Immunology Quiz -the T Cell Receptor (Tcr)

15 Questions | By Smb6 | Updated: Mar 22, 2022 | Attempts: 1356

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1.

Superantigens such as staphylococcal enterotoxins bind to certain TCR____ chains and to MHC class II molecules. MHC binding does not involve the peptide groove. T cells can then release extremely high levels of cytokines, which lead to toxic shock syndrome (TSS) when they appear in the blood.
- A.
  
  Alpha
- B.
  
  Beta
- C.
  
  Delta
- D.
  
  Gamma
2.

Protein and nucleic acid sequence data have been obtained for many TCRs with different specificities. Analyses of these sequences suggest the existence of how many hypervariable (hv) regions within the variable region?
- A.
  
  1
- B.
  
  2
- C.
  
  3
- D.
  
  4
- E.
  
  5
3.

The biochemical structure of the T-cell receptor (TCR) of the!" type (95% of human TCRs) is comparable to a____ immunoglobulin____ fragment, having very short cytoplasmic tails.
- A.
  
  Secreted; Fab
- B.
  
  Secreted; Fc
- C.
  
  Membrane-bound; Fab
- D.
  
  Membrane-bound; Fc
4.

Where are#$ T cells generally found in the body (location of TCR rearrangement)?
- A.
  
  Spleen
- B.
  
  Bone marrow
- C.
  
  Thyroid
- D.
  
  Thymus
- E.
  
  Thalamus
5.

In comparison to alph beta T cells, lamba delta T cells____ and are hypothesized to be a____ line of immune defense.
- A.
  
  Recognize peptide antigens by MHC; Primary
- B.
  
  Do not recognize peptide antigens by MHC; Primary
- C.
  
  Recognize peptide antigens by MHC; Secondary
- D.
  
  Do not recognize peptide antigens by MHC; Secondary
6.

Which of the following best describes the location of the delta (#)-chain locus in human T-cell receptors?
- A.
  
  Chromosome 7
- B.
  
  Chromosome 7 within the alpha (!)-locus
- C.
  
  Chromosome 14
- D.
  
  Chromosome 14 within the beta (")-locus
- E.
  
  Chromosome 14 within the alpha (!)-locus
7.

Which of the following are located in chromosome 7 within human T-cell receptors?
- A.
  
  ) Alpha
- B.
  
  ) Beta
- C.
  
  Gamma
- D.
  
  A & B
- E.
  
  B & C
8.

Comparing the arrangement of TCR genes and BCR genes, the____ chain is analogous to the heavy (H) chain and the____ chain is analogous to the light (L) chain.
- A.
  
  Alpha (!); Beta (")
- B.
  
  Beta ("); Alpha (!)
- C.
  
  Delta (#); Gamma ($)
- D.
  
  Gamma ($); Delta (#)
9.

Which of the following TCR genetic chains contain D-segments, similar to immunoglobulin heavy chains?
- A.
  
  ) Alpha (!); Beta (")
- B.
  
  Delta (#); Gamma ($)
- C.
  
  Beta ("); Delta (#)
- D.
  
  Gamma ($); Alpha (!)
- E.
  
  Alpha (!); Delta (#)
10.

Which of the following TCR genetic chains contains V and J segments, similar to genes for immunoglobulin kappa and lambda light chains?
- A.
  
  Alpha (!); Beta (")
- B.
  
  Delta (#); Gamma ($)
- C.
  
  Beta ("); Delta (#)
- D.
  
  Gamma ($); Alpha (!)
- E.
  
  Alpha (!); Delta (#)
11.

The process used to increase antigen binding affinity is called somatic____ and occurs in____ cells but not____ cells.
- A.
  
  Cell hybridization; B; T
- B.
  
  Cell hybridization; T; B
- C.
  
  Hypermutation; B; T
- D.
  
  Hypermutation; T; B
12.

Deficiencies in____ lead to autosomal-recessive severe combined immunodeficiency disease (SCID).
- A.
  
  RAG-1
- B.
  
  RAG-2
- C.
  
  RAG-1 or RAG-2
- D.
  
  Both RAG-1 and RAG-2
13.

If both RAG-1 and RAG-2 mutations occur, which of the following is true?
- A.
  
  T cells will be absent but B and NK cells will be present
- B.
  
  T and B cells will be absent but NK cells will be present
- C.
  
  B cells will be absent but T and NK cells will be present
- D.
  
  B and NK cells will be present but T cells will be absent
- E.
  
  B, T, and NK cells will be absent
14.

If a B cell successfully rearranges the first heavy chain locus, it inhibits the rearrangement of the other heavy chain on the other chromosome. What is this called?
- A.
  
  Affinity maturation
- B.
  
  Allelic exclusion
- C.
  
  Class switching
- D.
  
  Somatic cell hybridization
- E.
  
  Somatic hypermutation
- F.
  
  V(D)J gene rearrangement
15.

Allelic exclusion is a process by which the protein from only one allele is expressed while other allele(s) are silenced. Allelic exclusion occurs (generally) in which of the following?
- A.
  
  B cells and TCR beta chains, but not in alpha chains
- B.
  
  B cells and TCR alpha chains, but not in beta chains
- C.
  
  TCR beta chains, but not in alpha chains or B cells
- D.
  
  TCR alpha chains, but not in beta chains or B cells
- E.
  
  B cells, TCR beta chains, and TCR alpha chains