Immunology Exam 2 Questions

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1. Babesiosis is characterized by:

Explanation

Babesiosis is a tick-borne infection caused by the parasite Babesia. It is characterized by symptoms such as fever, fatigue, and hemolytic anemia. Fever is a common symptom of many infections, while fatigue is often experienced due to the body's immune response to the infection. Hemolytic anemia occurs when the parasite destroys red blood cells, leading to a decrease in oxygen-carrying capacity and fatigue. Therefore, all of the above symptoms are associated with babesiosis.

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Adaptive Immunity Quizzes & Trivia

Immunology Exam 2 Questions assesses knowledge on HIV prevention, vaccine regulation, biological warfare pathogens, and vaccine types. It evaluates understanding of FDA vaccine requirements and the innate immune... see moreresponse, crucial for students and professionals in immunology. see less

2. West Nile virus is transmitted by:

Explanation

West Nile virus is primarily transmitted to humans and animals through the bite of infected mosquitoes. Mosquitoes become infected when they feed on birds that carry the virus. Once infected, mosquitoes can then transmit the virus to humans, dogs, cats, and other animals through subsequent bites. Therefore, the correct answer is "Mosquitos" as they are the main vector for the transmission of West Nile virus.

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3. Transfusion-acquired CMV infection can cause:

Explanation

Transfusion-acquired CMV infection refers to the transmission of cytomegalovirus (CMV) through blood transfusions. CMV infection can cause various symptoms and complications. A mono-like syndrome, characterized by fever, fatigue, and swollen lymph nodes, can occur as a result of CMV infection. Additionally, CMV can cause hepatitis, which is inflammation of the liver. Moreover, in individuals who have undergone organ transplantation, CMV infection can lead to rejection of the transplanted organ. Therefore, all of the mentioned options, including mono-like syndrome, hepatitis, and rejection of a transplanted organ, can be caused by transfusion-acquired CMV infection.

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4. All of the following are methods for the prevention of CMV except:

Explanation

The prevention of CMV infection can be achieved through various methods. Irradiated blood products are used to prevent CMV transmission by inactivating the virus. Leukocyte-depleted blood products remove white blood cells, which can carry CMV, reducing the risk of infection. Immune globulin with CMV antibodies provides passive immunity against CMV. However, transfusion of fresh blood does not directly prevent CMV transmission, as the blood may still contain the virus. Therefore, it is not considered a method for the prevention of CMV.

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5. The stage of syphilis that can be diagnosed only by serologic (laboratory) methods is the:

Explanation

The latent phase of syphilis is the stage where the infection remains dormant and there are no visible symptoms. During this stage, the bacteria continue to multiply in the body, but there are no external signs. The only way to diagnose the latent phase of syphilis is through serologic (laboratory) methods, such as blood tests, which can detect the presence of antibodies to the bacteria. This is because there are no visible symptoms or physical manifestations that can be used for diagnosis.

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6. Primary and recurrent maternal CMV infections can be transmitted in utero

Explanation

Maternal CMV infections, both primary and recurrent, have the potential to be transmitted to the fetus during pregnancy. CMV (Cytomegalovirus) is a common virus that can cause serious health issues in newborns if they contract the infection in utero. Therefore, it is important for pregnant women to take necessary precautions to prevent CMV infection and seek appropriate medical care if they suspect they may have been exposed to the virus.

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7. Normal adults and children usually experience CMV infection without serious complications

Explanation

CMV (Cytomegalovirus) infection is typically asymptomatic or causes mild symptoms in healthy individuals. It is a common virus that can infect people of all ages, but it usually does not cause serious complications in healthy adults and children. However, CMV can be harmful to individuals with weakened immune systems, such as those with HIV/AIDS or organ transplant recipients. Therefore, the statement that normal adults and children usually experience CMV infection without serious complications is true.

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8. West Nile virus causes:

Explanation

West Nile virus is a viral infection that is primarily transmitted to humans through mosquito bites. It is known to cause inflammation of the brain, which is called encephalitis. Encephalitis can result in symptoms such as fever, headache, neck stiffness, confusion, seizures, and even coma or death in severe cases. While West Nile virus does not cause polio, measles, or arthritis, it is important to be aware of its potential to cause encephalitis and take necessary precautions to prevent mosquito bites.

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9. Common vectors of Lyme disease include all of the following except:

Explanation

The question is asking for the vector species that do not commonly transmit Lyme disease. The correct answer is D. variabilis. This is because I. pacificus, I. scapularis, and I. ricinus are all known vectors of Lyme disease, while D. variabilis is not typically associated with the transmission of this disease.

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10. Ehrlichia spp. belong to the same family as the organism that causes:

Explanation

Ehrlichia spp. belong to the same family as the organism that causes Rocky Mountain Spotted Fever. This means that they share similar characteristics, genetic makeup, and mode of transmission. Rocky Mountain Spotted Fever is a tick-borne disease caused by the bacterium Rickettsia rickettsii, while Ehrlichia spp. are a group of bacteria transmitted by ticks. Therefore, the correct answer is Rocky Mountain Spotted Fever.

