How Much Do You Know About Apoptosis? Quiz
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What is apoptosis?
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Uncontrolled cell growth
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Programmed cell death
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Random mutation
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Cell division
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Apoptosis, or programmed cell death, is an essential biological process that maintains balance in the body by eliminating damaged or unnecessary cells. This Apoptosis Quiz will test your understanding of apoptosis mechanisms, the molecular pathways involved, and their role in health and disease.
Learn how apoptosis prevents uncontrolled cell growth, regulates immune responses, and plays a crucial role in development. See moreIf you are a student or simply curious about cell death, this quiz will challenge your knowledge with scientifically accurate questions. Understanding apoptosis is key to grasping its impact on cancer research, neurodegenerative diseases, and overall cellular health.
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- 2.
Which organelle plays a key role in apoptosis?
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Mitochondria
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Nucleus
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Golgi apparatus
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Lysosome
Correct Answer
A. MitochondriaExplanation
Mitochondria are central to intrinsic apoptosis, acting as energy regulators and cell fate determinants. When a cell receives stress signals, the mitochondrial membrane releases cytochrome c, which binds to apoptotic protease-activating factor-1 (Apaf-1) and forms the apoptosome. This complex activates caspase-9, initiating a caspase cascade leading to cell dismantling. Mitochondria also regulate apoptosis by controlling the balance between pro-apoptotic (Bax, Bak) and anti-apoptotic (Bcl-2, Bcl-xL) proteins. If apoptosis is dysregulated, excessive cell death can lead to degenerative diseases, while insufficient apoptosis allows cancerous cells to survive. Mitochondria thus serve as a checkpoint for cellular life and death.Rate this question:
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- 3.
Which protein family regulates apoptosis?
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Histones
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Caspases
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Collagens
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Actins
Correct Answer
A. CaspasesExplanation
Caspases (cysteine-aspartic proteases) are enzymes crucial for apoptosis. These proteases exist as inactive zymogens and require activation through cleavage. There are two types: initiator caspases (caspase-8, -9, -10) and executioner caspases (caspase-3, -6, -7). Initiator caspases receive apoptotic signals and activate executioner caspases, which dismantle cellular components by cleaving specific proteins. This cascade ensures an irreversible commitment to apoptosis. The precise regulation of caspase activity prevents unnecessary cell loss. Dysregulated caspase function is linked to cancer, where apoptosis is suppressed, and neurodegenerative diseases, where excessive apoptosis leads to neuron loss, emphasizing their critical role in cell survival.Rate this question:
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- 4.
What is the function of caspases in apoptosis?
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DNA replication
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Breaking down cellular components
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Energy production
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Protein synthesis
Correct Answer
A. Breaking down cellular componentsExplanation
Caspases execute apoptosis by cleaving proteins at specific aspartic acid residues, leading to controlled cellular disassembly. Activated by intrinsic or extrinsic pathways, they degrade key structural and regulatory proteins. Executioner caspases target cytoskeletal proteins, nuclear lamins, and DNA repair enzymes, ensuring cell collapse without inflammation. For example, caspase-3 cleaves poly(ADP-ribose) polymerase (PARP), preventing DNA repair and leading to fragmentation. The caspase cascade amplifies apoptotic signals, making the process irreversible. If caspases fail, defective cells may survive, increasing cancer risk. Conversely, overactivation causes excessive cell death, contributing to conditions like Alzheimer’s disease, making their regulation essential for health.Rate this question:
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- 5.
How does apoptosis differ from necrosis?
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It is a controlled process.
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It causes inflammation.
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It happens due to infection.
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It always results in cell survival.
Correct Answer
A. It is a controlled process.Explanation
Apoptosis is a highly regulated, controlled process, whereas necrosis results from external damage and causes inflammation. Apoptosis involves cell shrinkage, nuclear condensation, DNA fragmentation, and phagocytosis by immune cells, preventing immune response activation. In contrast, necrosis causes cell swelling, membrane rupture, and the uncontrolled release of cellular contents, triggering inflammation. The controlled nature of apoptosis ensures proper development and immune regulation. If apoptosis fails, unregulated cell growth can lead to cancer, while excessive apoptosis contributes to degenerative diseases. The ability to distinguish between apoptosis and necrosis is crucial in medical research, particularly for targeted therapies in cancer treatment.Rate this question:
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- 6.
What is the role of cytochrome c in apoptosis?
