NIPER Mock Test! Hardest Trivia Questions
.
- 1.
![Hat is the lmax for the following compound? Use the provided parameters for your calculation. - ProProfs]( "Hat is the lmax for the following compound? Use the provided parameters for your calculation.")
Hat is the lmax for the following compound? Use the provided parameters for your calculation.- A.
234 nm
- B.
244 nm
- C.
273 nm
- D.
283 nm
- 2.
![What is the name of the following anticancer drug? - ProProfs]( "What is the name of the following anticancer drug?")
What is the name of the following anticancer drug?- A.
Spongistatin 1
- B.
Cryptophycin 1
- C.
Phyllanthoside
- D.
Maytansine 1
- 3.
![The following structure is an inhibitor of the enzyme responsible for adding a farnesyl chain to the Ras protein.Which feature binds to the zinc cofactor of the enzyme? - ProProfs]( "The following structure is an inhibitor of the enzyme responsible for adding a farnesyl chain to the Ras protein.Which feature binds to the zinc cofactor of the enzyme?")
The following structure is an inhibitor of the enzyme responsible for adding a farnesyl chain to the Ras protein.Which feature binds to the zinc cofactor of the enzyme?- A.
The tricyclic system
- B.
The piperazine ring
- C.
The aromatic ring
- D.
The imidazole ring
- 4.
![The following structure is a natural product having anticancer properties, which was isolated from a marine worm.What is it called? - ProProfs]( "The following structure is a natural product having anticancer properties, which was isolated from a marine worm.What is it called?")
The following structure is a natural product having anticancer properties, which was isolated from a marine worm.What is it called?- A.
Pancratistatin
- B.
Cephalostatin 1
- C.
Bryostatin 1
- D.
Dolostatin 15
- 5.Which of the following inhibits angiogenesis?
- A.
VEGF
- B.
FGF-2
- C.
Angiostatin
- D.
Interleukin-6
- 6.
![The tetracyclines act as intercalating anticancer agents.Which of the following is a simplified analogue of tetracyclines? - ProProfs]( "The tetracyclines act as intercalating anticancer agents.Which of the following is a simplified analogue of tetracyclines?")
The tetracyclines act as intercalating anticancer agents.Which of the following is a simplified analogue of tetracyclines?- A.
Mitoxantrone
- B.
Teniposide
- C.
Daunorubicin
- D.
Dactinomycin
- 7.
![Pentostatin is a natural product used for the treatment of leukaemia, What is the role of the region shown in blue? - ProProfs]( "Pentostatin is a natural product used for the treatment of leukaemia, What is the role of the region shown in blue?")
Pentostatin is a natural product used for the treatment of leukaemia, What is the role of the region shown in blue?- A.
Transition-state isostere
- B.
Transition-state analogue
- C.
Suicide substrate
- D.
Transition-state bioisostere
- 8.
![What is the name of the following anticancer drug? - ProProfs]( "What is the name of the following anticancer drug?")
What is the name of the following anticancer drug?- A.
Spongistatin 1
- B.
Cryptophycin 1
- C.
Phyllanthoside
- D.
Maytansine 1
- 9.
![Imatinib is an important anticancer drug which targets a protein kinase.The piperazine ring has an important interaction with an amino acid in the binding site. Which amino acid is involved? - ProProfs]( "Imatinib is an important anticancer drug which targets a protein kinase.The piperazine ring has an important interaction with an amino acid in the binding site. Which amino acid is involved?")
Imatinib is an important anticancer drug which targets a protein kinase.The piperazine ring has an important interaction with an amino acid in the binding site. Which amino acid is involved?- A.
Aspartic acid
- B.
Glutamic acid
- C.
Methionine
- D.
Leucine
- 10.
