Immunology: Tcrs, Cytokines, Immunity Reactions At The Cellular Level

37 Questions | Total Attempts: 574

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Immunology Quizzes & Trivia

TEST 3 IMMUNOLOGY


Questions and Answers
  • 1. 
    Cytokines involved in acquired immunity
    • A. 

      IL-1, IL-6, IL-18, IFN-A, IFN-B, AND TNF-A

    • B. 

      IL-2, IL-4, IL-5, IL-13, IFN-G, TNF-B, AND TGF-B

    • C. 

      ONLY IL-1, IL-6, IL-12, AND TNF-A

    • D. 

      ONLY IFN-G, AND IL-10

  • 2. 
    CHEMOKINES ARE PRODUCED MOSTLY BY WHICH MOLECULES
    • A. 

      NK CELLS

    • B. 

      MACROPHAGES

    • C. 

      ENDOTHELIAL CELLS, EPITHELIAL CELLS, AND FIBROBLASTS

    • D. 

      TH1 AND TH2 CELLS

  • 3. 
    WHICH OF THE FOLLOWING MOLECULES ARE MACROPHAGE DEACTIVATING FACTORS BLOCKING MACROPHAGE FUNCTIONS, INCLUDING TNF-A RELEASE:
    • A. 

      E SERIES PROSTAGLANDINS

    • B. 

      TGF-B

    • C. 

      IL-4 AND IL-10

  • 4. 
    IL-8 IS WHICH TYPE OF CHEMOKINE
    • A. 

      CC-CC

    • B. 

      CXC

    • C. 

      CXCX

    • D. 

      CXXC

  • 5. 
    WHICH OF THE FOLLOWING IS TRUE REGARDING THE NUMBER OF SUBFAMILIES OF CHEMOKINES
    • A. 

      2

    • B. 

      4

    • C. 

      3

    • D. 

      0 SUBFAMILIES

  • 6. 
    THE INNATE IMMUNITY CYTOKINES ARE:
    • A. 

      IL-1, IL-6, IL-12 AND TNF-A ONLY

    • B. 

      IL-2, IL-4, IL-5, IL-13, IFN-G, TNF-B, AND TGF-B

    • C. 

      ONLY IFN-G AND IL-2

    • D. 

      IL-1, IL-6, IL-12, IL-18, IFN-A, IFN-B, AND TNF-A

  • 7. 
    THE SIGNATURE CYTOKINES PRODUCED BY TH1 CELLS 
    • A. 

      IL-10

    • B. 

      IFN-G AND SOMETIMES IL-2

    • C. 

      TNF-A

  • 8. 
    WHICH ARE THE SIGNATURE CYTOKINES PRODUCED BY TH2 CELLS
    • A. 

      IL-4

    • B. 

      IL-2

    • C. 

      IL-10

  • 9. 
    WHICH INTERLUEKIN IS ALSO LAF?
  • 10. 
    TRUE OR FALSE: A T CELL CAN RELEASE ITS RECEPTOR AND RECOGNIZE ANTIGEN IN ITS NATURAL STATE
    • A. 

      FALSE

    • B. 

      TRUE

  • 11. 
    WHICH OF THE FOLLOWING ARE ANTIGEN PRESENTING CELLS
    • A. 

      MACROPHAGE

    • B. 

      DENDRITIC CELLS

    • C. 

      B CELLS

  • 12. 
    A/B TCRs HAVE A TOTAL DIVERSITY OF:
    • A. 

      ~ 1O^18

    • B. 

      ~ 10^13

    • C. 

      ~ 10^14

    • D. 

      ~ 10^15

  • 13. 
    COLIGATION OF TCR WITH MHC/PEPTIDE CTLA-4 WITH B7 LEADS TO 
    • A. 

      ARREST OF CELL-CYCLE AND TERMINATION OF T-CELL ACTIVATION

    • B. 

      ENABLES T CELL TO BE RECOGIZED BY BOTH CELL-CLL CONTACT AND CYTOKINES

    • C. 

      PROMOTES B-CELL PROLIFERATION AND DIFFERENTIATION, PREVENTS APOPTOSIS OF GERMINAL CENTER B CELLS AND PROMOTES ANTIBODY CLASS SWITCHING

  • 14. 
    WHICH INTERACTIONS ARE ESSENTIAL FOR DIALOGUE BETWEN B AND T CELLS?
    • A. 

