Hematology & Coagulation
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Cells for the transport of O2 and CO2 are:
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Erythrocytes
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Granulocytes
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Lymphocytes
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Thrombocytes
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Registry study questions
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- 2.
The majority of the iron in an adult is found as a constituent of:
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Hemoglobin
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Hemosiderin
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Myoglobin
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Transferrin
Correct Answer
A. HemoglobinExplanation
2/3 iron in the body is bound to HgbRate this question:
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- 3.
Erythropoietin acts to:
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Shorten the replication time of the granulocytes
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Stimulate RNA syntheses of erythroid cells
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Increase colony-stimulating factors produced by the B-lymphocytes
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Decrease the release of marrow reticulocytes
Correct Answer
A. Stimulate RNA syntheses of erythroid cellsExplanation
Erythropoietin actionRate this question:
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- 4.
The principle confirmatory test for hereditary spherocytosis is:
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Osmotic fragility
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Sucrose hemolysis
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Heat instability test
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Kleinhauer-Betke
Correct Answer
A. Osmotic fragility -
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- 7.
The characteristic morphologic feature in lead poisoning is:
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Macrocytosis
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Target cells (codocytes)
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Basophilic stippling
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Rouleaux formation
Correct Answer
A. Basophilic stippling -
- 8.
The term "shift to the left" refers to:
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A microscope adjustment
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Immature cell forms in the peripheral blood
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A trend on a Levy-Jennings chart
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A calibration adjustment on an instrument
Correct Answer
A. Immature cell forms in the peripheral blood -
- 9.
In order for hemoglobin to combine reversibly with oxygen, the iron must be:
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Complexed with haptoglobin
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Freely circulating in the cytoplasm
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Attached to transferrin
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In the ferrous state
Correct Answer
A. In the ferrous stateExplanation
Functional form of Fe (reduced)Rate this question:
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- 10.
What cell shape is most commonly associated with an increased MCHC?
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Teardrop cells
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Target cells
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Spherocytes
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Sickle cells
Correct Answer
A. SpherocytesExplanation
May be referred to as hyperchromic because of decreased MCHCRate this question:
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- 11.
A patient with polycythemia vera who is treated by phlebotomy is most likely to develop a deficiency of:
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Iron
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Vitamin B12
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Folic acid
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Erythropoietin
Correct Answer
A. IronExplanation
Iron loss with loss of bloodRate this question:
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- 12.
After the removal of red blood cells from the circulation hemoglobin is broken down into:
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Iron, porphyrin, and amino acids
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Iron, protoporphyrin, and globin
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Heme, protoporphyrin, and amino acids
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Heme, hemosiderin, and globin
Correct Answer
A. Iron, protoporphyrin, and globinExplanation
Normal degradation products of red blood cellsRate this question:
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- 15.
Using a supra vital stain, the polychromatic red blood cells below would probably be:
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Rubricytes (polychromatophilic normoblast)
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Reticulocytes
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Sickle cells
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Target cells
Correct Answer
A. Reticulocytes -
- 16.
In polycythemia vera, the hemoglobin, hematocrit, red blood cell count and red cell mass are:
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Elevated
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Normal
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Decreased
Correct Answer
A. Elevated -
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- 18.
The main function of the hexose monophosphate shunt in the erythrocyte is to:
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Regulate the level of 2,3-DPG
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Provide reduced glutathione to prevent oxidation of hemoglobin
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Prevent the reduction of heme iron
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Provide energy for membrane maintenance
Correct Answer
A. Provide reduced glutathione to prevent oxidation of hemoglobinExplanation
Maintains in Fe++ form by way of reduced glutathioneRate this question:
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- 19.
In the normal adult, the spleen acts as a site for:
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Storage of red blood cells
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Production of red blood cells
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Synthesis of erythropoietin
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Removal of imperfect and aging cells
Correct Answer
A. Removal of imperfect and aging cellsExplanation
Major site of destruction of senescent red blood cellsRate this question:
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- 20.
An enzyme deficiency associated with a moderate to severe hemolytic anemia after the patient is exposed to certain drugs and characterized by red cell inclusions formed by denatured hemoglobin in:
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Lactate dehydrogenase deficiency
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G-6-PD deficiency
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Pyruvate kinase deficiency
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Hexokinase deficiency
Correct Answer
A. G-6-PD deficiency -
- 21.