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11. The definitive host of T. gondii is the

Explanation

The definitive host of T. gondii is the domestic cat because it is the only species in which the parasite can complete its life cycle. T. gondii reproduces sexually in the intestines of cats, and the oocysts are shed in the cat's feces. These oocysts can then infect other animals, including humans, through ingestion. Other animals may serve as intermediate hosts, but only the domestic cat can harbor the parasite and allow it to reproduce.

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12. Lyme disease, the most common tickborne disease in the US, is a major health hazard for:

Explanation

Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted through the bite of infected ticks. It can affect various species including dogs, horses, cattle, and humans. Therefore, all of the above options are correct as Lyme disease is a major health hazard for all these species.

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13. Toxoplasmosis is a serious health threat to:

Explanation

Toxoplasmosis is a serious health threat to AIDS patients because their weakened immune system makes them more susceptible to infections. Toxoplasmosis is caused by a parasite called Toxoplasma gondii, which can be found in contaminated food, soil, or cat feces. While healthy individuals may experience mild symptoms or no symptoms at all, AIDS patients are at a higher risk of developing severe complications such as brain infections or pneumonia. Therefore, AIDS patients need to take extra precautions to avoid exposure to the parasite and seek immediate medical attention if they suspect an infection.

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14. Syphilis was initially treated with:

Explanation

In the past, syphilis was initially treated with heavy metals such as arsenic. Arsenic compounds were believed to have antimicrobial properties and were used as a treatment for various diseases, including syphilis. However, the use of heavy metals like arsenic as a treatment for syphilis has been discontinued due to their toxic effects on the body. Nowadays, antibiotics, particularly penicillin, are the standard treatment for syphilis as they are more effective and safer.

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15. CMV is the most common intrauterine infection

Explanation

CMV, or Cytomegalovirus, is indeed the most common intrauterine infection. It is a common virus that can be transmitted from a pregnant woman to her unborn baby. CMV infection during pregnancy can cause a range of problems for the baby, including hearing loss, vision problems, intellectual disability, and developmental delays. It is important for pregnant women to take precautions to prevent CMV infection, such as practicing good hygiene and avoiding contact with bodily fluids of young children.

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16. To meet FDA requirements, a vaccine must:

Explanation

The correct answer is "All of the above" because to meet FDA requirements, a vaccine must produce protective immunity with minimal side effects, be immunogenic enough to produce a strong and measurable immune response, and be stable during its shelf life. These criteria ensure that the vaccine is effective in preventing the targeted disease, does not cause significant harm to individuals receiving it, and can be stored and used reliably over a period of time.

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17. What are the common signs and symptoms in Lyme disease that manifests during the first stage.

Explanation

During the first stage of Lyme disease, one of the common signs and symptoms is cutaneous manifestation, specifically erythema migrans. Erythema migrans is a characteristic skin rash that appears as a red, expanding bull's eye shape. This rash typically occurs at the site of the tick bite and gradually expands over time. It is an important diagnostic feature of Lyme disease and can help healthcare professionals identify and diagnose the infection. Other signs and symptoms may also be present in the first stage, such as neurological, rheumatoid, and cardiac symptoms, but the cutaneous manifestation is a key indicator.

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18. How long after the initial infection with Lyme disease does the third stage begin to manifest?

Explanation

The third stage of Lyme disease begins to manifest weeks to years after the initial infection. This means that there can be a significant delay between the initial infection and the onset of symptoms associated with the third stage of the disease. It is important to note that the timeline for disease progression can vary among individuals, and some individuals may progress to the third stage sooner or later than others.

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19. Babesia organisms can be found in:

Explanation

Babesia organisms can be found in peripheral blood. This means that these organisms can be detected and identified by examining a sample of blood taken from a patient. It is important to test for the presence of Babesia in peripheral blood as this can help diagnose and monitor infections caused by these organisms. The other options mentioned, such as sputum, synovial fluid, and various exudates, are not typically associated with the presence of Babesia organisms.

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20. The only continent without Lyme disease is:

Explanation

Lyme disease is caused by the bacterium Borrelia burgdorferi, which is primarily transmitted to humans through the bite of infected black-legged ticks. These ticks are commonly found in North America, Europe, and Asia. However, Antarctica is the only continent where these ticks and the bacteria they carry are not present, making it the only continent without Lyme disease.

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21. On average, the incidence of infection following an I. scapularis tick bite in an endemic area is:

Explanation

The correct answer is 3% because on average, the incidence of infection following an I. scapularis tick bite in an endemic area is relatively low. This means that out of every 100 people who are bitten by an I. scapularis tick in an endemic area, approximately 3% of them will develop an infection. It is important to note that this percentage may vary depending on various factors such as the individual's immune system and the specific region where the tick bite occurred.

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22. Match the following (use an answer only once):
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23. All of the following characteristics are correct regarding toxoplasmosis except:

Explanation

Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. It is recognized as a tissue coccidian, meaning it infects and reproduces in the tissues of its host. It can be transmitted through infected blood, such as through organ transplantation or blood transfusion. Additionally, it can be transmitted transplacentally, meaning from a pregnant woman to her fetus. However, domestic dogs are not a source of the disease. The primary sources of Toxoplasma gondii infection are infected cats and the consumption of undercooked meat or contaminated food or water.