      CD28-B7

    • B. 

      CD2-CD58

    • C. 

      CD40-CD40L

  • 15. 
    FOLLICULAR DENDRITIC CELLS
    • A. 

      HOLD PROCESSED ANTIGEN ON SURFACE IN THE FORM OF SHORT-LIVED IMMUNE COMPLEXES

    • B. 

      HOLD UNPROCESSED, INTACT, ANTIGEN ON THEIR SURFACE INT HE FORM OF SHORT LIVED IMMUNE COMPLEXES

    • C. 

      HOLD INTACT, UNPROCESSED LONG LIVED IMMUNE COMPLEXES ON THEIR SURFACE

    • D. 

      HOLD PROCESSED, INTACT LONG LIVED ANTIGEN IN THE FORM OF LONG LIVED IMMUNE COMPLEXES ON THEIR SURFACE

  • 16. 
    THYMUS IS ROUGHLY DIVIDED INTO
    • A. 

      4 REGIONS

    • B. 

      2 REGIONS

    • C. 

      3 REGIONS

    • D. 

      5 REGIONS

  • 17. 
    CELLS ENTERING THE CORTICO-MEDULLARY JUNCTION EXPRESS CD3 ON THEIR CELL SURFACE
    • A. 

      True

    • B. 

      False

  • 18. 
    WHERE MIGHT ONE FIND CD25+CD44+CD4-CD8-
    • A. 

      REGION 1 OF THE THYMUS

    • B. 

      REGION 2 OF THE THYMUS

    • C. 

      REGION 3 OF THE THYMUS

    • D. 

      REGION 4 THE THYMUS

  • 19. 
    WHICH OF THE FOLLOWING CORRESPOND TO THE DN1 PHASE OF T CELL DEVELOPMENT
    • A. 

      UNCOMMITTED PROGENITORS; CD44+CD25-CD4-CD8-

    • B. 

      CLONAL EXPANSION

    • C. 

      LOSE POTENTIAL TO BECOME B CELLS OR NK CELLS

    • D. 

      CELLS COMMIT TO T CELL LINEAGE AND TCR B-CHAIN REARRANGEMENT OCCURS

  • 20. 
    DOUBLE POSITIVE CD44-CD25-CD4+CD8+ CELLS ARE FOUND 
    • A. 

      IN REGION 1 OF THE THYMUS

    • B. 

      IN REGION 2 OF THE THYMUS

    • C. 

      IN REGION 3 OF THE THYMUS

    • D. 

      IN REGION 4 OF THE THYMUS

  • 21. 
    AT WHICH STAGE IS THE T CELL'S FATE DETERMINED 
    • A. 

      STAGE 1

    • B. 

      STAGE 2

    • C. 

      STAGE 3

    • D. 

      STAGE 4

  • 22. 
    WHICH OF THE FOLLOWING ARE CHARACTERISTICS OF THE DN3 PHASE OR REGION 3 OF T CELL DEVELOPMENT?
    • A. 

      CELLS COMMIT TO T CELL LINEAGE

    • B. 

      TCR B-CHAIN REARRANGEMENT OCCURS

    • C. 

      T CELL LINEAGES ALPHA/BETA OR GAMMA/DELTA DIVERGE

    • D. 

      CD44-CD25+CD4-CD8-

    • E. 

      ALL OF THE ABOVE

  • 23. 
    POSITIVE SELECTION OCCURS MAINLY
    • A. 

      IN THE MEDULLA

    • B. 

      IN THE SUBCAPSULAR EPITHELIUM

    • C. 

      IN THE CORTEX

    • D. 

      IN THE CORTICO-MEDULLARY JUNTION

  • 24. 
    NEGATIVE SELECTION OCCURS MAINLY 
    • A. 

      IN THE CORTEX

    • B. 

      IN THE SUBCAPSULAR EPITHELIUM

    • C. 

      IN THE MEDULLA

    • D. 

      IN THE CORTICO-MEDULLARY JUNCTION

  • 25. 
    WHICH CELLS MEDIATE NEGATIVE SELECTION
    • A. 

      THYMIC EPITHELIAL CELLS

    • B. 

      THYMIC DENDRITIC CELLS

    • C. 

      THYMIC MACROPHAGES

    • D. 

      CD3+TCR+ T CELLS

    • E. 

      A, B, AND C