Gout and hyperuricemia.
Cancer cell growth and replication
Nausea and vomiting.
Inability to ingest food orally due to stomatitis and mucositis.
Stimulating neuroreceptors in the medulla.
Inhibiting the release of catecholamines.
Irritating the gastric mucosa.
It destroys the myelocytes (muscle cells).
It reduces the size of the cancer tumor.
After surgery. it reduces the amount of chemotherapy needed.
It destroys the bone marrow prior to transplant.
Within the first 24 hours after chemotherapy.
1-5 days after chemotherapy.
Before chemotherapy administration.
While chemotherapy is being administered.
Enhancement of drug availability.
Rapid distribution of the drug to receptor sites.
The more drug bound to protein. the less available for desired effect.
Increased metabolism of the drug by the liver.
Increased therapeutic effects of Drug A.
Increased adverse effects of Drug B.
Decreased therapeutic effects of Drug A.
Decreased therapeutic effects of Drug B.