![The following structure is called marimastat and is a matrix metalloproteinase inhibitor that has undergone clinical trials for the treatment of breast and prostate cancers.What role is played by the hydroxamic acid group? - ProProfs]( "The following structure is called marimastat and is a matrix metalloproteinase inhibitor that has undergone clinical trials for the treatment of breast and prostate cancers.What role is played by the hydroxamic acid group?")
The following structure is called marimastat and is a matrix metalloproteinase inhibitor that has undergone clinical trials for the treatment of breast and prostate cancers.What role is played by the hydroxamic acid group?- A.
It acts as a transition-state isostere.
- B.
It binds to the zinc ion cofactor.
- C.
It binds to a binding sub pocket in the active site.
- D.
It acts as a steric shield.
- 11.
![The following structure is a natural product currently being studied as an anticancer agent.What is the name of the structure? - ProProfs]( "The following structure is a natural product currently being studied as an anticancer agent.What is the name of the structure?")
The following structure is a natural product currently being studied as an anticancer agent.What is the name of the structure?- A.
Thalidomide
- B.
Fumagillin
- C.
Depsipeptide
- D.
Aclarubicin
- 12.To what extent are the three nitrogens of histamine ionised at blood pH?
- A.
All three nitrogens are fully ionised
- B.
All three nitrogens are not ionised at all
- C.
The side chain nitrogen is fully ionised and the heterocyclic nitrogens are not ionised
- D.
The side chain nitrogen and one of the heterocyclic nitrogens are fully ionised
- 13.Three binding regions were proposed to be present in the binding site of the H2 receptor. Which of the following statements is incorrect?
- A.
There is a binding region for the imidazole ring of histamine analogues which is common for agonists and antagonists.
- B.
There is a binding region which interacts ionically with the α-nitrogen of histamine and results in agonist activity.
- C.
There is a binding region further away from the imidazole ring that produces an antagonist effect if occupied.
- D.
The α-nitrogen of histamine can only bind to the agonist binding region while the guanyl group of Nα-guanylhistamine can only bind to the antagonist binding region.
- 14.
![The following structures show some of the important molecules leading to the discovery of burimamide (B).What strategy was used in developing burimamide from SK&F 91581? - ProProfs]( "The following structures show some of the important molecules leading to the discovery of burimamide (B).What strategy was used in developing burimamide from SK&F 91581?")
The following structures show some of the important molecules leading to the discovery of burimamide (B).What strategy was used in developing burimamide from SK&F 91581?- A.
Extension
- B.
Chain extension
- C.
Substituent variation
- D.
Isosteric replacement
- 15.
![The following structures show some of the important molecules leading to the discovery of burimamide (B).Which of the following statements concerning burimamide is untrue? - ProProfs]( "The following structures show some of the important molecules leading to the discovery of burimamide (B).Which of the following statements concerning burimamide is untrue?")
The following structures show some of the important molecules leading to the discovery of burimamide (B).Which of the following statements concerning burimamide is untrue?- A.
It established the existence of H2-receptors
- B.
It was a good antagonist at H2 receptors with only weak partial agonist activity
- C.
It inhibited gastric acid release from parietal cells
- D.
It indicated that binding to the antagonist binding region involved hydrogen bonding and not ionic bonding
- 16.
![The following diagram shows development of H2-antagonists from burimamide (structure B).A sulphur atom was inserted into the side chain of structure C. What effect did this change have? - ProProfs]( "The following diagram shows development of H2-antagonists from burimamide (structure B).A sulphur atom was inserted into the side chain of structure C. What effect did this change have?")
The following diagram shows development of H2-antagonists from burimamide (structure B).A sulphur atom was inserted into the side chain of structure C. What effect did this change have?- A.
It introduced an extra binding interaction
- B.
It stabilised the molecule
- C.
It increased the percentage population of the active heterocyclic tautomer
- D.
It prevented ionisation of the terminal functional group
- 17.
![The following diagram shows development of H2-antagonists from burimamide (structure B).What was the rationale for the introduction of the coloured methyl group? - ProProfs]( "The following diagram shows development of H2-antagonists from burimamide (structure B).What was the rationale for the introduction of the coloured methyl group?")