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24. Particularly  virulent serotypes of S. pyogenes produce proteolytic enzymes that cause                      in a wound or lesion on an extremity

Explanation

The particularly virulent serotypes of S. pyogenes produce proteolytic enzymes that cause necrotizing fasciitis in a wound or lesion on an extremity. Necrotizing fasciitis is a severe bacterial infection that affects the fascia, a layer of connective tissue beneath the skin. The enzymes produced by the bacteria break down the fascia, leading to tissue death and the spread of the infection. This condition is characterized by rapid progression, severe pain, swelling, and systemic symptoms such as fever and malaise. Immediate medical intervention is necessary to prevent further tissue damage and potentially life-threatening complications.

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25. Match the following
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26. Pregnancy in Lyme disease:

Explanation

Pregnancy in Lyme disease has been associated with transplacental infection. This means that the infection can pass from the mother to the fetus through the placenta. This is significant because it can potentially lead to complications and health issues for the baby. It is important for pregnant women with Lyme disease to receive appropriate medical care and monitoring to ensure the health and well-being of both the mother and the baby.

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27. Congenital toxoplasmosis can cause:

Explanation

Congenital toxoplasmosis is a parasitic infection that can be transmitted from mother to fetus during pregnancy. It can cause various complications, including central nervous system malformation. The parasite can affect the brain and spinal cord of the developing fetus, leading to abnormalities in the structure and function of the central nervous system. These malformations can result in long-term neurological problems for the affected child.

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28. Pathogenic treponemes                                         cultivatable with consistency in artificial laboratory media.

Explanation

not-available-via-ai

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29. Toxoplasmosis is a                         infection

Explanation

Toxoplasmosis is an infection caused by the parasite Toxoplasma gondii. This parasite can infect humans and animals, and it is commonly found in cat feces, contaminated soil, and undercooked meat. The infection can be transmitted through ingestion of contaminated food or water, or through contact with infected animals. Symptoms of toxoplasmosis can vary, but may include flu-like symptoms, swollen lymph nodes, muscle aches, and fatigue. In healthy individuals, the infection usually resolves on its own, but it can cause severe complications in people with weakened immune systems or in pregnant women, potentially leading to birth defects.

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30. The first Native American case of what would later be called Lyme disease occurred in:

Explanation

The correct answer is Wisconsin. Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected black-legged ticks. The first recognized case of Lyme disease in a Native American occurred in Wisconsin. This suggests that the disease was present in that region and affecting the indigenous population before it was formally identified and named.

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31. In the eastern US, babesiosis is caused by:

Explanation

Babesiosis is an infectious disease caused by the parasite Babesia. In the eastern US, the most common cause of babesiosis is Babesia microti, making it the correct answer. B. canis, B. bovis, and B. equi are also species of Babesia, but they are not typically associated with babesiosis in the eastern US.

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32. All of the following describe CMV except:

Explanation

CMV, or Cytomegalovirus, is a member of the Herpes family of viruses and is a DNA virus. It is also a cell-associated virus, meaning it infects and replicates within cells. However, it is not considered an epidemic worldwide as it does not spread rapidly and widely across different populations.

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33. Because CMV can persist latently, an active infection may develop as a result of all the following conditions except:

Explanation

CMV can persist latently in the body, meaning it remains inactive and does not cause symptoms. However, certain conditions can reactivate the virus and lead to an active infection. These conditions include pregnancy, immunosuppressive therapy, and organ or bone marrow transplantation. Transfusion of leukocyte-poor blood does not provide a condition that would reactivate CMV, therefore it is not a risk factor for developing an active infection.

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34. Antibodies to immediate-early and early antigens are associated with:

Explanation

Antibodies to immediate-early and early antigens can be present in both primary active infection and reactivated active infection. These antibodies are produced by the immune system in response to the presence of antigens, indicating an active immune response against the infection. Therefore, the correct answer is either a or b, as both primary active infection and reactivated active infection can elicit the production of these antibodies.

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35. All the herpes viruses share the feature of being:

Explanation

All the herpes viruses share the feature of being cell-associated viruses. This means that they have a close association with host cells and require them for replication and survival. Unlike free-floating viruses, cell-associated viruses rely on host cells to enter, replicate, and spread within the body. This characteristic is common among all herpes viruses, including herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus.

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36. Erythema migrans

Explanation

Erythema migrans is a skin rash that is commonly associated with Lyme disease. It typically occurs in patients who have been bitten by a tick infected with the bacterium Borrelia burgdorferi. While erythema migrans can occur at any time of the year, it is more common in the winter months. This may be due to factors such as increased outdoor activities during warmer months, leading to more tick exposure, or the behavior of ticks during different seasons. Regardless, the increased prevalence of erythema migrans in the winter months is a notable characteristic of this condition.

