Immunology
Immunology Quiz
- 1.
What T cells activate Macrophages?
- A.
CD8+ CTL and CD4+ helpers
- B.
CD4+ CTL and CD8+ helpers
- C.
CD4- CTL and CD8- helpers
- D.
CD8- CTL and CD8+ helpers
Correct Answer
A. CD8+ CTL and CD4+ helpers -
- 2.
Antibodies are inable to penetrate a tumor
- A.
True
- B.
False
Correct Answer
A. True -
- 3.
Select the antigen(s) which is expressed on Melanoma
- A.
Cyclin dependent kinase 4
- B.
B-Catenin
- C.
Caspase-8
- D.
MAGE-1/MAGE-3
- E.
Tyrosinase
- F.
Surface Ig idiotype
- G.
Her-2/neu
- H.
MUC-1
Correct Answer(s)
A. Cyclin dependent kinase 4
B. B-Catenin
D. MAGE-1/MAGE-3
E. Tyrosinase -
- 4.
Select the antigen(s) which is expressed on Squamous cell Carcinoma
- A.
Cyclin dependent kinase 4
- B.
B-Catenin
- C.
Caspase-8
- D.
MAGE-1/MAGE-3
- E.
Tyrosinase
- F.
Surface Ig idiotype
- G.
Her-2/neu
- H.
MUC-1
Correct Answer
C. Caspase-8 -
- 5.
Select the antigen(s) which is expressed on Lymphoma
- A.
Cyclin dependent kinase 4
- B.
B-Catenin
- C.
Caspase-8
- D.
MAGE-1/MAGE-3
- E.
Tyrosinase
- F.
Surface Ig idiotype
- G.
Her-2/neu
- H.
MUC-1
Correct Answer
F. Surface Ig idiotype -
- 6.
Select the antigen(s) which is expressed on Breast Cancer
- A.
Cyclin dependent kinase 4
- B.
B-Catenin
- C.
Caspase-8
- D.
MAGE-1/MAGE-3
- E.
Tyrosinase
- F.
Surface Ig idiotype
- G.
Her-2/neu
- H.
MUC-1
Correct Answer(s)
D. MAGE-1/MAGE-3
G. Her-2/neu
H. MUC-1 -
- 7.
Natural Killer Cells are proliferated to
- A.
IL-1
- B.
IL-2
- C.
IL-3
- D.
IL-4
Correct Answer
B. IL-2 -
- 8.
In a normal NK cell, where does the inhibitory receptor bind?
- A.
To the NK cell ligand
- B.
MHC class I molecules
- C.
To the foreign antigen cell ligand
- D.
To IL-2
Correct Answer
B. MHC class I molecules -
- 9.
How are NK cells activated on Viruses
- A.
ITAMS (immunoreceptor tyrosine based activation motifs)
- B.
ITIMS (immunoreceptor tyrosine based inhibitory motifs)
Correct Answer
B. ITIMS (immunoreceptor tyrosine based inhibitory motifs) -
- 10.
What causes a increase in lytic machinery in NK cells after the recruitment and activation of the protein kinase?
- A.
Production of IFN gamma; Increase in IL-2R
- B.
Halt production of IFN gamma; Decrease IL-2R
- C.
Production of IFN beta; Increase in IL-4
- D.
Production of IFN beta; Increase in IL-4
Correct Answer
A. Production of IFN gamma; Increase in IL-2R -
- 11.
When ITIMS is activated on NK cells, removal of phosphate groups happens
- A.
True
- B.
False
Correct Answer
B. False -
- 12.
If you wanted to utilizes NK cells to kill a tumor, the tumor would have to lack class I MHC; have a sepcific NIK antibody; or have specific NK adhesion molecules
- A.
True
- B.
False
Correct Answer
A. True -
- 13.
______ is the corecptor which assists the T cell receptor with an antigen presenting cell
- A.
CD4
- B.
CD8
- C.
CD1
- D.
CD2
Correct Answer
A. CD4 -
- 14.
