Immunology

1. A larger redness in a wheel and flare reaction means that you are ______

More allergic

Less allergic

2. The goal of active immunization is the elicitation of protective immunity and immunologic memory

True

False

3. ____ is involved in allergenic reactions and is referred to as a reaginic antibody. It laos has a Fc region that binds to receptors on basophils and mast cells.

IgG

IgA

IgM

IgD

IgE

4. ____ is found in serum, secreted fluids (sliva tears etc) and is an important component in mucosal immunity

IgG

IgA

IgM

IgD

IgE

5. A person with persistant, recurrent infections or severe infection by microorganisms that do not usually cause severe infection could potentially have a immunodeficiency disorder

True

False

6. ______ is capable of stimulating an immune response

Antigen

Antibody

7. Which type of PMN is 60-70% of WBC?

Neutrophils

Basophils

Eosphiophils

Macrophage

8. 50% of patients with SCID lack adenosine deaminase (ADA)

True

False

9. A non-hodgkins lymphoma and kaposis sarcoma are two examples of someone who could potentially have a immunodeficiency disorder

True

False

10. Type II hypersensitivity is mediated by

IgE

IgM

IgA

IgG and IgM

11. Type I hypersensitivity is mediated by

IgA

IgE

IgG

IgM

12. IgE binds to high affinity IgE specific FC receptors on basophils and mast cells which are cross linked by allergens

True

False

13. Active immunotherapy stimulates an immune response that can directly target tumor antigens

True

False

14. Which class of MHC molecules present peptides to CD4+ lymphocytes

Class I

Class II

Class III

15. Type II hypersensitivities can be drug induced

True

False

16. A bee sting is considered a Type ____ hypersensitivity

I

II

III

IV

17. Which class of MHC proteins interacts with the TCRs of CD8+ T lymphocytes

MHC Class I

MHC Class II

MHC Class III

18. If you wanted to utilizes NK cells to kill a tumor, the tumor would have to lack class I MHC; have a sepcific NIK antibody; or have specific NK adhesion molecules

True

False

19. T cell receptors are responsible for

Recognizing antigens bound to MHC molecules

Recognizing antibodies on foreign cells

Recognizing B cell antibodies

Expressing CD2

20. ______ is the corecptor which assists the T cell receptor with an antigen presenting cell

CD4

CD8

CD1

CD2

21. ____ is the predominant antibody in secondary immune responses

IgG

IgA

IgM

IgD

IgE

22. ____ is the first immunoglobulin to appear in phylogeny, the first immunoglobulin to appear in response to antigen stimulation, and is the first antigen to appear in otogeny.

IgG

IgA

IgM

IgD

IgE

23. What type of cell is not involved in innate immunity

Macrophages

Neutrophils

Natural Kiler Cells

T Lymphocyte

24. PAMPs are recognized by

Antigens

Pattern Recognition Receptor

Antibodies

Phagocytes

25. Antibodies are inable to penetrate a tumor

True

False

26. Natural Killer Cells are proliferated to

IL-1

IL-2

IL-3

IL-4

27. Perforin is ______ dependent

Ca++

Na+

K+

Cl-

28. A patient with wiskott aldrich symptoms would have excellent blood clotting

True

False

29. Asthma, insect venom sesnitivity, and atropic dermatitis is an example of what type of hypersensitivity?

I

II

III

IV

30. _____ is the coreceptor which is found on cytotoxic T cells

CD1

CD2

CD4

CD8

31. Which molecule mediates interactions of leukocytes with other leukokocytes or body cells?

MHC

Mast Cells

Antigens

Antibodies

32. What T cells activate Macrophages?

CD8+ CTL and CD4+ helpers

CD4+ CTL and CD8+ helpers

CD4- CTL and CD8- helpers

CD8- CTL and CD8+ helpers

33. What molecule does IgE use to bind and activate eosinophils?

CD4

CD18

CD23 (FceRII)

CD8

34. If a antibody covers the TSA, will the tumor escape the immune system?

Yes

No

35. An example of a microbial non-self molecule is a

PAMP

Neutrophils

Eosinophils

Heparin

FC Receptor

36. Which PMN stains red in a geimsa stain?

Neutrophil

Eosinophil

Basophil

Macrophage

37. The goal of active immunization is transient protection or alleviation of an existing condition

True

False

38. Autoimmune/drug induced hemolytic anemia, transfusion reactions, rhematic fever are an example of wht type of hypersensitivity?