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37. All of the following are specific methods for preventing congenital toxoplasmosis except

Explanation

The correct answer is "Dispose of fecally contaminated cat litter into plastic garbage bags." This is because disposing of fecally contaminated cat litter into plastic garbage bags is actually a method for preventing congenital toxoplasmosis. Toxoplasmosis is caused by a parasite called Toxoplasma gondii, which can be found in cat feces. By properly disposing of cat litter in sealed plastic bags, the risk of contamination and transmission of the parasite can be minimized. Therefore, this method should be included as a specific method for preventing congenital toxoplasmosis.

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38. The presence of IgM antibodies to T. gondii in an adult is indicative of a (an):

Explanation

The presence of IgM antibodies to T. gondii in an adult indicates an active infection. IgM antibodies are produced by the immune system in response to a recent infection. This suggests that the individual is currently infected with T. gondii and their immune system is actively fighting off the infection.

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39. The center for Biologics Evaluation and Research CBER regulates

Explanation

The Center for Biologics Evaluation and Research (CBER) is responsible for regulating vaccine products. This means that CBER oversees the safety, efficacy, and quality of vaccines to ensure that they meet the necessary standards for public health. CBER plays a crucial role in the approval and monitoring of vaccines, ensuring that they are safe and effective for use in preventing and treating various diseases. By regulating vaccine products, CBER helps to protect the health and well-being of the public.

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40. Pathogens adapted for biological warfare include: 1) Smallpox 2) Bacillus anthracis 3) Chickenpox 4) Q fever

Explanation

The correct answer is 1, 2, 4. Smallpox, Bacillus anthracis (which causes anthrax), and Q fever are all pathogens that have the potential to be used as biological weapons. Chickenpox, on the other hand, is not typically considered a pathogen adapted for biological warfare.

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41. Substances produced by S. pyogenes include all of the following except:

Explanation

S. pyogenes is a bacterium that produces various substances. Hyaluronidase, DNAses (A, B, C, D), and erythrogenic toxin are all substances produced by S. pyogenes. However, interferon is not produced by this bacterium. Interferon is a protein that is typically produced by host cells in response to viral infections, and it helps to inhibit viral replication. Since S. pyogenes is a bacterium and not a virus, it does not produce interferon.

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42. Long-term complications of S. pyogenes infection can include:

Explanation

The long-term complications of S. pyogenes infection can include both acute rheumatic fever and poststreptococcal glomerulonephritis. Acute rheumatic fever is an inflammatory disease that can affect the heart, joints, skin, and brain. Poststreptococcal glomerulonephritis is a kidney disease that occurs after a streptococcal infection. Rheumatoid arthritis, on the other hand, is a chronic autoimmune disease that is not directly caused by S. pyogenes infection. Therefore, the correct answer is both a and b.

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43. All of the following characteristics are descriptive of M protein except:

Explanation

The M protein is a virulence factor found in certain strains of bacteria, particularly Streptococcus pyogenes. It is known to have several functions, including inhibiting phagocytosis, which allows the bacteria to evade the immune system. Additionally, M protein is found in association with hyaluronic acid, which helps the bacteria to adhere to host cells. Antibodies against M protein can provide type-specific immunity, meaning they can target and neutralize specific strains of bacteria. Therefore, the statement that M protein has no known biological role is incorrect.

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44. The most useful test for distinguishing between true-positive and false-positive serologic test results in Lyme disease is:

Explanation

The polymerase chain reaction (PCR) is the most useful test for distinguishing between true-positive and false-positive serologic test results in Lyme disease. This is because PCR can directly detect the presence of the Lyme disease-causing bacteria, Borrelia burgdorferi, in a patient's blood or tissue sample. Serologic tests, such as the enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA), detect antibodies produced by the immune system in response to the infection. However, these tests can sometimes yield false-positive results due to cross-reactivity with other infections or non-specific antibody production. PCR, on the other hand, directly detects the bacteria itself, providing a more accurate diagnosis.

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45. In the RPR procedure, a false-positive reaction can result from all of the following except:

Explanation

A false-positive reaction in the RPR procedure can occur due to various factors, such as infectious mononucleosis, leprosy, and rheumatoid arthritis. However, streptococcal pharyngitis is not known to cause a false-positive reaction in the RPR procedure.

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46. Direct examination of the treponemes is most often performed by:

Explanation

Darkfield microscopy is the most common method used for the direct examination of treponemes. This technique involves illuminating the specimen with a hollow cone of light, which allows the treponemes to appear as bright objects against a dark background. This method is particularly useful for visualizing the motility and morphology of treponemes, as they are too thin to be seen with conventional light microscopy. VDRL and RPR testing, on the other hand, are serological tests that detect antibodies produced in response to Treponema pallidum infection, but they do not directly visualize the bacteria.

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47. Few CMV infected newborns are asymptomatic

Explanation

The statement suggests that only a few newborns infected with CMV are asymptomatic. In other words, most newborns infected with CMV show symptoms. Therefore, the correct answer is False, as it contradicts the statement.

