NIPER Test Series-no.1-developed By Dr.anwar R. Shaikh

100 Questions

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NIPER Test Series-no.1-developed By Dr.anwar R. Shaikh

NIPER Test Series-No. 1: Developed by Dr. Anwar R. ShaikhTotal Questions 100, Marks:400 Marks for every correct answer: 04Marks for every wrong answer:-1Passing criteria:75 %


Questions and Answers
  • 1. 
    What is the name of the following anticancer drug?
    • A. 

      Spongistatin 1

    • B. 

      Cryptophycin 1

    • C. 

      Phyllanthoside

    • D. 

      Maytansine 1

  • 2. 
    The following structure is an inhibitor of the enzyme responsible for adding a farnesyl chain to the Ras protein.Which feature binds to the zinc cofactor of the enzyme?
    • A. 

      The tricyclic system

    • B. 

      The piperazine ring

    • C. 

      The aromatic ring

    • D. 

      The imidazole ring

  • 3. 
    The following structure is a natural product having anticancer properties, which was isolated from a marine worm.What is it called?
    • A. 

      Pancratistatin

    • B. 

      Cephalostatin 1

    • C. 

      Bryostatin 1

    • D. 

      Dolostatin 15

  • 4. 
    Which of the following inhibits angiogenesis?
    • A. 

      VEGF

    • B. 

      FGF-2

    • C. 

      Angiostatin

    • D. 

      Interleukin-6

  • 5. 
    The tetracyclines act as intercalating anticancer agents.Which of the following is a simplified analogue of tetracyclines?
    • A. 

      Mitoxantrone

    • B. 

      Teniposide

    • C. 

      Daunorubicin

    • D. 

      Dactinomycin

  • 6. 
    Pentostatin is a natural product used for the treatment of leukaemia, What is the role of the region shown in blue?
    • A. 

      Transition-state isostere

    • B. 

      Transition-state analogue

    • C. 

      Suicide substrate

    • D. 

      Transition-state bioisostere

  • 7. 
    What is the name of the following anticancer drug? 
    • A. 

      Spongistatin 1

    • B. 

      Cryptophycin 1

    • C. 

      Phyllanthoside

    • D. 

      Maytansine 1

  • 8. 
    Imatinib is an important anticancer drug which targets a protein kinase.The piperazine ring has an important interaction with an amino acid in the binding site. Which amino acid is involved?
    • A. 

      Aspartic acid

    • B. 

      Glutamic acid

    • C. 

      Methionine

    • D. 

      Leucine

  • 9. 
    The following structure is called marimastat and is a matrix metalloproteinase inhibitor that has undergone clinical trials for the treatment of breast and prostate cancers.What role is played by the hydroxamic acid group? 
    • A. 

      It acts as a transition-state isostere.

    • B. 

      It binds to the zinc ion cofactor.

    • C. 

      It binds to a binding sub pocket in the active site.

    • D. 

      It acts as a steric shield.

  • 10. 
    The following structure is a natural product currently being studied as an anticancer agent.What is the name of the structure? 
    • A. 

      Thalidomide

    • B. 

      Fumagillin

    • C. 

      Depsipeptide

    • D. 

      Aclarubicin

  • 11. 
    To what extent are the three nitrogens of histamine ionised at blood pH?
    • A. 

      All three nitrogens are fully ionised

    • B. 

      All three nitrogens are not ionised at all

    • C. 

      The side chain nitrogen is fully ionised and the heterocyclic nitrogens are not ionised

    • D. 

      The side chain nitrogen and one of the heterocyclic nitrogens are fully ionised

  • 12. 
    Three binding regions were proposed to be present in the binding site of the H2 receptor. Which of the following statements is incorrect?
    • A. 

      There is a binding region for the imidazole ring of histamine analogues which is common for agonists and antagonists.

    • B. 

      There is a binding region which interacts ionically with the α-nitrogen of histamine and results in agonist activity.

    • C. 

      There is a binding region further away from the imidazole ring that produces an antagonist effect if occupied.

    • D. 

      The α-nitrogen of histamine can only bind to the agonist binding region while the guanyl group of Nα-guanylhistamine can only bind to the antagonist binding region.

  • 13. 
    The following structures show some of the important molecules leading to the discovery of burimamide (B).What strategy was used in developing burimamide from SK&F 91581?
    • A. 

