Immunology

38 Questions

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Immunology Quizzes & Trivia

Questions and Answers
  • 1. 
    Which Leukocyte respondes to bacterial infection and are the first leukocyte to migrate to site of infection? They bind to antigen/antibody complexes and perform phagocytosis 
    • A. 

      Neutrophil

    • B. 

      Basophil

    • C. 

      Eosinophil

    • D. 

      Monocyte

    • E. 

      LYmphocyte

  • 2. 
    Which leukocyte responds to parasitic infection?
    • A. 

      Neutrophil

    • B. 

      Monocyte

    • C. 

      Esoinophil

    • D. 

      Basophil

    • E. 

      Lymphocyte

  • 3. 
    Which leukocyte responds to allergic infection?
    • A. 

      Neutrophil

    • B. 

      Monocyte

    • C. 

      Esoinophil

    • D. 

      Basophil

    • E. 

      Lymphocyte

  • 4. 
    Macrophages differentiate into Monocytes
    • A. 

      True

    • B. 

      False

  • 5. 
    Phagocytosis By Neutrophils: 1. They recognise and bind to antigens through Fab receptors 2. The antigen is then engulfed by pseudopods and internalised forming a phagosome 3. Granules fuse with phagosome forming phagolysosome  4. Enzymatic contents kill and digest micro-orgaanism 5. Digested material is then endocytosed. 
    • A. 

      True

    • B. 

      False

  • 6. 
    Which leukocyte also secrete substances called interleukins that send chemical signals round the body to activate complement system, trigger inflamation and recruit macrophages. 
    • A. 

      Monocytes

    • B. 

      Neutrophils

    • C. 

      Basophils

    • D. 

      Esoinophils

  • 7. 
    Which T cell binds to MHC I?
    • A. 

      Helper

    • B. 

      Cytotoxic

  • 8. 
    Which T cell binds to MHC II?
    • A. 

      Helper

    • B. 

      Cytotoxic

  • 9. 
    Which type of immunity is rapid and non-specific 
    • A. 

      Innate

    • B. 

      Acquired

    • C. 

      Artificial

  • 10. 
    Which type of immunity iincludes the humoral (antibody) and the cellmediated (T Cell)
    • A. 

      Innate

    • B. 

      Acquired

    • C. 

      Artificial

  • 11. 
    The Passive Immune System is immunity that can be transferred across the placenta in all animal or through colostrum. It is long-lasting and breaks down easily.  Antibodies are static and don't replicate. Colostrum contains trypsin inhibitors, IgG and IgA
    • A. 

      True

    • B. 

      False

  • 12. 
    Which of these is true about ARTIFICIAL immunity?
    • A. 

      Induced by exposure to antigen by vaccination

    • B. 

      Antigen is presented to T and B cells by APCs

    • C. 

      This mounts an immune response that is re-inforced by boosters

    • D. 

      Antigen is presented to T and B cells by anitbodies

  • 13. 
    What is the first cell recruited to site of infection?
    • A. 

      Neutrophil

    • B. 

      Macrophage

    • C. 

      Dendritic Cell

    • D. 

      Antibody

  • 14. 
    Which of these are caused by interleukins released by Neutrophils?
    • A. 

      Triggers Inflammation

    • B. 

      Recruits macrophages and other cells to site of infection

    • C. 

      Phagocytosis

    • D. 

      Activate Complement System

    • E. 

      Chemolysis

  • 15. 
    Complement is a set of protein (C1-C8) produced by the liver that circulate in the blood. Once activated they damage the pathogen by creating pores allowing osmosis = lysis, also cause opsonisation and guide other immune cells by chemotaxis. 
    • A. 

      True

    • B. 

      False

  • 16. 
    Which 2 cells act as APCs and engulf pathogens, displaying the fragments on MHC II surface proteins. 
    • A. 

      Macrophages

    • B. 

      Dendritic Cells

    • C. 

      Dendrites

    • D. 

      Antibodies

    • E. 

      Infected Cells

  • 17. 
    When the cell mediated response is initiated, T cell mature in the Bursa by clonal selection and proliferation. APCs present MHC II fragments to Helper T cell causes the release of cytokines which stimulate division of Cytotoxic T cells which secrete toxins that kill infected cells displaying antigen fragments on MHC I proteins - create pores in membrane. 
    • A. 

      True

    • B. 

      False

  • 18. 
    Cytokines released by helper T cells cause proliferation of B cells into plasma cells which dosplay antibodies and Memory B cells 
    • A. 