I

II (cytotoxic)

II (noncytotoxic)

III

IV

39. A NK cell expresses

CD16 (FcgRIII)

CD8

CD4

CD2

40. What type of receptor found on the surface of certain cells binds to antibodies on invading cells or pathogens?

Fc receptors

Toll Like Receptor

C3a

FCeR1

IL4 Receptor

None of the above

41. Type III hypersensitivity is mediated by

IgE

Soluble antibodies to moleculeso in cells and tissues

Immune complexes from chronic exposure to antigens

Immunocytes

42. A coombs reagent is

Anti-IgG

Anti-IgA

Anti-IgM

Anti-IgE

43. What causes a increase in lytic machinery in NK cells after the recruitment and activation of the protein kinase?

Production of IFN gamma; Increase in IL-2R

Halt production of IFN gamma; Decrease IL-2R

Production of IFN beta; Increase in IL-4

44. Which disease is charactarized by creamy white or bluish white patches on the tounge?

Chronic Mucocutaneous candidiasis

DiGeorge Syndrome

Severe combined deficiencies disease (SCID)

X linked infantile aggaglobulinemia

45. Give an example of a PMN

T lymphocyte

Erythrocyte

Eosinophil

Macrophage

Natural Killer Cell

46. Which type of cell participates ONLY in innate immunity?

Macrophage

T lymphocyte

B lymphocyte

Natural Killer Cells

47. Type II Hypersensitivity is mediated by

IgE

Soluble antibodies to molecules on cells and tissues

Immune complexes from chronic exposure to antigens

Immunocytes

48. Which B lymphocyte disorder causes decreased immune function in the mucosal surface in the mouth, GI tract, and lungs resulting in an increased risk for respiratory and GI infections?

X-linked infantile aggaglobulinemia

Transient hypogammaglobulinemia

Common variable hypogammaglobulinemia

IgA deficiency

49. Foreign antigens such as blood transfusion reactoin and hemolytic disease of the newborn, along with autoimmune diseases such as autoimmune hemolytic anemia and myasthenia graves are examples of Type ____ hypersenstiivit

Type I

Type II

Type III

Type IV

50. Cytotoxic T Lymphocyte mediated destruction of cells are _________ mediated

Perforin

Na+ / K+

CD18

CD4

51. Cell mediated immunity is an example of which type of hypersensitivity reaction

I

II

III

IV

52. Which disease is characterized by a defective thymus, low calcium, and speech/feeding problems?

DiGeorge Syndrome

Chronic Mucocutaneous candiasis

Severe combined deficiencies disease (SCID)

Transient hypogammaglobulinemia

53. The recognition of molecular structure that is unique to a microorganism and not produced by a host is an example of

Microbial Non-Self

Missing Self

NK Cell Activation

T cell up-regulation theory

54. What fraction of lymphocytes are B cells

1/2

1/3

1/4

1/8

55. Which PMN contains a multi-looped nuclei?

Neutrophils

Basophils

Eosinophils

All of the above

56. Which of the following is not a risk associated with passive immunotherapy?

Introduction of antibodies from other species can generate IgE antibodies, which may cause systemic anaphylaxis

Intorduction of antibodies from humans can eleicit responses against minor immunoglobulin polymorphisms (allotypes)

leads to type III hypersensitivity rxns

Explanation

leads to type III hypersensitivity rxns

57. Which disease involves defective oxidative metabolism and an inability of the bodies phagocytic cells to make hydrogen peroxide / other oxidants needed to kill microorganisms?