      Extension

    • B. 

      Chain extension

    • C. 

      Substituent variation

    • D. 

      Isosteric replacement

  • 14. 
    The following structures show some of the important molecules leading to the discovery of burimamide (B).Which of the following statements concerning burimamide is untrue?
    • A. 

      It established the existence of H2-receptors

    • B. 

      It was a good antagonist at H2 receptors with only weak partial agonist activity

    • C. 

      It inhibited gastric acid release from parietal cells

    • D. 

      It indicated that binding to the antagonist binding region involved hydrogen bonding and not ionic bonding

  • 15. 
    The following diagram shows development of H2-antagonists from burimamide (structure B).A sulphur atom was inserted into the side chain of structure C. What effect did this change have?
    • A. 

      It introduced an extra binding interaction

    • B. 

      It stabilised the molecule

    • C. 

      It increased the percentage population of the active heterocyclic tautomer

    • D. 

      It prevented ionisation of the terminal functional group

  • 16. 
    The following diagram shows development of H2-antagonists from burimamide (structure B).What was the rationale for the introduction of the coloured methyl group?
    • A. 

      To block metabolism at that region of the heterocyclic ring

    • B. 

      To introduce a group which would be metabolised in a predictable fashion

    • C. 

      To introduce an electron withdrawing group on the heterocyclic ring to reduce the chance of ionisation

    • D. 

      To introduce an electron donating group on the heterocyclic ring to favour the active tautomer

  • 17. 
    The following diagram shows development of H2-antagonists from burimamide (structure B). Why was the thiourea functional group in structure D changed to a guanidine group in structure E?What was the rationale for the introduction of the coloured methyl group?
    • A. 

      To introduce a basic group which could ionise and allow ionic interactions with the binding region.

    • B. 

      To replace an unnatural functional group with a naturally occurring group in order to reduce side effects.

    • C. 

      To increase the number of hydrogen bond donors present to acquire extra binding interactions.

    • D. 

      To change the geometry and stereochemistry of the functional group such that it fitted the binding region more closely.

  • 18. 
    The following diagram shows development of H2-antagonists from burimamide (structure B). Why was the cyanide group introduced into structure F (cimetidine)?
    • A. 

      It is an electron donating group and increases the basicity of the functional group such that it protonates and becomes ionised.

    • B. 

      It is an electron withdrawing group and increases the basicity of the functional group such that it protonates and becomes ionised.

    • C. 

      It is an electron donating group and decreases the basicity of the functional group such that it does not become protonated and remains un-ionised.

    • D. 

      It is an electron withdrawing group and decreases the basicity of the functional group such that it does not become protonated and remains un-ionised.

  • 19. 
    Two regions of cimetidine are susceptible to metabolism. Which regions?Why was the cyanide group introduced into structure F (cimetidine)?
    • A. 

      A and B

    • B. 

      A and C

    • C. 

      B and D

    • D. 

      A and D

  • 20. 
    The following diagram shows various conformations for the cyanoguanidine group of cimetidine.Two of these conformations were found to be disfavoured. Which ones and what was the implication of this for receptor binding?
    • A. 

      EZ and ZE. It proved the chelation theory of hydrogen bonding.

    • B. 

      EZ and ZZ. It established that there was only one hydrogen bonding interaction with the receptor in this region.

    • C. 

      EE and ZZ. It established that there were two hydrogen bonding interactions to different groups within the same binding region.

    • D. 

      EE and ZE. No conclusions could be drawn.

  • 21. 
    Once activated, the proton pump inhibitors bind to exposed amino acids in the proton pump. Which amino acid is involved?
    • A. 

      Serine

    • B. 

      Cysteine

    • C. 

      Lysine

    • D. 

      Histidine

  • 22. 
    The following mechanism shows how proton pump inhibitors are activated. Which arrow is incorrect?
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 23. 
    Omeprazole is an important proton pump inhibitor. 
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 24. 
    Which microorganism has been associated with the appearance of ulcers?
    • A. 

      Eschericia coli

    • B. 

      Staphylococcus aureus

    • C. 

      Enterococcus faecalis

    • D. 

      Helicobacter pylori

  • 25. 
    What bacterial enzyme aids the survival of Helicobacter pylori in the stomach?
    • A. 

