Pharmparty Quiz
Literally, a pharmparty is a situation in which we have random exchange in prescription drugs to be toxicated. This quiz however, dwells more on the different aspects of drugs and chemical components.
- 1.Ion-trapping in the kidney
- A.
Weak acids are usually excreted slower in alkaline urine
- B.
Weak bases are usually excreted faster in acidic urine
- C.
Both
- D.
Neither
- 2.Lipid solubility and drugs
- A.
More of the weak acid drug will be in the lipid-soluble form at alkaline pH.
- B.
More of the weak acid drug will be in the lipid soluble form at acid pH.
- C.
More of the weak base drug will be in the lipid soluble form at alkaline pH
- D.
A & C
- E.
B & C
- 3.Dramatic decrease in systemic availability of a drug following oral administration is most likely due to:
- A.
Extreme drug instability at stomach pH
- B.
Hepatic "first-pass" effect
- C.
drug metabolized by gut flora
- D.
tablet does not dissolve
- E.
Patient non-complance
- 4.Increasing ionization at pH ABOVE pKa:
- A.
Weak acid
- B.
Weak base
- 5.Weak organic acid, pKa 6.5. Percent ionization at pH 7.5
- A.
1%
- B.
10%
- C.
50%
- D.
90%
- E.
99%
- 6.Drug with this ionization property most likely to diffuse from intestine (pH 8.4) to blood (pH 7.4)
- A.
Weak acid (pKa 7.4)
- B.
weak base (pKa 8.4)
- C.
Weak acid (pKa 8.4)
- D.
Weak base (pKa 6.4)
- E.
Weak acid (pKa 6.4)
- 7.Weak base at alkaline pH
- A.
Relatively lipid-soluble
- B.
Probably uncharged
- C.
Both
- D.
Neither
- 8.Factor(s) which may change intrinsic drug clearance:
- A.
Smoking
- B.
Dietary consideration
- C.
Age
- D.
Genetics
- E.
All of the above
- 9.Factor(s) influencing the volume of distribution:
- A.
Patient's gender
- B.
Patient's age
- C.
Patient's disease state
- D.
Patient's body composition
- E.
All of the above
- 10.Property/properties of phase II conjugates
- A.
Don't pick me, I am wrong (FREEEBIE!!!)
- B.
Relatively nonpolar
- C.
Generally biologically active
- D.
Rapidly excreted in the urine
- E.
All of the above
- 11.Most important organ for unchanged drug/drug metabolite elimination
- A.
Liver
- B.
Lung
- C.
Kidney
- D.
None of the above
- E.
All of the above
- 12.Absorption rate proportional to the drug concentration dissolved in the gastrointestinal tract
- A.
Zero order
- B.
First order
- C.
Neither
- D.
Both
- E.
All of the above
- 13.Drug mechanism/mechanisms which may increase the amount of cytochrome P450 enzyme
- A.
Increase enzyme degradation rate
- B.
Increase enzyme synthesis rate
- C.
Both
- D.
Neither
- E.
All of the above
- 14.Parent drug is altered by introducing or exposing a functional group such as -OH or NH2
- A.
Phase 1
- B.
Phase 2
Questions: 10 | Attempts: 43291 | Last updated: Aug 26, 2021
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