The following diagram shows development of H2-antagonists from burimamide (structure B).What was the rationale for the introduction of the coloured methyl group?- A.
To block metabolism at that region of the heterocyclic ring
- B.
To introduce a group which would be metabolised in a predictable fashion
- C.
To introduce an electron withdrawing group on the heterocyclic ring to reduce the chance of ionisation
- D.
To introduce an electron donating group on the heterocyclic ring to favour the active tautomer
- 18.
![The following diagram shows development of H2-antagonists from burimamide (structure B). Why was the thiourea functional group in structure D changed to a guanidine group in structure E?What was the rationale for the introduction of the coloured methyl group? - ProProfs]( "The following diagram shows development of H2-antagonists from burimamide (structure B). Why was the thiourea functional group in structure D changed to a guanidine group in structure E?What was the rationale for the introduction of the coloured methyl group?")
The following diagram shows development of H2-antagonists from burimamide (structure B). Why was the thiourea functional group in structure D changed to a guanidine group in structure E?What was the rationale for the introduction of the coloured methyl group?- A.
To introduce a basic group which could ionise and allow ionic interactions with the binding region.
- B.
To replace an unnatural functional group with a naturally occurring group in order to reduce side effects.
- C.
To increase the number of hydrogen bond donors present to acquire extra binding interactions.
- D.
To change the geometry and stereochemistry of the functional group such that it fitted the binding region more closely.
- 19.
![The following diagram shows development of H2-antagonists from burimamide (structure B). Why was the cyanide group introduced into structure F (cimetidine)? - ProProfs]( "The following diagram shows development of H2-antagonists from burimamide (structure B). Why was the cyanide group introduced into structure F (cimetidine)?")
The following diagram shows development of H2-antagonists from burimamide (structure B). Why was the cyanide group introduced into structure F (cimetidine)?- A.
It is an electron donating group and increases the basicity of the functional group such that it protonates and becomes ionised.
- B.
It is an electron withdrawing group and increases the basicity of the functional group such that it protonates and becomes ionised.
- C.
It is an electron donating group and decreases the basicity of the functional group such that it does not become protonated and remains un-ionised.
- D.
It is an electron withdrawing group and decreases the basicity of the functional group such that it does not become protonated and remains un-ionised.
- 20.
![Two regions of cimetidine are susceptible to metabolism. Which regions?Why was the cyanide group introduced into structure F (cimetidine)? - ProProfs]( "Two regions of cimetidine are susceptible to metabolism. Which regions?Why was the cyanide group introduced into structure F (cimetidine)?")
Two regions of cimetidine are susceptible to metabolism. Which regions?Why was the cyanide group introduced into structure F (cimetidine)?- A.
A and B
- B.
A and C
- C.
B and D
- D.
A and D
- 21.
![The following diagram shows various conformations for the cyanoguanidine group of cimetidine.Two of these conformations were found to be disfavoured. Which ones and what was the implication of this for receptor binding? - ProProfs]( "The following diagram shows various conformations for the cyanoguanidine group of cimetidine.Two of these conformations were found to be disfavoured. Which ones and what was the implication of this for receptor binding?")
The following diagram shows various conformations for the cyanoguanidine group of cimetidine.Two of these conformations were found to be disfavoured. Which ones and what was the implication of this for receptor binding?- A.
EZ and ZE. It proved the chelation theory of hydrogen bonding.
- B.
EZ and ZZ. It established that there was only one hydrogen bonding interaction with the receptor in this region.
- C.
EE and ZZ. It established that there were two hydrogen bonding interactions to different groups within the same binding region.
- D.
EE and ZE. No conclusions could be drawn.
- 22.Once activated, the proton pump inhibitors bind to exposed amino acids in the proton pump. Which amino acid is involved?
- A.