      Carbonic anhydrase

    • B. 

      β-lactamase

    • C. 

      Urease

    • D. 

      Transpeptidase

  • 26. 
    Which of the following compounds would have the highest boiling point? 
    • A. 

      CH3CH2CH2CH3

    • B. 

      CH3NH2

    • C. 

      CH3OH

    • D. 

      CH2F2

  • 27. 
    Which of the following alkanes would have the highest boiling point?
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 28. 
    How are the following compounds related?
    • A. 

      Isoelectronic species

    • B. 

      Isotopes

    • C. 

      Isomers

    • D. 

      These compounds are not related at all...they are totally different

  • 29. 
    What is the total number of sigma bonds found in the following compound?
    • A. 

      8

    • B. 

      10

    • C. 

      11

    • D. 

      15

  • 30. 
    What is the total number of pi bonds found in the following compound?
    • A. 

      1

    • B. 

      2

    • C. 

      3

    • D. 

      4

  • 31. 
    What is the IUPAC name for the following compound?
    • A. 

      1,3-pentamethylpropane

    • B. 

      1,1,3,3-tetramethylbutane

    • C. 

      2,4,4-trimethylpentane

    • D. 

      2,2,4-trimethylpentane

  • 32. 
    What is the IUPAC name for the following compound?
    • A. 

      Dimethylcyclohexane

    • B. 

      1,3-dimethylcyclohexane

    • C. 

      Cis-1,3-dimethylcyclohexane

    • D. 

      Trans-1,3-dimethylcyclohexane

  • 33. 
    The most stable conformational isomer of cis-1-bromo-2-chlorocyclohexane will have...
    • A. 

      Both halide atoms in axial positions.

    • B. 

      Both halide atoms in equatorial positions.

    • C. 

      The bromine atom in an axial position and the chlorine atom in an equatorial position.

    • D. 

      The bromine atom in an equatorial position and the chlorine atom in an axial position.

  • 34. 
    The most stable conformational isomer of trans-1-ethyl-2-methylcyclohexane will be...
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 35. 
    Which Newman projection shows the most stable conformation of the following compound?
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 36. 
    Which of the these compounds represents the major monochlorination isomer formed in the following reaction?
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 37. 
    How many dichlorinated isomers can be formed by the halogenation of CH3CH2CH2CH3 with Cl2 in the presence of light? 
    • A. 

      2

    • B. 

      3

    • C. 

      5

    • D. 

      6

  • 38. 
    Which of the following nuclei will have a magnetic moment?
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 39. 
    The CMR spectrum of an unknown compound shows 6 absorptions and the PMR spectrum shows 5 absorptions. Which of the following compounds is the unknown compound?
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 40. 
    The CMR spectrum of an unknown compound shows 4 absorptions and the PMR spectrum shows 4 absorptions. Which of the following compounds is the unknown compound? 
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 41. 
    What is the multiplicity expected in the hydrogen NMR spectrum for the hydrogen atoms marked by a "star" in the following compound? 
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 42. 
    Which of the Fischer projections correctly depicts the following compound? 
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 43. 
    The following stereoisomers are related as...
    • A. 

      Enantiomers.

    • B. 

      Diastereomers.

    • C. 

      Epimers.

    • D. 

      Identical compounds.

  • 44. 
    Which of the following compounds exhibit optical activity?
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 45. 
    What is the major product of the following reaction?
    • A. 

      S-2-butanol

    • B. 

      R-2-butanol

    • C. 

      A racemic mixture of 2-butanol

    • D. 

      The hemiketal of 2-butanone and methanol...2-hydroxy-2-methoxybutane

  • 46. 
    Which of the following transitions is the highest energy transition?a) n to s*b) n to p*c) s to s*d) p to p* 
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 47. 
    Which of the following alkenes would have the largest lmax?
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 48. 
    Which of the following alkenes would have the largest lmax?
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

  • 49. 
    What is the lmax for the following compound? Use the below parameters for your calculation.
    • A. 

      229 nm

    • B. 

      249 nm

    • C. 

      254 nm

    • D. 

      259 nm

  • 50. 
    Hat is the lmax for the following compound? Use the provided parameters for your calculation. 
    • A. 