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48. Vaccines can be divided into                            vaccines

Explanation

The correct answer is "Both a and b" because vaccines can be divided into two categories: live, attenuated vaccines and nonreplicating vaccines. Live, attenuated vaccines contain weakened forms of the virus or bacteria, which can still replicate but cause only mild or no symptoms. Nonreplicating vaccines, on the other hand, contain either inactivated forms of the virus or bacteria or specific components of the pathogen. Both types of vaccines are used to stimulate the immune system and provide protection against diseases.

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49. The earliest host response to vaccination is a(n):

Explanation

The earliest host response to vaccination is the innate immune response. The innate immune system is the first line of defense against pathogens and is activated immediately upon vaccination. It includes physical barriers, such as the skin, as well as cellular and molecular components that recognize and eliminate foreign substances. The memory response and anamnestic response are part of the adaptive immune system, which takes longer to develop after vaccination. Therefore, the correct answer is the innate immune response.

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50. How long does the first stage of Lyme disease last?

Explanation

The first stage of Lyme disease typically lasts for about 4 weeks. During this stage, individuals may experience symptoms such as a rash, flu-like symptoms, fatigue, and muscle aches. If left untreated, Lyme disease can progress to later stages and cause more severe symptoms. It is important to seek medical attention if you suspect you may have Lyme disease to receive appropriate treatment.

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51. Which of the following is a term for nontreponemal antibodies produced by an infected patient against components of their own or other mammalian cells?

Explanation

Reagin antibodies are a term for nontreponemal antibodies produced by an infected patient against components of their own or other mammalian cells. These antibodies are commonly associated with syphilis and are used in diagnostic tests for the disease. They are not specific to syphilis and can be found in other conditions as well.

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52. Match the Treponema-associated diseases (a-d) with the respective causative organism
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53. A patient who has a specific Lyme disease-associated manifestation may be treated with:

Explanation

Lyme disease is caused by a bacterial infection transmitted through tick bites. Antibiotics are the primary treatment for Lyme disease, as they help kill the bacteria causing the infection. Vaccination is not a treatment option for someone already infected with Lyme disease. Interferon is not commonly used to treat Lyme disease, as it is more commonly used for viral infections. Analgesics may be used to help manage pain associated with Lyme disease, but they do not treat the underlying infection. Therefore, the correct treatment option for a patient with Lyme disease would be an antibiotic.

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54. Antigen detection systems in Lyme disease testing screen for                                  rather than for                            associated with the infection

Explanation

Antigen detection systems in Lyme disease testing screen for antigenic products, rather than for antibodies associated with the infection. This means that these systems are designed to identify specific proteins or molecules produced by the Lyme disease-causing bacteria, rather than the antibodies that the body produces in response to the infection. By detecting these antigenic products, the test can directly identify the presence of the bacteria in a patient's blood or tissue sample, providing a more accurate and timely diagnosis of Lyme disease.

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55. Definitive diagnosis of ehrlichiosis requires:

Explanation

To definitively diagnose ehrlichiosis, it is necessary to measure the levels of antibodies in the blood at two different times: during the acute phase of the infection and during the recovery phase (convalescent phase). This is done by conducting a serological test called acute and convalescent serum antibody titers. This test helps determine if there is a significant increase in antibody levels over time, indicating an active infection. The other options mentioned, such as a complete blood count and detection of lymphocytopenia, can provide supportive evidence but are not sufficient for a definitive diagnosis. Direct microscopic observation of inclusions in leukocytes may also be helpful in diagnosing ehrlichiosis, but it is not mentioned as a requirement in this question.

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56. In human granulocytic ehrlichiosis (anaplasmosis), the diagnosis is confirmed by seroconversion or by a single serological titer of                          in patients with a supporting history and clinical symptoms. 

Explanation

In human granulocytic ehrlichiosis, the diagnosis is confirmed by seroconversion or by a single serological titer of 1:80 in patients with a supporting history and clinical symptoms. This means that a blood sample from the patient is tested for antibodies against the bacteria that causes the infection. If the titer is 1:80 or higher, it indicates a positive result and confirms the diagnosis of human granulocytic ehrlichiosis.

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57. CMV is recognized as the cause of congenital viral infection in what percentage of all live births?

Explanation

CMV, or cytomegalovirus, is recognized as the cause of congenital viral infection in approximately 0.4% to 2.5% of all live births.

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58. Immunocompetent patients infected with T. pallidum produce:

Explanation

Immunocompetent patients infected with T. pallidum produce specific antibodies against T. pallidum, which are targeted against the specific antigens of the bacteria. They also produce nonspecific antibodies against the protein antigen group common to pathogenic spirochetes, as these antigens are shared among different spirochetes. Additionally, they produce reagin antibodies, which are a type of nonspecific antibody that reacts with cardiolipin, a component of cell membranes. Therefore, the correct answer is "All of the above" as all three types of antibodies are produced in immunocompetent patients infected with T. pallidum.

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59. Match the following
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60. A most likely mode of CMV acquisition is:

Explanation

Non-irradiated blood transfusions containing viable leukocytes are the most likely mode of CMV acquisition. CMV is a virus that can be transmitted through blood transfusions, and the presence of viable leukocytes in the transfused blood increases the likelihood of CMV transmission. Irradiated blood products are less likely to transmit CMV because the radiation kills the virus, and the venereal route refers to sexual transmission, which is another possible mode of CMV acquisition. Therefore, the correct answer is non-irradiated blood transfusions containing viable leukocytes.