Serine
- B.
Cysteine
- C.
Lysine
- D.
Histidine
- 23.
![The following mechanism shows how proton pump inhibitors are activated. Which arrow is incorrect? - ProProfs]( "The following mechanism shows how proton pump inhibitors are activated. Which arrow is incorrect?")
The following mechanism shows how proton pump inhibitors are activated. Which arrow is incorrect?- A.
A
- B.
B
- C.
C
- D.
D
- 24.
![Omeprazole is an important proton pump inhibitor. - ProProfs]( "Omeprazole is an important proton pump inhibitor.")
Omeprazole is an important proton pump inhibitor.- A.
A
- B.
B
- C.
C
- D.
D
- 25.Which microorganism has been associated with the appearance of ulcers?
- A.
Eschericia coli
- B.
Staphylococcus aureus
- C.
Enterococcus faecalis
- D.
Helicobacter pylori
.gif "Hat is the lmax for the following compound? Use the provided parameters for your calculation.")
.png "What is the name of the following anticancer drug?")
.png "The following structure is an inhibitor of the enzyme responsible for adding a farnesyl chain to the Ras protein.Which feature binds to the zinc cofactor of the enzyme?")
.png "The following structure is a natural product having anticancer properties, which was isolated from a marine worm.What is it called?")
.png "The tetracyclines act as intercalating anticancer agents.Which of the following is a simplified analogue of tetracyclines?")
.png "Pentostatin is a natural product used for the treatment of leukaemia, What is the role of the region shown in blue?")
.png "What is the name of the following anticancer drug?")
.png "Imatinib is an important anticancer drug which targets a protein kinase.The piperazine ring has an important interaction with an amino acid in the binding site. Which amino acid is involved?")
.png "The following structure is called marimastat and is a matrix metalloproteinase inhibitor that has undergone clinical trials for the treatment of breast and prostate cancers.What role is played by the hydroxamic acid group?")
.png "The following structure is a natural product currently being studied as an anticancer agent.What is the name of the structure?")
.png "The following structures show some of the important molecules leading to the discovery of burimamide (B).What strategy was used in developing burimamide from SK&F 91581?")
.png "The following structures show some of the important molecules leading to the discovery of burimamide (B).Which of the following statements concerning burimamide is untrue?")
.png "The following diagram shows development of H2-antagonists from burimamide (structure B).A sulphur atom was inserted into the side chain of structure C. What effect did this change have?")
.png "The following diagram shows development of H2-antagonists from burimamide (structure B).What was the rationale for the introduction of the coloured methyl group?")
.png "The following diagram shows development of H2-antagonists from burimamide (structure B). Why was the thiourea functional group in structure D changed to a guanidine group in structure E?What was the rationale for the introduction of the coloured methyl group?")
.png "The following diagram shows development of H2-antagonists from burimamide (structure B). Why was the cyanide group introduced into structure F (cimetidine)?")
.png "Two regions of cimetidine are susceptible to metabolism. Which regions?Why was the cyanide group introduced into structure F (cimetidine)?")
.png "The following diagram shows various conformations for the cyanoguanidine group of cimetidine.Two of these conformations were found to be disfavoured. Which ones and what was the implication of this for receptor binding?")
.png "The following mechanism shows how proton pump inhibitors are activated. Which arrow is incorrect?")
.png "Omeprazole is an important proton pump inhibitor.")
Questions: 29 | Attempts: 9315 | Last updated: Aug 24, 2020
-
Sample QuestionThe Product Owner manages the Product Backlog. Who is accountable for estimating the effort to complete the Product Backlog items?
Questions: 20 | Attempts: 8818 | Last updated: May 29, 2013
-
Sample QuestionWhich one of the following is not a permanent magnetic material ?
Questions: 10 | Attempts: 5642 | Last updated: Jan 12, 2018
-
Sample QuestionWhere was the first General Indian Post established?
Back to top