Immunology Quiz- Antibody Diversity
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- 1.
- A.
A single continuous DNA sequence; B cell
- B.
A single continuous DNA sequence; T cell
- C.
Sets of gene segments; B cell
- D.
Sets of gene segments; T cell
- 2.Which of the following is only contained in heavy chains and not in light chains?
- A.
Leader (L)
- B.
Joining (J)
- C.
Diversity (D)
- D.
Variable (V)
- E.
Constant (C)
- 3.
- A.
RAG-1 (Recombination-Activating Gene)
- B.
RAG-2 (Recombination-Activating Gene)
- C.
V(D)J-recombinase
- D.
V(D)J-lyase
- E.
A & B
- 4.In somatic recombination, the____ rearranges first. The____ region of the antibody molecule is generated via somatic recombination as it binds to the antigen and contains both a constant region and a variable region.
- A.
Heavy chain; Fab
- B.
Light chain; Fab
- C.
Heavy chain; Fc
- D.
Light chain; Fc
- 5.The two types of light chains are:
- A.
Alpha (a) and beta (b)
- B.
Sigma (s) and gamma (g)
- C.
Epsilon (e) and delta (d)
- D.
Omega (o) and zeta (z)
- E.
Lambda (l) and kappa (k)
- 6.During the final step of synthesis for heavy and light immunoglobulin chains, which of the following peptides is cleaved?
- A.
Leader (L)
- B.
Joining (J)
- C.
Diversity (D)
- D.
Variable (V)
- E.
Constant (C)
- 7.
- A.
V, D, and J gene segments are present in multiple copies (germline diversity)
- B.
VJ and VDJ gene segments can recombine in multiple combinations (combinatorial diversity)
- C.
Different sequences at the joint lead to greater antibody diversity (junctional diversity)
- D.
A single combination of light and heavy chains
- E.
Somatic hypermutation after antigenic stimulation
- 8.Class switching (isotype switching) involves rearrangement of the V(H) exon toassociate with a different C(H) exon at different times in the course of an immuneresponse. The____ region of the antibody molecule is affected (changed) via class switching and, unlike somatic recombination, this process is antigen____.
- A.
Fab; Dependent
- B.
Fab; Independent
- C.
Fc; Dependent
- D.
Fc; Independent
- 9.____ is frequently found on the surface of B cells co-expressed with____. These two classes are co-expressed not by class switching but by alternative processing of a primary RNA transcript. Both molecules expressed on the single mature B cell have the same binding specificity for antigen.
- A.
IgA & IgG
- B.
IgD & IgM
- C.
IgE & IgA
- D.
IgG & IgM
- E.
IgM & IgE
- 10.If alternative processing uses the first polyadenylation site, then what type of heavy chain mRNA is derived?
- A.
(alpha)
- B.
(gamma)
- C.
(delta)
- D.
(epsilon)
- E.
(mu)
- 11.If alternative processing uses the second polyadenylation site, then what type of heavy chain mRNA is derived?
- A.
(alpha)
- B.
(gamma)
- C.
(delta)
- D.
(epsilon)
- E.
(mu)
- 12.Production of secreted antibodies (pAs site) involves a____ chain of amino acids with a stretch of charged (versus non charged) amino acids at the____ terminus, in comparison to membrane bound antibody production (pAm site).
- A.
Shorter; NH2
- B.
Shorter; COOH
- C.
Longer; NH2
- D.
Longer; COOH
- 13.
- A.
It will be of the IgG1m(1) type
- B.
It will be of the IgG1m(2) type
- C.
It will contain both types
- D.
It will contain neither type
- E.
It will contain only one of the types
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