Chronic granulomatous disease

Complement deficiency

Severe combined deficiencies disease (SCID)

DiGeorge syndrome

58. Someone who has systemic infections which involves recurrent bacterial infections, impaired pus formation, and impaired wound healing is a immune deficient patient with a suceptibility in

B-cells

T-cells

Phagocytes

Complement

Leukocyte Adhesion Molecules

59. Which type of cell stains purple in a Geimsa stain?

Neutrophil

Basophil

Eosinophil

Macrophage

60. How are NK cells activated on Viruses

ITAMS (immunoreceptor tyrosine based activation motifs)

ITIMS (immunoreceptor tyrosine based inhibitory motifs)

61. Type III hypersensitivity is mediated by Th1 cells and a reaction occurs 24-48 hours after contact

True

False

type4

Explanation

type4

62. The recognition of molecular structures which are expressed only on normal and unifected cells of the host is what strategy for recognition

Microbial Non Self

Missing Self

T Cell Activation Theory

NK Cellular Activation Theory

63. Which of the following is NOT a molecule which could be considred a PAMP

DsRNA

TLR

Mannan binding lectin

Unmethylated CpG DNA

DNA repair enzymes

64. In a normal NK cell, where does the inhibitory receptor bind?

To the NK cell ligand

MHC class I molecules

To the foreign antigen cell ligand

To IL-2

65. Which disease is treated by isolation, replacement therapy, and bone marrow transplantation?

Severe ocmbined deficiencies disease (SCID)

Chediak Higashi Syndrome

Complement Deficiency

Herediatry angioneurotic edema

66. Which PMN contains 1-4% of WBC concentration?

Neutrophil

Eosinophil

Basophil

Macrophage

67. _______ is a molecule released by NK cells which promote cell death and apoptosis

IFN gamma

CD8

MHC Class I

Caspase Cascade

68. Which disease is caused by genes which encode preoteins necessary for the development of T and B lymphocytes?

Severe combined deficiencies disease (SCID)

Chediak Higashi Syndrome

Chronic granulomatous disease

Complement deficiency

69. What percentage of lymphocytes are T cells?

1/4

1/3

1/2

1/8

70. Which type of hypersensitivity involves CD4+ TH1 cells which secrete cytokines that activate macrophages (IFN-y_ that induce inflammation (TNF)

I

II

III

IV

71. Which class of HSP are components of the compliment system (C2, C4, B Factor) cytokines (TNF-a, LTA, LTB), and heat shock proteins (hsp)

I

II

III

72. Someone who has a recurrent bacterial infections (otitis media and pneumonia) is a immune deficient patient with a suceptibility in

B-cells

T-cells

Phagocytes

Complement

Leukocyte Adhesion Molecules

73. Someone who has a recurrent intracellular infections (viral, bacterial, fungal, protozoal infections) is a immune deficient patient with a suceptibility in

B-cells

T-cells

Phagocytes

Complement

Leukocyte Adhesion Molecules

74. What fraction of lymphocytes are NK cells?

1/2

1/3

1/4

1/8

75. Which disease is characterized by a low level of lysosomal enzyme

Chediak Higashi Syndrome

Chronic granulomatous disease

Compliment deficiency

Hereditary agnineurotic edema

76. Which PMN stains blue in a geimsa stain?

Neutrophil

Eosinophil

Basophil

Macrophage

77. Which Type of Hypersensitivity involves interaction with the lytic complemetn pathway?

I

II

III

IV

78. Myasthenai gravis, graves disease are an example of what type of hypersensitivity

I

II (cytotoxic)

II (noncytotoxic)

III

IV

79. Which B Lympocyte disorder is classified by there being no B cells, along with pre-B cells which failt to develop into mature B cells? In addtion, ALL CLASSES of Ig are absent

X-linked infantile aggaglobulinemia

Transient hypogammaglobulinemia

Common variable hypogammaglobulinemia

IgA deficiency

80. Activated ______ produce TNFa which induces apoptosis of tumor cells through Fas pathway

CTL

NK Cells

Macrophages

Mast Cells

81. Which disease is characterized by a staggering gait and spider like vascular dilation?

Ataxia telangiectasis

Wiskott-Adlrich syndrome

Chediak Higashi syndrome

Chronic granulomatous disease

82. Which type of hypersensitivty is caused to due to persistant microbial infection (eg chronic exposure to extrinsic antigens?)