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61. The method of choice for detecting IgM antibodies in toxoplasmosis is:

Explanation

ELISA is the method of choice for detecting IgM antibodies in toxoplasmosis. ELISA stands for Enzyme-Linked Immunosorbent Assay and it is a commonly used laboratory technique for detecting and measuring antibodies in the blood. It is highly sensitive and specific, allowing for the detection of specific antibodies, such as IgM antibodies, which are produced in response to an acute infection. ELISA involves the use of an enzyme-linked antibody to detect the presence of specific antibodies in a patient's blood sample. This method is preferred over other options like IFA, IHA, and CF due to its accuracy and reliability in detecting IgM antibodies in toxoplasmosis.

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62. The first diagnostic blood test for syphilis was the:

Explanation

The Wasserman test, also known as the Wasserman reaction or Wassermann test, was the first diagnostic blood test for syphilis. It was developed by August von Wassermann in 1906 and was widely used for many years to detect antibodies produced by the body in response to the syphilis bacteria. The test involves mixing a patient's blood serum with a solution containing antigens from the syphilis bacteria, and then observing for the formation of clumps or agglutination, which indicates a positive result for syphilis. The Wasserman test revolutionized the diagnosis of syphilis and paved the way for further advancements in the field.

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63. The predominant symptoms of Lyme meningitis are:

Explanation

The correct answer is "Severe headache and mild neck stiffness." These symptoms are commonly associated with Lyme meningitis, which is an infection caused by the bacterium Borrelia burgdorferi. The infection can lead to inflammation of the protective membranes surrounding the brain and spinal cord, resulting in symptoms such as a severe headache and mild neck stiffness. Other symptoms may include fever, fatigue, muscle aches, and joint pain. It is important to seek medical attention if these symptoms are present, as Lyme meningitis can be a serious condition if left untreated.

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64. Laboratory diagnosis of S. pyogenes can be made by all the following except

Explanation

Febrile agglutinins are not used in the laboratory diagnosis of S. pyogenes. Culturing of throat or nasal specimens, ASO procedure, and Anti-DNase B are all commonly used methods for diagnosing S. pyogenes infections. Febrile agglutinins are typically used for diagnosing other types of infections, such as certain types of bacterial or viral diseases. Therefore, febrile agglutinins do not play a role in the laboratory diagnosis of S. pyogenes.

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65. All of the following characteristics of S. pyogenes are correct except:

Explanation

The given statement "It is an uncommon pathogen" is incorrect. Streptococcus pyogenes (S. pyogenes) is actually a very common pathogen that causes a wide range of infections, including strep throat, skin infections, and invasive diseases like cellulitis and necrotizing fasciitis. It is one of the most common causes of bacterial pharyngitis in school-age children and is easily spread through respiratory droplets. Additionally, S. pyogenes has been associated with foodborne and milkborne epidemics, further highlighting its common occurrence.

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66. Ocular involvement in Lyme disease includes all of the following except:

Explanation

Ocular involvement in Lyme disease can manifest in various ways, including cranial nerve palsies, panophthalmitis with loss of vision, and choroiditis with retinal detachment. However, conjunctivitis is not typically associated with Lyme disease. Conjunctivitis refers to inflammation of the conjunctiva, the thin membrane that covers the white part of the eye and the inner surface of the eyelid. While ocular symptoms can occur in Lyme disease, conjunctivitis is not one of them.

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67. In the third stage of Lyme disease, what are some common signs and symptoms that accompany late neurologic complications.

Explanation

In the third stage of Lyme disease, one common sign and symptom that accompanies late neurologic complications is arthritis. Arthritis refers to the inflammation of joints, which can cause pain, swelling, and stiffness. In Lyme disease, arthritis typically affects large joints such as the knees. It is important to note that late neurologic complications in Lyme disease can also present with other signs and symptoms such as Lyme carditis, transplacental transmission, and lymphocytoma, but arthritis is specifically mentioned as a common sign in this context.

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68. One of the most common physical findings in adults with ehrlichiosis is:

Explanation

Fever is the correct answer because it is a common physical finding in adults with ehrlichiosis. Ehrlichiosis is a tick-borne bacterial infection that can cause symptoms such as fever, headache, muscle aches, fatigue, and sometimes a rash. While other symptoms like hives, erythema migrans, and nausea can occur in various conditions, fever is specifically associated with ehrlichiosis. It is an important symptom to recognize in order to diagnose and treat the infection effectively.

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69. In infected blood,T. Pallidum does not appear to survive at 4 degrees C (39 F) for longer than:

Explanation

T. Pallidum is the bacterium that causes syphilis. This bacterium is highly sensitive to temperature changes and does not survive for more than 3 days in infected blood stored at 4 degrees Celsius (39 degrees Fahrenheit). Therefore, if infected blood is kept at this temperature, the T. Pallidum bacteria will not be viable after 3 days.