      234 nm

    • B. 

      244 nm

    • C. 

      273 nm

    • D. 

      283 nm

  • 51. 
    All the following products used in the treatment of glaucoma are appliedtopically EXCEPT:
    • A. 

      Xalatan

    • B. 

      Diamox

    • C. 

      Trusopt

    • D. 

      Timoptol

  • 52. 
    Which is an alternative preparation of Lipitor?
    • A. 

      Cozaar

    • B. 

      Lescol

    • C. 

      Zestril

    • D. 

      Cardura

  • 53. 
    Tambocor:
    • A. 

      May be of value in serious symptomatic ventricular arrhythmias

    • B. 

      Is a beta-adrenoceptor blocker

    • C. 

      Is available only for parenteral administration

    • D. 

      Cannot be administered concurrently with antibacterial agents

  • 54. 
    Terazosin:
    • A. 

      Constricts smooth muscle

    • B. 

      Is a selective beta-blocker

    • C. 

      Increases urinary flow rate

    • D. 

      May cause an increase in blood pressure

  • 55. 
    Legionnaires’ disease:
    • A. 

      Is caused by a Gram-positive coccus

    • B. 

      Is a chronic infectious disease

    • C. 

      Has an incubation period of 2 days to 3 years

    • D. 

      Is characterised by the development of pneumonia

  • 56. 
    Trigger factors for migraine include all EXCEPT:
    • A. 

      Use of caffeine

    • B. 

      Exposure to sunlight

    • C. 

      Missed meals

    • D. 

      Lack of sleep

  • 57. 
    All the following products contain a local anaesthetic EXCEPT:
    • A. 

      Dequacaine

    • B. 

      Merocaine

    • C. 

      BurnEze

    • D. 

      Anthisan

  • 58. 
    Good pharmacy practice guidelines:
    • A. 

      Have been established by the International Pharmaceutical Federation (FIP)

    • B. 

      Comply with ISO 9000

    • C. 

      Consist of an audit process

    • D. 

      Relate to pharmaceutical marketing

  • 59. 
    Anti-D immunoglobulin:
    • A. 

      Is available as oral tablets

    • B. 

      Is a vaccination for tetanus

    • C. 

      Should be administered preferably within 72 h of a sensitising episode

    • D. 

      Is intended to protect the mother from haemolytic disease

  • 60. 
    Which of the following products is NOT indicated for the management of peptic ulceration?
    • A. 

      Buscopan

    • B. 

      Gaviscon

    • C. 

      Nexium

    • D. 

