Nitrogen Metabolism

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1. The most important source of amino acids for the amino acid pool is dietary ____ digestion (60-100 g/day)
slide 4
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Nitrogen Metabolism - Quiz

Lecture 63Biochemistry spring 2010SGU

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2. During growth periods during childhood and adolescence, pregnancy 11
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3. In a healthy, well-fed adult, input of amino acids = _____ of amino acids. The amino acid pool is in a steady state / equilibrium. 6
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4. ____ is the site where most of the amino acids release their amino groups as ammonia 16
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5. Seen in starvation, chronic illness (infections), cancer, uncontrolled diabetes mellitus 12
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6. Degrades plasma proteins and proteins taken up by endocytosis 8
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7. ____ is the major end product of nitrogen metabolism 16
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8. Positive nitrogen balance: Intake of dietary nitrogen is ___ the output of nitrogen 11
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9. Urea formed in the liver is transported to the kidneys, where it is excreted in the urine.  The kidneys also excrete ammonia as ammonium ions.  The other non-protein nitrogenous substances that are excreted by the kidney are creatinine and _____ acid. 17
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10. Amino acids are used in amino acid catabolism and in the _______ of nitrogen containing compounds.
slide 4
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11. Non-energy dependent degradative pathway 8
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12. Increase in urinary excretion of urea 12
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13. ATP dependent 8
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14. Increased tissue protein synthesis
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15. Which of the following statements is true? 13
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16. In a patient with renal disease, which of the following parameters would be the best indicators of renal function? 19
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17. Niacin deficiency's 3 d's: dermatitis, diarrhea, and ______. 23
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18. In infection, the liver synthesizes a group of proteins known as the ____-phase proteins.  C-reactive protein, serum amyloid A protein, haptoglobin, ceruloplasmin levels are increased in circulation in any type of inflammation. 15
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19. The rate of tissue protein synthesis is equal to the rate of protein ________. slide 5
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20. Damaged or unneeded proteins are degraded by two mechanisms: the lysosomal pathway that degrades extracellular proteins and the ubiquitin-______ pathway that degrades proteins synthesized by the cell 7
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21. Tubular reabsorption of cystine is decreased due to an inherited deficiency of the cystine transporter.  Cystine is excreted in urine and tends to precipitate in the renal tubules in the renal tract - one of the causes of renal ____ in children 21.
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22. _____ supplements can be used as treatment for pellagra 22
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23. Compounds that contain nitrogen: proteins, derivatives of amino acids: creatine, ________, purines and pyrimidines, heme
slide 2
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24. Hartnup's disease - inherited defect in the transport of the ___ amino acids like tryptophan 22
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25. A 12 year old child is suspected of having pellagra because of chronic symptoms including diarrhea, a red scaly rash, and mild cerebellar ataxia.  However, his diet is not deficient in protein and he appears to be ingesting adequate amounts of niacin.  A sister has a similar problem.  Chemical analysis of his urine demonstrates large amounts of free amino acids.  Which amino acid do you expect to find in the urine? 23
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26. The carbon skeletons of the amino acids are used for __________. 16
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The most important source of amino acids for the amino acid pool is...
During growth periods during childhood and adolescence, pregnancy 11
In a healthy, well-fed adult, input of amino acids = _____ of amino...
____ is the site where most of the amino acids release their amino...
Seen in starvation, chronic illness (infections), cancer, uncontrolled...
Degrades plasma proteins and proteins taken up by endocytosis 8
____ is the major end product of nitrogen metabolism 16
Positive nitrogen balance: Intake of dietary nitrogen is ___ the...
Urea formed in the liver is transported to the kidneys, where it is...
Amino acids are used in amino acid catabolism and in the _______ of...
Non-energy dependent degradative pathway 8
Increase in urinary excretion of urea 12
ATP dependent 8
Increased tissue protein synthesis
Which of the following statements is true? 13
In a patient with renal disease, which of the following parameters...
Niacin deficiency's 3 d's: dermatitis, diarrhea, and ______. 23
In infection, the liver synthesizes a group of proteins known as the...
The rate of tissue protein synthesis is equal to the rate of protein...
Damaged or unneeded proteins are degraded by two mechanisms: the...
Tubular reabsorption of cystine is decreased due to an inherited...
_____ supplements can be used as treatment for pellagra 22
Compounds that contain nitrogen: proteins, derivatives of amino acids:...
Hartnup's disease - inherited defect in the transport of the ___ amino...
A 12 year old child is suspected of having pellagra because of chronic...
The carbon skeletons of the amino acids are used for __________. 16
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