Immunology Quiz- Antibody Diversity
(238).jpg "Immunology Quiz- Antibody Diversity")
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- 1.Each polypeptide chain (heavy and light) on immunoglobulin has a variable (V) andconstant (C) region. Immunoglobulin chains are encoded by_____ that is/are rearrangedduring____ development to assemble a functional gene encoding either a heavy or a light chain.
- A.
A single continuous DNA sequence; B cell
- B.
A single continuous DNA sequence; T cell
- C.
Sets of gene segments; B cell
- D.
Sets of gene segments; T cell
- 2.Which of the following is only contained in heavy chains and not in light chains?
- A.
Leader (L)
- B.
Joining (J)
- C.
Diversity (D)
- D.
Variable (V)
- E.
Constant (C)
- 3.During the development of B cells, the Ig gene segments are rearranged and brought next to each other to form a contiguous functional gene (somatic recombination). The complex of enzymes involved in somatic recombination in lymphocytes is called:
- A.
RAG-1 (Recombination-Activating Gene)
- B.
RAG-2 (Recombination-Activating Gene)
- C.
V(D)J-recombinase
- D.
V(D)J-lyase
- E.
A & B
- 4.In somatic recombination, the____ rearranges first. The____ region of the antibody molecule is generated via somatic recombination as it binds to the antigen and contains both a constant region and a variable region.
- A.
Heavy chain; Fab
- B.
Light chain; Fab
- C.
Heavy chain; Fc
- D.
Light chain; Fc
- 5.The two types of light chains are:
- A.
Alpha (a) and beta (b)
- B.
Sigma (s) and gamma (g)
- C.
Epsilon (e) and delta (d)
- D.
Omega (o) and zeta (z)
- E.
Lambda (l) and kappa (k)
- 6.During the final step of synthesis for heavy and light immunoglobulin chains, which of the following peptides is cleaved?
- A.
Leader (L)
- B.
Joining (J)
- C.
Diversity (D)
- D.
Variable (V)
- E.
Constant (C)
- 7.Which of the following is NOT true regarding the mechanisms of generating antibody diversity?
- A.
V, D, and J gene segments are present in multiple copies (germline diversity)
- B.
VJ and VDJ gene segments can recombine in multiple combinations (combinatorial diversity)
- C.
Different sequences at the joint lead to greater antibody diversity (junctional diversity)
- D.
A single combination of light and heavy chains
- E.
Somatic hypermutation after antigenic stimulation
- 8.Class switching (isotype switching) involves rearrangement of the V(H) exon toassociate with a different C(H) exon at different times in the course of an immuneresponse. The____ region of the antibody molecule is affected (changed) via class switching and, unlike somatic recombination, this process is antigen____.
- A.
Fab; Dependent
- B.
Fab; Independent
- C.
Fc; Dependent
- D.
Fc; Independent
- 9.____ is frequently found on the surface of B cells co-expressed with____. These two classes are co-expressed not by class switching but by alternative processing of a primary RNA transcript. Both molecules expressed on the single mature B cell have the same binding specificity for antigen.
- A.
IgA & IgG
- B.
IgD & IgM
- C.
IgE & IgA
- D.
IgG & IgM
- E.
IgM & IgE
- 10.If alternative processing uses the first polyadenylation site, then what type of heavy chain mRNA is derived?
- A.
(alpha)
- B.
(gamma)
- C.
(delta)
- D.
(epsilon)
- E.
(mu)
- 11.If alternative processing uses the second polyadenylation site, then what type of heavy chain mRNA is derived?
- A.
(alpha)
- B.
(gamma)
- C.
(delta)
- D.
(epsilon)
- E.
(mu)
- 12.Production of secreted antibodies (pAs site) involves a____ chain of amino acids with a stretch of charged (versus non charged) amino acids at the____ terminus, in comparison to membrane bound antibody production (pAm site).
- A.
Shorter; NH2
- B.
Shorter; COOH
- C.
Longer; NH2
- D.
Longer; COOH
- 13.In heterozygous individuals who have, for example, inherited two alternative forms of the constant region gene for IgG1 (i.e., IgG1m(1) and IgG1m(2)), which of the following is true regarding the Ig expression by a particular B cell, according to allelic exclusion?
- A.
It will be of the IgG1m(1) type
- B.
It will be of the IgG1m(2) type
- C.
It will contain both types
- D.
It will contain neither type
- E.
It will contain only one of the types
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