in clots
  • 42. 

    The majority of the bodies serotonin is stored where?

    • Pineal Body in the brain

    • In the intermediate lobe of pituitary gland

    • Enterochromaffin cells of small intestine

    • Serovessicle cells of large intestine

    Correct Answer
    A. Enterochromaffin cells of small intestine
  • 43. 

    What is the mechanism of action of Levodopa?

    • It saunters up to the hot chic at the bar, really smoothly, then softly murmurs “Hey baby, are you a parking ticket? Because you have FINE written all over you!”

    • Blockade of dopamine D2 receptors in the basal ganglia and the limbic portions of the forebrain.

    • Selectively block the reuptake of serotonin and thus enhance serotogenic activity.

    • Converts to dopamine by dopa decarboxylase enzyme to replenish stores in the basal ganglia

    Correct Answer
    A. Converts to dopamine by dopa decarboxylase enzyme to replenish stores in the basal ganglia
  • 44. 

    You are the SRNA for Mrs.Pukefest today. She has a past medical history of cataracts, DM, peripheral neuropathy, GERD,arthritis, DVT,and PONV. She is also allergic to PCN’s and Zofran. The states she afraid of having sever nausea after surgery and you give her dexamethasone at the beginning of the case to help with this. Given her past medical history, what might you be concerned about with this patient?

    • Dexamethasone may worsen her joint pain and make her more susceptible to post op pain and muscle weakness

    • Her blood glucose levels may be elevated and she will need to be checked more frequently

    • She may be more prone to post-op bleeding since the dexamethsone will potentiate the effects of the anticoagulant she takes for DVT prevention.

    • All the above.

    Correct Answer
    A. Her blood glucose levels may be elevated and she will need to be checked more frequently
  • 45. 

    You are the SRNA for Mr. Kust who is having surgery to correct a Bowel Obstruction. He has no history of drug allergies, which of the following would be the most appropriate pre-op antibiotic?

    • Cefoxitin

    • Cefazolin

    • Clindamycin

    • Vancomycin

    Correct Answer
    A. Cefoxitin
  • 46. 

    For which of the following drugs would you want to replace fluid with colloids instead of crystalloids?

    • Metronidazole

    • Doxorubicin

    • 5 – FU

    • Bleomycin

    Correct Answer
    A. Bleomycin
  • 47. 

    Anticoagulants like Heparin and Coumadin have absolutely no effect on clots already formed.

    • True

    • False

    Correct Answer
    A. True
  • 48. 

    Which of the following would not be a clinical use of steroids?

    • Pneumothorax

    • Ulcerative colitis

    • Myasthenia gravis

    • Cerebral edema

    Correct Answer
    A. Pneumothorax
  • 49. 

    What is the Mechanism of action of MAO inhibitors?

    • Potentiate effects biogenic amines by inhibiting reuptake of norepi and serotonin thus making more available in the synaptic space

    • Forms a stabe, irreversible complex with MAO to prevent demaination of monoamines.

    • Selectively block the reuptake of serotonin and thus enhance serotogenic activity.

    • Converts to dopamine by dopa decarboxylase enzyme to replenish stores in the basal ganglia

    Correct Answer
    A. Forms a stabe, irreversible complex with MAO to prevent demaination of monoamines.

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