_____ is the coreceptor which is found on cytotoxic T cells
- A.
CD1
- B.
CD2
- C.
CD4
- D.
CD8
Correct Answer
D. CD8 -
- 15.
______ is capable of stimulating an immune response
- A.
Antigen
- B.
Antibody
Correct Answer
A. Antigen -
- 16.
T cell receptors are responsible for
- A.
Recognizing antigens bound to MHC molecules
- B.
Recognizing antibodies on foreign cells
- C.
Recognizing B cell antibodies
- D.
Expressing CD2
Correct Answer
A. Recognizing antigens bound to MHC molecules -
- 17.
A NK cell expresses
- A.
CD16 (FcgRIII)
- B.
CD8
- C.
CD4
- D.
CD2
Correct Answer
A. CD16 (FcgRIII) -
- 18.
_______ is a molecule released by NK cells which promote cell death and apoptosis
- A.
IFN gamma
- B.
CD8
- C.
MHC Class I
- D.
Caspase Cascade
Correct Answer
A. IFN gamma -
- 19.
Cytotoxic T Lymphocyte mediated destruction of cells are _________ mediated
- A.
Perforin
- B.
Na+ / K+
- C.
CD18
- D.
CD4
Correct Answer
A. Perforin -
- 20.
Perforin is ______ dependent
- A.
Ca++
- B.
Na+
- C.
K+
- D.
Cl-
Correct Answer
A. Ca++ -
- 21.
Granzymes are sereine proteases which are produced by NK cells and CTL cells. They enter the invading cell through pores created by perfornin and cause apoptosis via the DEATH pathway.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
Via the caspase pathwayRate this question:
-
- 22.
Activated ______ produce TNFa which induces apoptosis of tumor cells through Fas pathway
- A.
CTL
- B.
NK Cells
- C.
Macrophages
- D.
Mast Cells
Correct Answer
C. Macrophages -
- 23.
If a antibody covers the TSA, will the tumor escape the immune system?
- A.
Yes
- B.
No
Correct Answer
A. Yes -
- 24.
Active immunotherapy stimulates an immune response that can directly target tumor antigens
- A.
True
- B.
False
Correct Answer
A. True -
- 25.
Type I hypersensitivity is mediated by
- A.
IgA
- B.
IgE
- C.
IgG
- D.
IgM
Correct Answer
B. IgE -
- 26.
Type II Hypersensitivity is mediated by
- A.
IgE
- B.
Soluble antibodies to molecules on cells and tissues
- C.
Immune complexes from chronic exposure to antigens
- D.
Immunocytes
Correct Answer
B. Soluble antibodies to molecules on cells and tissues -
- 27.
Type III hypersensitivity is mediated by
- A.
IgE
- B.
Soluble antibodies to moleculeso in cells and tissues
- C.
Immune complexes from chronic exposure to antigens
- D.
Immunocytes
Correct Answer
C. Immune complexes from chronic exposure to antigens -
- 28.
Type IV Hypersensitivity is mediated by
- A.
IgE
- B.
Soluble antibodies to molecules on cells and tissues
- C.
Immune complexes from chronic exposure to antigens
- D.
Immunocytes
Correct Answer
C. Immune complexes from chronic exposure to antigens -
- 29.
A bee sting is considered a Type ____ hypersensitivity
- A.
I
- B.
II
- C.
III
- D.
IV
Correct Answer
A. I -
- 30.
____ is the predominant antibody in secondary immune responses
- A.
IgG
- B.
IgA
- C.
IgM
- D.
IgD
- E.
IgE
Correct Answer
A. IgG -
- 31.
____ is found in serum, secreted fluids (sliva tears etc) and is an important component in mucosal immunity
- A.
IgG
- B.
IgA
- C.
IgM
- D.
IgD
- E.
IgE
Correct Answer
B. IgA -
- 32.
____ is the first immunoglobulin to appear in phylogeny, the first immunoglobulin to appear in response to antigen stimulation, and is the first antigen to appear in otogeny.