      Pariet

  • 61. 
    Concern the following drugs:A  valaciclovirB  griseofulvinC  itraconazoleE  terbinafineAnswer the question Select, from A to E, which one of the above corresponds to the brand name: Sporanox
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 62. 
    Concern the following drugs:A  valaciclovirB  griseofulvinC  itraconazoleE  terbinafineAnswer the question Select, from A to E, which one of the above corresponds to the brand name: Lamisil 
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 63. 
    Concern the following drugs:A  valaciclovirB  griseofulvinC  itraconazoleE  terbinafineAnswer the question Select, from A to E, which one of the above corresponds to the brand name: Famvir
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 64. 
    Concern the following drugs:A ❏ nalidixic acidB ❏ norfloxacinC ❏ levofloxacinD ❏ ofloxacinE ❏ amphotericinSelect, from A to E, which one of the above:Drug which can be used for intestinal candidiasis
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 65. 
    Concern the following drugs:A ❏ nalidixic acidB ❏ norfloxacinC ❏ levofloxacinD ❏ ofloxacinE ❏ amphotericinSelect, from A to E, which one of the above:Drug which has greater activity than ciprofloxacin against pneumococci
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 66. 
    Concern the following drugs:A ❏ nalidixic acidB ❏ norfloxacinC ❏ levofloxacinD ❏ ofloxacinE ❏ amphotericinSelect, from A to E, which one of the above:Drug which is marketed as Tavanic
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 67. 
    Concern the following drugs:A ❏ nalidixic acidB ❏ norfloxacinC ❏ levofloxacinD ❏ ofloxacinE ❏ amphotericinSelect, from A to E, which one of the above:Drug which is is only indicated in urinary tract infection
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 68. 
    Concern the following drugs:A ❏ atenololB ❏ folic acidC ❏ imipramineD ❏ carbamazepineE ❏ co-trimoxazoleSelect, from A to E, during pregnancy which one of the above:may cause intrauterine growth restriction
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 69. 
    Concern the following drugs:A ❏ atenololB ❏ folic acidC ❏ imipramineD ❏ carbamazepineE ❏ co-trimoxazoleSelect, from A to E, during pregnancy which one of the above:may increase the risk of neural tube defects
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 70. 
    Concern the following drugs:A ❏ atenololB ❏ folic acidC ❏ imipramineD ❏ carbamazepineE ❏ co-trimoxazoleSelect, from A to E, during pregnancy which one of the above:may increase the risk of tachycardia in neonate
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 71. 
    Concern the following maximum oral daily doses:A ❏ 200 mg dailyB ❏ 150 mg dailyC ❏ 100 mg dailyD ❏ 50 mg dailyE ❏ 300 mg dailySelect, from A to E, which one of the above corresponds to:diclofenac
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 72. 
    Concern the following maximum oral daily doses:A ❏ 200 mg dailyB ❏ 150 mg dailyC ❏ 100 mg dailyD ❏ 50 mg dailyE ❏ 300 mg dailySelect, from A to E, which one of the above corresponds to:sildenafil
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 73. 
    Concern the following maximum oral daily doses:A ❏ 200 mg dailyB ❏ 150 mg dailyC ❏ 100 mg dailyD ❏ 50 mg dailyE ❏ 300 mg dailySelect, from A to E, which one of the above corresponds to:sumatriptan
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 74. 
    Concern the following cautionary labels:A ❏ To be sucked or chewed.B ❏ With or after food.C ❏ Follow the printed instructions you have been given with thismedicine.D ❏ Avoid exposure of skin to direct sunlight or sun lamps.E ❏ Do not stop taking this medicine except on your doctor’sadvice.Select, from A to E, which one of the above corresponds to chlorpromazine​: 
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 75. 
    Concern the following cautionary labels:A ❏ To be sucked or chewed.B ❏ With or after food.C ❏ Follow the printed instructions you have been given with thismedicine.D ❏ Avoid exposure of skin to direct sunlight or sun lamps.E ❏ Do not stop taking this medicine except on your doctor’sadvice.Select, from A to E, which one of the above corresponds to dapsone​:
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 76. 
    Concern the following cautionary labels:A ❏ To be sucked or chewed.B ❏ With or after food.C ❏ Follow the printed instructions you have been given with thismedicine.D ❏ Avoid exposure of skin to direct sunlight or sun lamps.E ❏ Do not stop taking this medicine except on your doctor’sadvice.Select, from A to E, which one of the above corresponds to warfarin:
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 77. 
    Concern the following products:A ❏ AeroChamberB ❏ NuelinC ❏ AtroventD ❏ BeconaseE ❏ AlupentSelect, from A to E, which one of the above corresponds to the following presentations: syrup
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 78. 
    Concern the following products:A ❏ AeroChamberB ❏ NuelinC ❏ AtroventD ❏ BeconaseE ❏ AlupentSelect, from A to E, which one of the above corresponds to the following presentations: aerosol for inhalation
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 79. 
    Concern the following products:A ❏ AeroChamberB ❏ NuelinC ❏ AtroventD ❏ BeconaseE ❏ AlupentSelect, from A to E, which one of the above corresponds to the following presentations: spacer device
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 80. 
    Concern the following products:A ❏ AeroChamberB ❏ NuelinC ❏ AtroventD ❏ BeconaseE ❏ AlupentSelect, from A to E, which one of the above corresponds to the following presentations: nasal spray
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 81. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctWhen administering cisplatin powder for injection:1 ❏ it should be reconstituted with water for injection2 ❏ it should be given over 6–8 h3 ❏ the infusion fluid used is Ringer’s solution
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 82. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctCeftazidime:1 ❏ is a ‘third-generation’ cephalosporin antibacterial2 ❏ is more active than cefuroxime against Gram-positive bacteria3 ❏ is available as tablets and injections
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 83. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctPotentially hazardous interactions could occur between:1 ❏ ergotamine and zolmitriptan2 ❏ warfarin and gliclazide3 ❏ combined oral contraceptives and clindamycin
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 84. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctExamples of enzyme inducers include:1 ❏ griseofulvin2 ❏ rifampicin3 ❏ warfarin
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 85. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctWhich of the following drugs may be used in patients with liver diseasebut require a dose reduction?1 ❏ Natrilix2 ❏ Nizoral3 ❏ Zyloric
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 86. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctCapsulitis:1 ❏ is a disorder affecting the shoulder2 ❏ may be caused by unaccustomed movement3 ❏ is an inflammatory process
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 87. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctPresentations of a facial lesion that warrant referral include:1 ❏ swollen lymph glands in the neck2 ❏ butterfly distribution of a rash over the nose and cheeks3 ❏ a scaly rash with mild erythema affecting the forehead andeyebrows
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 88. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctAntacid preparations containing sodium bicarbonate include:1 ❏ Gaviscon liquid2 ❏ Bisodol Heartburn Relief tablets3 ❏ Maalox Plus tablets
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 89. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctThe agents associated with pain and inflammation of a bee sting include:1 ❏ histamine2 ❏ apamin3 ❏ hyaluronidase
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 90. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctAntispasmodics that could be recommended for irritable bowelsyndrome include:1 ❏ Colofac2 ❏ Spasmonal3 ❏ Fybogel
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 91. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctParadichlorobenzene:1 ❏ has antifungal properties2 ❏ is used as a disinfectant3 ❏ is present in Cerumol drops
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 92. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctAspirin:1 ❏ potentiates the anticoagulant effect of warfarin2 ❏ inhibits platelet aggregation3 ❏ promotes vitamin K synthesis
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 93. 
    Directions: For each of the questions below, ONE or MORE of theresponses is (are) correct. Decide which of the responses is(are) correct. Then choose:A ❏ if 1, 2 and 3 are correctB ❏ if 1 and 2 only are correctC ❏ if 2 and 3 only are correctD ❏ if 1 only is correctE ❏ if 3 only is correctMale pattern baldness:1 ❏ is androgenetic alopecia2 ❏ is caused by the release of prostaglandins3 ❏ may be precipitated by chemical hair preparations
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 94. 
    A parent requests a multivitamin preparation for a 6-year-old child.Which product could be recommended?A ❏ ForcevalB ❏ VivioptalC ❏ MaxepaD ❏ En-De-KayE ❏ Calcium-Sandoz
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 95. 
    A mother requests a preparation for her 5-year-old son for a chestycough. Which of the following products is the most appropriate?A ❏ Benylin with Codeine syrupB ❏ Alupent syrupC ❏ Actifed Chesty Coughs syrupD ❏ Vicks Medinite syrupE ❏ Neoclarityn syrup
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      A