Supravital staining is important for reticulocytes since the cells must be living in order to stain the:
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Remaining RNA in the cell
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Iron before it precipitates
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Cell membrance before it dries out
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Denatured hemoglobin in the cell
Correct Answer
A. Remaining RNA in the cell -
- 22.
Peripheral blood smears from patients with untreated pernicious anemia are characterized by:
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Pancytopenia and macrocytosis
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Leukocytosis and elliptocytosis
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Leukocytosis and ovalocytosis
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Pancytopenia and microcytosis
Correct Answer
A. Pancytopenia and macrocytosis -
- 23.
Heinz bodies are:
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Readily identified with polychrome stains
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Rarely found in glucose-6-phosphate dehydrogenase deficient erythrocytes
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Closely associated with spherocytes
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Denatured hemoglobin inclusions that are readily removed by the spleen
Correct Answer
A. Denatured hemoglobin inclusions that are readily removed by the spleenExplanation
Formed with oxidization of Fe and formation of methemoglobinRate this question:
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- 24.
The light-colored zone adjacent to the nucleus in a plasmacyte is the:
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Ribosome
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Chromatin
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Mitochondria
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Golgi area
Correct Answer
A. Golgi areaExplanation
Morphological identifiable perinuclear haloRate this question:
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- 25.
Refer to the following illustration: Which curve represents the production of epsilon polypeptide chains of hemoglobin?
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A
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B
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C
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D
Correct Answer
A. A -
- 26.
Hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) is:
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Temperature-dependent
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Complement-independent
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Antibody-mediated
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Caused by a red cell membrane defect
Correct Answer
A. Caused by a red cell membrane defectExplanation
RBC membrane defect increases susceptibility to complement mediated lysisRate this question:
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- 27.
Phagocytosis is a function of:
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Erythrocytes
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Granulocytes
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Lymphocytes
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Thrombocytes
Correct Answer
A. Granulocytes -
- 28.
Which of the following sets of laboratory finding is consistent with hemolytic anemia?
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Normal or slightly increased erythrocyte survival; normal osmotic fragility
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Decreased erythrocyte survival; increased catabolism of heme
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Decreased serum lactate dehydrogenase activity; normal catabolish of heme
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Normal concentration of haptoglobin; marked hemoglobinuria
Correct Answer
A. Decreased erythrocyte survival; increased catabolism of heme -
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- 30.
Cells that produce antibodies and lymphokines are:
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Erythrocytes
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Granulocytes
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Lymphocytes
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Thrombocytes
Correct Answer
A. Lymphocytes -
- 31.
Which of the following characteristics are common to hereditary spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal hemoglobinuria?
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Autosomal dominant inheritance
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Red cell membrane defects
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Positive DAT
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Measured platelet count
Correct Answer
A. Red cell membrane defects -
- 32.
A 89-year-old Caucasian female was transferred from a nursing facility for treatment of chronic urinary tract infection with proteinuria. WBC: 10.0x10^3 RBC: 3.1x10^6 Hgb: 7.2 g/dL Hct: 24% MCV: 78 um^3 MCHC: 31% Serum iron: 29 ug/dL TIBC: 160 ug/dL Serum ferritin: 100 ng/mL These data are most consistent with which of the following conditions?
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Iron deficiency anemia
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Anemia of chronic inflammation
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Hemochromatosis
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Acute blood loss
Correct Answer
A. Anemia of chronic inflammationExplanation
RBC membrane defects are common to PNH, HS, and HERate this question:
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- 33.
A patient has the following lab data: RBC: 2.35x10^6/uL WBC: 3.0x10^3/uL Plt: 95.0x10^3 Hgb: 9.5 g/dL Hct: 27% MCV: 115 um^3 MCHC: 35% MCH: 40 pg Which of the following tests would contribute toward the diagnosis?
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Reticulocyte count
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Platelet factor 3
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Serum B12 and folate
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Leukocyte alkaline phosphatase
Correct Answer
A. Serum B12 and folate -
- 34.
The characteristic morphologic feature in folic acid deficiency is:
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Macrocytosis
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Target cells
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Basophilis stippling
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Rouleaux formation
Correct Answer
A. Macrocytosis -
- 35.
