Each polypeptide chain (heavy and light) on immunoglobulin has a variable (V) andconstant (C) region. Immunoglobulin chains are encoded by_____ that is/are rearrangedduring____ development to assemble a functional gene encoding either a heavy or a light chain.

A single continuous DNA sequence; B cell

A single continuous DNA sequence; T cell

During the development of B cells, the Ig gene segments are rearranged and brought next to each other to form a contiguous functional gene (somatic recombination). The complex of enzymes involved in somatic recombination in lymphocytes is called:

RAG-1 (Recombination-Activating Gene)

RAG-2 (Recombination-Activating Gene)

Which of the following is NOT true regarding the mechanisms of generating antibody diversity?

A single combination of light and heavy chains

V, D, and J gene segments are present in multiple copies (germline diversity)

VJ and VDJ gene segments can recombine in multiple combinations (combinatorial diversity)

Different sequences at the joint lead to greater antibody diversity (junctional diversity)

A single combination of light and heavy chains

Somatic hypermutation after antigenic stimulation

In heterozygous individuals who have, for example, inherited two alternative forms of the constant region gene for IgG1 (i.e., IgG1m(1) and IgG1m(2)), which of the following is true regarding the Ig expression by a particular B cell, according to allelic exclusion?

It will contain only one of the types

It will be of the IgG1m(1) type

It will be of the IgG1m(2) type

It will contain only one of the types

Anti Body Diversity In Immunology MCQ Quiz Question & Answers

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Anti Body Diversity In Immunology MCQ Quiz Question & Answers - Quiz

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Anti Body Diversity In Immunology MCQ Quiz Question & Answers

Each polypeptide chain (heavy and light) on immunoglobulin has a variable (V) andconstant (C) region. Immunoglobulin chains are encoded by_ that is/are rearrangedduring development to assemble a functional gene encoding either a heavy or a light chain.

Which of the following is only contained in heavy chains and not in light chains?

During the development of B cells, the Ig gene segments are rearranged and brought next to each other to form a contiguous functional gene (somatic recombination). The complex of enzymes involved in somatic recombination in lymphocytes is called:

In somatic recombination, the rearranges first. The region of the antibody molecule is generated via somatic recombination as it binds to the antigen and contains both a constant region and a variable region.

The two types of light chains are:

During the final step of synthesis for heavy and light immunoglobulin chains, which of the following peptides is cleaved?

Which of the following is NOT true regarding the mechanisms of generating antibody diversity?

is frequently found on the surface of B cells co-expressed with. These two classes are co-expressed not by class switching but by alternative processing of a primary RNA transcript. Both molecules expressed on the single mature B cell have the same binding specificity for antigen.

If alternative processing uses the first polyadenylation site, then what type of heavy chain mRNA is derived?

If alternative processing uses the second polyadenylation site, then what type of heavy chain mRNA is derived?

Production of secreted antibodies (pAs site) involves a chain of amino acids with a stretch of charged (versus non charged) amino acids at the terminus, in comparison to membrane bound antibody production (pAm site).

In heterozygous individuals who have, for example, inherited two alternative forms of the constant region gene for IgG1 (i.e., IgG1m(1) and IgG1m(2)), which of the following is true regarding the Ig expression by a particular B cell, according to allelic exclusion?

Anti Body Diversity In Immunology MCQ Quiz Question & Answers

Each polypeptide chain (heavy and light) on immunoglobulin has a variable (V) andconstant (C) region. Immunoglobulin chains are encoded by_____ that is/are rearrangedduring____ development to assemble a functional gene encoding either a heavy or a light chain.

Which of the following is only contained in heavy chains and not in light chains?

During the development of B cells, the Ig gene segments are rearranged and brought next to each other to form a contiguous functional gene (somatic recombination). The complex of enzymes involved in somatic recombination in lymphocytes is called:

In somatic recombination, the____ rearranges first. The____ region of the antibody molecule is generated via somatic recombination as it binds to the antigen and contains both a constant region and a variable region.

The two types of light chains are:

During the final step of synthesis for heavy and light immunoglobulin chains, which of the following peptides is cleaved?

Which of the following is NOT true regarding the mechanisms of generating antibody diversity?

____ is frequently found on the surface of B cells co-expressed with____. These two classes are co-expressed not by class switching but by alternative processing of a primary RNA transcript. Both molecules expressed on the single mature B cell have the same binding specificity for antigen.

If alternative processing uses the first polyadenylation site, then what type of heavy chain mRNA is derived?

If alternative processing uses the second polyadenylation site, then what type of heavy chain mRNA is derived?

Production of secreted antibodies (pAs site) involves a____ chain of amino acids with a stretch of charged (versus non charged) amino acids at the____ terminus, in comparison to membrane bound antibody production (pAm site).

In heterozygous individuals who have, for example, inherited two alternative forms of the constant region gene for IgG1 (i.e., IgG1m(1) and IgG1m(2)), which of the following is true regarding the Ig expression by a particular B cell, according to allelic exclusion?

Each polypeptide chain (heavy and light) on immunoglobulin has a variable (V) andconstant (C) region. Immunoglobulin chains are encoded by_ that is/are rearrangedduring development to assemble a functional gene encoding either a heavy or a light chain.

In somatic recombination, the rearranges first. The region of the antibody molecule is generated via somatic recombination as it binds to the antigen and contains both a constant region and a variable region.

is frequently found on the surface of B cells co-expressed with. These two classes are co-expressed not by class switching but by alternative processing of a primary RNA transcript. Both molecules expressed on the single mature B cell have the same binding specificity for antigen.

Production of secreted antibodies (pAs site) involves a chain of amino acids with a stretch of charged (versus non charged) amino acids at the terminus, in comparison to membrane bound antibody production (pAm site).