Pharmparty Quiz

14 Questions | By Dorj | Updated: Mar 22, 2022 | Attempts: 1292

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Literally, a pharmparty is a situation in which we have random exchange in prescription drugs to be toxicated. This quiz however, dwells more on the different aspects of drugs and chemical components.

Questions and Answers

1.

Ion-trapping in the kidney
- A.
  
  Weak acids are usually excreted slower in alkaline urine
- B.
  
  Weak bases are usually excreted faster in acidic urine
- C.
  
  Both
- D.
  
  Neither
2.

Lipid solubility and drugs
- A.
  
  More of the weak acid drug will be in the lipid-soluble form at alkaline pH.
- B.
  
  More of the weak acid drug will be in the lipid soluble form at acid pH.
- C.
  
  More of the weak base drug will be in the lipid soluble form at alkaline pH
- D.
  
  A & C
- E.
  
  B & C
3.

Dramatic decrease in systemic availability of a drug following oral administration is most likely due to:
- A.
  
  Extreme drug instability at stomach pH
- B.
  
  Hepatic "first-pass" effect
- C.
  
  drug metabolized by gut flora
- D.
  
  tablet does not dissolve
- E.
  
  Patient non-complance
4.

Increasing ionization at pH ABOVE pKa:
- A.
  
  Weak acid
- B.
  
  Weak base
5.

Weak organic acid, pKa 6.5. Percent ionization at pH 7.5
- A.
  
  1%
- B.
  
  10%
- C.
  
  50%
- D.
  
  90%
- E.
  
  99%
6.

Drug with this ionization property most likely to diffuse from intestine (pH 8.4) to blood (pH 7.4)
- A.
  
  Weak acid (pKa 7.4)
- B.
  
  weak base (pKa 8.4)
- C.
  
  Weak acid (pKa 8.4)
- D.
  
  Weak base (pKa 6.4)
- E.
  
  Weak acid (pKa 6.4)
7.

Weak base at alkaline pH
- A.
  
  Relatively lipid-soluble
- B.
  
  Probably uncharged
- C.
  
  Both
- D.
  
  Neither
8.

Factor(s) which may change intrinsic drug clearance:
- A.
  
  Smoking
- B.
  
  Dietary consideration
- C.
  
  Age
- D.
  
  Genetics
- E.
  
  All of the above
9.

Factor(s) influencing the volume of distribution:
- A.
  
  Patient's gender
- B.
  
  Patient's age
- C.
  
  Patient's disease state
- D.
  
  Patient's body composition
- E.
  
  All of the above
10.

Property/properties of phase II conjugates
- A.
  
  Don't pick me, I am wrong (FREEEBIE!!!)
- B.
  
  Relatively nonpolar
- C.
  
  Generally biologically active
- D.
  
  Rapidly excreted in the urine
- E.
  
  All of the above
11.

Most important organ for unchanged drug/drug metabolite elimination
- A.
  
  Liver
- B.
  
  Lung
- C.
  
  Kidney
- D.
  
  None of the above
- E.
  
  All of the above
12.

Absorption rate proportional to the drug concentration dissolved in the gastrointestinal tract
- A.
  
  Zero order
- B.
  
  First order
- C.
  
  Neither
- D.
  
  Both
- E.
  
  All of the above
13.

Drug mechanism/mechanisms which may increase the amount of cytochrome P450 enzyme
- A.
  
  Increase enzyme degradation rate
- B.
  
  Increase enzyme synthesis rate
- C.
  
  Both
- D.
  
  Neither
- E.
  
  All of the above
14.

Parent drug is altered by introducing or exposing a functional group such as -OH or NH2
- A.
  
  Phase 1
- B.
  
  Phase 2