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Initiates caspase activation
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Repairs DNA
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Inhibits apoptosis
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Helps in mitosis
Correct Answer
A. Initiates caspase activationExplanation
Cytochrome c is a mitochondrial protein that plays a pivotal role in the intrinsic apoptotic pathway. When mitochondria experience stress, cytochrome c is released into the cytoplasm, where it binds to Apaf-1, forming the apoptosome. This complex recruits and activates caspase-9, which in turn activates executioner caspases, leading to cell death. This process ensures that cells with DNA damage, oxidative stress, or other defects do not survive. Cytochrome c release is tightly regulated by the Bcl-2 family of proteins, balancing pro-apoptotic and anti-apoptotic signals. Dysregulation can lead to excessive apoptosis (neurodegeneration) or insufficient apoptosis (cancer), highlighting its critical function.Rate this question:
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- 7.
Which pathway triggers apoptosis externally?
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Intrinsic pathway
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Extrinsic pathway
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Autophagy
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Endocytosis
Correct Answer
A. Extrinsic pathwayExplanation
The extrinsic pathway of apoptosis is triggered by external signals through death receptors on the cell membrane, such as Fas (CD95) and tumor necrosis factor receptor (TNFR). When ligands bind to these receptors, they recruit adaptor proteins and activate caspase-8, which directly activates executioner caspases or triggers the mitochondrial pathway. This mechanism allows immune cells to eliminate infected or dysfunctional cells. Unlike the intrinsic pathway, which responds to internal stress, the extrinsic pathway is crucial for immune surveillance and maintaining homeostasis. Dysregulation can result in immune disorders or cancer, making it a key target in apoptosis-related disease treatments.Rate this question:
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- 8.
What is a hallmark of apoptotic cells?
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Cell swelling
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Membrane blebbing
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Rapid mitosis
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Increased protein synthesis
Correct Answer
A. Membrane blebbingExplanation
Membrane blebbing is a hallmark of apoptosis, indicating cytoskeletal breakdown. During apoptosis, caspases cleave actin and other structural proteins, causing the plasma membrane to form small, rounded protrusions called blebs. These blebs help fragment the cell into apoptotic bodies, which are then engulfed by phagocytes. This process prevents inflammation and tissue damage. Blebbing differs from necrotic swelling, as apoptotic cells retain membrane integrity until clearance. Defective membrane blebbing can hinder apoptosis, contributing to uncontrolled cell proliferation and cancer. Conversely, excessive apoptosis, characterized by rapid blebbing, can lead to degenerative diseases, showing the importance of this process in cell death regulation.Rate this question:
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- 9.
Which gene is known as the "guardian of the genome" in apoptosis?
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TP53
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MYC
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BRCA1
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RAS
Correct Answer
A. TP53Explanation
TP53, known as the "guardian of the genome," regulates apoptosis by monitoring DNA damage. When damage is detected, p53 activates pro-apoptotic genes like Bax and Puma, promoting mitochondrial cytochrome c release and triggering caspase activation. If repair is impossible, p53 ensures cell death to prevent mutations. TP53 mutations are found in over 50% of cancers, leading to uncontrolled cell proliferation. A dysfunctional p53 pathway allows damaged cells to survive, increasing cancer risk. Conversely, excessive p53 activation can lead to tissue degeneration. Understanding p53's role in apoptosis is essential for developing targeted cancer therapies and maintaining cellular integrity.Rate this question:
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- 10.
What happens to apoptotic cells in the body?
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They burst open.
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They are engulfed by phagocytes.
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They turn into tumors.
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They multiply rapidly.
Correct Answer
A. They are engulfed by phagocytes.Explanation
Apoptotic cells are efficiently removed by phagocytes, preventing inflammation and tissue damage. After apoptosis, phosphatidylserine is exposed on the outer membrane, signaling macrophages to engulf and digest the dying cell. This process, called efferocytosis, ensures cellular debris is cleared without immune activation. In contrast, necrotic cells release contents that trigger inflammation. Defective apoptotic clearance contributes to autoimmune diseases, where dead cells accumulate and stimulate immune attacks. Overactive clearance may lead to excessive tissue loss. The balance between apoptosis and phagocytosis is crucial for immune tolerance, preventing chronic inflammation, and maintaining healthy tissue homeostasis in multicellular organisms.Rate this question:
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Mar 04, 2025Quiz Edited by
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Feb 24, 2025Quiz Created by
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