NCLEX Pharmacology Quiz 28 Anti-inflammatory And Antineoplastic Drugs

1. An appropriate nursing diagnosis for clients who are taking NSAIDs and anticoagulants would be which of the following?

Risk for injury related to prolonged bleeding time. inhibition of platelet aggregation. and increased risk of GI bleeding.

Potential for injury related to GI toxicity and decrease in bleeding time.

Altered protection related to GI bleeding and increasing platelet aggregation.

Risk for injury related to thrombocytosis prolonged prothrombin time.

The nursing diagnosis addresses all the interactions that pose a threat to the client taking both these drugs. Choice B is incorrect because bleeding time is prolonged not decreased when both drugs are used. Choice C is incorrect because platelet aggregation is inhibited not increased when both drugs are used. Choice D is incorrect because thrombocytosis does not occur with use of either drugs.

Explanation

The nursing diagnosis addresses all the interactions that pose a threat to the client taking both these drugs. Choice B is incorrect because bleeding time is prolonged not decreased when both drugs are used. Choice C is incorrect because platelet aggregation is inhibited not increased when both drugs are used. Choice D is incorrect because thrombocytosis does not occur with use of either drugs.

2. To minimize the risk of dyspnea and GI bleeding. OTC ibuprofen is given:

IV

With orange juice

On an empty stomach

With meals

Taking ibuprofen with meals will decrease GI irritation. Ibuprofen is never given IV. Orange juice may promote acidity and increase gastric irritation. Ibuprofen will cause GI upset if given on an empty stomach.

Explanation

Taking ibuprofen with meals will decrease GI irritation. Ibuprofen is never given IV. Orange juice may promote acidity and increase gastric irritation. Ibuprofen will cause GI upset if given on an empty stomach.

3. Orlando who has been taking steroids for rheumatoid arthritis over several years presents with a compression vertebral fracture. This fracture is due to:

An entirely separate condition.

The osteoporotic effect of long-term steroid use.

Deterioration in rheumatoid arthritis.

An excessively high dose of steroids.

In a client on long-term steroids. a compression vertebral fracture can be assumed to be due to the steroids’ bone-softening effect.

Explanation

In a client on long-term steroids. a compression vertebral fracture can be assumed to be due to the steroids’ bone-softening effect.

4. Which of the following NSAIDs is used to prevent thrombosis?

Motrin

Toradol

Aspirin

Naproxen

Aspirin prevents platelet aggregation and thereby has an anticoagulant effect.

Explanation

Aspirin prevents platelet aggregation and thereby has an anticoagulant effect.

5. Oral steroids are prescribed on a taper in order to:

Achieve optimal serum levels.

Ensure drug reliability.

Ensure compliance.

Prevent steroid withdrawal syndrome.

Steroids are tapered off in order to prevent a withdrawal syndrome. Optimal serum levels do not require tapering in order to be maintained. Tapering has nothing to do with drug reliability. Compliance is not dependent on tapering.

Explanation

Steroids are tapered off in order to prevent a withdrawal syndrome. Optimal serum levels do not require tapering in order to be maintained. Tapering has nothing to do with drug reliability. Compliance is not dependent on tapering.

6. As a well-rounded health care provider. you know that corticosteroid therapy is indicated in all of the following conditions except:

Osteoarthritis

Rheumatoid arthritis

Systemic lupus erythematosus

Acute spinal cord injury

Osteoarthritis is not an indication for corticosteroid therapy. It has an inflammatory component. but the disease is not severe enough to suppress the immune system. Lupus. spinal injury. and rheumatoid arthritis are conditions that require suppression of the immune system in order for the client to survive.

Explanation

Osteoarthritis is not an indication for corticosteroid therapy. It has an inflammatory component. but the disease is not severe enough to suppress the immune system. Lupus. spinal injury. and rheumatoid arthritis are conditions that require suppression of the immune system in order for the client to survive.

7. Tom is admitted into the emergency department with an acute spinal cord injury. Methylprednisolone is contraindicated for treatment when the injury:

Is a high cervical lesion.

Occurred less than 4 hours ago.

Occurred less than 8 hours ago.

Occurred more than 8 hours ago.

Research has shown that steroids are ineffective when given more than 8 hours after acute spinal injury.

Explanation

Research has shown that steroids are ineffective when given more than 8 hours after acute spinal injury.

8. Which of the following statements about intravenous administration of steroids is true?

Steroids administered intravenously must be diluted.

Steroids administered intravenously can be either in diluted or undiluted form.

Steroids should be given IV push only.

Intravenous administration of steroids is contraindicated in acutely ill clients.

IV steroids can either be diluted or given without dilution.

Explanation

IV steroids can either be diluted or given without dilution.

9. Teaching has been adequate when a client being treated with acetylsalicylic acid states:

“I can crush the pills before i swallow them.”

“I should take the pills with antacids.”

“Taking the pills on an empty stomach will help absorption.”

“If the pills smell like vinegar. I should throw them out.”

Any aspirin should be discarded if a vinegar odor is noticed. Crushing is not recommended for sustained-release preparations. Antacids impair absorption. Taking the medication on an empty stomach will increase GI irritation.

Explanation

Any aspirin should be discarded if a vinegar odor is noticed. Crushing is not recommended for sustained-release preparations. Antacids impair absorption. Taking the medication on an empty stomach will increase GI irritation.

10. Which of the following groups of clients are most at risk for GI bleeding from the use of NSAIDs?

Clients with dysmenorrhea

Clients with headaches

Clients with arthritis

Clients with renal failure

Clients with arthritis are taking the drugs for prolonged periods of time and may take higher doses. Choices A and B are incorrect because the use of NSAIDs with these clients is intermittent. Renal failure is a contraindication for NSAIDs because most of the drug is excreted through the kidneys.

Explanation

Clients with arthritis are taking the drugs for prolonged periods of time and may take higher doses. Choices A and B are incorrect because the use of NSAIDs with these clients is intermittent. Renal failure is a contraindication for NSAIDs because most of the drug is excreted through the kidneys.

NCLEX Pharmacology Quiz 28 Anti-iNFLammatory And Antineoplastic Drugs