- A.
IgG
- B.
IgA
- C.
IgM
- D.
IgD
- E.
IgE
Correct Answer
C. IgM -
- 33.
____ is involved in allergenic reactions and is referred to as a reaginic antibody. It laos has a Fc region that binds to receptors on basophils and mast cells.
- A.
IgG
- B.
IgA
- C.
IgM
- D.
IgD
- E.
IgE
Correct Answer
E. IgE -
- 34.
IgE binds to high affinity IgE specific FC receptors on basophils and mast cells which are cross linked by allergens
- A.
True
- B.
False
Correct Answer
A. True -
- 35.
Histamine binding on smooth muscle cells causes dilation
- A.
True
- B.
False
Correct Answer
B. False -
- 36.
H2 receptors are located on
- A.
Smooth muscle cells
- B.
Skeletal muscle cells
- C.
Endothelial Cells
- D.
Mucosa
Correct Answer
D. Mucosa -
- 37.
A larger redness in a wheel and flare reaction means that you are ______
- A.
More allergic
- B.
Less allergic
Correct Answer
A. More allergic -
- 38.
What molecule does IgE use to bind and activate eosinophils?
- A.
CD4
- B.
CD18
- C.
CD23 (FceRII)
- D.
CD8
Correct Answer
C. CD23 (FceRII) -
- 39.
Major Basic Protein is secreted by
- A.
Eosinophils
- B.
Mast Cells
- C.
Lymphocytes
- D.
Erythrocytes
Correct Answer
A. Eosinophils -
- 40.
Type II hypersensitivity is mediated by
- A.
IgE
- B.
IgM
- C.
IgA
- D.
IgG and IgM
Correct Answer
D. IgG and IgM -
- 41.
Foreign antigens such as blood transfusion reactoin and hemolytic disease of the newborn, along with autoimmune diseases such as autoimmune hemolytic anemia and myasthenia graves are examples of Type ____ hypersenstiivit
- A.
Type I
- B.
Type II
- C.
Type III
- D.
Type IV
Correct Answer
B. Type II -
- 42.
Which Type of Hypersensitivity involves interaction with the lytic complemetn pathway?
- A.
I
- B.
II
- C.
III
- D.
IV
Correct Answer
B. II -
- 43.
A coombs reagent is
- A.
Anti-IgG
- B.
Anti-IgA
- C.
Anti-IgM
- D.
Anti-IgE
Correct Answer
A. Anti-IgG -
- 44.
Type II hypersensitivities can be drug induced
- A.
True
- B.
False
Correct Answer
A. True -
- 45.
Which type of hypersensitivty is caused to due to persistant microbial infection (eg chronic exposure to extrinsic antigens?)
- A.
I
- B.
II
- C.
III
- D.
IV
Correct Answer
C. III -
- 46.
Platelet aggregation, activation of complement and release of anaphylatoxins and chemotactic facotrs, and clotting facotr formation is a consequence of which hypersensativity?
- A.
I
- B.
II
- C.
III
- D.
IV
Correct Answer
C. III -
- 47.
Cell mediated immunity is an example of which type of hypersensitivity reaction
- A.
I
- B.
II
- C.
III
- D.
IV
Correct Answer
D. IV -
- 48.
Type III hypersensitivity is mediated by Th1 cells and a reaction occurs 24-48 hours after contact
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
type4Rate this question:
-
- 49.
Which type of hypersensitivity involves CD4+ TH1 cells which secrete cytokines that activate macrophages (IFN-y_ that induce inflammation (TNF)
- A.
I
- B.
II
- C.
III
- D.
IV
Correct Answer
D. IV -
- 50.
Which hypersensitivity pathways utilize the compliment system?
- A.
I
- B.
II
- C.
III
- D.
IV
Correct Answer(s)
B. II
C. III -
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-
Current Version
-
Sep 23, 2012Quiz Edited by
ProProfs Editorial Team -
Sep 10, 2012Quiz Created by
Rickythegreat
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