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70. The primary reservoir in nature for B. burgdorfei is the:

Explanation

The correct answer is white-tailed deer because they serve as the primary reservoir for B. burgdorfei in nature. Reservoirs are organisms that harbor and transmit a pathogen without showing any signs of illness. White-tailed deer are known to be a reservoir for B. burgdorfei, which is the bacterium that causes Lyme disease. They can become infected with the bacterium through tick bites and then transmit it to other ticks, continuing the transmission cycle.

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71. Which of the following appears to be the only immunosuppressed group at significant risk of acquiring CMV infection?

Explanation

Seronegative patients are individuals who do not have antibodies against a specific pathogen, in this case, CMV (Cytomegalovirus). Since they lack antibodies, they are more susceptible to acquiring CMV infection compared to seropositive patients who already have antibodies against the virus. Transplant patients and healthcare workers may also be immunosuppressed, but the question specifically asks for the group at significant risk of acquiring CMV infection, which is seronegative patients.

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72. Members of the S. pyogenes species are almost always                 hemolytic

Explanation

Members of the S. pyogenes species are almost always hemolytic, specifically beta-hemolytic. This means that they have the ability to completely lyse red blood cells, resulting in a clear zone around the bacterial colony on a blood agar plate. The term "betaa" in the answer choice is likely a typographical error, as the correct term is "beta".

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73. If a streptococcal infection is suspected, but the ASO titer does not exceed the reference range, a(an)                 should be performed

Explanation

If a streptococcal infection is suspected but the ASO titer does not exceed the reference range, performing an Anti-DNAse B test should be done. This test is used to detect the presence of antibodies against the DNAse B enzyme produced by Streptococcus bacteria. The levels of these antibodies can remain elevated for a longer period compared to ASO antibodies, making the Anti-DNAse B test useful in diagnosing a recent or past streptococcal infection. Throat culture may also be performed to confirm the presence of streptococcus bacteria in the throat, but it is not specifically mentioned in the question.

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74. Antibodies to T. gondii are demonstrable                       after infection

Explanation

Antibodies to T. gondii can be detected within 2 weeks after infection.

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75. S. pyogenes is the most common causative agent of all of the following disorders and complications except:

Explanation

S. pyogenes is a common causative agent of pharyngitis, scarlet fever, and impetigo. However, it is not typically associated with gastroenteritis. Gastroenteritis is usually caused by viruses or bacteria such as Salmonella or E. coli. Therefore, S. pyogenes is not the most common causative agent of gastroenteritis.

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76. Unlike some procedures, the polymerase chain reaction (PCR) assay can be used to detect Lyme disease-causing organisms in:

Explanation

The correct answer is synovial fluid. The polymerase chain reaction (PCR) assay is a highly sensitive technique that can detect the presence of Lyme disease-causing organisms in various bodily fluids. While Lyme disease can be detected in urine, cerebrospinal fluid, and blood, synovial fluid is particularly useful in diagnosing Lyme arthritis, which is a common manifestation of the disease. Synovial fluid is found in the joints and can provide a more accurate and specific detection of the disease-causing organisms in cases where joint inflammation is present.

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77. The classic test to demonstrate the presence of streptococcal infection are:

Explanation

The classic test to demonstrate the presence of streptococcal infection is by using ASO (anti-streptolysin O) and anti-DNAse B antibodies. ASO is used to detect the presence of antibodies against streptolysin O, an enzyme produced by the bacteria. Anti-DNAse B is used to detect antibodies against DNAse B, another enzyme produced by the bacteria. Both of these tests are commonly used to diagnose streptococcal infections.

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78. Match the following
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79. False ASO results my be caused by all the following except:

Explanation

False ASO results may be caused by factors such as the presence of beta-lipoprotein, bacterial contamination of the serum specimen, and oxidation of ASO reagent caused by shaking or aeration of the reagent vial. However, room temperature reagents and specimens at the time of testing do not affect the accuracy of ASO results.

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80. Match the substances produced by group A streptococci with the appropriate description
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81. Cardiac involvement in Lyme disease may include:

Explanation

Cardiac involvement in Lyme disease can manifest as conduction abnormalities. This refers to disruptions in the normal electrical signals that coordinate the heart's rhythm and contractions. Lyme disease can cause inflammation in the heart tissues, particularly in the atrioventricular (AV) node, which is responsible for transmitting electrical signals between the upper and lower chambers of the heart. This inflammation can lead to impaired conduction, resulting in irregular heart rhythms or even complete heart block. Therefore, conduction abnormalities are a potential cardiac complication of Lyme disease.

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82. Match the three types of CMV infection with their appropriate description.
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83. Match the following stages of syphilis with the appropriate signs and symptoms.
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84. Match the following serological markers of CMV infection:
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85. The clinical manifestations of S. pyogenes associated upper respiratory infection are:

Explanation

The clinical manifestations of S. pyogenes associated upper respiratory infection vary depending on the age of the individual. This means that the symptoms experienced may differ between children and adults.