  • 96. 
    A patient asks for ibuprofen gel. The pharmacist may dispense:A ❏ OruvailB ❏ VoltarolC ❏ DubamD ❏ BrufenE ❏ Ibutop
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      A

  • 97. 
    Each of the questions or incomplete statements is followed byfive suggested answers. Select the best answer in each case.All the following products are selective inhibitors of cyclo-oxygenase-2EXCEPT:A ❏ CelebrexB ❏ ArcoxiaC ❏ MobicD ❏ FeldeneE ❏ Prexige
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      A

  • 98. 
    Each of the questions or incomplete statements is followed byfive suggested answers. Select the best answer in each case.What is an appropriate therapeutic alternative for Pulmicort?A ❏ ZaditenB ❏ BecotideC ❏ IntalD ❏ AtroventE ❏ Serevent
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 99. 
    Each of the questions or incomplete statements is followed byfive suggested answers. Select the best answer in each case.Raynaud’s phenomenon:A ❏ is characterised by vasodilationB ❏ causes hot, red feetC ❏ starts as white patches of skinD ❏ is caused by a bacterial infectionE ❏ may require vasodilator treatment
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 100. 
    Each of the questions or incomplete statements is followed byfive suggested answers. Select the best answer in each case.Leflunomide:A ❏ its therapeutic effect starts after 4–6 weeksB ❏ is given as an initial dose of 7.5 mgC ❏ is administered once a weekD ❏ is available only for parenteral administrationE ❏ no washout procedures are required when changing toanother product
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      A