The following are compounds formed in the synthesis of heme:
- coproporphyrinogen
- porphobilinogen
- uroporphyrinogen
- protoporphyrinogen
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4,3,1,2
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2,3,1,4
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4,2,3,1
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2,1,3,4
Correct Answer
A. 2,3,1,4Explanation
Correct order of heme synthesisRate this question:
- 36.
The lab findings on a patient are as follows: MCV: 55 um3 MCHC: 25% MCH:17pg A stained slide of this patient would reveal a red cell picture that is:
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Microcytic, hypochromic
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Macrocytic, hypochromic
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Normocytic, normochromic
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Microcytic, normochromic
Correct Answer
A. Microcytic, hypochromic -
- 37.
Which of the following stains can be used to differentiate siderotic granules (Pappenheimer bodies) from basophilic stippling?
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Wright
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Prussian blue
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Crystal violet
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Periodic acid-Schiff
Correct Answer
A. Prussian blue -
- 38.
The M:E ratio in acute myelocytic leukemia is usually:
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Normal
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High
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Low
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Variable
Correct Answer
A. High -
- 39.
In which of the following disease states are teardrop cells and abnormal platelets most characteristically seen?
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Hemolytic anemia
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Multiple myeloma
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G-6-PD deficiency
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Myeloid metaplasia
Correct Answer
A. Myeloid metaplasiaExplanation
RBC morphology; disease state identifiicationRate this question:
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- 40.
The presence of excessive rouleaux formation on a blood smear is often accompanied by an increased:
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Retic count
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Sedimentation rate
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Hematocrit
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Erythrocyte count
Correct Answer
A. Sedimentation rate -
- 41.
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- 42.
The direct antiglobulin test is often positive in:
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Congenital hemolytic spherocytosis
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March hemoglobinuria
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Acquired hemolytic anemia
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Thalassemia major
Correct Answer
A. Acquired hemolytic anemiaExplanation
Positive DATRate this question:
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- 43.
Which of teh following is a significant feature of erythroleukemia/acute erythroid leukemia (DiGuglielmo syndrome)?
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Persistently increased M:E ratio
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Megaloblastoid erythropoiesis
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Marked thrombocytosis
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Decreased ferritin levels
Correct Answer
A. Megaloblastoid erythropoiesis -
- 44.
A red blood cell about 5 um in diameter that stains bright red and shows no central pallor is a:
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Spherocyte
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Leptocyte
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Microcyte
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Macrocyte
Correct Answer
A. Spherocyte -
- 45.
A patient has pancytopenia, decreased total serum iron, decreased serum iron binding capicity, and shows a homogeneous fluorescence pattern with a high titer on fluorescent anti-nuclear antibody test. This is suggestive of:
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Polycythemia vera
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Systemic lupus erythematosus
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Iron deficiency anemia
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Hemoglobin SC disease
Correct Answer
A. Systemic lupus erythematosus -
- 46.
Megaloblastic asynchronous development in the bone marrow indicates which one of the following?
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Proliferation of erythrocyte precursors
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Impaired synthesis of DNA
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Inadequate production of erythropoietin
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Deficiency of G-6-PD
Correct Answer
A. Impaired synthesis of DNA -
- 47.
Which of the following are found in association with megaloblastic anemia?
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Neutropenia and thrombocytopenia
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Decreased LD activity
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Increased erythrocyte folate levels
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Decreased plasma bilirubin levels
Correct Answer
A. Neutropenia and thrombocytopenia -
- 48.
The smear represented below displays:
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Congenital ovalocytosis
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Hemoglobin C disease
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Poor RBC fixation
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Delay in smear preparation
Correct Answer
A. Hemoglobin C disease -
- 49.
Factors commonly involved in producing anemia in patients with chronic renal disease include:
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Marrow hypoplasia
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Inadequate erythropoiesis
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Vitamin B12 deficiency
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Increased erythropoietin production
Correct Answer
A. Inadequate erythropoiesisExplanation
Erythropoietin production questionable in chronic renal diseaseRate this question:
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Mar 20, 2022Quiz Edited by
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Jun 14, 2012Quiz Created by
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