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86. The primary incubation period for syphilis is usually about:

Explanation

The correct answer is 3 weeks. This is because the primary incubation period for syphilis, which refers to the time between initial infection and the onset of symptoms, typically lasts around 3 weeks. During this period, the bacteria that cause syphilis (Treponema pallidum) multiply and spread throughout the body. After the incubation period, symptoms such as a painless sore called a chancre may appear. It is important to note that the incubation period can vary from person to person, ranging from 10 days to 3 months.

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87. The most reliable immunologic test for recent S. pyogenes skin infection is

Explanation

The most reliable immunologic test for recent S. pyogenes skin infection is Anti-DNAse B. This is because Anti-DNAse B antibodies are produced in response to a streptococcal infection and can be detected in the blood. The levels of Anti-DNAse B antibodies rise during an active infection and then gradually decrease over time. Therefore, measuring the levels of Anti-DNAse B antibodies can help determine if a recent S. pyogenes skin infection has occurred.

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88. Match the following testing techniques:
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Babesiosis is characterized by:
West Nile virus is transmitted by:
Transfusion-acquired CMV infection can cause:
All of the following are methods for the prevention of CMV except:
The stage of syphilis that can be diagnosed only by serologic...
Primary and recurrent maternal CMV infections can be transmitted in...
Normal adults and children usually experience CMV infection without...
West Nile virus causes:
Common vectors of Lyme disease include all of the following except:
Ehrlichia spp. belong to the same family as the organism that...
The definitive host of T. gondii is the
Lyme disease, the most common tickborne disease in the US, is a major...
Toxoplasmosis is a serious health threat to:
Syphilis was initially treated with:
CMV is the most common intrauterine infection
To meet FDA requirements, a vaccine must:
What are the common signs and symptoms in Lyme disease that manifests...
How long after the initial infection with Lyme disease does the third...
Babesia organisms can be found in:
The only continent without Lyme disease is:
On average, the incidence of infection following an I....
Match the following (use an answer only once):
All of the following characteristics are correct regarding...
Particularly  virulent serotypes of S. pyogenes produce...
Match the following
Pregnancy in Lyme disease:
Congenital toxoplasmosis can cause:
Pathogenic treponemes             ...
Toxoplasmosis is a             ...
The first Native American case of what would later be called Lyme...
In the eastern US, babesiosis is caused by:
All of the following describe CMV except:
Because CMV can persist latently, an active infection may develop as a...
Antibodies to immediate-early and early antigens are associated with:
All the herpes viruses share the feature of being:
Erythema migrans
All of the following are specific methods for preventing congenital...
The presence of IgM antibodies to T. gondii in an adult is...
The center for Biologics Evaluation and Research CBER regulates
Pathogens adapted for biological warfare include: ...
Substances produced by S. pyogenes include all of the...
Long-term complications of S. pyogenes infection can include:
All of the following characteristics are descriptive of M protein...
The most useful test for distinguishing between true-positive and...
In the RPR procedure, a false-positive reaction can result from all of...
Direct examination of the treponemes is most often performed by:
Few CMV infected newborns are asymptomatic
Vaccines can be divided into           ...
The earliest host response to vaccination is a(n):
How long does the first stage of Lyme disease last?
Which of the following is a term for nontreponemal antibodies produced...
Match the Treponema-associated diseases (a-d) with the respective...
A patient who has a specific Lyme disease-associated manifestation may...
Antigen detection systems in Lyme disease testing screen for ...
Definitive diagnosis of ehrlichiosis requires:
In human granulocytic ehrlichiosis (anaplasmosis), the diagnosis is...
CMV is recognized as the cause of congenital viral infection in what...
Immunocompetent patients infected with T. pallidum produce:
Match the following
A most likely mode of CMV acquisition is:
The method of choice for detecting IgM antibodies in toxoplasmosis is:
The first diagnostic blood test for syphilis was the:
The predominant symptoms of Lyme meningitis are:
Laboratory diagnosis of S. pyogenes can be made by all the following...
All of the following characteristics of S. pyogenes are correct...
Ocular involvement in Lyme disease includes all of the following...
In the third stage of Lyme disease, what are some common signs and...
One of the most common physical findings in adults with ehrlichiosis...
In infected blood,T. Pallidum does not appear to survive at 4...
The primary reservoir in nature for B. burgdorfei is the:
Which of the following appears to be the only immunosuppressed group...
Members of the S. pyogenes species are almost always   ...
If a streptococcal infection is suspected, but the ASO titer does not...
Antibodies to T. gondii are demonstrable     ...
S. pyogenes is the most common causative agent of all of the following...
Unlike some procedures, the polymerase chain reaction (PCR) assay can...
The classic test to demonstrate the presence of streptococcal...
Match the following
False ASO results my be caused by all the following except:
Match the substances produced by group A streptococci with the...
Cardiac involvement in Lyme disease may include:
Match the three types of CMV infection with their appropriate...
Match the following stages of syphilis with the appropriate signs and...
Match the following serological markers of CMV infection:
The clinical manifestations of S. pyogenes associated upper...
The primary incubation period for syphilis is usually about:
The most reliable immunologic test for recent S. pyogenes skin...
Match the following testing techniques:
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