      True

    • B. 

      False

  • 19. 
    Which of these is true about B cells?
    • A. 

      Mature in the bone marrow

    • B. 

      Activated when it meets a matching antigen

    • C. 

      Engulfs matching antigens and display MHC I on surface protein which attracts helper T cells

    • D. 

      Cytokines released cause proliferation od B cells and antibody production

    • E. 

      Antigen/anitbody complex are then destroyed by Tc cells.

  • 20. 
    Which lasts longer, Memory T or B cells?
    • A. 

      B

    • B. 

      T

  • 21. 
    Antibodies recognise and bind to specific epitopes on antigens and 'tag' them for attack or directly neutralise thme
    • A. 

      True

    • B. 

      False

  • 22. 
    Which fragment deterimines epitope shape?
    • A. 

      Fab

    • B. 

      Fc

  • 23. 
    Which fragment deterimines biological properties and mediates different immune responses?
    • A. 

      Fab

    • B. 

      Fc

  • 24. 
    Which is the only Dimeric Antibody?
    • A. 

      IgM

    • B. 

      IgA

    • C. 

      IgD

    • D. 

      IgG

    • E. 

      IgE

  • 25. 
    Which antibody is monomeric when bound to a B cell and pentameric shen in serum?
    • A. 

      IgM

    • B. 

      IgA

    • C. 

      IgD

    • D. 

      IgG

    • E. 

      IgE

  • 26. 
    Which antibody do we not know much about except that it functions as an antigen receptor on naive B cells and may have a role in their maturation? Is also monomeric
    • A. 

      IgM

    • B. 

      IgA

    • C. 

      IgD

    • D. 

      IgG

    • E. 

      IgE

  • 27. 
    Which antibody is most abundant at end of primary and beginning of secondary immune response?
    • A. 

      IgM

    • B. 

      IgA

    • C. 

      IgD

    • D. 

      IgG

    • E. 

      IgE

  • 28. 
    Which antibody is found ont he suface of mast cells in tissue and basophils in blood?
    • A. 

      IgM

    • B. 

      IgA

    • C. 

      IgD

    • D. 

      IgG

    • E. 

      IgE

  • 29. 
    Which is the only antibody that can be pentameric?
    • A. 

      IgM

    • B. 

      IgE

    • C. 

      IgA

  • 30. 
    Which  antibody is the most important placentally?
    • A. 

      IgM

    • B. 

      IgG

    • C. 

      IgA

  • 31. 
    Antibodies are produced by plasma cells either in a soluble form, or in a  membrane bound form attached to B cells called B Cell receptors (eg IgM, IgD and IgE)
    • A. 

      True

    • B. 

      False

  • 32. 
    BCRs are antibodies attached to membrane of B cells that cailitate the activiation of that cell either to plasma or memory. 
    • A. 

      True

    • B. 

      False

  • 33. 
    Which antibody is secreted when B cells differentiate into plasma cels? Its presence therefore indicates recent infection. 
    • A. 

      IgM

    • B. 

      IgG

    • C. 

      IgA

  • 34. 
    As the primary immune response progresses, SWITCHING occurs. T cell cytokines direct plasma cells o alter the type of antibody being prodced - Seroconversion
    • A. 

      True

    • B. 

      False

  • 35. 
    What are the stimulus for Seroconversion?
    • A. 

      Cytokines

    • B. 

      Interleukins

    • C. 

      Antigen/Antibody complexes

  • 36. 
    What are the effects of antibodies?
    • A. 

      Immobilise pathogens by binding to them - then broken down in liver and spleen by macrophages

    • B. 

      Immobilise toxins y binding to them

    • C. 

      Immobilise Parasites by binding to them

    • D. 

      Opsonise Pathogens by binding to them via Fab fragment and then binding a phagocytic cell by Fc, making phagoytsosi more efficient - IgG is the most important Opsonin

    • E. 

      Opsonise Pathogens by binding to them via Fc fragment and then binding a phagocytic cell by Fab, making phagoytsosi more efficient - IgG is the most important Opsonin

    • F. 

      Stimulate Complement system to lyse pathogens

    • G. 

      Phagocytose pathogens directly

  • 37. 
    Which of these are non-specific and recognise many epitopes on one antigen?
    • A. 

      Polyclonal

    • B. 

      Monoclonal

  • 38. 
    Monoclonal Antibodies are produces by the           Method