I

II

III

IV

83. Type IV Hypersensitivity is mediated by

IgE

Soluble antibodies to molecules on cells and tissues

Immune complexes from chronic exposure to antigens

Immunocytes

84. Which Immunoglubin is useful in diagnosing infections in neonate?

IgM

IgD

IgG

IgA

85. Granzymes are sereine proteases which are produced by NK cells and CTL cells. They enter the invading cell through pores created by perfornin and cause apoptosis via the DEATH pathway.

True

False

Via the caspase pathway

Explanation

Via the caspase pathway

86. H2 receptors are located on

Smooth muscle cells

Skeletal muscle cells

Endothelial Cells

Mucosa

87. Which disease is diagnosed by utilizing serum immunoelectrophoresis and quantitattive immunoglobulins

IgA deficiency

DiGeorge Syndrome

Severe combined deficiencies disease (SCID)

Compliment Deficiency

88. When ITIMS is activated on NK cells, removal of phosphate groups happens

True

False

89. Which hypersensitivity pathways utilize the compliment system?

I

II

III

IV

Submit

90. Histamine binding on smooth muscle cells causes dilation

True

False

91. Which B lympocyte disorder involves the failure of a B cell to mature into a plasma cell?

X linked infantile aggagolubulinemia

Transient hypogammaglobulinemia

Common variable hypogammaglobulinemia

IgA deficiency

92. Major Basic Protein is secreted by

Eosinophils

Mast Cells

Lymphocytes

Erythrocytes

93. Someone who has systemic infections with bacteria that are normally of low virulence is a immune deficient patient with a suceptibility in

B-cells

T-cells

Phagocytes

Complement

Leukocyte Adhesion Molecules

94. Microbial Non-Self molecules vary among pathogens of a given class

True

False

95. Platelet aggregation, activation of complement and release of anaphylatoxins and chemotactic facotrs, and clotting facotr formation is a consequence of which hypersensativity?

I

II

III

IV

96. Someone who has systemic infections with bacterial infection and autoimmune disease is a immune deficient patient with a suceptibility in

B-cells

T-cells

Phagocytes

Complement

Leukocyte Adhesion Molecules

97. Which disease is caused by a deficiencies in the regulators of complement?

Hereditary angioneurotic edema

Chronic granulamouts disease

Severe combinded deficiencies disease (SCID)

Chronic muscocutaneous candidiasis

98. Select the antigen(s) which is expressed on Lymphoma

Cyclin dependent kinase 4

B-Catenin

Caspase-8

MAGE-1/MAGE-3

Tyrosinase

Surface Ig idiotype

Her-2/neu

MUC-1

99. Select the antigen(s) which is expressed on Squamous cell Carcinoma

Cyclin dependent kinase 4

B-Catenin

Caspase-8

MAGE-1/MAGE-3

Tyrosinase

Surface Ig idiotype

Her-2/neu

MUC-1

100. Select the antigen(s) which is expressed on Breast Cancer

Cyclin dependent kinase 4

B-Catenin

Caspase-8

MAGE-1/MAGE-3

Tyrosinase

Surface Ig idiotype

Her-2/neu

MUC-1

Submit

101. Select the antigen(s) which is expressed on Melanoma

Cyclin dependent kinase 4

B-Catenin

Caspase-8

MAGE-1/MAGE-3

Tyrosinase

Surface Ig idiotype

Her-2/neu

MUC-1

Submit