Pharmacology Of Hematopoiesis Quiz!

20 Questions | Total Attempts: 56

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Pharmacology Of Hematopoiesis Quiz!

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Questions and Answers
  • 1. 
    Where is erythropoietin produced?
    • A. 

      Proximal tubular cells of kidney

    • B. 

      β islet cells of pancreas

    • C. 

      Gallbladder

    • D. 

      Hepatic cells

  • 2. 
    Which of the following is not a function of erythropoietin?
    • A. 

      CFU-E proliferation

    • B. 

      Expansion of BFU-E cell population

    • C. 

      Release reticulocytes into circulation

    • D. 

      Regulates maturation of red cell blasts

    • E. 

      Increase phagocytic and cytotoxic potential of mature granulocytes

  • 3. 
    For patients with iron deficiency anemia who needs constant blood cell transfusions, a combination of what therapy would be beneficial?
    • A. 

      Iron

    • B. 

      Erythropoeitin

    • C. 

      Folic acid

    • D. 

      Vitamin D

  • 4. 
    Hypoxic conditions causes an increase in which intracellular molecule?
    • A. 

      CAMP

    • B. 

      GTP

    • C. 

      Calcium ions

    • D. 

      Cobalt

  • 5. 
    Before erythropoietin can be released into circulation, what molecule has to be activated?
    • A. 

      Protein kinase A

    • B. 

      Procaspase 8

    • C. 

      Methyltransferase

    • D. 

      IP3 receptor

  • 6. 
    An increase in what molecule promotes erythropoietin production?
    • A. 

      Hypoxanthine

    • B. 

      ATP

    • C. 

      Oxygen

    • D. 

      GM-CSF

  • 7. 
    In a patient currently undergoing chemotherapy, which of the following would best alleviate the duration of severe neutropenia?
    • A. 

      Myeloid growth factors

    • B. 

      Erythropoietin

    • C. 

      Methotrexate

    • D. 

      NSAIDs

  • 8. 
    Administering myeloid growth factors can have dose-limiting toxicities. What does this mean?
    • A. 

      Severe toxicities occur during the first cycle of therapy

    • B. 

      Deep thickening of skin due to irritation

    • C. 

      Appearance of local thrombophlebitis at infusion site

    • D. 

      The increase in body temperature following certain medications, such as a blood transfusions

  • 9. 
    What is the common treatment for sickle cell disease?
    • A. 

      Hydroxyurea

    • B. 

      Myeloid growth factors

    • C. 

      Pantothenic acid

    • D. 

      Cryoprecipitate transfusion to restore clotting factors

  • 10. 
    Over half of the body's iron is associated with:
    • A. 

      Hemoglobin

    • B. 

      Myoglobin

    • C. 

      Ferritin

    • D. 

      Transferrin

  • 11. 
    What vitamin increases iron absorption?
    • A. 

      Vitamin C

    • B. 

      Vitamin D

    • C. 

      Folic acid

    • D. 

      Pyridoxine

  • 12. 
    Which two vitamins assist with methionine synthesis?
    • A. 

      Vitamin B12

    • B. 

      Vitamin B9

    • C. 

      Vitamin B5

    • D. 

      Vitamin B6

  • 13. 
    Methyl groups from which vitamins are donated to Vitamin B12 for methionine synthesis?
    • A. 

      Vitamin B9

    • B. 

      Vitamin C

    • C. 

      Vitamin B6

    • D. 

      Vitamin K

  • 14. 
    Deficiency of vitamin B12 causes megaloblastic anemia due to:
    • A. 

      Decreased methionine synthesis interferes with protein synthesis, compromising production of new cells

    • B. 

      Decreased ability to donate methyl groups to proteins that are needed for DNA replication, such as DNA polymerase I

    • C. 

      Increased ability to replicate DNA, leading to increase in cell size

    • D. 

      No cobalamin binding to its receptor on bone marrow tissue, signaling the release of red cells

  • 15. 
    With what protein is vitamin B12 absorbed in the small intestine?
    • A. 

      Intrinsic factor

    • B. 

      Methyltransferase

    • C. 

      Albumin carrier protein

    • D. 

      IL-3

  • 16. 
    Is there a carrier protein for vitamin B12?
    • A. 

      Yes, transcobalamin II

    • B. 

      Yes, albumin carrier protein

    • C. 

      No

    • D. 

      Yes, intrinsic factor

  • 17. 
    What protein is necessary for the metabolism of folic acid?
    • A. 

      Pteroyl-γ-glutamyl carboxypeptidase

    • B. 

      Pancreatic lipase

    • C. 

      Trypsin

    • D. 

      Pepsin

  • 18. 
    Menke's disease is characterized by:
    • A. 

      Granulocytopenia and anemia

    • B. 

      Increased activity of copper dependent enzymes

    • C. 

      Megaloblastic anemia

    • D. 

      Spontaneous red cell aplasia

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